Composti eterociclici

M02322 - Parthenolide

M02705 - 5-Bromo-3-indolyl-b-D-galactopyranoside

Applications N-Nitroso-5-hydroxy Pyrrolidone is an N-Nitroso impurity, Nitrosamines are known carcinogens in a wide range of animal species.
References Ohshima, H., et al.: Cancer Lett., 26, 153, (1985);

Applications (2,4-Dioxo-thiazolidin-3-yl)-acetic Acid is a useful compound for preparation of novel thiazolidinedione-​hydroxamates as Zmp1 inhibitors.
References Slachtova, V., et al.: Eur. J. Med. Chem., 185, 111812 (2020)

Applications Ethyl 1-Piperazine-d8-acetate 2HCl is a useful isotopically labeled compound

Applications Methyl Hyroxy-2-(tetrahydro-2H-pyran-4-yl)acetate is a useful research intermediate for organic synthesis.

Applications 2-(Thiophen-2-yl)acetamide is used in preparation of [18F]Maleimide-based Glycogen synthase kinase-3β ligands for positron emission tomography imaging.
References Lee, Katarzyna N., et al.: PCT Int. Appl., (2018);

Applications Phenazine (cas# 92-82-0) is a compound useful in organic synthesis.

Applications 6-Ethoxy-3-hydroxypyrazine-2-carboxamide is a useful intermediate for organic synthesis.

Applications Phenazine methosulfate is a compound used to determine nitric oxide reductase activity. Used in the discovery of potent bromophenazine antibacterial agents against Staphylococcus.
References Watanabe, A. et al.: Neurosci., 339, 139 (2016);

Impurity Abacavir - In House Impurity
Applications rac 2-Azabicyclo[2.2.1]hept-5-en-3-one (Abacavir - In House Impurity) is a useful reagent in the synthesis of carbocyclic sugar amines, carbanucleosides, and carbocyclic dinucleotide analogues (1). rac 2-Azabicyclo[2.2.1]hept-5-en-3-one is also an intermediate of Abacavir (A104990), a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.
References (1) Slama, J.T., et al.: Biochemistry, 27, 183 (1988) (2) Jackson, A., et al.: Antivir Ther. 17, 19 (2012) (3) Yuen, G. J., et al.: Clin Pharmacokinet. 47, 351 (2008)

Applications pyridazin-4-ylmethanol (cas# 50901-43-4) is a useful research chemical.

Applications N-Nitroso-3-hydroxy Pyrrolidone is an N-Nitroso impurity, Nitrosamines are known carcinogens in a wide range of animal species.
References Ohshima, H., et al.: Cancer Lett., 26, 153, (1985)