Building Blocks

BG45 is a mutant strain of the bacterium Lactobacillus plantarum that has been modified to express a protein that inhibits the growth of tumor cells. The BG45 bacterium is capable of inducing an inhibitory effect on cancer cell growth in vitro and in vivo. This inhibitory effect is due to the immunomodulatory effects of the bacterium, which are mediated by suppressing genes that are involved in immune response and lipid metabolism. Furthermore, BG45 has significant cytotoxicity when cultured with human cancer cells and suppressed tumor growth in murine xenografts. This bacterium also has lysine residues that can be used as an indicator for identifying nutrient-poor environments such as microenvironments, suggesting that it may have potential use as a probiotic for patients with gastrointestinal disorders. In vitro assays have shown that BG45 produces fatty acids, which may be responsible for its activity against tumors.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

D-Leucine-d10-N-Fmoc is a cox-2 inhibitor that inhibits the activity of cyclooxygenase enzymes, which are involved in the formation of prostaglandins from arachidonic acid. It has been shown to have an anticancer effect against cells in culture and also inhibits the growth of tumors in mice. D-Leucine-d10-N-Fmoc is a molecule with a structure similar to celecoxib, a selective COX 2 inhibitor that is currently used for treatment of arthritis. However, unlike celecoxib, D-Leucine-d10-N-Fmoc does not inhibit any other isoforms of cyclooxygenase.END>>

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

1-Bromo-4-N-phthalimido-2-butanone is a quinazolinone that has been shown to be active against a number of bacterial strains, including Staphylococcus aureus, Salmonella typhi, and Escherichia coli. It also has cytotoxic effects on the human breast cancer cell line MCF-7. 1-Bromo-4-N-phthalimido-2-butanone has been shown to inhibit the growth of human prostate cancer cells by binding to the DNA in these cells and inhibiting RNA synthesis. This drug also prevents the development of influenza A virus in mice by acting as an analgesic and an antitumor agent. The antiinflammatory activities of 1BBA may be due to its inhibition of prostaglandin synthesis.

Versatile small molecule scaffold

Versatile small molecule scaffold