Standard farmaceutici

2,4-Dimethyl-5-nitropyridine is a hydroxyurea analog that inhibits the synthesis of ribonucleotides by competitively binding to the enzyme ribonucleotide reductase. This inhibition leads to the accumulation of diphosphate and deoxyribonucleotides, which are necessary for DNA synthesis. 2,4-Dimethyl-5-nitropyridine was found to be more potent than hydroxyurea as an inhibitor of cellular growth in vitro and cancer cell lines in vivo. The potency of 2,4-dimethyl-5-nitropyridine can be attributed to its ability to bind very tightly with ribonucleotide reductase and form a stable complex.

2',4'-Dibromoacetophenone is a 3',5'-cyclic monophosphate (cAMP) analogue that inhibits protein kinase and phospholipase C. It has been shown to inhibit the production of adenosine in endothelial cells by acting as an antagonist at the adenosine receptor. 2',4'-Dibromoacetophenone also has a strong inhibitory effect on human endothelial cells, which may be due to its ability to inhibit DNA synthesis and protein synthesis. This compound binds to the endothelial cell membrane and blocks the activation of phospholipase A2, preventing the release of arachidonic acid from phospholipids. Arachidonic acid is required for prostaglandin synthesis, which leads to inflammation.

Fmoc-L-aspartic acid beta-2-phenylisopropyl ester is a macrocyclic amino acid with conformational and anti-inflammatory properties. It has been shown to inhibit the proliferation of cancer cells in vitro, as well as the osteolytic, lymphoproliferative, and inflammatory activities in vivo. Fmoc-L-aspartic acid beta-2-phenylisopropyl ester also has antiarrhythmic effects on cardiac tissue that are caused by its ability to bind to chloride channels. This compound also inhibits the production of inflammatory cytokines such as tumor necrosis factor alpha (TNFα) and interleukin 6 (IL6).

17alpha-Methyl-19-nortestosterone (17MT) is an anti-cancer agent that has been used as a contraceptive. It inhibits the conversion of testosterone to dihydrotestosterone by competitive inhibition of the enzyme 3beta-hydroxysteroid dehydrogenase, which is responsible for the first step in the biosynthesis of androgens. 17MT has also been shown to inhibit angiotensin II formation, thereby reducing blood pressure. This drug acts as a structural analogue of progesterone and binds to progesterone receptors, as well as other steroid receptors, with high affinity. 17MT also inhibits fatty acid synthesis in cancer cells, leading to decreased tumor growth.

2,4,5,6-Tetramethoxyacetophenone is a versatile building block that can be used as an intermediate in the production of complex compounds and speciality chemicals. This compound is a useful scaffold for research chemicals and reaction components. It has CAS No. 7508-05-6 and a high quality.

1,3-Bis(4-fluorophenyl)urea is a crystalline solid that is soluble in organic solvents. It has been used as an intermediate in the synthesis of other compounds. 1,3-Bis(4-fluorophenyl)urea is an electron acceptor and can be used to produce diphenyl ethers. This compound has been synthesized using ethyl acetoacetate and anilines. It can be used to treat infectious diseases such as tuberculosis, where it inhibits protein synthesis and cell growth by disrupting the formation of bacterial DNA.

Deoxyshikonin is an analytical method for determining the amount of shikonin in a sample. It is used in vitro to determine the biological properties of shikonin. Deoxyshikonin has been shown to have synergic effects with other drugs, such as basic structure, skin cancer, and natural compounds. Deoxyshikonin also has in vitro antifungal activity against Candida glabrata.

2,4,5-Trimethylacetophenone is a versatile building block used in the synthesis of complex compounds and research chemicals. It is a high quality chemical that can be used as a reagent or speciality chemical. 2,4,5-Trimethylacetophenone is also an intermediate for the synthesis of other useful compounds. This compound can be used as a reaction component to synthesize various types of scaffolds.

Copper-containing enzyme that catalyzes the first step in the synthesis of melanin

2,6-Naphthalenedicarboxylic acid is a synthetic organic compound that belongs to the group of fatty acids. It is produced by oxidation of 2,6-naphthoquinone with sodium carbonate and glycol ester in the presence of an oxidation catalyst. The reaction mechanism appears to involve hydrogen bonding interactions between the hydroxyl groups on the glycol ester and the carboxyl groups on 2,6-naphthoquinone. 2,6-Naphthalenedicarboxylic acid has been shown to bind to intracellular targets such as transfer reactions and fatty acid synthesis. The analytical method for this compound is based on its formation of an adduct with p-hydroxybenzoic acid in hydrochloric acid solution.

(6α,11β,16α,17α)-6,9-Difluoro-11-hydroxy-16-methyl-spiro[androsta-1,4-diene-17,5'-[1,3]oxathiolane]-2',3,4'-trione is a fine chemical that can be used as a building block for the synthesis of complex compounds. This compound is also useful as a reagent and specialty chemical. (6α,11β,16α,17α)-6,9-Difluoro-11-hydroxy-16-methyl spiro[androsta-1,4 diene 17.beta., 5'(1'3'oxathiolane)] 2',3',4'-trione has been shown to be an excellent intermediate for organic reactions and may be used as a scaffold in drug design.

4-Methoxycinnamylidene acetaldehyde is a versatile building block with a CAS number of 27394-81-6. It is used in the research and production of fine chemicals, pharmaceuticals, and high quality reagents. 4-Methoxycinnamylidene acetaldehyde can be used as a useful scaffold for the synthesis of complex compounds. This building block is also a useful intermediate in organic chemistry reactions.

Applications Sodium Deuteroxide (40% w/w in D2O) (cas# 14014-06-3) is a compound useful in organic synthesis.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications trans-Cinnamoyl chloride (cas# 102-92-1) is a useful research chemical.

Applications 4-[1-(4-Iodophenyl)-5-(2,4-dinitrophenyl)-formaz-3-yl]-1,3-benzene Disulfonate, Disodium Salt (cas# 161617-44-3) is a compound useful in organic synthesis.

Applications Intermediate in the synthesis of Oxamyl.

Applications N-Ethyl-N-methyl-O-(4-nitrophenyl)carbamate (cas# 90870-20-5) is a compound useful in organic synthesis.

Applications 5-Amino-3-(1-naphthyl)-4-cyano-1-tert-butylpyrazole (cas# 221243-34-1) is a compound useful in organic synthesis.
References Bishop, A.C., et al.: J. Am. Chem. Soc., 121, 627 (1999)

Applications L-Aspartic Anhydride Hydrochloride is a chemical acylating reagent used in friedel-crafts reactions such as in the preparation of L-homophenylalanine.
References Lin, W. et al.: Synthesis, 7, 1007 (2001);

Applications N-(4-Methoxyphenyl)-N'-1,2,3-thiadiazol-5-yl-urea is an intermediate in the synthesis of N-4-Hydroxyphenyl-N'-1,2,3-thiadiazol-5-ylurea (H949385), a metabolite of Thidiazuron (T344275), a non-purine containing urea derivative with cytokinin activity.
References Orlikowska, T., et al.: Plant Cell Tissue Org. Cult., 59, 95 (1999), Ray, T., et al.: Mol. Biol., 6, 35 (2005), Kanwar, J., et al.: Hort Sci., 2008, 35, 35 (2008),

Applications tert-Butyldimethylsilyloxy-5-aza-2'-deoxycytidine is an intermediate in the synthesis of metabolites of Azadeoxycytidine (A796950), as neoplasm inhibitor.
References Cihak, A., et al.: Eur. J. Cancer, 14, 117 (1978),

Applications O-TBS 2'-Deoxy-N-methyl-cytidine-d3 is an intermediate used in the synthesis of 2'-Deoxy-N-methyl-cytidine-d3 (D242412), which is the labelled form of 2'-Deoxy-N-methyl-cytidine (D242410). 2'-Deoxy-N-methyl-cytidine is a nucleotide derivative used as an analytical reagent.
References Dupret, D.: Biomed. Health. Res., 23(Human Genome Analysis), 244-255 (1998)

Applications 2-Bromo-5-nitropyridine (cas# 4487-59-6) is a compound useful in organic synthesis.

Applications 2-tert-Butyl-1,3-diisopropylisourea is a useful synthetic intermediate in the synthesis of 5-Oxo Atorvastatin tert-Butyl Ester (O847160) which is a Boc-protected derivative of Atorvastatin (A791750, Ca Salt). 2-tert-Butyl-1,3-diisopropylisourea is also used as a reagent in the total synthesis of Citrafungin A which is an antifungal natural product.
References Kearney, A.S., et al.: Pharm. Res., 10, 1461 (1993); Heinonen, T.M., et al.: Clin. Ther., 18, 853 (1996); Whitfield, L.R., et al.: Eur. J. Drug Metab. Pharmacokinet., 25, 97 (2000); Calo, F., et al.: J. Org. Chem., 73, 9692 (2008)

Applications Protected 2-Thiouridine.
References El-Tayeb, A., et al.: J. Med. Chem., 49, 7076 (2006),

Applications (2R,​3E)​-2,​4-​Dimethyl-​2-​[(1-​oxopropyl)​thio]​-​3,​5-​hexadienoic Acid Ethyl Ester is an intermediate in synthesizing (R)-(+)-Thiolactomycin (T350880). It is a natural product inhibitor of β-Ketoacyl-AcpM Synthase A (KasA). It inhibits the synthesis of mycolic acid which is a major cell wall component of Mycobacterium tuberculosis. Also an inhibitor of D-Aspartate oxidase (DDO).
References Kapilashrami, K., et al.: J. Biol. Chem., 288, 6045 (2013); Paneerselvam, V., et al.: J. Pharm. Res., 4, 4618 (2011); Katane, M., et al.: Biochimie, 92, 1371 (2010)

Applications 4-Nitrophenoxyacetic Acid is a butyl p-nitrophenyl ether metabolite. Plant growth regulatory activity.
References Yoshimura, H., et al.: Biochem. Pharmacol., 16, 1953 (1967); Aaberg, B.: Swedish J. Agric. Res., 10, 101 (1980)