Reagenti sintetici

<p>Applications ABT-888 is a potent, orally bioavailable PARP-1/-2 inhibitor shown to potentiate DNA damaging agents. The ability to potentiate temozolomide (TMZ) and develop a biological marker for PARP inhibition was evaluated in vivo. Potent PARP inhibitor.<br>References Virag, L., et al.: Pharmacol. Rev., 54, 375 (2002), Tentori, L., et al.: Clin. Cancer Res., 9, 5370 (2003), Kim, M., et al.: Cell, 119, 803 (2004), Tentori, L., et al.: Pharmacol. Res., 52, 25 (2005),<br></p>

<p>Applications A tankyrase (TNKS) inhibitor that antagonizes Wnt signaling via stimulation of β-catenin degradation and stabilization of axin. XAV 939 inhibits proliferation of the μ-catenin-dependent colon carcinoma cell line DLD-1.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Huang, S. et al.: Nature, 461, 614 (2009); Wang, H. et al.: ACS Chem. Biol., 6, 192 (2011); Adles, M.E. et al.: Sci. Signal., 91, ec326 (2009);<br></p>

<p>Applications Iron(III) Chloride is commonly employed as a Lewis acid for catalysing reactions such as chlorination of aromatic compounds and Friedel-Crafts reaction of aromatics. In industrial application, iron(III) chloride is used in sewage treatment and drinking water production. It is also used as a leaching agent in chloride hydrometallurgy.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Cox, D., et al.: J. Am. Chem. Soc., 110, 8085 (1988); Tauxe-Wuersch, A., et al.: Water Res., 39, 1761 (2005); Trebouet, D., et al.: Water Res., 35, 2935 (2001)<br></p>

<p>Stability Very Hygroscopic<br>Applications Magnesium Chloride is used in magnesium replacement therapy for those deficient in magnesium. Effective anaesthetic for cephalopods.<br>References Iezhitsa, I. et al.: Nutr. Neurosci., 14, 10 (2011); Culloty, S. et al.: Aquaculture., 107, 249 (1992);<br></p>

<p>Applications Cetyltrimethylammonium hydrogensulfate 99% (cas# 68214-07-3) is a useful research chemical.<br></p>

<p>Applications 1,4-Dihydropyridine calcium antagonist with antihypertensive and diuretic effects. A potential candidate in the treatment of patients with renal parenchymal hypertension.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ohya, Y. et al.: Int. J. Clin. Pharmacol. Therap., 38, 304 (2000); Huh, W. S. et al.: Curr. Therap. Res., 61, 395 (2000); Katoh, M. et al.: Eur. J. Clin. Pharmacol., 55, 843 (2000);<br></p>

<p>Applications PAC-1 is a caspase 3 activator. Caspase activation is a key strategy in cancer therapy. Caspase 3 is a key executioner caspase and direct effector of apoptosis. Hallmark of many cancers is the circumvention of signal in the activation of executioner caspases and loss of apoptotic response. EC50 for caspase 3 activation = 0.33 μM and caspase 7= 4.5 μM. The IC50 for apoptosis induction = 0.92 μM. Elevated caspase 3 level in cancerous cell lines and tissues allows PAC-1 to selectively induce apoptosis in tissues.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Slee, E., et al.: J. Biol. Chem., 276, 7320 (2001), Pop, C., et al.: Biochemistry, 42, 12311 (2003), Li, L., et al.: Science, 305, 1471 (2004), Green, D., et al.: J. Clin. Invest., 115, 2610 (2005), Satoh, T., et al.: Clin. Cancer Res., 15, 3872 (2009),<br></p>

<p>Applications 2-Pyrrolidinylphosphonic Acid, is an impurity of Alendronate (A521250), a bisphosphonate used as a bone reabsoption inhibitor.<br>References Wang, X.M., et al.: Clin. J. Dent. Res., 3, 26 (2000), Woo, T., et al.: Best Pract. Res. Clin. Rheumatol., 15, 469 (2001), Benford, H.L., et al.: Bone, 28, 465 (2001),<br></p>

<p>Applications Phosphomolybdic Acid Hydrate functions as catalyst, and also use in the preparation of other catalyst, e.g. the preparation of highly active deep HDS catalysts prepared using Mo and W heteropolyacids supported on SBA-15. It is also a reagent for the preparation of molybdophosphate complexes of rare earth elememts. Dyes and metabolites.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lizama, L., et al.: Appl. Catal., B: Env., 82, 139 (2008); Xiao, Z., et al.: Fujian Shifan Daxue Xuebao, Ziran Kexueban, 2, 77 (1986)<br></p>

<p>Stability Moisture Sensitive<br>Applications Ethyl Malonyl Chloride is used as a reagent in the synthesis of novel thiadiazoloacrylamide analogs as inhibitors of dengue-2 virus NS2B/NS3 protease. Ethyl Malonyl Chloride is also used as a reagent in the synthesis of quinolone-benzylpiperidine derivatives as acetylcholinesterase inhibitors and antioxidant hybrids for Alzheimer disease.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Liu, H., et al.: Bioorg. Med. Chem., 22, 6344 (2014); Pudlo, M., et al.: Bioorg. Med. Chem., 22, 2496 (2014)<br></p>

<p>Applications Alkaloid naturally occurring in the d-form. Shows GABA antagonist activity.<br>References Curtis, et al.: Nature, 226, 1222 (1970), Avoli, M., et al.: J. Physiol. Pharmacol., 75, 526 (1997), Chebib, M., et al.: Clin. Exp. Pharmacol. Physiol., 26, 927 (1999),<br></p>

<p>Applications Ammonium Iron(II) Sulfate Hexahydrate (Mohr’s Salt) is used in analytical chemistry allowing products to resist oxidation. In addition it is used in the measurement of high doses of gamma rays.<br>References Hickman, C. et al.: Rad. Prot. Dent., 17, 255 (1986);<br></p>

<p>Applications Serotonin antagonist structurally related to Cyproheptadine. Antimigraine; appetite stimulant.<br>References Geraud, G., et al.: Clin. Ther., 26, 1305 (2004), Bolay, H., et al.: Nat. Med., 8, 136 (2002), Scher, A., et al.: Pain, 106, 81 (2003), Richter, F., et al.: J. Cereb. Blood Flow Metab., 25, 1225 (2005),<br></p>

<p>Applications A highly potent (IC50=4.3 nM) and uniquely specific tyrosine kinase inhibitor of a rationally engineered v-Src tyrosine kinase.<br>References Bishop, A.C., et al.: J. Am. Chem. Soc., 121, 627 (1999), Davies, S., et al.: Biochem. J., 351, 95 (2000), Regan, J., et al.: J. Med. Chem., 45, 2994 (2002), Bain, J., et al.: Biochem. J., 371, 199 (2003), Kuma, Y., et al.: J. Biol. Chem., 280, 19472 (2005),<br></p>

<p>Applications RAD 140 is a potent, orally bio-available, and non-steroidal selective androgen receptor modulator (SARM).<br>References Miller, C.P., et al.: ACS Med. Chem. Lett., 2, 124-129 (2011)<br></p>

<p>Applications Ethyl 3-Bromopyruvate is used in the preparation of 1,2,4-trisubstituted imidazoles as inhibitors of growth factor-β type I ALK5 inhibitors.<br>References Guo, C. et al.: Bioorg. Med. Chem. Lett., 23, 5850 (2013); Catarzi, D. et al.: Farmaco, 48, 447 (1993);<br></p>

<p>Applications (+)-Muscarine Chloride modulates calcium channel currents in rats.<br>References Stewart, A. E., et al.: J. Neurophysiol., 81, 72-84 (1999);<br></p>

<p>Applications 1-Chloropentane is used for studies on the antimicrobial activity of some halogenated hydrocarbons and their derivatives, effect of chlorinated hydrocarbons on the myelin sheath of peripheral nerve tissues.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kalatskaya, L. M., et al.: Fiziologicheski Aktivnye Veshchestva; 20, 77 (1988); Rumsby, M. G., et al.: J. Neurochem., 13, 1513 (1966)<br></p>

<p>Applications Tris(dibenzylideneacetone)dipalladium is used in the preparation of semiconducting polymers processed from nonchlorinated solvents into high performance thin film transistors. Also used in the synthesis of polymer bulk-heterojunction solar sells as a semiconductor.<br>References Matthews, J. et al.: Chem. Mat., 25, 782 (2013); Hwang, Y. et al.: Macromol., 45, 9056 (2012);<br></p>

<p>Applications Nickel(II) chloride anhydrous (cas# 7718-54-9) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 1,5-Diazabicyclo[4.3.0]non-5-ene is used as a nucleophilic catalyst for the Freidel-Crafts C-acylation of pyrroles and indoles. 1,5-Diazabicyclo[4.3.0]non-5-ene is also an inhibitor of indoleamine-N-methyltransferase (II) of rabbit lung in vitro.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Mandel, L.: Biochem. Pharmacol., 25, 2251 (1976); Taylor, J., et al.: Org. Lett., 12, 5740 (2010)<br></p>

<p>Applications Atosiban is an oxytocin receptor blocking agent in the treatment of experimental endometriosis and was shown exhibit significant therapeutic efficiency.<br>References Simsek, Y., et al.: Arch. Gynecol. Obstet., 286, 777 (2012); Mak, P., et al.: J. Psychopharmacol., 26, 532 (2012); Simsek, Y., et al.: Arch. Gynecol. Obstet., 285, 655 (2012);<br></p>

<p>Applications (1S,2S,3R,5S)-(+)-2,3-Pinanediol is a bicyclic monoterpene diols that has been shown to induce differentiation of S91 melanoma and PC12 pheochromocytoma cells and thus provide possible therapeutic and sunless tanning use. It is also used in the transformation of isopinocampheol and caryophyllene oxide.<br>References Brown, D.A. et al.: Pigment Cell Res., 12, 36 (1999); Noma, Y. et al.: Flav. Frag. J., 25, 161 (2010);<br></p>

<p>Stability Air Sensitive<br>Applications Thioglycolic Acid is an organic compound containing both a thiol and a carboxylic acid. Thioglycolic Acid is a precursor to ammonium thioglycolate, a chemical used for permanents. Thioglycolic Acid is used in organic synthesis as a nucleophile in thioglycolysis reactions and is used as a S transfer agent for sulfonyl chloride synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kim, T.R. et al.: Bull. Kor. Chem. Soc., 3, 162 (1982); Badr, M.Z.A. et al.: Bull. Chem. Soc. Jap., 56, 326 (1983); Langler, R.F. et al.: Can. J. Chem., 57, 3193 (1979);<br></p>

<p>Applications Azilsartan medoxomil is a long-acting angiotensin II receptor blocker (ARB) that is used to lower hypertension. When Azilsartan medoxomil enters the gastrointestinal tract, it is rapidly converted to its active form, Azilsartan (A926900).<br>References Baker, W. &amp; White, W.: Pharmacotherapy, 45, 1506 (2011); Cushman, W., et al.: Hypertension, 60, 310 (2012); Lastra, G., et al.: Cardio. Med. 3, 154 (2013); Miura, S., et al.: Hypertens. Res., 36, 134 (2012); Rakugi, H., et al.: Hypertens. Res., 35, 552 (2012)<br></p>

<p>Applications Sodium Chlorite is used as a bleaching agent for cotton textiles.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Shenai, V.A., Pai, S.M.: Textile Dyer Printer, 3, 153 (1969)<br></p>

<p>Applications (1R)-(+)-α-Pinene is used in hydroboration reactions and the reduction of ketones.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Brown, H. et al.: J. Org. Chem., 50, 1384 (1985);<br></p>

<p>Applications Tacrolimus Hydrate is a disease-modifying antirheumatic drugs (DMARDs)<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ogasawara, M., et al.: Mod. Rheumatol., 22, 831-836 (2012)<br></p>

<p>Stability Hygroscopic<br>Applications The R-enantiomer of Lansoprazole; a gastric proton pump inhibitor. An antiulcerative.<br>References Figgitt, D., et al.: Drugs, 60, 925 (2000), Katsuki, H., et al.: Eur. J. Clin. Pharmacol., 57, 709 (2001), Barradell, L.B., et al.: Drugs, 44, 225 (1992), Kim, K., et al.: Clin. Pharmacol. Ther., 72, 90 (2002), Niioka, T., et al.: Ther. Drug Monit., 28, 321 (2006),<br></p>

<p>Applications A selective 5-HT4 receptor agonist. Gastroprokinetic.<br>References Yoshida, N., et al.: Arch. Int. Pharmacodyn. Ther., 300, 51 (1989), Yatera, S., et al.: Japan. Pharmacol. Ther., 21, 21 (1993), Ruth, M., et al.: Aliment Pharmacol. Ther., 12, 35 (1998),<br></p>

<p>Applications Indigopurpurin is a purple 3,2-bisindole derivative and was shown to exhibit inhibitory allergic contact dermatitis via regulating T helper (Th)-mediated immune system in DNCB-induced model. A possible glycogen synthase kinase-3 (GSK-3) inhibitor the active component of a traditional Congolese antiepilepsy treatment.<br>References Kim, M.H., et al.: J. Ethnopharmacol., 145, 214 (2013); Tahtouh, T., et al.: J. Med. Chem., 55, 9312 (2012); Hsieh, W.L., et al.: J. Dermatol. Sci., 67, 140 (2012); Chem. and Eng. News page 6 Nov. 10 (2018)<br></p>

<p>Applications A nucleotide analog, useful as an oral reverse transcriptase inhibitor (ntRTI).<br>References Fliri, A., et al.: J. Med. Chem., 52, 8038 (2009), Fourches, D., et al.: Chem. Res. Toxicol., 23, 171 (2010), Ming, X., et al.: Biochem. Pharmacol., 79, 455 (2010),<br></p>

<p>Applications 3-Carboxyphenylboronic Acid is used in phenylboronic acid-decorated gelatin nanoparticles for enhanced tumor targeting and penetration.<br>References Wang, X., et al.: Nanotechnology, 27, 385101 (2016); Wang, X., et al.: Eur. J. Pharm. Biopharm., 113, 168 (2017)<br></p>

<p>Applications Labelled selective phosphodiesterase 4(PDE4) inhibitor. Antiasthmatic; in treatment of chronic obstructive pulmonary disease.<br>References Hatzelmann, A., et al.: J. Pharmacol. Exp. Ther., 297, 267 (2001), Schmidt, B.M.W., et al.: J. Allergy Clin. Immunol., 108, 530 (2001), Timmer, W., et al.: J. Clin. Pharmacol., 42, 297 (2002), Rabe, K.F., et al.: Lancet, 366, 563 (2005),<br></p>

<p>Applications Antipsychotic used in the treatment of schizophrenia.<br>References Nourian, Z., et al.: Eur. J. Pharmacol., 596, 32 (2008), Karczewski, J., et al.: Biochem. Pharmacol., 77, 1602 (2009), Isoherranen, N., et al.: Chem. Res. Toxicol., 22, 294 (2009), Goetghebeur, P., et al.: Psychopharmacol., 202, 287 (2009),<br></p>

<p>Applications N-Methyl-2-(4-nitrophenyl)ethanamine Hydrochloride is used as a reactant in the preparation of small molecule CDC25 phosphatases inhibitors.<br>References Contour-Galcera, Marie-Odile, et al.: Bioorg. &amp; Med. Chem. Let., 14(23), 5809-5812 (2004)<br></p>

<p>Stability Light Sensitive<br>Applications 2-Methyl-2-propen-1-ol has been used in the synthesis of C2-methyl-1,2-di-O-hexadecylglycerophosphocholine.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bittman, R., Witzke N.M.: Chem. Physics Lipid, 50, 99 (1989)<br></p>

<p>Applications The Shvo catalyst is an organoruthenium compound that is used for transfer hydrogenation<br>References Shvo, Y.; Czarkie, D.; Rahamim, Y. (1986). "A new group of ruthenium complexes: structure and catalysis". J. Am. Chem. Soc. 108 (23): 7400–2.<br></p>

<p>Applications Carphedone is a GABA derivative that exhibited apparent immunocorrection properties during immunosuppression induced by cyclophosphamide.<br>References Boghosian, T., et al.: J. Anal. Toxicol., 35, 613 (2011); Malykh, A.G., et al.: Drugs., 70, 287 (2010);<br></p>

<p>Stability Light Sensitive<br>Applications Methyl 2-Iodobenzoate is used as a reagent in the synthesis of Montelukast Sodium Salt (M568000); a selective leukotriene D4-receptor antagonist that is used as an antiasthmatic. Methyl 2-Iodobenzoate is also used as a reagent in the synthesis of isoquinolinone-based tricycles as polyribose polymerase-1 inhibitors.<br>References Bollikonda, S., et al.: J. Org. Chem., 80, 3891 (2015); Labelle, M., et al.: Bioorg. Med. Chem. Lett., 5, 283 (1995); Jones, T.R., et al.: Can. J. Physiol. Pharmacol., 73, 191 (1995); Markham, A. and Faulds, D.: Drugs, 56, 251 (1998); Chen, J., et al.: Bioorg. Med. Chem. Lett., 24, 2669 (2014)<br></p>

<p>Applications D-(-)-Tartaric Acid the synthetic enantiomer of L-(+)-Tartaric Acid (T007630), used in the preparation of synthetic analgesics.<br>References Van Bever, W. et al.: J. Med. Chem., 17, 1047 (1974);<br></p>

<p>Stability Very Hygroscopic<br>Applications Potassium trifluoroacetate (cas# 2923-16-2) is a useful research chemical.<br></p>

<p>Applications Used for preparation of hydrophilic polymers for biomedical devices.<br>References Delbressine, L., et al.: Xenobiotica, 11, 241 (1981), Gerberick, G., et al.: Toxicol. Sci., 97, 417 (2007),<br></p>

<p>Applications Used in the one-pot synthesis of 2-aminobenzimidazoles.<br>References Artman, G.D., et al.: Tetrahedron Lett., 51, 5319 (2010),<br></p>

<p>Applications A chelator that could replace disferrioxamine. It is orally and parenterally effective in the removal of iron in vivo from rabbits and mice and also from transferrin and ferritin in vitro.<br>References Kontoghiorghes, G.J.: Lancet I, 817 (1985), Kontoghiorghes, G.J., et al.: Br. J. Haematol., 62, 607 (1986), Kontoghiorghes, G.J., et al.: Biochem. Biophys. Acta, 869, 141 (1986), Kontoghiorghes, G.J., et al.: Arzneim.-Forsch., 37, 1099 (1987),<br></p>

<p>Applications Benzensulfonic Acid Monohydrate is used in the synthesis of HER2/EFGR dual inhibitors in the treatment of cancers and displaying potency towards anti-tumor activity.<br>References Kawakita, Y. et al.: Bioorg. Med. Chem. Lett., 20, 6171 (2012);<br></p>

<p>Applications 2-Chloroethyl isocyanate is used as a reagent and building block in chemical synthesis. In particular, it is used in the preparation of functionalized aminobenzoboroxoles which are potential anti-cancer agents and also the synthesis of 3-(2-chloroethyl)-5-methyl-6-phenyl-8-(trifluoromethyl)-5,6-dihydropyrazolo[3,4-f][1,2,3,5]tetrazepin-4-(3H)-one which also exhibit antiproliferative activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Suman, P., et al.: J. Organomet. Chem., Ahead of Print (2015); Maggio, B., et al.: Eur. J. Med. Chem., 96, 98 (2015)<br></p>

<p>Applications An anti-ulcer drug. Potent PDE4 inhibitor<br>References Kishimoto, A., et al.: J. Periodont. Res., 43, 508 (2008), Masuyama, H., et al.: Ther. Res., 29, 415 (2008), Fliri, A., et al.: J. Med. Chem., 52, 8038 (2009),<br></p>

<p>Applications MTEP Hydrochloride is a potent mGlu5 receptor antagonist, acting as a negative allosteric modulator.<br>References Hao, J. et al.: Bioorg. Med. Chem. Lett., 23, 1249 (2013);<br></p>

<p>Applications DMTMM, a conjugating agent that efficiently conjugat PnPS to Luminex microspheres without affecting the antigenicity of a broad set of PnPS.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Wrzesien, J. &amp; Graham, D.: Tetrahedron, 68, 1230 (2012); Schlottmann, S. et al.: J. Im. Meth., 309, 75 (2006)<br></p>

<p>Applications DL-Dapoxetine HCl (cas# 1071929-03-7) is a useful research chemical.<br></p>

<p>Applications An irreversible inhibitor of the mammalian DNA repair protein, O6-alkylguanine-DNA alkyltransferase. Assists in the protection against carcinogenic and therapeutic alkylating agents.<br>References Dolan, M.E., et al.: Proc. Natl. Acad. Sci. USA, 87, 5356 (1990), Goodtzova, K., et al.: Biochemistry, 33, 385 (1994), Elder, R.H., et al.: Biochem. J., 298, 231 (1994)<br></p>

<p>Applications Saxagliptin Hydrate is a selective and reversible dipeptidyl peptidase-4 (DPP4) inhibitor that may be used to develop treatment for type 2 diabetes.<br>References Gu, S., et al.: PLoS One. 11, e0167190 (2016); Dave, D. J.: J Pharmacol Pharmacother 2, 230 (2011)<br></p>

<p>Applications Furyl Hydroxymethyl Ketone is a reagent in the preparation of 3-iodocoumarins. Also used in the preparation of quinoxalines generally used in dyes and pharmaceuticals.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Reddy, M. et al.: J. Org. Chem., 78, 5878 (2013); Cho, C. et al.: J. Mol. Catal. A. Chem., 276, 205 (2007);<br></p>

<p>Applications N-(Benzyloxycarbonyl)ethanolamine is an intermediate used to prepare alkynylaryladenines as A2A adenosine receptor agonists and effects on hepatic glucose production. It is also used in the synthesis of functionalized N-arylaminoethyl amides as noncovalent inhibitors of cathepsin S.<br>References Harada, H., et al.: Bioorg. Med. Chem., 9, 2709 (2001); Tully, D., et al.: Bioorg. Med. Chem. Lett., 16, 5112 (2006)<br></p>

<p>Applications VX 809 is used in the stabilization of the CFTR protein used in the treatment of cystic fibrosis.<br>References Loo, T. et al.: Biochem. Pharm., 86, 612 (2013); McPhail, G.. et al.: Drugs. Future., 37, 717 (2012);<br></p>

<p>Applications A potent and selective inhibitor of farnesyltransferase that induces mitochondrial apoptosis in chronic myeloid leukemia stem/progenitor cells, including CD34+38- cells, through activation of protein kinase Cβ.<br>References Rose, W.C. et al.: Cancer Res., 61, 7507 (2001); Tabernero, J. et al.: J. Clin. Oncol., 23, 2521 (2005); Pellicano, F. et al.: Blood, 114, 4186 (2009);<br></p>

<p>Applications A piperazine derivative and a selective antagonist at D3 receptors that influences the expression of cocaine-induced conditioned place preference (CPP).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Byrska, B. et al.: Zagadnien Nauk Sadowych 81, 101 (2010); Cervo, L. et al.: Pharmacol Biochem Be 82, 727 (2005)<br></p>

<p>Applications L-threo-Phenylserine is a valuable chiral synthon.<br></p>

<p>Stability Hygroscopic<br>Applications (R)-Phenylephrine Hydrochloride is an α-Adrenergic agonist. Mydriatic; decongestant.<br>References Warren, M.R., et al.: J. Pharmacol. Exp. Ther., 86, 284 (1946); Gaglia, C.A., et al.: Anal. Profiles Drug Subs., 3, 483 (1974);<br></p>

<p>Applications β-Methylphenethylamine is a positional isomer of Amphetamine (HCl: A634240), and as a result, has been classified as a doping agent by the World-Anti Doping Agency.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Cho?bi?ski, P., et al.: Anal. Bioanal. Chem., No vol. given, 1 (2014); Cohen, P., et al.: New Engl. J. Med., 370, 1277 (2014); Pawar, R., et al.: J. Pharm. Biomed. Anal., 88, 457 (2014); Vaclavik, L., et al.: Anal. Chim. Acta, 810, 45 (2014)<br></p>

<p>Stability Freezer at -20°C<br>Applications A potent and discriminating antagonist for AMPA binding sites. This compound has neuroprotective properties.<br>References HonorÈ, T., et al.: Science, 241, 701 (1988), Gill, et al.: Brain Res., 580, 35 (1992), Pook, et al.: Br. J. Pharmacol., 108, 179 (1993)<br></p>

<p>Applications Blebbistatin blocked myosin II-dependent cell processes. It blocks cell blebbing rapidly and reversibly. Also rapidly disrupted directed cell migration and cytokinesis in vertebrate cell. It blocks both blebbing and cytokinesis at 50-100µM.(±)-1-Phenyl-1,2,3,4-tetrahydro-4-hydroxypyrrolo[2,3-b]-7-methylquinolin-4-oneSelective inhibitor of nonmuscle myosin II; inhibits contraction of the cleavage furrow without disrupting mitosis or contractile ring assembly. Rapidly and reversibly blocks cell blebbing, and disrupts directed cell migration and cytokinesis in vertebrate cells.<br>References Straight, A.F., et al.: Science, 299, 1743 (2003), Duxbury, M.S., et al.: Biochem. Biophys. Res. Commun., 313, 992 (2004), Kovacs, M., et al.: J. Biol. Chem., 279, 34 35557 (2004)<br></p>

<p>Applications A semi-synthetic β-lactamase inhibitor. It is used in combination with β-lactam antibiotics as antibacterial.<br>References English, A.R., et al.: Antimicrob. Agents Chemother., 14, 414 (1978), Stromberg, B.V., Surg. Gynecol. Obstet., 162, 575 (1986), Mehtar, S., et al.: J. Antimicrob. Chemother., 17, 389 (1986), Campoli-Richards, D.M., et al.: Drugs, 33, 577 (1987),<br></p>

<p>Stability Hygroscopic and Moisture Sensitive<br>Applications Bortezomib is the first proteasome inhibitor to be approved by the US FDA for multiple myeloma, a blood cancer. A reversible inhibitor of the 26S proteasome-a barrel-shaped multiprotein particle found in the nucleus and cytosol of all eukaryotic cells. Targets the ubiquitin-proteasome pathway.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Nawrocki, S.T., et al: Cancer Research, 65, 11510 (2005); Drahl C.: Chem. and Eng. News, 87, 41 (2009);<br></p>

<p>Applications MEK 162 is a MEK1/2 inhibitor allowing it to be a effective anti-cancer medication.<br>References Kopetz,S., et al.: N. Engl., 381, 1632-1643<br></p>

<p>Applications Protected 1,2-Phenyldiamine, an intermediate in the synthesis of histone deacetylase agents and antitumor agents.<br>References Andrews, D., et al.: Bioorg. Med. Chem. Lett., 18, 2580 (2008), Mahboobi, S., et al.: J. Med. Chem., 52, 2265 (2009),<br></p>

<p>Applications Bromochloroacetic acid is a halogenated disinfection byproduct commonly found in drinking water, fruit juice, and cheese. Bromochloroacetic acid has been shown to cause mesothelioma, fibroadenomas, and adenomas in rats<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hang, C., et al.: Sci Total Environ. 543, 425 (2016); Cardador, M. J. and Gallego, M.: Food Chem. 173, 685 (2015); Natl Toxicol Program Tech Rep Ser. 549, 1 (2009)<br></p>

<p>Stability -200C<br>Applications A pyridinyl imidazole which acts as a specific inhibitor of p38 MAP kinase. Does not inhibit the MAP kinase homologs JNK and p42 MAP kinase.<br>References Kawasaki, H., et al.: J. Biol. Chem., 272, 18518 (1997), Ward, S.G., et al.: Biochem. Soc. Trans., 245, 304S (1997), Clerk, A., et al.: FEBS Lett., 426, 93 (1998),<br></p>

<p>Applications 5-Fluoroindole is a reactant used in various syntheses. It was used in the synthesis of Spirotetrahydro β-Carbolines (Spiroindolones), which is a new class of potent and orally efficacious compounds for the treatment of malaria. 5-Fluoroindole was also a reactant in direct indole and pyrrole couplings to carbonyl compound in total synthesis of Acremoauxin A and Oxazinin 3.<br>References Richter, J., et al.: J. Am. Chem. Soc., 129, 12857 (2007); Yeung, B., et al.: J. Med. Chem., 53, 5155 (2010);<br></p>

<p>Applications Ulipristal acetate is a selective progesterone receptor modulator. Ulipristal acetate is used during pregnancy.<br>References Gronemeijer, H., et al.: J. Steroid Biochem., 40, 271 (1991), Spitz, I., et al.: Contraception, 48, 403 (1993), Conneely, O., et al.: Steroids, 68, 771 (2003), Chwalisz, K., et al.: Endocr. Rev., 26, 423 (2005),<br></p>

<p>Applications Potassium Thiocyanate has been used as a catalyst in a one-pot reaction of dialkyl acetylenedicarboxylates with indane-1,3-dione. Potassium Thiocyanate has been used as a selective bacterial inhibitor to create ESS-3 broth to allow co-​enrichment of the target pathogens and suppress growth of some non-​target pathogens<br>References Hassanabadi, A., Zhiani, R., et. al.: J. Chem. Res., 37, 458 (2013); Zhang, Q., et. al.: Plant. Biotech., 29, 103 (2012)<br></p>

<p>Applications The naturally occuring isomer is the L-form which has been found in apples and many other fruits and plants. Selective α-amino protecting reagent for amino acid derivatives. Versatile synthon for the preparation of chiral compounds including κ-opioid receptor agonists, 1α,25-dihydroxyvitamin D3 analogue, and phoslactomycin B.<br>References Rindi, G., et al.: Biochem. J., 80, 214 (1961), Wolfgang, M., et al.: J. Biol. Chem., 281, 37265 (2006), Navarro, D., et al.: Metab. Brain Dis., 23, 115 (2008),<br></p>

<p>Stability Hygroscopic<br>Applications Methanesulfonic acid is a strong acid and is an important intermediate in the cycling process of sulfur in the environment. Methanesulfonic acid is an oxidation product of Dimethyl sulfide (T348000), and is also used as a sole source of carbon and energy for some gram-negative methylotropic bacteria.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References de Marco, P., et al.: J. Bacteriol., 181, 2244 (1999); Kolaitis, L., et al.: Env. Sci. Tech., 23, 236 (1989); Saltzman, E., et al.: Geophys. Res. Lett., 12, 437 (1985)<br></p>