Building Blocks

Versatile small molecule scaffold

Boc-His(Trt)-OH is a chemical compound that has been used in the laboratory to study uptake and binding of compounds. It is stable in complex with albumin, which has led to its use as a model system for studying hepatic steatosis. This chemical can be synthesized by solid-phase synthesis with trifluoroacetic acid and polypeptide synthesis. FT-IR spectroscopy has been used to characterize Boc-His(Trt)-OH, revealing its chemical diversity.

(-)-Corey lactone diol is a synthetic compound that is soluble in organic solvents. It is used for the synthesis of carbocyclic nucleosides, which are analogs of pyrimidine nucleosides. (-)-Corey lactone diol has been shown to inhibit cholesterol synthesis and the synthesis of alkene. (-)-Corey lactone diol also shows anti-inflammatory properties, which may be due to its inhibition of prostaglandin synthesis.

Phentolamine is a synthetic mesylate that is used as an antihypertensive agent, and for the treatment of Raynaud's syndrome and pheochromocytoma. Phentolamine is also used to prevent frostbite and to treat various types of shock. Phentolamine blocks alpha-2-adrenergic receptors, thereby decreasing sympathetic nerve impulses to the heart, blood vessels, kidneys, and other organs. This drug also acts as a histamine antagonist by blocking H1-receptors on vascular smooth muscle cells. Phentolamine has been shown to have no significant effects on 5-hydroxytryptamine (5HT) release in vitro or in vivo.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

2-Amino-6-chloropurine is a nucleophilic substituent that is used in the synthesis of 2-amino-6-chloropurine. It reacts with hydroxyl groups to form a palladium-catalyzed coupling reaction solution, which is then treated with hydrochloric acid and trifluoroacetic acid. The product is purified by crystallization and recrystallization. This compound has potent antitumor activity against carcinoma cell lines, but it has not been shown to have any effect against Mycobacterium tuberculosis.

Leu-Leu-Leu-OH is a pentapeptide that is used in cancer treatment to inhibit the growth of cancer cells. It prevents the production of proteins and, as a result, cell division. Leu-Leu-Leu-OH has been shown to be effective against tumor cells with an antibody that binds to the surface of cells. The monoclonal antibody is taken up by the cancer cells through receptor mediated endocytosis, which leads to inhibition of protein synthesis and cell death.

2-(2-Azidoethoxy)acetic Acid is a hydrophobic antibacterial agent that can be used to inhibit bacterial growth by disrupting the cell membrane. It has been shown to inhibit the growth of Staphylococcus aureus and Escherichia coli, which may be due to its ability to bind to the glutathione moiety in the bacterial cell membrane. 2-(2-Azidoethoxy)acetic Acid has been shown to have antimicrobial activity against both Gram-positive and Gram-negative bacteria in vitro. This compound is also able to cross the cell membrane, inhibiting bacterial replication in vivo.

3,6-Dichloropicolinonitrile is a peroxide that is used in the synthesis of organic compounds. It is produced by the reaction of sodium carbonate and hydrochloric acid with nitric acid as a catalyst. 3,6-Dichloropicolinonitrile has been shown to be more selective than other oxidizing agents such as hydrogen peroxide and potassium permanganate. The product can then be purified by adding diacetate, which selectively reacts with the chlorine to form acetyl chloride and glycolic acid. The resulting mixture can then be distilled to produce 3,6-dichloropicolinonitrile in high purity. 3,6-Dichloropicolinonitrile can also be used in electrochemical methods for the synthesis of cyanides or biochemically for virulent products such as pesticides and organic solvents.

Methyl trans-4-bromo-2-butenoate is a synthetic compound that contains a hydroxyl group and two bromine atoms. It is synthesized by the reaction of diethyl succinate, hydrogen, and piperazine in an aqueous solution. Methyl trans-4-bromo-2-butenoate has been shown to have antineoplastic activity in combination with epidermal growth factor (EGF) and carbohydrate conjugates. It also binds to cell surface receptors on the epidermal cells, inhibiting their growth. The structural formula of methyl trans-4-bromo-2-butenoate can be seen below: [[File:Methyltrans4bromobutanoate.png|thumb|300px|left|The structural formula of methyl trans-[4] -[bromo]-[2] -butenoate.]]

3-Methoxythiophene-2-carbaldehyde is a ligand that has been shown to form a stable complex with potassium chloride. This compound is also reactive, and can be stabilized in the reaction vessel. In the presence of sulfate ions, 3-methoxythiophene-2-carbaldehyde will react to form a phosphotungstic acid precipitate. The dehydrated salt can be recrystallized by adding phosphotungstic acid, which stabilizes the product.

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Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Used in the preparation of metal-diene reagents (e.g. for carbocyclization)

Methyl 5-hexynoate is a synthetic product that can be synthesized from soybean lipoxygenase and hydrogenation reduction. This product has been shown to be a useful synthon for the synthesis of monoclonal antibodies with high binding affinity. The synthetic pathway, which involves cross-coupling and asymmetric synthesis, is outlined in the diagram below. The following are the steps involved in the production of methyl 5-hexynoate: 1) Addition of ethyl bromide to terminal alkynes 2) Addition of hydrochloric acid 3) Reaction with potassium tert-butoxide 4) Hydrogenation reduction 5) Cross-coupling reaction 6) Asymmetric synthesis

Versatile small molecule scaffold

3-Cyano-2-methylphenylboronic acid is a high quality compound that can be used as a reagent, intermediate, or building block in the synthesis of complex compounds. This chemical is also useful as a speciality chemical and research chemical. 3-Cyano-2-methylphenylboronic acid has versatile uses in organic synthesis due to its versatility in reactions and building blocks.

Versatile small molecule scaffold

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Isocytosine is a prodrug that has been synthesized with the intramolecular hydrogen on the nitrogen atoms, which makes it more chemically stable. Isocytosine is a reactive molecule, and can react with tautomers to form isocytosine derivatives. Isocytosine contains three hydrogen atoms that are transferable through reactions to other molecules. The chemical stability of isocytosine allows for its use in wastewater treatment. It also has metabolic effects, such as the inhibition of colorectal adenocarcinoma and metabolic disorders. Isocytosine can be used as a model system for studying transfer reactions and reaction mechanisms.

2,4,6-Triphenylpyridine is an aromatic heterocycle with a benzyl group and trifluoroacetic acid at the 2-, 4-, and 6-positions. It is a colorless solid that has a melting point of 183 °C. In the gas phase, it exists as three anion radicals (2-, 4-, and 6-). These radicals are responsible for its optical properties. The 2-anion radical has a blue emission spectrum while the 4- and 6-anion radicals have red emission spectra. 2,4,6-Triphenylpyridine can be used as an indicator for trifluoroacetic acid or benzonitrile. It is soluble in primary alcohols such as methanol and ethanol at lower temperatures, but becomes insoluble at higher temperatures. 2,4,6-Triphenylpyridine also has functional theory applications due to its ability to

(Chloromethyl)cyclohexane is a synthase gene that is responsible for synthesizing the enzyme chloromethyl cyclohexane, which is used as a solid catalyst. The synthesis of (chloromethyl)cyclohexane from phenyl groups and liquid crystal composition has been demonstrated using expression plasmids and active oxygen. The compound inhibits inflammatory diseases by preventing the production of arachidonic acid, which is an inflammatory agent. This compound also inhibits the production of prostaglandins, which are involved in the release of histamine from mast cells. Pharmaceutical preparations that contain this compound are primarily used to treat rheumatoid arthritis and other inflammatory diseases.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

1-Hydroxycyclopentane-1-carbonitrile is a monomer that is hydrolyzed to form benzoin and cyanohydrins. It can be used in the production of scifinder as a monomer or dimerizer.

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4-Bromo-2,5-dimethoxybenzaldehyde is a nucleophilic compound that can act as an iminium. It is used in the synthesis of chalcones, which are aromatic compounds that have been found to have anticancer properties. 4-Bromo-2,5-dimethoxybenzaldehyde has two isomers: 2,4-dimethoxybenzaldehyde and 2,5-dimethoxybenzaldehyde. The separation of these compounds can be achieved using chromatography with a silica gel column. This process can be done on both the mixture of the two isomers or on one specific isomer. The synthetic pathway for this product begins with benzylpiperazine and piperazine. These two molecules react to form 3,4-dichlorobenzylpiperazine, which reacts with dimethoxybenzyl chloride to form 4-bromo-2,5-dim

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

3-Aminopyrrolidin-2-one hcl is an antibiotic that is used to treat tuberculosis. It inhibits the enzyme transacylase, which catalyses the conversion of L-lysine into L-pipecolic acid in bacteria. This antibiotic has been shown to be effective against Mycobacterium tuberculosis and Mycobacterium avium complex. 3-Aminopyrrolidin-2-one hcl has a broad spectrum of activity against gram positive and gram negative bacteria, but it is not active against acid-fast bacteria.

Versatile small molecule scaffold

2,3-Dihydro-1H-pyrrolo[3,2-c]pyridine is an alkaloid compound that has various applications in research and chemical studies. It has been found to interact with dopamine receptors and exhibit photothermal properties. This compound has been studied in the context of G. lucidum (also known as Reishi mushroom) and its potential therapeutic effects. Additionally, it has shown interactions with quinpirole, lithium, ergovaline, efrotomycin, and other compounds. The photocatalytic and fatty acid properties of 2,3-Dihydro-1H-pyrrolo[3,2-c]pyridine make it a versatile compound for various research purposes.

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2,4-Dibromopyridine is a brominated derivative of pyridine. It is synthesized through the substitution of two bromine atoms for two hydrogens on the pyridine ring. This synthesis can be achieved by disubstitution or cross-coupling reactions. The reaction products are nucleophilic and react with electrophiles to produce substitution products. The reaction mechanism is thought to involve a six-membered transition state, which has been observed using X-ray absorption spectroscopy.

Versatile small molecule scaffold

4-Acetamidobenzenesulfonyl azide (4ABS) is a low detection reagent that can be used for the determination of 4-acetamidobenzoic acid. It reacts with the amine group in 4-acetamidobenzoic acid to form a sulfonamide intermediate and releases an azide ion. The linear calibration curve was obtained using vibrational spectroscopy and has a detection sensitivity of 0.03 ppm. This method can also be used to determine the functional groups present in dopamine, which have been shown to affect electrochemical impedance spectroscopy measurements.

Versatile small molecule scaffold

3,5-Dimethylbenzaldehyde is an organic compound that is a colorless liquid. It has a chemical formula of C9H12O2 and is classified as an aldehyde. 3,5-Dimethylbenzaldehyde can be synthesized by the reaction of isopropyl palmitate with xylene in the presence of carbon as a source. The reaction time required for this synthesis is approximately one day. The major products of this reaction are 3,5-dimethylbenzaldehyde and 2-methylbutanal. This reaction mechanism can also be used to determine the concentration of urinary metabolites in human urine samples. Analysis of these samples requires an organic solvent such as hexane or dichloromethane. Kinetic data was collected from the rate at which zinc powder reacts with 3,5-dimethylbenzaldehyde over time at different concentrations. A kinetic experiment was conducted using c–h bond activation to produce 3,5-dimethoxy

ABX464 is a monoclonal antibody that targets bacterial translocation. It has been shown to have clinical efficacy in preventing the recurrence of inflammatory bowel disease. ABX464 binds to the M2 phenotype of macrophages and blocks the binding of chemoattractant protein to its receptor, leading to decreased inflammation and less bacterial translocation. It also prevents HIV infection by blocking viral attachment to CD4 cells and inhibiting HIV-1 replication.

Versatile small molecule scaffold

Diethyl Acetylphosphonate is a synthetic chemical that is used in the production of ethyl esters, which are used as intermediates for the production of epoxides. It has shown to be a bidentate ligand and reacts with primary amines. Diethyl Acetylphosphonate can be made by reacting phosphorus pentachloride with ethyl acetate and hydrochloric acid. The reaction mechanism is similar to that of other organophosphorus compounds, in which a phosphine oxide intermediate reacts with an organic halide. Diethyl Acetylphosphonate has shown to be effective in detergent compositions and triethyl orthoformate, as well as alkanoic acid.

2-Methoxy-benzenesulfonic acid is a synthetic chemical compound that is used in the production of polymers and other ester compounds. It can be produced by reacting benzenesulfonyl chloride with methanol in the presence of a strong acid catalyst. 2-Methoxy-benzenesulfonic acid reacts with radiation to produce reactive oxygen species that are capable of damaging cellular structures. The molecule contains an intramolecular hydrogen bond, which stabilizes the structure and helps to form hydrogen bonds with other molecules. 2-Methoxy-benzenesulfonic acid also has a hydroxyl group, which allows it to function as an acidic compound that can react with water and cause inflammation. This functional group also makes it soluble in water, allowing it to penetrate tissue structures.

Versatile small molecule scaffold

Versatile small molecule scaffold

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2-Methyl-5-nitrobenzaldehyde is a nitro compound that is used in the synthesis of dobutamine. It has been shown to undergo rearrangements, with the formation of 2-methyl-5-nitrophenol. Kinetic studies have shown that chlorine can be substituted for hydrogen at the 2 position, and this substitution leads to an increase in reactivity. 2-methyl-5-nitrobenzaldehyde also reacts with dopamine to form a ketone. The hydroxy group on this molecule is nucleophilic and can attack electrophiles, making it useful as an active site for synthetic reactions. This compound is also pyrophoric, which means it will spontaneously ignite in air and burn until all its fuel is consumed.

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Versatile small molecule scaffold

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Versatile small molecule scaffold

Versatile small molecule scaffold

Cabozantinib is a small molecule that is the first to target VEGFR-2, which is a receptor tyrosine kinase involved in the development of fibrosis. Cabozantinib inhibits the activity of VEGFR-2 by binding to its ATP-binding site and blocking the phosphorylation of downstream signaling pathways. Cabozantinib has been shown to have antifibrotic properties in both preclinical and clinical models. The drug candidate has been shown to reduce kidney fibrosis in animal models. The standard dose for cabozantinib was found to be 5 mg/kg, with a maximum tolerated dose of 20 mg/kg. In vitro studies have indicated that cabozantinib binds with high affinity to the ATP-binding pocket of VEGFR-2, exhibiting competitive inhibition against other kinases such as PDGFR-beta and cKit, as well as diaryliodonium (a specific inhibitor). Caboz

MW 20,000 - 30,000

Versatile small molecule scaffold

Versatile small molecule scaffold

4-Bromopyridine HCl is a chemical compound with the molecular formula C6H5BrN. It is an aromatic heterocycle and is used in organic synthesis as a coupling partner in cross-coupling reactions. The bromine atom of 4-bromopyridine is replaced by chloride, resulting in 4-chloropyridine. The chlorination reaction can be conducted using either hydrochloric acid or thionyl chloride. This process can be done on an industrial scale and the chlorinated product has been used in the manufacture of pharmaceuticals, dyes, and pesticides. The reaction mechanism for this substitution reaction involves a nucleophilic attack by chlorine on the pyridine ring at carbon atom 2 followed by displacement of hydrogen from the adjacent position on nitrogen atom 3. Acylation reactions are oxidation processes that involve conversion of carboxylic acids to acyl halides or acyl chlorides through treatment with acidified halogenating agents such

2,4-Dichloropyrido [2,3-D] pyrimidine is a regioselective chlorination agent that can be used for the synthesis of various organic compounds. It is often used in cross-coupling reactions to form carbon-carbon bonds. 2,4-Dichloropyrido [2,3-D] pyrimidine has been shown to give high yields and is selective for disubstituted or monosubstituted substrates. This compound is also useful for the functionalization of C-H bonds via palladium-catalyzed coupling reactions.

5-Bromo-2-iodopyridine is an antibiotic that is used to treat bacterial infections. It has been shown to inhibit the growth of bacteria by binding to the 50S ribosomal subunit. This drug also has a toxic effect on respiratory system cells, which may be due to its ability to induce apoptosis. 5-Bromo-2-iodopyridine interacts with DNA in a triazine ring and inhibits bacterial growth by inhibiting protein synthesis. The drug binds to the 50S ribosomal subunit at a site that is different from that of rifampin and other antibiotics. The reaction is catalyzed by palladium at high temperatures and takes place in organic solvents such as chloroform or benzene. This synthetic process can be made more efficient by using inexpensive starting materials, such as bromine, iodine, and acetone, rather than expensive starting materials like platinum or gold salts.

2,2-Paracyclophane is a high-sensitivity c-reactive protein (hsCRP) that has been isolated from the fungus Cryptococcus neoformans. This compound has shown to have anti-cancer properties in animal studies. 2,2-Paracyclophane binds to fatty acids and is soluble in water, which may be due to its hydrogen bonding with the hydroxyl group at C1. The crystal structure of this compound reveals that it has a cyclohexane ring and two fatty acids. The thermal expansion coefficient of this molecule is also high, which suggests that it may be suitable for use as a solid lubricant.

2-Bromo-3,3,3-trifluoro-1-propene is a chemical compound that has been synthesized in an asymmetric reaction. The reactant is bromopropane and the product is 2,2,2-trifluoropropene. The methylene group on the propene molecule is activated by the nucleophilic attack of a fluoride ion from hydrogen fluoride to form a cavity with a highly strained bond. The kinetic study of this reaction revealed that the activation energy for the reaction is 42 kJ/mol. Palladium-catalyzed coupling reactions are catalyzed by palladium and require nonpolar solvents such as toluene or dichloromethane. This type of reaction has been shown to be exothermic with an isolated yield of 1%.

3-Bromo-4-chloroaniline is a chloroaniline compound. It is synthesized by reacting hexamethylenetetramine with chlorine gas in the presence of formaldehyde and paraformaldehyde. 3-Bromo-4-chloroaniline has been used to produce other compounds, such as trimethylchlorosilane, which is used in the production of silicone rubber. Chloroanilines are toxic chemicals that can be found in the environment and react with formaldehyde to produce carcinogenic substances called halofuginones.

Versatile small molecule scaffold

Versatile small molecule scaffold

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8-Chloro-3,7-dihydro-1H-purine-2,6-dione is a reactive molecule that binds to the active site of bacterial cyclic nucleotide phosphodiesterases and inhibits their activity. This inhibition prevents the breakdown of cAMP and cGMP, which are important second messengers in eukaryotic cells. 8-Chloro-3,7-dihydro-1H-purine-2,6-dione is also a potent inhibitor of protein synthesis and has been used in research studies on wheat leaves.

4,5-Dihydroxy-2,3-pentanedione is a carbonyl compound that is the product of the oxidation of ascorbic acid. It is used in wastewater treatment and has antimicrobial properties against infectious diseases. This compound has been shown to inhibit protein synthesis by binding to the ribosome and preventing the formation of peptide bonds between amino acids. 4,5-Dihydroxy-2,3-pentanedione has also been shown to bind to plasma proteins, which may be due to its acyl chain structure. 4,5-Dihydroxy-2,3-pentanedione can be synthesized in a catalytic mechanism that involves dehydroascorbic acid and molecular oxygen.

Poly(dioxanone) is a biocompatible polymer that has been shown to promote bone growth in animal models. It is a cross-linking agent and can be used as an alternative to copper chromite, which is the most common cross-linking agent used in tissue engineering. Poly(dioxanone) has been shown to promote bone growth by stimulating the production of growth factors and increasing the activity of osteoblasts, cells that produce new bone. The material also promotes matrix deposition and remodeling, leading to increased bone density.

Versatile small molecule scaffold

Versatile small molecule scaffold