Standard farmaceutici

Applications Methyl Benzilate is a reactant in the synthesis of Trimethadione (T796155), an anticonvulsant and antiepileptic agent used in the treatment of pregnant women. Prenatal exposure to snti-epileptic drugs (AEDs) has indicated increased risk of major or minor congenital malformation.
References Pastore, V., et. al.: Bioorg. Med. Chem., 21, 841 (2013); Ahir, B. et al.: Toxicol. Vitro., 28, 948 (2014); Pastore, V. et al.: Bioorg. Med. Chem., 21, 841 (2013)

Applications 2-[3-(Aminosulfonyl)-4-chlorobenzoyl]-benzonic Acid is a potential metabolite of Chlorthalidone.
References Salado C., et al.: J. Chromatography. Biomed. App., 690, 195 (1997);

Applications A metabolite of Clomipramine.
References McTavish, D., et al.: Drugs, 39, 136 (1990), Chauret, N., et al.: Drug Metab. Dispos., 25, 1130 (1997), Gex-Fabry, M., et al.: Ther. Drug Monit., 22, 701 (2000), Herrera, D., et al.: J. Clin. Pharmacol., 40, 1488 (2000),

Stability Temperature Sensitive
Applications Indole-3-acetic acid is a plant growth regulator. It induces cell division and cell elongation that promotes plant growth.
References Fawcett, C., et al.: Nature, 178, 972 (1956); Fawcett, C., et al.: Annals Appl. Bio., 43, 342 (1955); Korshak, V., et al.:Vysokomolekulyarnye Soedineniya, Seriya B:  Kratkie Soobshcheniya, 22, 791 (1980)

Applications (±)-trans-α-Bergamotene is an essential oil from medicinal plants of Cameroon.
References Boyom, F. F., et al.: Phytochem., 64, 1269 (2003);

Applications An intermediate in the preparation of detoxification inhibitors of the crucifer phytoalexin Brassinin, as potential fungicides against Leptosphaeria maculans.
References Gaspari, P., et al.: J. Med. Chem., 49, 684 (2006), Pedras, M., et al.: Bioorg. Med. Chem., 14, 714 (2006),

Applications Terazosin-md is an analog of Terazosin (T105000) which is an α1-adrenergic receptor antagonist alleviating organ damage in studies done on rodent models of stroke and sepsis and has potential to be used for treatment for diseases.
References Chen, X., et al.: Nat. Chem. Biol, 11, 19 (2015)

Applications Magnesium Carbonate is a chemical reagent used in the production of magnesium oxide in the synthesis of ceramics.
References Seabra, M. et al.: Mat. Res. Bull., 37, 255 (2002); Kumar, T. et al.: Biomat., 21, 1623 (2000);

Applications Boldenone Propionate is a metabolite of Boldenone (B675100), which is an anabolic steroid.
References Watanabe, K., et al.: J. Appl. Bacteriol., 62, 151 (1987) ; Liu, W., et al.: J. Ind. Microbiol., 13, 167 (1994) ; Barthakur, S., et al.: J. Basic Microbiol., 36, 383 (1996); Grinenko, G., et al.: Pharmaceut. Chem. J., 36, 510 (2002) ; de Brabander, H., et al.: Food Addit. Contam., 21, 515 (2004); Le Bizec, B., et al.: Steroids, 71, 1078 (2006);

Applications 1,2,5,6-Tetramethylnaphthalene is a polycyclic aromatic hydrocarbon that has been found in petroleum.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Forster, P.G., et. al.: J. Chromatogr., 483, 384 (1989)

Applications Tirofiban intermediate.

Applications 7α-Hydroxy-4-cholesten-3-one is a metabolite of Cholesterol (C432501).
References Connor, W., et al.: J, Clin. Invest., 48, 1363 (1969), Nestel, P., et al.: Metabolism, 24, 189 (1975), Ellegard, L., et al.: Eur. J. Clin. Nutr., 45, 451 (1991), Pedersen, A., et al.: J. Lipid Res., 41, 1901 (2000),

Applications A novel utilization of aminophenone derivative in toxicology, for treating intoxications with cyanogenic toxic substances.
References Donoghue, N., et al.: Eur. J. Biochem., 60, 1 (1975), Chen, Y., et al.: J. Bacteriol., 170, 781 (1988),

Applications Triacetin-d5 is the isotope labelled analog of Triacetin (T720850); a compound used as a food additive and flavoring. Triacetin can be used as an excipient in pharmaceutical products where it is used as a humectant, a plasticizer, and as a solvent. Triacetin can also be used as a fuel additive as an antiknock agent.
References Mouret, A., et al.: Green Chem., 16 (1), 269 (2014); Snejdrova, E., et al.: Inter. J. Pharma., 458, 282 (2013)

Applications 5-(4-Fluorophenyl)-2,3-dihydro-3-(1-methylethyl)-2-oxo-N,4-diphenyl-1-[2-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1H-pyrrole-3-carboxamide is a photodegradation product of Atorvastatin (A791750).
References Cermola, F., et al.: Tetrahedron., 62, 7390 (2006);

Applications An enantiomeric impurity of Ezetimibe (E975005), an antihyperlipoproteinemic and cholesterol absorption inhibitor.

Applications (+)-Citronellal is a monoterpene compound that is formed by the metabolism of plants. (+)-Citronellal is a natural insect repellant, and is the main component of citronellal oil. (+)-Citronellal is also used as a starting material in the one pot synthesis of (-)-Menthol (M218875).
References Kwon, Y., et al.: Curr. Biol., 20, 1672 (2010); Lenardão, E., et al.: Tetrahedron, 63, 6671 (2007); Milone, C., et al.: Appl. Catal. A-Gen., 199, 239 (2000)

Applications It is listed as a known human carcinogen. Used in manufacturing of dyes, as antioxidant in rubber.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References IARC Monographs, 4, 97 (1974),

Stability Hygroscopic
Applications A bile salt formed in the liver from chenodeoxycholate and glycine, usually as the sodium salt. It acts as a detergent to solubilize fats for absorption and is itself absorbed. It is a cholagogue and choleretic.
References Parmentier, G. , et al.: Steroids, 30, 583 (1977), Tserng, K.Y., et al.: Lipids, 13, 479 (1978),

Applications 4’-Hydroxyphenprocoumon is a metabolite of the oral anticoagulant Phenprocoumon (P318820).
References De Vries, J. et al.: J. Chrom. Biomed. Appl., 529, 479 (1990);

Applications A metabolite of Benzydamine (B209950).
References Kataoka, S., et al.: Chem. Pharma. Bull., 21, 358 (1973),

Applications Methyl Lithocholate is an derivative of Lithocholic Acid (L469180),a cholic acid derivative as TGR5 modulator. Found in ox bile, human bile, rabbit bile, and in ox and pig gallstones.
References Roleira, F.M., et al.: Lett. Drug. Design. Discovery., 7, 610 (2010);

Applications The major metabolite of Mosapride (M731000).
References Somogyi, A., et al.: Clin. Pharmacokinet., 8, 463 (1983), Cashman, J., et al.: Drug Metab. Dispos., 21, 587 (1993), Berkman, C., et al.: Biochem. Pharmacol., 50, 565(1995), Blake, B., et al.: Xenobiotica, 25, 377 (1995),

Applications Diltiazem (D460620) intermediate (impurity B).
References Chaffman, M., et al.: Drugs, 29, 387 (1985), Kamath, B., et al.: J. Pharm. Biomed. Anal., 11, 407 (1993), Chankvetadze, B., et al.: J. Pharm. Biomed. Anal., 27, 161 (2002),

Applications: 2,4-Dinitrophenylhydrazone (DNPH) derivative. Also, it is used in TLC as internal standards.
References Lindsay, R.C., et al.: J. Food Sci., 29, 266 (1964),

Applications Nonpeptide endothelin ETA receptor antagonist. Antihypertensive.
References Riechers, H., et al.: J. Med. Chem., 39, 2123 (1996), Billman, G.E., et al.: Curr. Opin. Invest. Drugs, 3, 1483 (2002), Vatter, H., et al.: Clin. Neuropharmacol., 26, 73 (2003),

Applications N-Acetylthiourea is a derivative of Thiourea (T375450); a compound used in biochemistry to increase the solubility (and resolution) of membrane proteins in two-dimensional electrophoresis. N-Acetylthiourea can be used as a reducing agent in a two-part self curing endodontic sealing system.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Jabbour, S.: Am. J. Clin. Dermatol., 4, 315 (2003); Himsworth, H.: Lancet, 242, 465 (1943); Rabilloud, T., et al.: Electrophoresis, 19, 758 (1998); Jin, S. et al. Self-curing system for endodontic sealant applications. PCT Int. Appl. WO 2009018464 A2 20090205. Feb 5, 2009

Applications Ethyl Cinnamate, is used in the preparation of polymer-encapsulated osmonium used as a catalyst for the dihydroxylation of alkenes and preparation of a camptothecin intermediate, anticancer drug. Also used in the synthesis of substrate specific ERK1/2 inhibitors used to induce apoptosis and inhibit cell proliferation.
References Akiyama, R. et al.: RSC Adv., 2, 7456 (2012); Li, Q. et al.: Bioorg. Med. Chem. Lett., 19, 6042 (2009);

Applications Impurity of Bivalirudin, a direct thrombin inhibitor acting as an anticoagulant through inhibition of the enzyme thrombin.
References Bertrand, O. et al.: Am. J. Cardio., 110, 599 (2012); Patti, G. et al.: Am. J. Cardio., 110, 478 (2012);

Applications Carvedilol (C184625) derivative.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Stability Hygroscopic
Applications 4-Hydroxy Estrone 1-N7-Guanine is an estrogen metabolite formed with DNA which can lead to the mutations that initiate breast, prostate, and other types of cancer. Estrogen-DNA depurinating adducts as biomarkers of cancer risk and their use in cancer detection and prevention.
References Chakravarti, D., et al.: Mutat. Res., 456, 17 (2000), Liehr, J., et al.: Endocr. Rev., 21, 4054 (2000), Chakravarti, D., et al.: Oncogene, 20, 7945 (2001), Cavalieri, E., et al.: Chem. Res. Toxicol., 14, 1041 (2002),

Applications CRL-40,941 is a wakefulness-promoting agent. It was found to produce antiaggressive effects in animals.
References Lafon, L.: US4489095 (A) (1984)

Applications An impurity of the analgesic Ketorolac (K235650).

Applications 6-Hydroxynaphthalene-2-sulfonic Acid Potassium Salt is used the in the synthesis of azo dyes and pigments.
References Gao, Pu. et al., Dyes Pigm. 179, 108376(2020);

Applications Diazoxide-d3 is the labeled analogue of Diazoxide (D417305), which reduces status epilepticus neuron damage in diabetes.
References Baba, A., et al.: J. Neurosci., 23, 7737 (2003); Bancila, V., et al.: J. Neurochem., 90, 1243 (2004); Bancila, V., et al.: J. Biol. Chem., 280, 8793 (2005)

Applications A labelled metabolite of Spironolactone.
References Gochman, N., et al.: J. Pharmacol. Exp. Ther., 135, 312 (1962), Tori, K., et al.: Steroids, 4, 713 (1964), Solymoss, B., et al.: Toxicol. Appli. Pharmacol., 18, 586 (1971),

Applications (cas# 53188-20-8) is a useful research chemical.

Applications The main basic metabolite of Diethylpropione.
References Banci, F., et al.: Arzneim.-Forsch., 21, 1616 (1971), Mikhailova, D., et al.: Eur. J. Med. Chem., 13, 49 (1978),

Applications Betamethasone 6α-Bromo 17-Valerate is an impurity of Betamethasone (B327000), which is a glucocorticoid used as an anti-inflammatory agent.
References Ferrante, M.G., et al.: Anal. Profiles Drug Subs., 6, 43 (1977), Li, A., et al.: Chem. Biol. Interact., 142, 7 (2002), Cruz-Monteagudo, M., et al.: Eur. J. Med. Chem., 40, 1030 (2005), Rothfuss, A., et al.: Chem. Res. Toxicol., 19, 1313 (2006),

Stability Hygroscopic
Applications A metabolite of Cortisol (H714615).
References Quinkler, M., et al.: J. Clin. Endocrinol. Metab., 88, 2384 (2003), Draper, N., et al.: J. Endocrinol., 186, 251 (2005), Kotlowska, A., et al.: Clin. Biochem., 42, 448 (2009),

Applications Bromantane is an adamantane derivative used as an anxiolytic agent.
References Reznikov, A., et al.: Endokrinologie, 73, 11 (1979), Grekhova, T., et al.: Bull. Eksp. Biol. Med., 119, 302 (1995),

Impurity Diltiazem EP Impurity F
Applications Desacetyl Diltiazem (Diltiazem EP Impurity F) is a metabolite of Diltiazem (D460620).
References Shallcross, H., et al.: Br. Med. J., 295, 1236 (1987), Yeung, P.K.F., et al.: Drug Metab. Dispos., 18, 1055 (1990), Cashman, J.R., et al.: J. Med. Chem., 34,2049 (1991),

Stability Hygroscopic
Applications Synthetic thrombin inhibitor. Thrombin mutant anticoagulant antagonist. Antithrombotic.
References Dewanjee, M., et al.: J. Nucl. Med., 22, 981 (1981), Goodman, S., et al.: J. Biomed. Mater. Res., 45, 240 (1999), Carlsson, S., et al.: Thromb. Res., 115, 9 (2005),

Applications Bromfenac is a non-steroidal anti-inflammatory agent.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Obach, R., et al.: Drug Metab. Disposition, 36, 1385 (2008), MacDonald, J., et al.: Toxicol. Sci., 110, 40 (2009), Varma, M., et al.: J. Med. Chem., 52, 4844 (2009),

Applications 2,3,4-Trihydroxybenzophenone-2’,3’,4’,5’,6’-d5 is the isotope labelled analog of 2,3,4-Trihydroxybenzophenone; a trihydroxy derivative of Benzophenone (B204980) which is a compound used in the manufacturing of antihistamines, hypnotics, and insecticides.
References Wallace, W., et al.: Environ. Toxicol. Chem., 19, 962 (2000); Hayashi, T., et al.: Toxicol. Lett., 167, 1 (2006); Bechard, K., et al.: Aquat. Toxicol., 90, 310 (2008)

Applications The 5-hydroxy analogue of the bronchodilator, Albuterol (A514500).

Applications (-)-Biotin Sulfoxide, is a metabolite of Biotin (B389040), which is a growth factor present in minute amounts in every living cell, and plays an indispensable role in numerous naturally occurring carboxylation reactions.
References du Vigneaud, et al.: J. Biol. Chem., 146, 475 (1942), Traub, et al.: Nature, 178, 649 (1956), Siegel, H., et al.: Experienta, 37, 789 (1981), Vesely, D.L., Science, 216, 1329 (1982), Hugues, M., et al.: Biochemistry, 31, 12 (1992),

Applications (+)-(S)-Dihydrokavain is a kavalactone found in kava beverages consumed by South Pacific islanders. Furthermore, roots and extracts of the kava plant have been used in herbal medicine to treat sleep disturbances, as well as stress and anxiety.
References Warburton, E., et al.: Eur. J. Mass Spectrom., 12, 223(2006); Wang, J., et al.: J. Food Sci. Technol., 52, 1164 (2015)

Stability Hygroscopic
Applications 3-Sulfoglycolithocholic Acid Disodium Salt is a derivative of Lithocholic acid (L469180). Lithocholic acid (LCA) is a putative tumor promoter,that is shown to be able to inhibit mammalian DNA polymerase β.
References Ogawa, A., et al.: Jap. J. Canc. Res., 89, 1154 (1998)

Applications N-Nitrosodimethylamine-d6 (1.0 mg/mL in Methanol) is a highly toxic semi-volatile organic compound and a suspected human carcinogen. It induces liver tumors in rats after chronic exposure to low doses (1,2). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA). Environmental contaminants; Food contaminants.
References Chem. and Eng. News, p.5, Feb. 25, 2019

Applications Metabolite of 5α-Androst-16-en-3β-ol
References Gower, D., et al.: J. Steroid Biochem. Mol. Biol., 63, 81 (1997), Zorko, M., et al.: Steroids, 65, 46 (2000), Diel, P., et al.: Toxicol. Lett., 169, 64 (2007),

Impurity Carvedilol EP Impurity B; Carvedilol Impurity B; Carvedilol USP B
Applications Carvedilol Bis-carbazole (Carvedilol EP Impurity B; Carvedilol Impurity B; Carvedilol USP B) is an impurity from the process of Carvedilol (C184625).

Stability Hygroscopic
Applications Fluorescein-Cadaverine is a fluorescein derivative used in the preparation of biologically active fluorescent-labeled vitamin K analogues and monitoring of their subcellular distribution.
References Suhara, Y. et al.: Tetrahedron, 64, 8789 (2008);

Applications A bronchodilator.
References Daly, J. W., et al.: J. Med. Chem., 9(3), 273 (1966).

Applications The primary component of Vanilla bean extract.
References Nazeruddin, G., et al.: Res. J. Pharm., Biol. Chem. Sci., 2, 71 (2011), Yang, X., et al.: Biores. Technol., 102, 3498 (2011),

Applications Used in the compositions for the treatment of blood disorders using α-methylhydrocinnamic acid.
References Migliaccio, A., et al.: Blood, 76, 1150 (1990), McDonagh, K., et al.: J. Biol. Chem., 266, 11965 (1991),

Applications A metabolite of Desogestrel.
References Back, D., et al.: Br. J. Clin. Pharmacol., 26, 23 (1988), Wienkers, L., et al.: Drug Metab. Dispos., 1990, 24, 610 (1990), Bourrie, M., et al.: J. Pharmacol. Exp. Ther., 277, 321 (1996), Ono, S., et al.: Xenobiotica, 26, 681 (1996),

Stability Hygroscopic
Applications Perfluorodecane Sulfonic Acid, is a micropollutant found in marine organisms and waste water sludge.
References Wille, K., et. al.: Anal. Bioanal. Chem., 400, 1459 (2011); Arvaniti, O.S., et. al.: J. Hazard. Mater., 239, 24 (2012)

Applications Glutaurine Sodium Salt is the salt of Glutaurine (G597350) which has been observed to display antiepileptic effects with anti-amnesia properties. Mimics anxiolytic drug Diazepam (D416855).
References Bittner, S. et al.: Amino Acids., 28, 343 (2005); Uemura, S. et al.: Brain. res., 594, 347 (1992);

Applications Methyltriphenylphosphonium Bromide is a lipophilic molecule with a cation allowing for it to be used to deliver molecules to specific cell components. Also considered an antineoplastic agent.
References Selassie, C.D. et al.: J. Med. Chem., 33, 1914 (1990); Venkatachalam, M.A et al.: Kidney Int., 49, 449 (1996);

Stability Hygroscopic
Applications A metabolite of Equilin (E592800).
References Enmark, E., et al.: J. Clin. Endocrinol. Metab., 82, 4258 (1997), Wang, Z., et al.: J. Med. Chem., 43, 2419 (2000), Jiang, X., et al.: Steroids, 71, 334 (2006),

Applications A metabolite of Atorvastatin, a selective, competitive HMG-CoA reductase inhibitor. Atorvastatin is the only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglycerides in patients with hypercholesterolemia.
References Smith, S., et al.: Am. J. Cardiol., 80, 10H (1997), Jacobsen, W., et al.: Drug Metab. Dispos., 28, 1369 (2000), Istvan, E., et al.: Science, 292, 1160 (2001), Tabernero, L., et al.: J. Biol. Chem., 278, 19933 (2003), Bratton, L., et al.: Bioorg. Med. Chem., 15, 5576 (2007),

Applications Labelled Indoleacetic Acid (I577343) has the potential to be used in anti-cancer therapy in conjunction with horseradish peroxidase (HRP).
References Kawano, T. et al.: Gen. Hypo. 60, 664 (2003);

Applications α-Propyl-α-(1-demethylethyl)-Verapamil is an impurity of Verapamil (V125000, HCl salt) which is a calcium channel blocker.
References Atlas, D, and Adler, M.: Proc. Natl. Acad. Sci. USA, 78, 1237 (1981), Janis, R., et al.: Adv. Drug. Res., 16, 309 (1987)

Applications Pipamazine is a drug od the phenothiazine class which used to be used as an antiemetic.
References Bhargava, K. et al.: Br. J. Pharmacol. Chemother., 22, 154 (1964); Bhargava, K. et al.: Br. J. Pharmacol. Chemother., 21, 436 (1963);

Applications A metabolite of Temozolomide, an antineoplastic.

Stability Hygroscopic
Applications Glycocholic Acid Sodium Salt is a biochemical formed by the conjugation of cholic acid (C432600) with glycine (G615990).
References Monalisa, M., et al.: Langmuir, 27 (2011);

Applications (-)-Terpinen-4-ol (cas# 20126-76-5) is a useful research chemical.

Applications A new indicator for the determination of organic acid anhydrides by the morpholine method.
References Ruch, J.E., et al.: Anal. Chem., 47, 2057 (1975),

Applications Linagliptin is a novel potent and selective dipeptidyl peptidase-4 (DPP-4) inhibitor with potential use in the treatment of type 2 diabetes.
References Prabavathy, N. et al.: Int. J. Pharm. Bio. Sci., 2, 438 (2011); Deacon, C.F.: Diab. Obes. Metab., 13, 7 (2011);

Stability Air Sensitive, Hygroscopic
Applications N-1-Naphthylethylenediamine Dihydrochloride, is an organic building block used for the chemical synthesis. It can also be used as highly selective organic fluorescent probe for azide ion.
References Sahana, A., et al.: Analyst , 137, 1544 (2012);

Applications Propoxyphenyl-thiohydroxyhomosildenafil is an analogue of Hydroxythiohomo Sildenafil (H963150).
References Balayssac, S., et. al.: J. Pharmaceut. Biomed., 63, 135 (2012)