Reagenti sintetici

<p>Applications An oral angiogenesis inhibitor targeting VEGFR and PDGFR.<br>References Olaussen, K., et al.: Oncogen., 28, 4249 (2009), Sleijfer, S., et al.: J. Clin. Oncol., 27, 3126 (2009), Chan, A., et al.: Drugs, 69, 167 (2009),<br></p>

<p>Applications SODIUM ARSENATE, HEPTAHYDRATE (cas# 10048-95-0) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Stability Light Sensitive<br>Applications Physiological metabolite of vitamin A. Effects gene expression via nuclear retinoic acid receptors (RAR); mediates cellular growth and differentiation.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kamm, J.J., et al.: J. Am. Acad. Dermatol., 6, 652 (1982), Warrel, R.P., et al.: Leukemia, 8, 929 (1994), Sasai, Y., et al.: J. Neurol., 249, 41 (2002),<br></p>

<p>Applications LY 294002 is a Phosphatidylinositol 3-kinase (PI3K) inhibitor which has shown to block the formation of tumor tissues in bone marrow cavity an abolish multiple myeloma (MM) induced osteoclast formation and osteolysis in SCID mice.<br>References Lin, C., et. al.: J. Biol. Chem., 286, 10483 (2011); Cao, H., et. al.: J. Biol. Chem., 288, 30399 (2013);<br></p>

<p>Applications (-)-Terpinen-4-ol (cas# 20126-76-5) is a useful research chemical.<br></p>

<p>Stability Hygroscopic<br>Applications (S)-3-Aminoazepan-2-one hydrochloride (cas# 26081-07-2) is a useful research chemical.<br></p>

<p>Applications (+)-MK 801 Hydrogen Maleate acts as an NMDA receptor antagonist. It is selective and potent, but noncompetitive, used in various ischemia treatments.<br>References Ma, J. et al.: Hippocamp., 22, 2208 (2012); Cao, Z. et al.: Toxicol. Sci., 130, 362 (2012);<br></p>

<p>Applications TEMPO is a stable radical prepared through the oxidation of 2,2,6,6-tetramethylpiperidine. TEMPO has a wide range of applications including use as a free radical scavenger, a reagent in organic synthesis and as a structural probe in electron spin resonance spectroscopy. TEMPO can also be used as a mediator in free radical polymerization.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Seaton, T.A. et al.: Brain Res., 777, 110 (1997); Tanielyan, S.K. et al.: Top. Catal., 55, 556 (2012); Wolinska-Grabczyk, A. et al.: Polymer, 46, 2461 (2005); Keoshkerian, B. et al.: Polym. Prep., 35, 675 (1994);<br></p>

<p>Applications Metabolite fingerprinting in transgenic Nicotiana tabacum altered by the Escherichia coli glutamate dehydrogenase gene. A synthetic intermediate in the preparation of CNS depressants.<br>References Mungur, R., et al.: J. Biomed. Biotechnol., 2, 198 (2005), Young, J., et al.: Bioorg. Med. Chem. Lett., 17, 5310 (2007),<br></p>

<p>Applications Zinc Chloride is a common chemical reagent used in organic syntheses, often alkylation reactions.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Huo, S. et al.: Org. Lett., 5, 423 (2003);<br></p>

<p>Stability Sensitive to moisture<br>Applications Isonicotinyl Chloride Hydrochloride, is a heterocyclic building block used for the synthesis of various pharmaceutical and biologically active compounds. It can be used for the preparation of Tetrahydropyrroloquinolinone type dual inhibitors of Aromatase/Aldosterone Synthase, as a novel stagey for breast cancer patients with the risk of cardiovascular diseases.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Yin, L., et al.: J. Med. Chem., 56 (2), 460 (2013);<br></p>

<p>Applications 2-Fluoro-3-methoxyphenylboronic acid<br></p>

<p>Applications Cobalt(II) chloride hexahydrate (cas# 7791-13-1) is a useful research chemical.<br></p>

<p>Applications SB 431542 is a known Src family kinase inhibitor that effectively blocks the transforming growth factor-β1-induced cell migration and invasion in both established and primary carcinoma cells. Potent TGF-beta inhibitor.<br>References Tobias, B., et al.: Cancer. Chemother. Pharmacol., 70, 221 (2012); James, J., et al.: Molec. Cancer. Therap., 11, 930 (2012);<br></p>

<p>Stability Hygroscopic<br>Applications Brobactam is a potent semi-synthetic β-lactamase inhibitor as well as an impurity of Sulbactam (S699185).<br>References Melchior, N.H. et al.: Proc. Int. Congr. Chemother., 3, 55 (1983);<br></p>

<p>Applications 4-Chlorobenzenethiol is a reagent used in the synthesis of small-molecule inhibitors of the protein geranylgeranyltransferase Type I (GGTase-I), acting as anti-tumor agents. Also is used in the synthesis of β-sulfanyl carbonyl compounds via Michael addition.<br>References Ranu, B. et al.: Tetrahedron, 60, 4183 (2004); J. Med. Chem., 43, 2310 (2000);<br></p>

<p>Stability Hygroscopic<br>Applications (S)-(+)-2-Methylbutyric Acid is a chiral starting reagent used in various synthetic preparations.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Neves, F., et al.: Beilstein. J. Org. Chem., 7, 1504 (2011); King, A.M., et al.: J. Medn. Chem., 54, 6432 (2011); Ferrarni, A., et al.: Chirality., 26, 9 (2011);<br></p>

<p>Applications Barium hydroxide octahydrate is a reagent that is used in solid state metathesis of rocksalt oxides for synthesis of perovskite oxides.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Mandal, T. K., et al.: J. Mat. Chem., 14, 1273 (2004);<br></p>

<p>Applications TG101348 is a selective inhibitor of JAK2 tyrosine kinase. Potent JAK2 inhibitor.<br>References Rosenthal, A., et al.: Expert Opin. Pharmacotherapy, 15, 1265 (2014); Geyer, H.L., et al.: Hematol., 17, s129 (2012); Zhou, T. et al.: Leukemia, 28, 404 (2014)<br></p>

<p>Stability Light Sensitive<br>Applications Gallic Acid is a phenolic acid with antioxidant activity. Gallic acid was found to protect human cells against oxidative damage and showed cytotoxicity against cancer cells. Gallic Acid and its esters also show antiviral and antifungal activities.<br>References Yen, G. et al.: Food Chem., 79, 307 (2002); Chen, C. et al.: Mol. Nutrit. Food Res., 51, 962 (2007); Kratz, J. et al.: Mem. Inst. Oswaldo Cruz, 103, 437 (2008); Osborne, L. et al.: Infect. Immun., 33, 769 (1981);<br></p>

<p>Applications ORM-15341 is a metabolite of Darolutamide. Darolutamide is a potent androgen receptor antagonist with strong efficacy in prostate cancer models.<br>References Sugawara, T., et al.: Int. J. Cancer, 145, 1382 (2019); Yu, J., et al.: Eur. J. Med. Chem., 182, 111608 (2019)<br></p>

<p>Applications 4-(Trifluoromethyl)benzyl Bromide is a useful building block. It is used in the synthesis of 1-(Substituted benzyl)-2-substituted-5,6-dichlorobenzimidazoles with antiviral activities.It is also used to prepare 2-[(4-diarylmethoxy)phenyl]benzimidazoles as potent inhibitors of hepatitis C virus NS5B polymerase.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Porcari, A., et al.: J. Med. Chem., 41, 1252 (1998); Ishida, T., et al.: Bioorg. Med. Chem. Lett., 16, 1859 (2006)<br></p>

<p>Applications Girard’s reagent used in the identification and quantification of protein carbonylation as well as in the modification of nucleosides and nucleotides. Used in the preparation of potent photoactive agents.<br>References Mirzaei, H., et al.: J. Chrom. A, 1134, 122 (2007); Kanofsky, J.R., et al.: Photochem. Photobiol., 73, 349 (2001);<br></p>

<p>Applications A useful phase transfer catalyst.<br></p>

<p>Stability Hygroscopic<br>Applications Sodium Sulfide Nonahydrate is used as a reagent in the synthesis of surface functionalized cadmium sulfide quantum dots.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Veinot, J.G.C., et al.: Chem. Mater., 9, 2117 (1997)<br></p>

<p>Applications A nonpeptide angiotensin II AT1-receptor antagonist. Antihypertensive.<br>References Chiu, T.A., et al.: J. Pharmacol. Exp. Ther., 252, 711 (1990), McIntyre, M., et al.: Pharmacol. Ther., 74, 181 (1997), Pitt, B., et al.: Lancet, 355, 1582 (2000);<br></p>

<p>Applications Barium chloride dihydrate is used in the synthesis of 2R, 3S-Dihydroxy-4-oxo-butanoic Acid (D450800).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Stability Hygroscopic<br>Applications Hydrochloride salt of isotope labelled N,N-Di(methyl)methanamine is an intermediate in the preparation of Trimethylamine N-Oxide Dihydrate, an oxygen transfer agent.<br>References Li, Q. et al.: Fen. Cuihua, 12, 1 (1998); Patra, N. et al. Polym. Degrad. Stab., 96, 1377 (2011); Cozzoli, P.D. et al.: J. Am. Chem. Soc., 126, 3868 (2004);<br></p>

<p>Applications AD-mix-β is a catalyst employed in the Sharpless Asymmetric Dihyroxylation of (E,E)- or (E,Z)-1,3-dienoates. It is also used in the preparation of ß-hydroxy-γ-lactones from ß,γ-unsaturated esters.<br>References Ahmed, M., et al.: J. Org. Chem., 71, 7741 (2006); Tretyakov, E., et al.: Eur. J. Org. Chem., 12, 2669 (2006)<br></p>

<p>Applications SRT1720 acts as a therapeutic in the treatment of type 2 diabetes. It modulates calories and contributes to glucose homeostasis and insulin sensitivity.<br>References Milne, J. et al.: Nature, 450, 712 (2007);<br></p>

<p>Applications Tivozanib is known as an oral VEGF receptor tyrosine kinase inhibitor, exhibiting antitumor effects towards renal cell carcinoma.. Tivozanib suppresses angiogenesis by selectively inhibiting against vascular endothelial growth factor. Potent VEGFR inhibitor.<br>References Nosov, D.A., et al.: J. Clinical. Oncol., 30, 1678 (2012); Pal, S.K., et al., Molec. Cancer. Thr, 11, 526 (2012);<br></p>

<p>Applications Sodium Phosphate Dibasic Dihydrate is a treatment of Ischemic stroke with aptamers targeting toll-like receptor 4 (TLR-4).<br>References Perez Rodriguez, D., et al.: PCT Int. Appl., (2020);<br></p>

<p>Stability Hygroscopic<br>Applications A deuterated selective, competitive HMG-CoA reductase inhibitor. Atorvastatin is the only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglycerides in patients with hypercholesterolemia.<br>References Kearney, A.S., et al.: Pharm. Res., 10, 1461 (1993), Heinonen, T.M., et al.: Clin. Ther., 18, 853 (1996), Whitfield, L.R., et al.: Eur. J. Drug Metab. Pharmacokinet., 25, 97 (2000),<br></p>

<p>Applications Phosphoric Acid Monosodium Salt Dihydrate, is a reagent widely used in the preparation of biological buffers. It is highly hygroscopic and can be used in many applications including in gel electrophoresis.<br>References Salaun, F.: "Influence of mineral environment on the buffering capacity of casein micelles", "Milchwissenschaft", 62(1):3<br></p>

<p>Applications Vincamine is often used as a nootropic agent to combat the effects of aging, or in conjunction with other nootropics (such as piracetam) for a variety of purposes. Vincamine is a peripheral vasodilator that increases blood flow to the brain.<br>References Cook, P., James, I.: New England J. Med. 305, 1560 (1981); DeNoble, V., et al.: Pharmacol. Biochem. Be., 24, 1123 (1986)<br></p>

<p>Applications Sodium selenite is used in reducing carcinogenesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Betrixaban is a novel anticoagulant. An oral direct inhibitor of factor Xa (FXa) for use in the prevention of venous thromboembolism (VTE).<br>References Turpie, A.G.G. et al.: Thromb. Haemost., 101, 68 (2009); Gomez-Outes, A. et al.: Curr. Vasc. Pharmacol., 7, 309 (2009);<br></p>

<p>Applications GBT 440 is a potent allosteric effector of sickle cell hemoglobin (Hb) that increases the affinity of Hb for oxygen and inhibits its polymerization when subjected to hypoxic conditions.<br>References Metcalf, B., et al.: ACS Med. Chem., 8, 321-326 (2017); Li, Q., et al.: Proc. Natl. Acad. Sci. U.S.A., 114, E689-E696 (2017)<br></p>

<p>Applications 4-Pyridylthioacetic Acid (cas# 10351-19-6) is a compound useful in organic synthesis.<br></p>

<p>Applications Vanadyl Meso-Tetraphenylporphine (1-3% Chlorin) (cas# 14705-63-6) is a useful research chemical.<br></p>

<p>Applications (S)-α,α-Bis[3,5-di(trifluoromethyl)phenyl]-O-(trimethylsilyl)pyrrolidine-2-methanol, is a diarylprolinol silyl ether organocatalyst. It is able to catalyze a variety of bond-forming reactions such as C-C, C-N, C-O, C-S, and C-Hal in high yields and excellent levels of enantiocontrol.<br>References Jensen KL, et al. Accounts of Chemical Research 45(2), 248-264, (2011);<br></p>

<p>Applications A receptor adenine derivative binding membrane brain animal cell line.<br>References Camaioni, E., et al.: Bioorg. Med. Chem., 6, 523 (1998), Kelly, M., et al.: Br. J. Pharmacol., 125, 979 (1998), Redzic, Z., et al.: Brain Res., 888, 66 (2001), Levy, D., et al.: J. Med. Chem., 46, 2177 (2003),<br></p>

<p>Applications 3-Mercapto-3-methylbutyl formate is one of the major odor-active thiol in pan-roasted white sesame seeds.<br>References Czerny, M., et al.: J .Agric. Food Chem., 47, 695 (1999), Steinhaus, M., et al.: Eur. Food Res. Technol., 226, 45 (2007), Tamura, H., et al.: Agric. Food Chem., 2010, 58, 7368 (2010),<br></p>

<p>Applications Icatibant Acetate is a bradykinin B2 receptor antagonist that has been recently approved for treatment of acute attacks of hereditary angioedema (HAE).<br>References Greve, J., et al.: Int. J. Dermatol., 50, 1294 (2011); Cole, S.W., et al.: Ann. Pharmacother., 47, 49 (2013)<br></p>

<p>Applications Anticholinergic. Antispasmodic.<br>References Lundstam, S., et al.: Lancet, 1, 1096 (1982), Thompson, J., et al.: Br. Med. J., 299, 1140 (1989), Marthak, K., et al.: Curr. Med. Res. Opi., 12, 366 (1991), Panderi, I., et al.: J. Pharm. Biomed. Anal., 12, 151 (1994),<br></p>

<p>Stability Hygroscopic<br>Applications Tris(3-sulfophenyl)phosphine Trisodium Salt is a reagent used in organic synthesis such as benzothiazole-based cycloplatinated chromophores.<br>References Lalinde, E. et al.: Chem. A Eur. J., 24. 2440 (2018);<br></p>

<p>Stability Moisture Sensitive<br>Applications Tetrakis(triphenylphosphine)palladium(0) is widely used as a catalyst for palladium-catalyzed coupling reactions.<br>References Malatesta. L., et al.: J. Chem. Soc., 1186 (1957);<br></p>

<p>Applications Ivacaftor is used in the treatment of cystic fibrosis.<br>References Clancy, J. et al.: Am. J. Resp. Crit. Care. Med., 186, 593 (2012);<br></p>

<p>Applications 5,6-Dehydropregabalin is an impurity of the anticonvulsant, Pregabalin (P704800).<br>References Dousa, M, et al.: J. Pharmac. Biomed. Anal., 53, 717 (2010);<br></p>

<p>Applications Zinc Sulfate Monohydrate is a special compound fertilizer for improving rapeseed yield.<br>References Liu, H., et al.: Faming Zhuanli Shenqing, (2020);<br></p>

<p>Applications Atipamezole Hydrochloride, is the a synthetic α2-adrenergic antagonist, usually used to reverse the sedative and analgesic effects of dexmedetomidine and medetomidine in dogs. It has also been shown to be used as possible anti-Parkinsonian drug in humans.<br>References Pertovaara A., CNS Drug Reviews 11 (3), 273 (2005);<br></p>

<p>Applications 2-Chlorophenylboronic Acid used in the preparation of imidazo[1,2-a]pyridine amides which has tuberculostatic activity.<br>References Kang, S., et al.: J. Med. Chem., 57, 5293 (2014);<br></p>

<p>Applications Sodium Phosphate Dibasic Heptahydrate is used as precursor in the preparation of cobalt-based molecular catalyst for water oxidation.<br>References Huang, Z., et al.: J. Am. Chem. Soc., 133, 2068 (2011);<br></p>

<p>Applications An oral, small-molecule inhibitor of FLT3 for the treatment of AML (acute myelogenous leukemia) and other cancer indications. The drug exhibited limited activity as a single agent in phase I and II clinical trials in patients with AML and myelodysplastic syndrome, but displayed promising antileukemic activity (90% complete remissions) in a phase I/II trial in patients with newly diagnosed AML when administered in combination with cytarabine and daunorubicin.<br>References Manning, G., et al.: Science, 298, 1912 (2002), Lombardo, L., et al.: J. Med. Chem., 47, 6658 (2004), Knight, Z., et al.: Chem. Biol., 12, 621 (2005), Baselga, J., et al.: Science, 312, 1175 (2006), Garber, K., et al.: Nat. Biotechnol., 24, 127 (2006), Flaherty, K., et al.: Clin. Cancer Res., 13, 747 (2007),<br></p>

<p>Applications Ammonium iron(III) citrate (cas# 1185-57-5) is a useful research chemical.<br>Chemical Name: Ammonium iron(III) citrate (cas# 1185-57-5) is a useful research chemical.<br></p>

<p>Applications (1S,3R)-Camphoric Acid (cas# 560-09-8) is a compound useful in organic synthesis.<br></p>

<p>Applications (-)-Nopol, is a chiral building block used in chemical synthesis. It is an intermediate that can be used for the synthesis of bulky moiety-modified analogs to the sandalwood odorant Polysantol.<br>References Chapado, L., et al.: Molecules, 14, 2780 (2009);<br></p>

<p>Applications Carmofur is a derivative of fluorouracil (F596002) an is an antineoplastic agent showing antitumor activity against several cells including L1210 leukemia and L5178Y lymphoma cells.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hoshi, A., et al.: J. Pharmacobio-dynam., 3, 478 (1980);<br></p>

<p>Applications Methyl 6-aminohexanoate is used as a reagent to synthesize straight chain hydroxamates, compounds that act as inhibitors of Human Histone Deacetylase (HDAC) that have the potential to treat cancer. Methyl 6-aminohexanoate is also sometimes used as a spacer unit for peptide synthesis.<br>References Matthews, S., et al.: J. Chem. Soc. Chem. Commun., 17, 1809 (1995); Remiszewski, S., et al.: J. Med. Chem., 45, 753 (2002)<br></p>

<p>Applications ABT-888 is a potent, orally bioavailable PARP-1/-2 inhibitor shown to potentiate DNA damaging agents. The ability to potentiate temozolomide (TMZ) and develop a biological marker for PARP inhibition was evaluated in vivo. Potent PARP inhibitor.<br>References Virag, L., et al.: Pharmacol. Rev., 54, 375 (2002), Tentori, L., et al.: Clin. Cancer Res., 9, 5370 (2003), Kim, M., et al.: Cell, 119, 803 (2004), Tentori, L., et al.: Pharmacol. Res., 52, 25 (2005),<br></p>

<p>Applications Cetyltrimethylammonium hydrogensulfate 99% (cas# 68214-07-3) is a useful research chemical.<br></p>

<p>Applications 5-Chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine, is a Anaplastic lymphoma kinase (ALK) inhibitor.<br>References Marsilje, T. H., et al.: J. Med. Chem., 56, 5675 (2013);<br></p>

<p>Applications Intermediate of Nafamostat mesilate (N210000).<br>References Rahimian, M., et al.: Biochemistry, 48, 1573 (2009),<br></p>

<p>Applications AHR 11652 is a metabolite of Bromfenac sodium (B678550).<br>References Walsh, D.A., et al.: J. Med. Chem., 25, 446 (1982),<br></p>

<p>Applications Lanreotide Acetate is a drug used in the control and prevention of glycemia and hypoglycemic brain damage without surgery in patients diagnosed with congenital hyperinsulinism. It improves outcomes in patients suffering from acromegalyresulting from invasive pituitary macroadenoma.<br>References Kuehnen, P. et al.: Horm. Res. Paediat., 78, 106 (2012); Li, Z. et al.: J. Int. Med. Res., 40, 517 (2012);<br></p>

<p>Applications Ultramark 1621, a commercially available mixture of fluorinated phosphazines, is a useful calibration compound for negative and positive ion fast-atom bombardment (FAB) high-resolution mass spectrometry.<br>References Jiang, L., et al.: J. Am. Soc. Mass Spec., 3, 842 (1992)<br></p>

<p>Applications Magnesium Chloride Hexahydrate is used in magnesium replacement therapy for those deficient in magnesium. Effective anaesthetic for cephalopods.<br>References Iezhitsa, I. et al.: Nutr. Neurosci., 14, 10 (2011); Culloty, S. et al.: Aquaculture., 107, 249 (1992);<br></p>

<p>Applications Alkaloid naturally occurring in the d-form. Shows GABA antagonist activity.<br>References Curtis, et al.: Nature, 226, 1222 (1970), Avoli, M., et al.: J. Physiol. Pharmacol., 75, 526 (1997), Chebib, M., et al.: Clin. Exp. Pharmacol. Physiol., 26, 927 (1999),<br></p>

<p>Stability Moisture Sensitive<br>Applications 1,1,1-Trifluoro-N-((trifluoromethyl)sulfonyl)methanesulfonamide (cas# 82113-65-3) is a useful research chemical.<br></p>

<p>Applications RAD 140 is a potent, orally bio-available, and non-steroidal selective androgen receptor modulator (SARM).<br>References Miller, C.P., et al.: ACS Med. Chem. Lett., 2, 124-129 (2011)<br></p>

<p>Applications 5-Amino-1-pentanol is an aliphatic amino alcohol with potential plasma lipid-lowering properties. 5-Amino-1-pentanol and other amino alcohols are used as emulsifying agents in dry-cleaning soaps, wax removers, cosmetics, paints and insecticides.<br>References Bondesson, G. et al.: Acta Pharm. Suec., 11, 417 (1974); Scheers, E.M. et al.: ALTA Alt. Lab. Anim., 30,309 (2002);<br></p>

<p>Applications Sodium Borohydride is used as a reagent in the reduction of amino acids and their derivatives. Also used in the catalysis of ammonia borane dehydrogenation.<br> E0<br>References McKennon, M. et al.: J. Org. Chem., 58, 3568 (1993); Denney, M. et al.: J. Am. Chem. Soc., 128, 12048 (2006);<br></p>

<p>Applications Ethyl 3-Bromopyruvate is used in the preparation of 1,2,4-trisubstituted imidazoles as inhibitors of growth factor-β type I ALK5 inhibitors.<br>References Guo, C. et al.: Bioorg. Med. Chem. Lett., 23, 5850 (2013); Catarzi, D. et al.: Farmaco, 48, 447 (1993);<br></p>

<p>Applications (+)-Muscarine Chloride modulates calcium channel currents in rats.<br>References Stewart, A. E., et al.: J. Neurophysiol., 81, 72-84 (1999);<br></p>

<p>Applications 1-Chloropentane is used for studies on the antimicrobial activity of some halogenated hydrocarbons and their derivatives, effect of chlorinated hydrocarbons on the myelin sheath of peripheral nerve tissues.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kalatskaya, L. M., et al.: Fiziologicheski Aktivnye Veshchestva; 20, 77 (1988); Rumsby, M. G., et al.: J. Neurochem., 13, 1513 (1966)<br></p>

<p>Applications Atosiban is an oxytocin receptor blocking agent in the treatment of experimental endometriosis and was shown exhibit significant therapeutic efficiency.<br>References Simsek, Y., et al.: Arch. Gynecol. Obstet., 286, 777 (2012); Mak, P., et al.: J. Psychopharmacol., 26, 532 (2012); Simsek, Y., et al.: Arch. Gynecol. Obstet., 285, 655 (2012);<br></p>

<p>Applications (1S,2S,3R,5S)-(+)-2,3-Pinanediol is a bicyclic monoterpene diols that has been shown to induce differentiation of S91 melanoma and PC12 pheochromocytoma cells and thus provide possible therapeutic and sunless tanning use. It is also used in the transformation of isopinocampheol and caryophyllene oxide.<br>References Brown, D.A. et al.: Pigment Cell Res., 12, 36 (1999); Noma, Y. et al.: Flav. Frag. J., 25, 161 (2010);<br></p>

<p>Applications Dofetilide is a potassium channel blocker. Antidysrhythmic drug.<br>References Carmeliet, D., et al.: J. Pharmacol. Exp. Ther., 262, 809 (1992); Norgaard, B.L., et al.: Am. Heart J., 137, 1062 (1999); Torp-Pedersen, C., et al.: N. Engl. J. Med. 341, 857 (1999);<br></p>