Reagenti sintetici

<p>Applications 5-Chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine, is a Anaplastic lymphoma kinase (ALK) inhibitor.<br>References Marsilje, T. H., et al.: J. Med. Chem., 56, 5675 (2013);<br></p>

<p>Stability Hygroscopic<br>Applications One of the most biologically studied of the primary prostaglandins. Closely related to Prostaglandin E2 (PGE2) in that both prostaglandins are biosynthesized from the same precursors and that PGF2 is the synthetic reduction product of PGE2. Phospholipase A2 (PLA2) is a key enzyme for biosynthesis of PGF2α. Oxytocic; abortifacient.<br>References Granstrom, S., et al.: J. Biol. Chem., 246, 5254 (1971), Kubota, Y., et al.: Eur. J. Pharmacol., 467, 191 (2003), Crowell, J., et al.: Toxicol. Sci., 82, 614 (20040,<br></p>

<p>Impurity Acetazolamide Disulphide Impurity<br>Applications bis(2-Acetamido-1,3,4-thiadiazol-5-yl) Disulfide is an impurity of Acetazolamide (A161500), a carbonic anhydrase inhibitor. Diuretic. (Acetazolamide Disulphide Impurity)<br>References Srinivasu, P., et. al.: J. Pharmaceut. Biomed. Anal., 52, 142 (2010); Vitale, R., et al.: J. Med. Chem., 52, 5990 (2009); Bell, H., et al.: Am. J. Physiol., 297, R370 (2009); Maresca, A., et al.: Bioorg. Med. Chem. Lett., 19, 4929 (2009); Liu, Y., et al.: Anal. Bioanal. Chem., 395, 591 (2009)<br></p>

<p>Applications Potassium Dichromate is toxic if ingested, however has been used in tracing methods. Also, is used in treating patients suffering from COPD and related tracheal secretions.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Frass, M. et al.: Chest., 127, 936 (2005); Mascorro, J. et al.: Stain. Technol., 50, 391 (1975);<br></p>

<p>Applications An oral angiogenesis inhibitor targeting VEGFR and PDGFR.<br>References Olaussen, K., et al.: Oncogen., 28, 4249 (2009), Sleijfer, S., et al.: J. Clin. Oncol., 27, 3126 (2009), Chan, A., et al.: Drugs, 69, 167 (2009),<br></p>

<p>Applications Inhibits release of allergic mediators from mast cells. Antiallergic; antiasthmatic. Amlexanox, used to treat asthma and mouth sores in humans, may also be a promising treatment for type 2 diabetes and obesity (Nat. Med., DOI: 10.1038/nm.3082).<br>References Rankov, G., et al.: Ophthalmic Res., 22, 359 (1990), Greer, R.O., et al.: J. Oral Mxillofac. Surg., 51, 243 (1993); Chem. and Eng. News p. 43, Feb. 18, 2013<br></p>

<p>Applications Potassium fluoride is used as a catalyst in the Aldol condensation of nitroalkanes (e.g. 1-Nitrohexane [N496125]) and aliphatic aldehydes (e.g. 2-Propyl Valeraldehyde [P838325]). Potassium fluoride is also used as a reference standard for fluoride ion activity in analytical samples. Potassium fluoride is also found in dental products, and is thought to be toxic in high amounts.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kambe, S. &amp; Yasuda, H.: Bull. Chem. Soc. Japan, 41, 1444 (1968); Robinson, R., et al.: Anal. Chem., 43, 1862 (1971); Whitford, G.: Dent. Res., 66, 1056 (1987)<br></p>

<p>Stability Corrosive, Moisture Sensitive<br>Applications Sodium Ethoxide is used as a catalyst in the transesterification of fish oil to produce fatty acid ethyl esters using ultrasonic energy.<br> E0<br>References Armenta, R.E., et al.: J. Am. Oil Chem. Soc., 84, 1045 (2007)<br></p>

<p>Applications D-Cysteine is a strong inhibitor of Escherichia coli growth and also functions to provide inorganic sulfates for the sulfation of xenobiotics. D-Cysteine is a non-physiological isomer of L-Cysteine (C995000), and is not involved in protein or glutathione synthesis.<br>References Glazenburg, E., et al.: Biochem. Pharm., 33, 625 (1984); Klassen, C. &amp; Boles, J.: FASEB J., 11, 404 (1997); Soutourina, J., et al.: J. Biol. Chem., 276, 40864 (2001);<br></p>

<p>Applications Ranitidine (cas# 66357-35-5) was used as a standard for testing the therapeutic effect of brown propolis extract against aspirin and ethanol- induced gastric ulcers.<br>References Patil, M., et al.: Eur. J. Biomed. Pharma. Sci., 7, 620 (2020)<br></p>

<p>Applications A Cyclosporin A (C988900) analog, an immunosuppressant.<br>References Emmer, G., et al.: J. Med. Chem., 37, 1918 (1994), High, K., et al.: J. Biol. Chem., 269, 9105 (1994),<br></p>

<p>Applications Calcium nitrate tetrahydrate is a chemical used in the manufacture of fertilizers.<br></p>

<p>Applications Arbutin is a glycosylated hydroquinone extracted from bearberry plant. Arbutin is a known inhibitor of tyrosinase, which in turn prevents the formation of melanin. Arbutin is often used as a skin-lightening agent in cosmetic products.<br>References Magnusson, B., et al.: J. Invest. Dermatol., 52, 268 (1969), Goodwin, B., et al.: Contact Dermatitis, 7, 248, (1981), ,Itoh, M., et al.: J. Dermatol., 9, 223 (1982), Sugimoto, K., et al.: Biol. Pharm. Bull., 24, 510 (2004)<br></p>

<p>Applications Potassium Hydrogen Sulfate is a reagent used in organic synthesis and ceramics production.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kromer, M. et al.: Langmuir, 33, 13295 (2017); Sevsek, A. et al.: MedChemComm., 8, 2050 (2017);<br></p>

<p>Applications Acalabrutinib, is an experimental anti-cancer drug and a selective Bruton's tyrosine kinase (BTK) inhibitor. This kinase transmits signals from B-cell Receptor (BCR), and thus any genetic BTK mutation causes B-Cell immunodeficiency. Therefore, BTK inhibitors targeting B-cell signaling has shown great promise for the treatment of chronic lymphocytic leukemia (CLL).<br>References Byrd; et al. (2015). "Acalabrutinib (ACP-196) in Relapsed Chronic Lymphocytic Leukemia."; "AstraZeneca to buy Acerta for blood cancer drug". www.rsc.org. Chemistry World - Royal Society of Chemistry. Retrieved 24 December 2015.<br></p>

<p>Applications 6-O-α-D-Maltosyl-β-cyclodextrin is an additive to improve the solubility of quetiapine.<br>References Ogawa, N., et. al.: Chem. Pharm. Bull., 31, 809 (2013)<br></p>

<p>Applications Intermediate of Nafamostat mesilate (N210000).<br>References Rahimian, M., et al.: Biochemistry, 48, 1573 (2009),<br></p>

<p>Applications Lanreotide Acetate is a drug used in the control and prevention of glycemia and hypoglycemic brain damage without surgery in patients diagnosed with congenital hyperinsulinism. It improves outcomes in patients suffering from acromegalyresulting from invasive pituitary macroadenoma.<br>References Kuehnen, P. et al.: Horm. Res. Paediat., 78, 106 (2012); Li, Z. et al.: J. Int. Med. Res., 40, 517 (2012);<br></p>

<p>Applications Cobalt(II) thiocyanate is best known for the cobalt thiocyanate test (or Scott test), which is a proven screening test for the presence of cocaine.<br>References Swiatko, J., et al.: J. Forensic Sci., 48, 581 (2003); O’ Neal, C., et al.: Forensic Sci. Inter., 109, 189 (2000)<br></p>

<p>Stability Moisture Sensitive<br>Applications Tributylphenyltin acts as a reagent for the synthetic preparation of tetrahydroisoquinolines and SAR as potential HIV-1 antivirals.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Swidorski, J. J., et al.: Bioorg. Med. Chem. Lett., 26, 160 (2016)<br></p>

<p>Stability Moisture Sensitive<br>Applications Tris(trimethylsiloxy)silane functions as a modified siloxane elastomer for controlled cell growth or as a biomaterial surface that induces a desired cellular response.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gibson, A. L., et al.: Mater. Res. Soc. Symp. Proc., 711, 169 (2002)<br></p>

<p>Applications A biphosphonate bone resorption inhibitor.<br>References Fraser, W.D., et al.: Postgrad. Med. J., 73, 496 (1997),<br></p>

<p>Applications A group of nonpolar cyclic oligopeptides with immunosupppressant activity.<br>References van Wartburg, A., et al.: Prog. Med. Chem., 25, 1 (1988), Jorgensen, K.A., et al.: Scand. J. Imunol., 57, 93 (2003), Vollenbroeker, et al.: Transplant. Proc., 37, 1741 (2005),<br></p>

<p>Applications Elacridar Hydrochloride is a dual P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) inhibitor.<br>References Chuan Tang, S., et al.: Int. J. Cancer, 134, 1484 (2014); Durmus, S., et al.: Mol. Pharm., 9, 3236 (2012)<br></p>

<p>Applications 5-Amino-1-pentanol is an aliphatic amino alcohol with potential plasma lipid-lowering properties. 5-Amino-1-pentanol and other amino alcohols are used as emulsifying agents in dry-cleaning soaps, wax removers, cosmetics, paints and insecticides.<br>References Bondesson, G. et al.: Acta Pharm. Suec., 11, 417 (1974); Scheers, E.M. et al.: ALTA Alt. Lab. Anim., 30,309 (2002);<br></p>

<p>Applications Labelled D-Glucose is a simple sugar that is present in plants. A monosaccharide that may exist in open chain or cyclic conformation if in solution. It plays a vital role in photosynthesis and fuels the energy required for cellular respiration. D-Glucose is used in various metabolic processes including enzymic synthesis of cyclohexyl-α and β-D-glucosides. Can also be used as a diagnostic tool in detection of type 2 diabetes mellitus and potentially Huntington's disease through analysis of blood-glucose in type 1 diabetes mellitus.<br>References Wang, R., et al.: J. Mol. Catal. B. Enz., 56, 131 (2009); Springhorn, C. et al.: J. Clin. Endocrinol. Metab., 97, 4640 (2012); Hashimoto, K. et al.: J. Clin. Endocrinol. Metab., 97, 3016 (2012); Avelange, M. et al.: Plant. Phys., 94, 1157 (1990); Cramer, C. et al.: J. Chem. Soc., 115, 5745 (1993);<br></p>

<p>Applications A synthetic diethyl-ether of Estradiol with no distal hormonal effects, in patients undergoing surgical correction for stress urinary incontinence (SUI).<br>References Kelleher, C., et al.: Br. J. Obstet. Gynaecol., 104, 1374 (1997), Deffieux, X., et al.: J. Gynecol. Obstet. Biol. Reprod., 35, 678 (2006),<br></p>

<p>Stability Moisture Sensitive<br>Applications Has cytotoxicity and mutagenicity effects.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Abril, N., et al.: Mutat. Res., 497, 111 (2001), Liu, L., et al.: Cancer Res., 62, 3037 (2002), Liu, L., et al.: J. Biol. Chem., 279, 4250 (2004), Marsch, G., et al.: Chem. Res. Toxicol., 17, 45 (2004),<br></p>

<p>Applications Grubbs Catalyst, 1st Generation is a ruthenium-based olefin metathesis catalyst.<br>References Rosen, E.L., et. al.: J. Organomet. Chem., 745 (2013)<br></p>

<p>Applications 1,5,7-Triazabicyclo[4.4.0]dec-5-ene (cas# 5807-14-7) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Synthetic pyrethroid insecticide, which acts as a potent inhibitor of calcineurin (protein phosphatase 2B) and has an IC50 of about 100pM. This inhibition action results in cellular hyperexcitability by causing non-mutated calcium channels to remain open for an extended period of time allowing an abundance of Ca2+ to enter the cell.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kavlock, R., et al.: J. Environ. Pathol. Toxicol., 2, 751 (1979), Enan, E., et al.: Biochem. Pharmacol., 43, 1777 (1992), Tan, J., et al.: Mol. Biol., 32, 445 (2002),<br></p>

<p>Applications Used in the synthesis of Capsaicin analogues, useful for their anti-tumor activity.<br>References Fusco, B., et al.: Drugs, 53, 909 (1997), Buisman, G., et al.: Biotechnol. Lett., 20, 131 (1998), Kobata, K., et al.: Bios. Biotechnol. Biochem., 66, 319 (2002), Aluru, M., et al.: J. Exp. Bot., 54, 1655 (2003),; Wang, W. et al.: Gaodeng Xuexiao Huaxue Xuebao 31, 2400(2010)<br></p>

<p>Stability Light and Temperature Sensitive<br>Applications A fatty acid ester from marine oils; it is used for prophylaxis and treatment of hypertension, hypertriglyceridemia, hypercholesterolemia.<br>References Chan., et al.: Clin. Chem., 48, 877 ( 2002), Yokoyama, et al.: Lancet, 369, 109 (2007),<br></p>

<p>Applications 1,3-Dihydroxyacetone Dimer is used in the synthesis of dihydropyrimidine calcium channel blockers. Also used in the preparation of a new antineoplastic and antifilarial agents as anticancer agents.<br>References Atwal, K. et al., J. Med. Chem., 33, 1510 (1990); Ram, S. et al.: J. Med. Chem., 35, 539 (1992);<br></p>

<p>Applications Hydrazine Dihydrochloride (cas# 5341-61-7) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Stability Light Sensitive, Temperature Sensitive<br>Applications 13-cis-Retinol is one of the active metabolite of Vitamin A (R252000).<br>References Shantz, E., et al.: J. Biol. Chem., 183, A61 (1950), Barua, A., et al.: Biochem. J., 164, 133 (1977), Brouwer, I., et al.: Nutr. Res. Rev., 14, 267 (2001), Grillenberger, M., et al.: Br. J. Nutr., 95, 379 (2006),<br></p>

<p>Applications Antidyskinetic; antipsychotic. Neuroprotective product.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Janicki, C.A., et al.: Anal. Profiles Drug Subs., 9, 341 (1980), Beresford, R., et al.: Drugs, 33, 31 (1987)<br></p>

<p>Applications Irreversible inhibitor of ornithine decarboxylase, an enzyme involved in polyamine biosynthesis. Antineoplastic; antipneumocystic; antiprotozoal (Trypanosoma). Used in the treatment of hirsutism.<br>References Bacchi, C.J., et al.: Science, 210, 332 (1980); Haegele, K.D., et al.: Clin. Pharmacol. Ther., 30, 210 (1981); Meyskens, F.L., et al.: Clin. Cancer Res., 5, 945 (1999);<br></p>

<p>Applications α-Arbutin is a component used in the skin-whitening cosmetics.<br>References Magnusson, B., et al.: J. Invest. Dermatol., 52, 268 (1969), Goodwin, B., et al.: Contact Dermatitis, 7, 248, (1981), ,Itoh, M., et al.: J. Dermatol., 9, 223 (1982), Sugimoto, K., et al.: Biol. Pharm. Bull., 24, 510 (2004),<br></p>

<p>Applications Mercury(II)Oxide is used in the synthesis of a mercury based superconductor.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Shimoyama, J. et al.: Phys. Super. Appl., 224, 1 (1994); Maignan, A. et al.: Phys. C. Super., 243, 233 (1995);<br></p>

<p>Applications A silicone oil consisting of a mixture of fully methylated linear siloxane polymers end-blocking with trimethylsiloxy units. Commonly used in skin and hair products. Approximate M.W. 4000.<br>References Disapio, A. et al.: Int. J. Cosmet. Sci. 10, 75(1988)<br></p>

<p>Applications A neuroprotective effect of lithium carbonate in amyotrophic lateral sclerosis (ALS). Dyes and metabolites.<br>References Gordon, P., et al.: Lancet Neurol., 6, 1045 ( 2007), Shin, J., et al.: Mol. Pharmacol., 71, 965 (2007), Chio, A., et al.: Amyotroph. Lateral Scler., 10, 310 (2009),<br></p>

<p>Applications Adenosine receptors are related to many diseases such as cardiovascular, autoimmune, and cancer. CGS 21680 is a potent and selective agonist of the adenosine A2A receptor, a member of G protein coupled receptor (1,2,3).<br>References (1) Jones, K. R., et al.: Sci Rep. 7, 44816 (2017) (2) Hutchison, A. J., et al.: J. Pharm. Exp. Ther. 251, 47 (1989) (3) Hasko, G., et al.: Nat. Rev. Drug Discov. 7, 759 (2008)<br></p>

<p>Applications A non-peptide proteaseinhibitor.<br>References Ayoyama, T., et al.: Chem. Pharm. Bull., 33, 1458 (1985)<br></p>

<p>Applications Tetraethylammonium Bromide, can be used as a source of tetraethylammonium ions for various pharmaceutical studies. It has also the ability to block K+ channels in various tissues.<br>References Kevill, D.N., et al.: J. Am. Chem. Soc., 83, 3812 (1961); Armstrong, C.M. et al.: J. Gen. Physiol. 59, 388 (1972);<br></p>

<p>Applications Alizapride is a dopamine antagonist with prokinetic and antiemetic effects. Alizapride is used in the treatment of post-operative nausea and vomitting.<br>References Bleiberg, H. et al.: Cancer Chemother. Pharmacol., 22, 316 (1988);<br></p>

<p>Applications 9-Fluorenemethanol is used in the design and in the synthesis of novel type somatostatin analogs with antiproliferative activities on A431 tumor cells.<br>References Miyazaki, A., et al.: Tetrahedron Lett., 45, 6323 (2004)<br></p>

<p>Applications Methyl (S)-N-Tritylaziridine-2-carboxylate (cas# 75154-68-6) is a compound useful in organic synthesis.<br></p>

<p>Applications Ethyl 3-Furoate is the ethyl ester derivative of 3-Furoic Acid (F863770) and is used as a reagent in the synthesis of disubstituted furan derivatives which exhibit antidiabetic activity. Also used as a reagent in the synthesis of sulfonylfuran ureas as selective endothelial lipase inhibitors.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Babu, S.P., et al.: Pharma Chem., 4, 2178 (2012); Goodman, K.B., et al.: Bioorg. Med. Chem. Lett., 19, 27 (2009)<br></p>

<p>Applications A PDE7 inhibitor that has acceptable selectivity for in vivo studies. Potent PDE-7 inhibitor.<br>References Smith, S.J., et al.: Mol. Pharmacol., 66, 1679 (2004)<br></p>

<p>Applications Hepes<br></p>

<p>Applications 5-Chloro-1-Indanone is used as a reagent in the synthesis of novel tricyclic pyrazoles as CB1 and CB2 cannabinoid receptors. Also used in he synthesis of heteroarylmethylidene cubstituted compounds as selective inhibitors of aldosterone synthase.<br>References Ulmschneider, S. et al.: J. Med. Chem., 48, 1563 (2005); Ulmschneider, S. et al.: J. Med. Chem., 48, 1563 (2005);<br></p>

<p>Applications Angiotensin-converting enzyme (ACE) inhibitor. Hydrolyzed in vivo to the active diacid metabolite.<br>References Qizumi, K., et al.: Jpn. J. Pharmacol., 48, 349 (1988), Arita, M., et al.: Clin. Exp. Pharmacol. Physiol., 21, 195 (1994), Tokunaga, S., et al.: Drug Invest., 7, 161 (1994)<br></p>

<p>Applications Diethyl Pyrocarbonate is used as a reagents for the comparative pharmacokinectic study of quinic acid as a potent drug candidate for prostrate cancer. Also used in the study of the critical modulating role of histidine imidazole ring on the amyloidogenicity of insulin.<br>References Yang, X., et al.: J. Biochem., 157, 45 92015); Inbathamizh, L., et al.: Asian J. Pharm. Clin. Res., 6, 106 (2013)<br></p>

<p>Applications 3-Oxohexanedioic Acid is a degradation product of catechol in the presence of hydrogen peroxide; Also, it is derived from 3-Oxohexanedioic Acid Diethyl Ester (O856830), which is an intermediate used to prepare CMPF (C595000) which is a drug-binding inhibitor which is also a constituent of urine. CMPF can inhibit specific T4 binding in serum by increasing the free concentration of direct competitors.<br>References Gogoi, A., et al.: Chem. Eng. J., 311, 153-162 (2017); Mabuchi, H., Nakahashi, H.: Nephron, 44, 277 (1986); Lim, C.F., et. al.: Metabolism Clin. Exp., 42, 1468 (1993)<br></p>

<p>Stability Hygroscopic<br>Applications Labelled Vincristine. An antitumor alkaloid isolated from Vinca rosea Linn. An antineoplastic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Burns, J.H., et al.: Anal. Profiles Drug Subs., 1, 463 (1972), Owellen, D., et al.: J. Med. Chem., 15, 894 (1972),<br></p>

<p>Applications 4-Acetylbenzenesulfonyl Chloride is used as one of the substances for mutagenic and carcinogenic risk assessment of carboxylic and sulfonic acid halides as drug impurities. Also, acts as a reagent for the synthesis of (+)-Dehydroabietylamine derivatives which are targeted for triple-negative breast cancer treatment.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Amberg, A., et al.: Org. Process Res. Dev., 19, 1495 (2015); Ling, T., et al.: Eur. J. Med. Chem., 102, 13, (2015)<br></p>

<p>Applications Copper(II) Trifluoromethanesulfonate is a metal triflate catalyst and is used in the synthesis of (+)-Citronellal (C525025); a monoterpene compound that is formed by the metabolism of plants. (+)-Citronellal is a natural insect repellant, and is the main component of citronellal oil.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Daniel, L., et al.: J. Am. Oil Chem. Soc., 91, 325 (2014); Kwon, Y., et al.: Curr. Biol., 20, 1672 (2010); Lenardão, E., et al.: Tetrahedron, 63, 6671 (2007); Milone, C., et al.: Appl. Catal. A-Gen., 199, 239 (2000)<br></p>

<p>Applications An antineoplastic.<br>References Hertel, L.W., et al.: Cancer Res., 50, 4417 (1990), Abbruzzese, J.L., et al.: J. Clin. Oncol., 9, 491 (1991), Ruiz, V.W.T., et al.: Biochem. Pharmacol., 46, 762 (1993),<br></p>

<p>Applications Sodium Phosphate Monobasic Monohydrate is often used in foods and in water treatment. it can be used as a buffer to adjust pH. In medicine, it is sometimes used as a stimulant laxative before certain operations and medical procedures.<br>References Krajewska, B., et al.: Biocat. Biotrans., 23, 225 (2005); Aliabadi, H., et al.: Am. J. Health-System Pharm., 65, 441 (2008); Henderson, J., et al. Gastrointestinal endoscopy 42, 238 (1995)<br></p>

<p>Applications Sodium Acetate is used in the textile industry to neutralize sulfuric acid waste streams, and as a photoresist while using aniline dyes. Sodium Acetate may be added to foods as a seasoning.<br>References Clayden, J., et al.: Org. Chem., 1st ed. (2001); Zhang, Z. et al.: Org. Lett., 16, 3292 (2014);<br></p>

<p>Applications Ethyl 3-Phenylpropionate is also used in the synthesis pyrimidine based inhibitors of cyclin-dependant kinases. It is also used to preparation of inhibitor BB-3497.<br>References Markwalder, J. et al.: J. Med. Chem., 47, 5894 (2004); Davies, S. et al.: Bioorg. Med. Chem. Lett., 13, 2709 (2003);<br></p>

<p>Applications Phloroglucinol Dihydrate is a reactant used in the synthesis of [2-13C, 4-13C]-(2R,3S)-catechin and [2-13C, 4-13C]-(2R,3R)-epicatechin.<br>References Sharma, P.K., et. al.: J. Labelled Compd. Rad., 53, 605 (2010)<br></p>

<p>Applications Sodium Borohydride is used as a reagent in the reduction of amino acids and their derivatives. Also used in the catalysis of ammonia borane dehydrogenation.<br> E0<br>References McKennon, M. et al.: J. Org. Chem., 58, 3568 (1993); Denney, M. et al.: J. Am. Chem. Soc., 128, 12048 (2006);<br></p>

<p>Applications N-(n-Butyl)deoxygalactonojirimycin is an extremely potent and selective a-D-galactosidase inhibitor. A selective inhibitior of GlcCer synthesis.<br>References Paulsen, H., et al.: Chem. Ber., 113, 2601 (1980), Daniel, P.F., et al.: Proc. Int. Carbo. Symp., 13th, Ithaca, NY, Abstr. C43 (1986), Platt, F.M., et al.: J. Biol. Chem., 269, 27108 (1994)<br></p>

<p>Applications Lumiracoxib is a selective cyclooxygenase-2-(COX-2) inhibitor and an anti-inflammatory agent (1,2,3,4).<br>References (1) Bitner, M., et al.: Int. J. Clin. Pract., 58, 340 (2004) (2) Packman, E., et al.: Headache, 45, 1163 (2005) (3) Rordorf, C.M., et al.: Clin. Pharmacokinet., 44. 1247 (2005) (4) Schnitzer, T.J., et al.: Curr. Med. Res. Opin., 21, 151 (2005)<br></p>

<p>Applications 1,8-Dichloroanthraquinone is a reagent in the preparation of anthraquinones, which has antitumor activities.<br>References Barasch, D., et al.: Eur. J. Med. Chem., 34, 597 (1999)<br></p>

<p>Applications Sodium Pyrophosphate has been shown to enhance the rate of pyrophosphate hydrolysis by nonenzymatic catlysis and by inorganic pyrophoshatase. Pyrophosphoric Acid can be used for the preparation of vanadyl pyrophosphato methoxide cluster anion. Pyrophosphoric Acid is used in anion binding of inorganic phosphates due to is ability to form complexes.<br>References Stockbridge, R. B., Wolfenden, R.: J. Biol. Chem., 286, 18538 (2011); Herron, N., et. al.: J. AM. Chem. Soc., 119, 7149 (1997); Nation, D., et. al.: Inorg. Chem., 35, 4597 (1996)<br></p>

<p>Applications 1-(3-DIMETHYLAMINOPROPYL)-3-ETHYLCARBODIIMIDE (cas# 1892-57-5) is a useful research chemical.<br></p>

<p>Applications Ponatinib is a tyrosine kinase inhibitors (TKI) and used to treat chronic myeloid leukemia (CML) (1,2,3). Ponatinib is also used in combination with other drugs, such as forskolin, to combat TKI resistance in patient with CML (3), targeted drug in small-cell lung cancer. Potent FAK inhibitor. FGFR/VEGFR/Bcr-Abl inhibitor It is a COVID19-related research product.<br>References (1) Poch, M. M., et al.: Expert Rev Hematol. 9, 923 (2016) (2) Shamroe, C. L. and Comeau, J. M. Ann Pharmacother. 47, 1540 (2013)(3) Oaxaca, D. M., et al.: Tumour Biol. 37, 12643 (2016)<br></p>

<p>Applications Tributyl(vinyl)tin is used as a reagent in the palladium catalyzed synthesis of allyl and benzyl ethers. Tributyl(vinyl)tin is also a vinyl nucleophile for bromoacetylene and bromoaromatics.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Scott, W. et al.: J. Am. Chem. Soc., 108, 3033 (1986); Therrien, B. et al.: Angew. Chem. Int. Ed., 38, 405 (1999);<br></p>

<p>Applications Raclopride is a potent D2DR/D3DR antagonist.<br>References Ogren et al (1986) The selective dopamine D2 receptor antagonist raclopride discriminates between dopamine-mediated motor functions. Psychopharmacology 90 287. Hall et al (1989) Animal pharmacology of raclopride, a selective dopamine D2 antagonist. Psychopharmacol.Ser. 7 123. Seeman and Van Tol (1994) Dopamine receptor pharmacology. TiPS 15 264.<br></p>

<p>Applications Gold(III) chloride (CAS# 13453-07-1) is a useful research chemical compound.<br></p>

<p>Applications Ammonium Chloride is used as a main component and source of nitrogen in fertilizer.<br>References Crill, P. et al.: Soil Biol. Biochem., 26, 1331 (1994); Zaman, M. et al.: Biol. Fert. Soils, 29, 178 (1999);<br></p>

<p>Applications MK 1775 is used in biological studies for the abrogation of G2/M checkpoint through WEE1 inhibition in combination with chemotherapy as a promising therapeutic approach for mesothelioma.<br>References Indovina, P., et al.: Cancer Bilo. Ther., 15, 380 (2014);<br></p>

<p>Applications Bucindolol is a high-affinity, competitive beta blocker used in the treatment of congestive heart failure and hypertension.<br>References Hershberger, R., et al.: J. Cardiovasc. Pharm., 15, 959 (1990); Pollock, S., et al.: Am. J. Cardiol., 66, 603 (1990); Rotmensch, H., et al.: Am. J. Cardiol., 54, 353 (1984)<br></p>

<p>Applications It is a tight-binding, uncompetitive inhibitor of mitogen-activated protein kinase kinases (MEK) 1 and 2 currently in clinical development. It is useful as biomarker in human lung cancer cell. Potent MEK inhibitor.<br>References Ciardiello, F., et al.: Clin. Cancer Res., 7, 1459 (2001), Hidalgo, M., et al.: J. Clin. Oncol., 19, 3267 (2001),<br></p>

<p>Stability Hygroscopic<br>Applications 2-(N-Methyl-2-pyrrolidinyl)ethyl Chloride is an intermediate used in the synthesis of reversed lactam analogues of ARC-111 with potent topoisomerase I-targeting activity and cytotoxcity.<br>References Zhu, S.J., et al.: Bioorg. Med. Chem., 14, 3131 (2006); Tanaka, N., et al.: Chem. Pharma. Bull., 48, 245 (2000);<br></p>

<p>Applications Magnesium Stearate is used in the synthesis of mini matrices for improved drug delivery.<br>References Sujja-areevath, J. et al.: Eur. J. Pharm. Sci., 6, 207 (1998); Sangalli, M. et al.: J. Control. Released., 73, 103 (2001);<br></p>