Building Blocks

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>3-Methyl-3-phenylpiperidine is a tertiary amine that contains a quaternary carbon. It has three different conformers, which can be determined by the presence of trifluoromethanesulfonic acid. The tertiary amine has two hydrogen atoms on the nitrogen atom and one hydrogen atom on the methyl group. 3-Methyl-3-phenylpiperidine is stable at room temperature in ethanol and preferentially reacts with sodium borohydride to form sodium N-(3-methyl-3-phenylpiperidinium) borohydride. This compound also has an electron withdrawing substituent, so it will have a higher thermodynamic stability than benzene or pyridinium salts.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-Oxo-1,3-thiazolidine-4-carboxylic acid is an immunosuppressive agent that binds to the IL2 receptor. It has been shown in toxicological studies to have a low level of toxicity and no mutagenic activity. 2-Oxo-1,3-thiazolidine-4-carboxylic acid has also been shown to bind to DNA polymerase and inhibit the enzyme's activity in vitro. Clinical pathology studies on rats have shown that 2-Oxo-1,3-thiazolidine-4 carboxylic acid induces an increase in eosinophil cationic protein levels. The drug also inhibits growth factor β1 and can be used as a model system for leukemia inhibitory factor (LIF).</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>1-Cyclopropylurea is a synthetic anticancer drug that was originally developed as an antihypertensive agent. It has been shown to have inhibitory effects on cancer cells and inflammatory diseases, including cyclic nucleotide phosphodiesterase (cNPD) and b-raf. 1-Cyclopropylurea also inhibits the synthesis of epoxyeicosatrienoic acids (EETs) in vitro, suggesting that it may be useful for the treatment of cardiovascular diseases such as hypertension.<br>1-Cyclopropylurea has been shown to inhibit cell proliferation in culture by causing G2/M phase arrest and apoptosis. The mechanism of action of 1-cyclopropylurea is not well understood, but it has been suggested that the drug prevents the phosphorylation of b-raf, which prevents the activation of mitogen activated protein kinases (MAPKs).</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>N-Methyl-1,3-benzoxazol-2-amine is a linker molecule that has been used in the synthesis of chlorides, molecular ions, trifluoroacetic acid, bromoacetone, yields and benzyne. It is also a precursor to the synthesis of benzoxazoles and alkylhalides. This compound reacts with cyclization reactions such as imino and benzoxazole. N-Methyl-1,3-benzoxazol-2-amine is also used in the gas phase to synthesize phenacyls.</p>

<p>Versatile small molecule scaffold</p>