Reagenti sintetici

<p>Applications rac FTY720 is a sphingosine 1-phosphate receptor modular, ameliorates experimental autoimmune encephalomyelitis by inhibition of T cell infiltration.<br>References Igarashi, J., et al.: J. Biol. Chem., 275, 32363 (2000), Bandhuvula, P., et al.: J. Biol. Chem., 280, 33697 (2005),<br></p>

<p>Applications Dofetilide is a potassium channel blocker. Antidysrhythmic drug.<br>References Carmeliet, D., et al.: J. Pharmacol. Exp. Ther., 262, 809 (1992); Norgaard, B.L., et al.: Am. Heart J., 137, 1062 (1999); Torp-Pedersen, C., et al.: N. Engl. J. Med. 341, 857 (1999);<br></p>

<p>Applications Trimethylamine is used as a reagent in the synthesis of L-Carnitine (C184110); an essential cofactor of fatty acid metabolism. L-Carnitine is required for the transport of fatty acids through the inner mitochondrial membrane and is synthetized primarily in the liver and kidney.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Mitchell, M.E., et al.: Am. J. Clin. Nutr., 31, 293 (1978); Lango, R., et al.: Cardiovasc. Res., 51, 21 (2001); Vaz, F.M., et al.: Biochem. J., et al.: 361, 417 (2002); Karlic, H., et al.: Nutrition, 20, 709 (2004); Wu, J., et al.: Faming Zhuanli Shenqing. CN 104030934 A 20140910. Sep 10, 2014<br></p>

<p>Applications Ammonium carbonate is a reagent that is used in the synthesis of D,L-Carbidopa (C175915 which is an inhibitor of aromatic amino acid decarboxylase.<br>References Sletzinger, M., et al.: J. Med. Chem., 6, 101 (1963),<br></p>

<p>Applications A synthetic, quaternary ammonium anticholinergic. Antispasmodic; preanesthetic medicant.<br>References Kaltiala, E., et al.: J. Pharm. Pharmacol., 26, 352 (1974), Kongsrud, F., et al.: Acta Anaesthesiol. Scand., 26, 620 (1982),<br></p>

<p>Applications A MEK inhibitor with antitumor activity.<br>References Lee, W., et al.: Bioorg. Med. Chem. Lett., 15, 3573 (2005), Normanno, N., et al.: J. Cell. Physiology, 207, 420 (2006), Narlawar, R., et al.: J. Med. Chem., 49, 7588 (2006),<br></p>

<p>Applications An inhibitor of serotonin (5-HT) uptake. Antidepressant.<br>References Christensen, A.V., et al.: Eur. J. Pharmacol., 41, 153 (1977), Keller, M.B., et al.: J. Clin. Psychiatry, 61, 896 (2000), Von Moltke, L.L., et al.: Drug Metab. Dispos., 29, 1102 (2001),<br></p>

<p>Applications Icilin is a potent agonist of the TRPM8 and ENaCδ ion channels.<br>References Noncovich, A., et al.: Bioorganic Med. Chem. Lett., 27, 3931-38 (2017);<br></p>

<p>Stability Light Sensitive<br>Applications Stereomeric with Cinchonidine (C441925). Antimalarial.<br>References Litchfield, J., et al.: J. Pharm. Exp. Ther., 96, 99 (1949), Trager, W., et al.: Science, 193, 673 (1976), Panisko, D., et al.: Drugs, 39, 160 (1990), Karle, J., et al.: Antimicrob. Agents Chemother., 36, 1538 (1992),<br></p>

<p>Applications Citraconic anhydride<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Stability Light Sensitive<br>Applications An unsaturated aldehyde used in the manufacture of polymers and synthetic resin. Cancer studies revealed consumption and release of this volatile organic compound in human small cell lung cancer line, a potential cancer biomarker.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sponring, A. et al.: Cancer Biomarkers, 7, 153 (2010); Ligor, M. et al.; Clin. Chem. Lab. Med., 47, 550 92009);<br></p>

<p>Applications β-Formylpropionic Acid is used in the synthesis of potent and orally available nonpeptide antagonist of human gonadotropin-releasing hormone receptor. It is also a reagent in the synthesis of human melanocortin-4 receptor antagonists with a pyrrolidinone moiety.<br>References Chen, C. et al.: J. Med. Chem., 51, 7478 (2008); Jiang, W. et al.: Bioorg. Med. Med. Chem. Lett., 17, 5610 (2007);<br></p>

<p>Applications An arginine-glycine-aspartate-mimetic, reversibly binds to platelets to reduce the risk of cardiac ischemic events.<br>References Pathak, A., et al.: Cardiovas. Diabetol., 7 (2008), Hantgan, R., et al.: Biochem., 48, 8355 (2009), Giugliano, R., et al.: New Eng. J. Med., 360, 2176 (2009),<br></p>

<p>Applications 1-Hexyne is a reagent used in the preparation of triazole hydroxamic acid derivatives as selective MMP-2 inhibitors using click chemistry. 1-Hexyne is a potent inhibitor of nitrification in soil. A reagent for the preparation of functionalized isoindolinones via ring closing metathesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Zapico, J., et al.: Anales de la Real Academia Nacional de Farmacia, 77, 99 (2011); El-Sayed, S., et al.: Alexandria Sci. Exchange, 24, 327 (2003); Pierce, J. G., et al.: J. Organomet. Chem., 692, 4618 (2007)<br></p>

<p>Applications (-)-α-Kainic Acid Monohydrate is the monohydrated form of (-)-α-Kainic Acid (K135010); a naturally occurring neuroexcitatory chemical that is a selective agonist for a subtype of ionotropic glutamate receptor. Administration of (-)-α-Kainic Acid has been shown to increase production of reactive oxygen species, mitochondrial dysfunction, and apoptosis in neurons in many regions of the brain, particularly in the hippocampal subregions and in the hilus of dentate gyrus.<br>References Wacker, D.A., et al.: Synlett, 503 (1997); Dunleavy, M., et al.: J. Molec. Neurosci., 49, 202 (2013); Zhang, J., et al.: Neuron., 76, 1133 (2012); Yamada, J., et al.: Neurosci., 226, 119 (2012); Wang,Q., et al.: Mol. Neurobiol., 31, 3 (2005)<br></p>

<p>Applications β-Glycerol Phosphate was shown to have promoted mineralization in vitro by modulating bone cell metabolic activity and/or serving as a local source of inorganic phosphate ions.<br>References Chung, C.H., et al.: Calcif. Tissue. Int., 51, 305 (1992);<br></p>

<p>Applications Cyclosporin is an immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection.A group of nonpolar cyclic oligopeptides with immunosupppressant activity.<br>References van Wartburg, A., et al.: Prog. Med. Chem., 25, 1 (1988), Jorgensen, K.A., et al.: Scand. J. Imunol., 57, 93 (2003), Vollenbroeker, et al.: Transplant. Proc., 37, 1741 (2005),<br></p>

<p>Applications Potassium Bisnonafluoro-1-butanesulfonimidate (cas# 129135-87-1) is a useful research chemical.<br></p>

<p>Applications Sclareolide is found in Salvia yosgadensis and is a close analog of sclareol, an antifungal diterpene.<br>References Topcu, G., et. al.: J. Nat. Prod., 59, 113 (1996); Jasinski, M., et. al.: Plant Cell, 13, 1095 (2001)<br></p>

<p>Applications (±)-Rolipram is a cAMP-specific phosphodiesterase 4 (PDE4) inhibitor.<br>References Xin, W., et. al.: J. Pharmacol. Exp. Ther., 349, 56 (2014);<br></p>

<p>Applications Ethyl Acetate is a chemical intermediate used in the production of various analgesics, antibiotics and antimalarial agents.<br>References Mutti, F.G., et al.: Adv. Syn. Cata., 354, 3409 (2012); Subudhi, B., et al.: Bull. Chem. Soc., Ethiopia., 26, 455 (2012);<br></p>

<p>Applications Sodium Triphosphate is used in method and device for preparing concrete board with adjustable light aggregate position.<br>References Zhong, B., et al.: Faming Zhuanli Shenqing, (2021);<br></p>

<p>Applications CDDO Methyl Ester is a synthetic triterpenoid that inhibits IκBα kinase and enhances apoptosis induced by TNF and chemotherapeutic agents through down-regulation of expression of nuclear factor κB-regulated gene products in human leukemic cells. CDDO Methyl Ester is a novel therapeutic agent in the treatment of acute myeloid leukemia and in the treatment of pancreatic cancer as well as other forms of cancer.<br>References Shishodia, S. et al.: Clin. Cancer Res., 12, 1828 (2006); Konopleva, M. et al.: Leukemia, 19, 1350 (2005); Deeb, D. et al.: Cancers, 2, 1779 (2010); Gao, X. et al.: J. Exp. Therap. Oncol., 9, 119 (2011);<br></p>

<p>Applications 2-Methylisoborneol solution - (CAS# 2371-42-8) is a useful research chemical compound.<br></p>

<p>Applications BARIUM CARBONATE (cas# 513-77-9) is a useful research chemical.<br></p>

<p>Applications (2R,3R)-rel-2,3-Dihydroxy-2-methylbutanoic Acid Sodium Salt, is the 3R-isomer of (2R,3S)-rel-2,3-Dihydroxy-2-methylbutanoic Acid (D453150); a synthetic organic compound used in studying the synthesis of chiral molecules from non-chiral reactants.<br>References Chenchaiah, P., et al.: J. Chem. Soc., Chem. Commun., 8, 436 (1982)<br></p>

<p>Stability Light Sensitive<br>Applications Thiacetic Acid is a commonly used reagent in organic synthesis for the introduction of thiol groups in molecules.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Chapman, J.H. et al.: J. Chem. Soc., 579 (1950); Hoque, A., et al.: Bioorg. Med. Chem. Lett., 22, 6770 (2012)<br></p>

<p>Applications Potassium Hydroxide is inorganic compound and strong base with many applications. It is used in the production of biodiesel. Potassium Hydroxide is also used in the manufacture of soaps.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Nadarajan, R., Ismail, R.: J. Surfactants Deterg., 14, 463 (2011); Hajek, M., et al.: Fuel, 96, 85 (2012);<br></p>

<p>Applications A tyrosine kinase inhibitor. Highly specific for BCR-ABL, the enzyme associated with chronic myelogenous leukemia (CML) and certain forms of acute lymphoblastic leukemia (ALL). It is a COVID19-related research product.<br>References Schindler, T., et al.: Science, 289, 1938 (2000), Drucker, B.J., et al.: N. Engl. J. Med., 344, 1031 (2001),<br></p>

<p>Stability Light Sensitive<br>Applications α-Methacrylic acid is used in chemistry as a stabilizing agent, forming a thin capping layer on the surface of nanoparticles. α-Methacrylic acid is also used as a surfactant, so that control is maintained during nanocrystal growth. α-Methacrylic acid is also used as a chelating agent.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Peng, W., et al.: J. Cryst. Growth, 279, 454 (2005); Qu, S., et al.: Appl. Phys. Lett., 80, 3605 (2002); Zhao, G., et al.: Phys. C: Supercond., 468, 2317 (2008)<br></p>

<p>Applications IHydroxylamine, is a useful reactant used that is mainly used as a reducing agent in organic reactions.<br></p>

<p>Applications Betrixaban is a novel anticoagulant. An oral direct inhibitor of factor Xa (FXa) for use in the prevention of venous thromboembolism (VTE).<br>References Turpie, A.G.G. et al.: Thromb. Haemost., 101, 68 (2009); Gomez-Outes, A. et al.: Curr. Vasc. Pharmacol., 7, 309 (2009);<br></p>

<p>Applications Deuterated Tolterodine (T535800), a muscarinic receptor antagonist. Used in the treatment of urinary incontinence.<br>References Nilvebrant, L., et al.: Life Sci., 60, 1129 (1997), Nilvebrant, L., et al.: Eur. J. Pharmacol., 327, 195 (1997), Brynne, N., et al.: Int. J. Clin. Pharmacol. Ther., 35, 287 (1997)<br></p>

<p>Applications 11α-Hydroxy Canrenone is the key intermediate in the synthesis of Eplerenone, a cardiovascular drug. Canrenone was biotransformed into 11α-Hydroxycanrenone by Aspergillus ochraceus SIT34205.<br>References Luetscher, J., et al.: J. Clin. Invest., 29, 1576 (1950), Gaunt, R., et al.: J. Clin. Endocrinol. Metab., 15, 621 (1955), McMahon, E., et al.: Curr. Opin. Pharm., 1, 190 (2001), McMahon, E., et al.: Curr. Pharm. Des., 9, 1065 (2003),<br></p>

<p>Applications Ipratropium Bromide is a nonselective muscarinic acetylcholine receptor antagonist; bronchodilator.<br>References Groeben, H., et al.: Anesthesiology, 85, 867 (1996); Haddad, et al.: Br. J. Pharmacol., 127, 413 (1999); Barnes, P. J., et al.: Chest, 117, 63S (2000)<br></p>

<p>Applications L-Homoserine Lactone Hydrobromide is a reactant in the synthesis of tritium labeled and photoactivatable N-acyl-L-homoserine lactones.<br>References Jakubczyk, D., et. al.: Eur. J. Org. Chem., 592, 2014 (2014)<br></p>

<p>Applications 6-Aminobenzothiazole is a useful intermediate in synthesizing N-phenyl-substituted and di-substituted guanidinyl benzothiazole derivatives. These derivatives act as antimicrobial and antioxidant agents.<br>References Mahesh, B., et al.: Res. Chem. Intermed., 42, 6195 (2016)<br></p>

<p>Applications A potent, selective, and orally bioavailable ATP-competitive mTOR kinase inhibitor with an IC50 of 0.8 nM. It inhibits the phosphorylation of mTORC1 substrates p70S6K and 4E-BP1 as well as phosphorylation of the mTORC2 substrate AKT and downstream proteins. The rapamycin-resistant T37/46 phosphorylation sites on 4E-BP1 were fully inhibited by AZD8055, resulting in significant inhibition of cap-dependent translation. In vitro, AZD8055 potently inhibits proliferation and induces autophagy in H838 and A549 cells. In vivo, AZD8055 induces a dose-dependent pharmacodynamic effect on phosphorylated S6 and phosphorylated AKT at plasma concentrations leading to tumor growth inhibition. Dual mTORC1/C2 inhibitor<br>References Chresta, C.M. et al.: Cancer Res., 70, 288 (2010); Sini, P. et al. Autophagy., 6 (2010); Marshall, G. et al.: Biochem. Soc. Trans., 39, 456 (2011);<br></p>

<p>Applications m-Toluic acid is used as a reagent in the preparation of hybrid molecules containing oxadiazole and thiadiazole bearing Schiff base moiety as it has antitumor activities.<br>References Zhang, K., et al.; Bioorg. Med. Chem. Lett., 24, 5154 (2014);<br></p>

<p>Applications VRT 043198, is an active metabolite of VX-765 (V900605), which is a Caspase inhibitor.<br>References Adriaenssens Y, et al.: Org Biomol Chem. 2017 Sep 13;15(35):7456-7473. doi: 10.1039/c7ob01403a. PubMed PMID: 28837200.<br></p>

<p>Applications Trimethylsilyl azide is used to mediate Schmidt rearragement reactions and is also used as a nucleophile in organic synthesis. Versatile azidonation reagent for amines, amides, aldehydes, and ketones.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Mphahlele, M.: J. Chem. Soc. Perk. T. 1, 23, 3477 (1999); Pastor, I. &amp; Yus, M.: Org. Chem., 9, 1 (2005)<br></p>

<p>Applications 3,4-Dimethoxy-3-cyclobutene-1,2-dione acts as a reagent for the synthesis and mechanism of action of squaramides with cytotoxic activity against human gastric carcinoma cells HGC-27.<br>References Quintana, M., et al.: MedChemComm, 7, 550 (2016)<br></p>

<p>Applications OCTADECYLTRIETHOXYSILANE (cas# 7399-00-0) is a useful research chemical.<br></p>

<p>Impurity Ziprasidone EP Impurity A<br>Applications 3-(1-Piperazinyl)-1,2-benzisothiazole (Ziprasidone EP Impurity A) is a reagent used to synthesize Ziprasidone (Z485000, HCl salt, monohydrate), a combined serotonin (5HT2) and dopamine (D2) receptor antagonist.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Prakash, C., et al.: Brit. J. Clin. Pharmacol., 49, 35S (2000); Orjales, A., et al.: J. Med. Chem., 46, 5512 (2003); Graham, J., et al.: Bioorg. Med. Chem. Lett., 18, 489 (2008); Bench, C.J., et al.: Psychopharmacology, 112, 308 (1993), Goldstein, J.M.: Exp. Opin. Invest. Drugs, 4, 291 (1995)<br></p>

<p>Applications LEE 011 can be used in biological study of kinome-wide RNA interference screen reveals a role for PDK1 in acquired resistance to CDK4/6 inhibition in ER-positive breast cancer.<br>References Jansen, V. M., et al.: Cancer Research, 77, 2488 (2017)<br></p>

<p>Applications 3,4-Dihydro-2H-benzo[b][1,4]oxazin-6-ol (cas# 26021-57-8) is a useful research chemical.<br></p>

<p>Applications Used in the synthesis of substituted terphenyls.<br>References Strukelj, M., et al.: Science, 267, 1969 (1995), Burroughes, J., et al.: Nature, 347, 589 (1990),<br></p>

<p>Applications Anhydrous silver(I) perchlorate is used in the engineering/chemical process of controlling silver nanoprism growth through plasmon excitation.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Jin, R., et al.: Nature, 425, 487 (2003)<br></p>

<p>Stability Hygroscopic<br>Applications Displays antibacterial properties due to the presence of the quaternary amine and the counter ion.<br>References Igalsbe, M. L. et al.; Bioorgan. Med. Chem Lett 19, 4984 (2009)<br></p>

<p>Applications Zinc Diethyldithiocarbamate is a chelating agent.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications N-Hydroxyphthalimide is used in the synthesis of a new class of antibacterials potent against macrolide resistant bacteria. Also used in the synthesis of pyrazolidines, isoxazolidines and tetrahydrooxazines.<br>References Agouridas, C. et al.: J. Med. Chem., 41, 4080 (1998); La Londe, R. et al.: Angew. Chem. Int. Ed., 49, 598 (2010);<br></p>

<p>Applications Sodium Bisulfite has been used as an additive used in the food and beverage industry. It is used to preserve apparent freshness. Used as a common general reagent in reduction reactions.<br>References W. Wright. et al.: Am. review Resp. Dis., 141, 1400 (1990);<br></p>

<p>Applications Sodium Hydrosulfite is used in the process of vat dyeing and as a reducing agent in solution.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Baumgarte, U., et al.: Textilveredlung, 2, 896 (1967); Ebel, R., et al.: Chem Lett., 9, 1091 (1977);<br></p>

<p>Applications Lesinurad is used to synthesize febuxostat which is a non-purine analog inhibitor of xanthine oxidase. Febuxostat is approved by the European Medicines Agency and the US Food and Drug Administration for treating gout.<br>References Burns, C., et al.: Lancet 377, 165 (2011); Miner, J. et al.: PCT Int. Appl. WO 2011159732 A1 20111222 (2011); Crittenden, D. B. et al.: Clinical Investigation 1, 1563-1575 (2011)<br></p>

<p>Applications Cyamemazine is an anxiolytic antipsychotic, which reduces ethanol withdrawal symptoms.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Robinson, et al.: J. Pharm. Pharmacol., 18, 19 (1966), Miller, L., et al.: J. Pharmacol. Exp. Ther., 246, 170 (1988), Podhorna, J., et al.: Curr. Pharm. Des., 8, 23 (2002), Hameg, A., et al.: Biochem. Pharmacol., 65, 435 (2003),<br></p>

<p>Applications Apatinib is an orally available, small molecule multitargeted tyrosine kinase inhibitor. Apatinib selectively inhibits the vascular endothelial growth factor receptor-2 (VEGFR2). Apatinib functions by inhibiting VEGF-mediated endothelial cell migration and proliferation thus blocking new blood vessel formation in tumor tissue. Recent studies have shown that Apatinib enhances the efficacy of conventional chemotherapeutical drugs in side population (SP) cells and ABCB1-overexpressing leukemia cells.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Mi, Y. et al.: Cancer Res., 70, 7981 (2010); Tong, X.Z. et al.: Biochem. Pharmacol., 83, 586 (2012); Ding, J, et al.: J. Chrom B Anal. Technol. Biomed. Life Sci., 895, 108 (2012);<br></p>

<p>Applications The R-enantiomer of Albuterol (A514500). A β2-adrenoceptor agonist. Bronchodilator; tocolytic.<br>References Han, et al.: Bioorg. Med. Chem., 14, 6043 (2006), Liyou, H., et al.: Biochem., 46, 1432 (2007), Agrawal, D., et al.: J. Allergy Clin. Immunol., 113, 503 (2004),<br></p>

<p>Applications 4-Hydroxyquinolineis a hydroxylated quinoline derivative with antimicrobial activity. 4-Hydroxyquinoline showed growth-inhibitory effects against intestinal bacteria. 4-Hydroxyquinoline act as sacrificial scavengers of the photogenerated oxygen species and has been shown to prevent the photodegradation of riboflavin.<br>References Kim, Y.-M. et al.: Food Sci. Biotechnol., 15, 817 (2006); Criado, S. et al.: J. Photochem. Photobiol. B Biol., 71, 19 (2003):<br></p>

<p>Applications Ethylenediamine-N,N'-diacetic Acid is a substance used in the preclinical evaluation of somatostatin analogs as new analogs in the detection of somatostatin receptor-positive tumors. Also acts as a reagent used in the synthesis of new class of aldehyde and aldose reductase inhibitors.<br>References Andleeb, H., et al.: RSC Advances, 6, 77688 (2016); Gandomkar, M., et al.: Nucl. Med. Biol., 34, 651 (2007)<br></p>

<p>Applications An angiotensin-converting enzyme (ACE) inhibitor. Antihypertensive.<br>References Lees, K.R., et al.: Brit. J. Clin. Pharmacol., 23, 159 (1987), Morgan, T., et al.: J. Cardiovasc. Pharmacol., 10, Supp. 7, S116, (1987)<br></p>

<p>Stability Hygroscopic, Moisture Sensitive<br>Applications Lead(IV) acetate is most commonly used in synthetic chemistry as an oxidizing agent, and is a versatile precursor for lead-containing compounds. Lead(IV) acetate is a toxic substance to humans, and is also known to induce oxidative damage and hyperlipidemia in rats.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Newairy, A., et al.: Food Chem. Toxicol., 47, 813 (2009); Rahman, S. &amp; Sultana, S.: Chem.-Biol. Int., 160, 61 (2006); Yadav, R.: Synlett, 2012, 1262 (2012)<br></p>

<p>Applications Vanadyl Meso-Tetraphenylporphine (1-3% Chlorin) (cas# 14705-63-6) is a useful research chemical.<br></p>

<p>Stability Hygroscopic<br>Applications NVP-BKM 120 is a novel anti-tumor active compound that is selective in that it inhibits specifically PI3 kinase activating cell death in glioma cells. Glioma cells being those that proliferate from tumors in the brain or the spine.<br>References Koul, D. et al.: Clin. Cancer Res., 18, 184 (2012);<br></p>

<p>Applications Mirtazapine is an α2-Adrenergic blocker; analogue of Mianserin. Antidepressant.<br>References De Boer, T., et al.: Neuropharmacology, 27, 399 (1988), Smith, W.T., et al.: Psychopharmacol. Bull., 26, 191 (1990)<br></p>

<p>Applications Abietic Acid is the primary component of resin acid found commonly in rosin. Abietic Acid exhibited potent testosterone 5α-reductase inhibitory activity in vitro.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Roh, S.-S. et al.: J. Health Sci., 56, 451 (2010); Harris, G.C. et al.: Org. Synth., 32, 1 (1963);<br></p>

<p>Applications WAY 127039-A-1 is a metabolite of Bromfenac sodium (B678550).<br>References Walsh, D.A., et al.: J. Med. Chem., 25, 446 (1982),<br></p>

<p>Stability Hygroscopic<br>Applications Cerivastatin is a competitive inhibitor of HMG-CoA reductase.<br>References Ness, C.G., et al.: Arch. Biochem. Biophys., 325, 242 (1996), Steinke, W., et al.: Japan. Pharmacol. Ther., 24, Suppl. 9, S1217 (1996),<br></p>

<p>Applications Apalutamide is a second-generation antiandrogen used in the treatment of prostate cancer.<br>References Li, Huifang, et al.: J. of Chem. Info. and Model., 53(1), 123-130 (2013);Joseph, James D., et al.: Cancer Disc., 3(9), 1020-1029 (2013)<br></p>

<p>Stability Hygroscopic<br>Applications Gondadotropin-releasing hormone agonist, used to treat hormone-responsive cancers such as prostate and breast cancer. Synthetic nonapeptide agonist analog of LH-RH. Antineolpastic (hormonal).<br>References Lam, P., et al.: Gynecol. Endocrinol., 24, 674 (2008), Chi, K., et al.: J. Urol., 180, 565 (2008), Menchaca, A., et al.: Theriogenol., 72, 477 (2009), Harada, T., et al.: Fertility and Sterility, 91, 675 (2009),<br></p>

<p>Applications Coprostan-3-ol is a 27-carbon stanol resulted from biohydrogenation of cholesterol in the gut of most higher animals. It is a common biomarker for the presence of human faecal matter in the environment (1,2).This compound is a contaminant of emerging concern (CECs).<br>References (1) Bull, I. D., et al.: Environ Int. 27, 647 (2002) (2) Bethell, P. H., et al.: J. Archaeol. Sci 21, 619 (1994)<br></p>

<p>Applications Decaborane is a useful building block mostly used in the preparation of carboranes. On its own, Decaborane is able to undergo reduction via acetate as a neat liquid.<br> E0<br>References Marsh, A. V.; et al.: Angew. Chem. Int. Ed., 57, 10640 (2018); Kelley, S. P.; et al.: ACS Omega, 3, 8491 (2018).<br></p>

<p>Stability Moisture Sensitive<br>Applications Reagent used to produce many guanidine based pharmaceuticals<br></p>

<p>Applications D-Citronellol is an monoterpene alcohol that is prevalent in essential oils of various aromatic plant species, such as Cymbopogon citratus.<br>References Brito, R.G., et al.: J. Nat. Med., 66, 637 (2012);<br></p>

<p>Applications 3-Oxohexanedioic Acid is a degradation product of catechol in the presence of hydrogen peroxide; Also, it is derived from 3-Oxohexanedioic Acid Diethyl Ester (O856830), which is an intermediate used to prepare CMPF (C595000) which is a drug-binding inhibitor which is also a constituent of urine. CMPF can inhibit specific T4 binding in serum by increasing the free concentration of direct competitors.<br>References Gogoi, A., et al.: Chem. Eng. J., 311, 153-162 (2017); Mabuchi, H., Nakahashi, H.: Nephron, 44, 277 (1986); Lim, C.F., et. al.: Metabolism Clin. Exp., 42, 1468 (1993)<br></p>