Building Blocks

PB-22 is a synthetic cannabinoid, which can be classified as a CB1 receptor agonist. It is one of the many cannabinoids that have been created in an attempt to circumvent drug laws by creating compounds that are similar to those found in cannabis but have different chemical structures. PB-22 has shown to increase locomotor activity and stimulate the cb1 receptor in mice. Magnetic resonance spectroscopy (MRS) and assays were used to determine the binding affinity of PB-22 for the CB1 receptor. The MRS data showed that PB-22 bound with high affinity to the CB1 receptor and had a lower affinity for CB2 receptors. This suggests that PB-22 may be more potent than other synthetic cannabinoids, such as JWH-018 and CP 55,940, which bind better with CB2 receptors than CB1 receptors.
PB-22 is an analog of JWH-073 and has been shown to have a stronger effect on locomotor activity than JWH

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

5-Carboxyoxindole is a synthetic compound that has been shown to be cytotoxic in vitro and in vivo. It has been found to bind to the DNA of cancer cells, preventing DNA synthesis and replication, resulting in cell death. The mechanism of 5-carboxyoxindole is not completely understood but it has been suggested that it inhibits the production of ATP, leading to cell death. Techniques used to synthesize this compound include multistep reactions with yields up to 69%. These reactions are typically carried out at room temperature, although they can also be performed under reflux or microwave conditions.

Versatile small molecule scaffold

2-Azido-1,3-difluorobenzene is a photoactive compound that can be used to form an azide. It has been shown to undergo photochemical reactions to form the triplet state and then isomerize to the singlet state. This reaction can be initiated by a laser beam or other light source, such as sunlight. The triplet state of 2-azido-1,3-difluorobenzene has been shown to react with organic molecules containing electron withdrawing groups on their molecules, such as 2-methoxy-2-methylpropane. When these two substances are mixed together, they react to form an isomerized product that has a carbonyl group in its structure. This reaction could be helpful for developing new synthetic methods for producing pharmaceuticals and other compounds with important functions in chemistry and physics.

Versatile small molecule scaffold

1-Benzothiophen-7-ol is a phenolic compound that is found in plants and fungi. It has been shown to be an antioxidant and interacts with other antioxidants to stabilize them. This molecule is also used for the synthesis of heterocycles. 1-Benzothiophen-7-ol has interactions with radicals, which are compounds that can cause damage to cells, proteins, and DNA. 1-Benzothiophen-7-ol can react with electrophiles to form covalent bonds, which makes it a good antioxidant. It is biocompatible and noncovalent, meaning that it does not bind strongly to cells or tissues. 1-Benzothiophen-7-ol also has structural features that make it an effective stabilizer for sulfur compounds.

1-Benzyl-3-bromopiperidin-2-one is an enantioselective synthesis of (R)-1-benzylpiperidin-2-one that has been shown to be effective against Pseudomonas cepacia and Pseudomonas aeruginosa. The enzyme pseudomonas lipase was used in the synthesis, which is immobilized onto a porous support to prevent it from being washed away by the organic solvent. This method results in a high yield of (S)-1-(benzyloxycarbonyl)piperidin-2-one, with little or no racemization.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold