Reagenti sintetici

<p>Applications 3-Cyanobenzoic Acid, is a building block used for the synthesis of a variety of 3,5-disubstituted 1,2,4-oxadiazoles from carboxylic acids, that can be used for the synthesis of a metabotropic glutamate subtype 5 (mGlu5) receptor antagonist.<br>References Ramu, T., et al.: Chem. Lett., 42, 722 (2013);<br></p>

<p>Applications Arimoclomol is a orally administered drug used to treat amyotrophic lateral sclerosis and was later discovered to be a potential insulin resistance treatment and diabetic complications.<br>References Kurthy, M., et al.: New. York. Acad. Sci., 967, 482 (2002); Kalmar, B., et al.: Exp. Neurol., 184, 636 (2003);<br></p>

<p>Applications DI-MU-HYDROXO-BIS[(N,N,N',N'-TETRAMETHYLETHYLENEDIAMINE)COPPER(II)] CHLORIDE (cas# 30698-64-7) is a useful research chemical.<br>Chemical Name: DI-MU-HYDROXO-BIS[(N,N,N',N'-TETRAMETHYLETHYLENEDIAMINE)COPPER(II)] CHLORIDE (cas# 30698-64-7) is a useful research chemical.<br></p>

<p>Stability Store in Freezer<br>Applications Benzyl 3-Amino-3-deoxy-α-D-mannopyranoside Hydrochloride can be used for preparation of swainsonine analogs as immunostimulants.<br>References Dime, D., et al.: PCT Int. Appl., 74 pp. (1993),<br></p>

<p>Applications A useful wittig reagent.<br></p>

<p>Stability Air Sensitive (Oxidize)<br>Applications 3,3-Dimethylbutyraldehyde is an intermediate used to prepare spiro-oxindoles as potent, specific small-molecule Inhibitors of the MDM2-p53 Interaction.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ding, K., et al.: J. Med. Chem., 49, 3432 (2006); Yu, S., et al.: J. Med. Chem., 52, 7970 (2009)<br></p>

<p>Stability Very Hygroscopic<br>Applications Gadolinium Trichloride is a calcium-sensing receptor agonist and is known to work by inducing NLRP3 inflammasome activation in bone marrow-derived macrophages.<br>References Toyoda, Y., et al.: Toxicol. Sci., 126, 16 (2012); Ciceri, P., et al.: Biochem. Biophy. Res. Comm., 418, 770 (2012); Dangi.A., et al.: J. Immunol., 188, 3667 (2012);<br></p>

<p>Applications Cediranib is a drug for blocking angiogenesis, study on cervical cancer molecular targeted drug and clinical application progress, value of correlative biomakers in the understanding of tumor biology.<br>References Shao, J., et al.: Shiyong Yixue Zazhi, 31, 4143 (2015); Gerstner, E. R., et al.: Transl. Cancer Res., 5, 211 (2016)<br></p>

<p>Applications Fmoc-beta-alaninol<br></p>

<p>Stability Hygroscopic<br>Applications Vasodilator (cerebral and peripheral). Neuroprotective agent.<br>References Carron, C., et al.: Arzneim.-Forsch., 21, 1992 (1971),<br></p>

<p>Applications Silver Acetate is used as a reagent in chemical synthesis in reaction such as carbonylation of primary and secondary amines as well as in woodward cis-hydroxylation converting alkenes into cis-diols. Also used in gum, lonzenges and sprays that are targeted to assist people in quitting the habit of smoking since it produces a bad taste when combined with cigarettes.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Wright, L., et al.: J. Phys. Chem., 59, 1060 (1955); Woodward, R., et al.: J. Am. Chem. Soc., 80, 209 (1958); Lancaster, T., et al.: Cochrane DB Syst. Rev., 2, 191 (2000);<br></p>

<p>Applications Darodipine, is a calcium channel antagonist.<br>References Matucci, R., et al.: British J. Pharmacol., 122, 1353 (1997);<br></p>

<p>Applications 4-Bromobutyric Acid is used in the preparation of analgesic and anti-inflammatory agents as nitroalkyl ethers. It is also used in the synthesis of Autotaxin (ENPP2) inhibitors, used in tissue fibrosis regulation, cancer cell invasion and metastasis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Anzini, M. et al.: J. Med. Chem., 56, 4821 (2013); Kawaguchi, M. et al.: ACS Chem. Biol. et al.: 8, 1713 (2013);<br></p>

<p>Applications 2-(Dicyclohexylphosphino)biphenyl is used as a catalyst for Suzuki coupling reactions.<br>References Wolfe, J., et al.: J. Am. Chem. Soc., 121, 9550 (1999);<br></p>

<p>Applications Procinolol is a beta adrenergic receptor antagonist. It is also an intermediate in synthesizing (±)-Procinolol Hydrochloride (P755815).<br>References Singh, K.: Indian J. Phsiol. Pharmacol., 27, 311 (1983)<br></p>

<p>Applications Diethyl L-(+)-Tartrate is used as a chiral reagent in a host of chemical reactions, such as the synthesis of isoquinoline alkaloids and arundic acid, which has been used in acute ischemic stroke therapy.<br>References Ziolkowski, M. et al.: Tetrahedron Lett., 41, 1963 (2000); Fernandes, R. et al.: Tetrahedron Lett. 50, 5903 (2009);<br></p>

<p>Applications A metabolite of Cilostazol (C441500), used as internal standard.<br>References Akiyama, H., et al.: Arzneim.-Forsch./Drug Res., 35, 1133 (1985), Akiyama, H., et al.: J. Chromatogr., 338, 456 (1985),<br></p>

<p>Applications Lithium Chloride is primarily used in the synthesis of lithium metal by electrolysis. Also acts as a prescribed drug for bipolar mood disorder, it may also exhibit anti-inflammatory properties. Anti-cancer agent.<br>References Tsao, N. et al.: Antimicrob. Agents Chemother., 59, 1525 (2015); Cockle, J. et al.: 112, 693 (2015);<br></p>

<p>Applications tert-Butylethyne, is an organic building block used for the synthesis of various pharmaceutical compounds, such as Terbinafine Hydrochloride (T107500), which is a synthetic allylamine antifungal.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hadi, V., et al.: Tetrahedron Letters, 50, 2370 (2009); Petranyi, G., et al.: Science, 224, 1239 (1984);<br></p>

<p>Applications Sildenafil (S435000) derivative.<br></p>

<p>Applications GSK 2606414 acts as a potent and selective inhibitor of protein kinase R and similarly endoplasmic reticulum kinase affecting numerous diseases such as cancer.<br>References Axten, J. et al.: J. Med. Chem., 55, 7193 (2012);<br></p>

<p>Applications 2-(1,3-Dioxolan-2-yl)ethyltriphenylphosphonium Bromide (cas# 86608-70-0) is a useful research chemical.<br></p>

<p>Applications 5-Chloropent-1-yne is an intermediate in the synthesis of Efavirenz (E425000), a nonnucleoside HIV-1 reverse transcriptase inhibitor. Antiviral.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Young, S.D., et al.: Antimicrob. Ag. Chemother., 39, 2602 (1995)<br></p>

<p>Applications (S)-4-(prop-1-En-2-yl)cyclohex-1-enecarbaldehyde (cas# 18031-40-8) is a useful research chemical. A possible biomarker of Parkinson’s disease.<br>References Drupad, K. T., et al.: ACS Central Science, (2019)<br></p>

<p>Applications Multi-drug resistance (MDR) modulator; selective inhibitor of P-glycoprotein (P-gp). Antineoplastic adjunct (chemosensitizer).<br>References Green, L.J., et al.: Biochem. Pharmacol., 61, 1393 (2001), Shepard, R.L., et al.: Int. J. Cancer, 103, 121 (2003),<br></p>

<p>Stability Volatile<br>Applications rac 1,2-Diaminopropane is used as model precursor in the electron induced deposition of amorphous carbon nitride films. It is also used to synthesize cage peroxide, 1,6-diaza-3,4,8,9-tetraoxa-11-methylbicyclo[4.4.2]dodecane.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Wnuk, J., et al.: J. Phys. Chem., 113, 12345 (2009); Edward, J., et al.: Can. J. Chem., 77, 1057 (1999)<br></p>

<p>Applications (-)-DIBENZOYL-L-TARTARIC ACID MONOHYDRATE (cas# 62708-56-9) is a useful research chemical.<br></p>

<p>Stability Very Hygroscopic<br>Applications Labelled Plerixafor, it is a hematopoietic stem cell (HSC) mobilizer that inhibits the CXCR4 chemokine receptor and blocks binding of its ligand, stromal cell-derived factor-1-α (SDF-1-α). This agent was approved on Dec. 15, 2008, as treatment in combination with granulocyte-colony stimulating factor (G-CSF) to mobilize HSCs to the peripheral blood for collection and subsequent autologous transplantation in patients with non-Hodgkin's lymphoma (NHL) and multiple myeloma (MM).<br>References Xie, T., et al.: Science, 290, 328 (2000), Leone, D., et al.: J. Pharmacol. Exp. Ther., 305, 1150 (2003), Chigaev, A., et al.: J. Immunol. 178, 6828 (2007), Kiel, M., et al.: Cell Stem Cell, 1, 204 (2007),<br></p>

<p>Applications 1,4-Diazabicyclo[2.2.2]octane is an aliphatic amine that is used as a catalyst in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Baghernejad, B.: Eur. J. Chem., 1, No pp. given (2010); Guzonas, D., et al.: Langmuir, 6, 11002 (1990)<br></p>

<p>Applications Tetraethyl Orthocarbonate is used in the synthesis of chemokine receptor-5 inhibitors against HIV-1. Also used in the synthesis of benzobisoxazoles used in the preparation of organic semiconductors.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kazmierski, W. et al.: J. Med. Chem., 54, 3756 (2011); Mike, J. et al.: Org. Lett., 10, 4915 (2008);<br></p>

<p>Applications A novel prodrug of dual vascular endothelial growth factor receptor-2 and fibroblast growth factor receptor-1 kinase inhibitor. Antitumor agent.<br>References Ellis, L., et al.: Eur. J. Cancer, 32A, 2451 (1996), Klagsbrun, M., et al.: Chem. Biol., 6, R217 (1999), Auguste, P., et al.: Cancer Res., 61, 1717 (2001), Bhide, R., et al.: J. Med. Chem., 49, 2143 (2006),<br></p>

<p>Applications Dimethyl Acetylenedicarboxylate is a biocide that is added to biodiesels to inhibit and remove microbial growth. It can rapidly penetrate the skin and cause aberrations in the activities of the glycogenic, lipogenic, and tricarboxylic acid metabollic pathways. It also causes delayed and pain-free dermal burns.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Poon, R., et al.: Arch. Toxicol., 85(11), 1419-1427 (2011); Klain, George J., et al.: Fund. Appl. Toxicol., 10(4), 730-5 (1988); Slovak, A. J. M., et al.: Contact Dermatitis, 11(1), 29-30 (1984)<br></p>