Standard farmaceutici

Applications L-2-Nitrophenylalanine is a derivative of L-phenylalanine (P319415), and is used in the photocleavage of polypeptide backbones. L-Phenylalanine is an essential amino acid. L-Phenylalanine is biologically converted into L-tyrosine, another one of the DNA-encoded amino acids, which in turn is converted to L-DOPA and further converted into dopamine, norepinephrine, and epinephrine.
References Peters, F. et al.: Chem. Biol., 16, 148 (2009); Hollunger, G. et al.: Acta Pharmacol. Toxicol., 34, 391 (1974); Bagchi, S.P. et al.: Biochem. Pharmacol., 26, 900 (1977);

Applications β-Elemene is an active constituent of Delonix regia and an anti-inflammatory agent. β-Elemene is a useful compound for investigating the toll-like receptor 4 signaling pathway and the inhibition of TNF-​a, IL-​1b, IL-​6 and IL-​12 expressions.
References Satajit, P., et al.: Int Immunopharmacol 34, 199 (2016);

Applications Testosterone-2,2,4,6,6-d5 Benzoate is a useful isotopically labeled compound of Testosterone Benzoate (T155015)

Applications 2,6-dibromoanthracene (cas# 186517-01-1) is a useful research chemical.

Applications (αE)-α-[(3,4-Dihydroxy-5-nitrophenyl)methylene]-β-oxo-1-piperidinepropanenitrile is an impurity of Entacapone (E558500), a peripherally acting inhibitor of catechol-O-methyl transferase (COMT), an enzyme involved in the metabolism of catecholamine neurotransmitters and related drugs. Antiparkinsonian.
References Karlsson, M., et al.: J. Pharm. Biomed. Anal., 10, 593 (1992), Nissinen, E., et al.: Arch. Pharmacol., 346, 262 (1992), Wikberg, T., et al.: Eur. J. Drug Metab. Pharmacokinet., 18, 359 (1993),

Applications Intermediate in the production of Losartan impurities

Applications Intermediate for the synthesis of 2-Hydroxymethyl Loratadine.
References Cerrada, V., et al.: ARKIVOC, 9, 200 (2005).

Stability Moisture Sensitive
Applications 1-Naphthyl Isocyanate was used in the preparation of cationic aromatic urethane.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References McEntyre, C.J., et al.: Anal. Chim. Acta, 644, 90-94 (2009)

Applications Bromo-2’-nitroacetophenone is used in the novel synthesis of 5-pyridylindolizine derivatives.
References Georgescu, E. et al.: J. Hetero. Chem., 50, 78 (2013);

Applications 2,2',4,4'-Tetranitro-1,1'-biphenyl is an intermediate used in the synthesis of substituted dibenzophospholes.
References Cornforth, J., et al.: J. Chem. Soc. Perkin Transactions 1:  Organic and Bio-Organic Chemistry, 10, 2299 (1982)

Applications 3-(Triisopropylsilyl)oxy-isourolithin A is an intermediate for the synthesis of Isourolithin A 9-Glucuronide (I917525), which is a metabolite of ellagitannins and ellagic acid in different mammals.
References Gonzalez-Barrio, R., et al.: J. Agric. Food Chem., 59, 1152 (2011)

Applications (3,4-Dinitrophenyl)(phenyl-d5)methanone is an intermediate for the synthesis of Mebendazole-d8 (M200502), which is labelled Mebendazole (M200500). Anthelmintic (Nematodes).
References Al-Badr, A.A., et al.: Anal. Profiles Drug Subs., 16, 291 (1987)

Applications Lactosyl-C18-sphingosine has been found to have a strong interaction with HIV-1 Gp120.
References McReynolds, K.D., et. al.: Bioconjugate Chem., 10, 1021 (1999)

Applications 2-Amino-3-chlorobenzoic Acid is a plant growth regulator.
References James, C. S., et a.: Ann. Appl. Biol., 61, 295 (1968)

Applications 3'-O-Levulinoyl-N-benzoyl-2'-deoxycytidine is a protected nucleotide derivative/building block.
References Kiuru, E., et al.: Helvetica Chimica Acta, 96, 1997-2008 (2013);

Applications 4-Chlorosulfonylcinnamic Acid (cas# 17641-30-4) is a compound useful in organic synthesis.

Applications (+)-Carotol is an essential oil extracted from Seseli libanotis plant. A natural product.
References Chizzola, R.: Chem. Biodivers., 16, 6 (2019), El O., et al.: Res. J. Pharm. Biol. Chem. Sci., 9, 1524 (2018)

Applications 1-(3-Bromophenyl)thiourea
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications A 9-substituted derivative of the polycyclic aromatic hydrocarbon (PAH) Anthracene (A678400).

Applications 1,2,3,4-Tetrahydro-1,2,8-naphthalenetriol is a reagent is used in the preparation of pharmaceuticals and in organic synthesis.

Applications Benzyl 4-Nitrophenyl Carbonate is used as a reagent in the synthesis of Janus PEG-based dendrimers for use in combination therapy by controlled multi-drug loading and sequential release. Benzyl 4-Nitrophenyl Carbonate is also used as a reagent in the synthesis of Norfloxacin analogs which can exhibit antibacterial and antifungal activities under visible and UV light.
References Acton, A.L., et al.: Biomacromolecules, 14, 564 (2013); Bakhotmah, D.A., et al.: ISRN Org. Chem., 184754, 11 (2011)

Applications Isotope labelled δ-Valerolactone used in the synthesis of various antibiotics including the ionophore antibiotic X-14547A. Also used in the preparation of polyesters via copolymerization.
References Nicolaou, K. et al.: J. Org. Chem., 50, 1440 (1985); Parrish, B. et al.: J. Polym. Sci. Polym, Chem., 40, 1983 (2002);

Applications 5’-Cholesteryl-TEG Phosphoramidite is used in the synthesis of immunostimulatory oligonucleotides for in vivo cell modification for immunotherapy.
References Liu, H. et al.: Angew. Chem. Int. Ed., 50, 7052 (2011);

Applications α-(Bromomethyl)-α-butyl-4-chlorobenzeneacetonitrile-d9 is an intermediate used in the synthesis of Myclobutanil-d9 (M831402), which is the labeled analogue of Myclobutanil (M831400), an fungicide used on a wide range of food crops. Myclobutanil inhibits the biosynthesis of ergosterol, a critical component of fungal membranes.
References Kumar, A., et al.: J. Mycol. Plant. Pathnol., 42, 443 (2012); An, Y.R., et al.: Toxicol., 303, 94 (2013); Keinath, A.P., et al.: Crop. Protect., 42, 338 (2012);

Applications Bis(carboxyethylgerm​anium) Sesquioxide is a reagent used in the synthesis of carbon nanotubes.
References She, X. et al.: ACS App. Mat. Inter., 8, 10383 (2016);

Applications 4-tert-Butyldimethylsiloxyacetophenone is an intermediate in the synthesis of 1-(4-(2-Cyclobutoxyethyl)phenoxy)-3-(isopropylamino)propan-2-ol (C988245), which is a derivative of Betaxolol (B328000).
References Philippe, M.M., et. al.: Am. Chem. Soc., 30, 1003 (1987)

Applications 3,4-Dihydro-1H-indolo[2,3-b][1,8]naphthyridin-2(10H)-one, is a derivative of 6,7,8,9-Tetrahydro-7-hydroxy-5-methyl-3-phenyl-pyrido[3’,2’:4,5]imidazo[1,2-a]pyrimidinium Chloride (H957770), a carcinogen used in the study of intestinal bacteria metaboism. Created through the heat processing of food.
References Vanhaecke, L.. et al.: Food Chem. Toxicol., 46, 140 (2008);

Applications 3-(4-Hydroxyphenyl)propionic Acid-d4 is the deuterated isotope of 3-(4-Hydroxyphenyl)propionic Acid (H9508200). Antioxidant
References Arnous, A., et al.: J. Agr. Food Chem., 49, 5736 (2001)

Applications N,N’-Bis(3-pyridyl)urea (cas# 39642-60-9) is a compound useful in organic synthesis.

Applications 1-[(2-Nitrophenyl)sulfonyl]-1H-pyrrole is used in the preparation of various 2-​substituted N-​nosylpyrroles.
References Shibata, M. et al. Tetrahedron. 71, 4495 (2015);

Applications Testosterone-16,16,17-d3 17-Phenylpropionate, is the labeled analogue of Testosterone 17-Phenylpropionate (T155150), a Testosterone ester being misused by athletes in an attempt to improve sports performance. It can also be used as a therapy in glucocorticoid-treated patients to increase the circulating testosterone concentration.
References Shackleton, C. H. L., et al.: Steroids, 62 (7), 523 (1997); Reid, I. R., et al.: Archives Internal Med., 156 (11), 1173 (1996);

Applications Intermediate for the synthesis of O-desmethylvenlafaxine.

Stability Hygroscopic
Applications 2’-Deoxyisoguanosine is a nucleoside which is used to synthesize Duplex DNA and DNA/RNA hybrids and DNA mismatch pairs for analysis of helix stability.
References Ingale, S. et al.: J. Org. Chem., 80, 3124 (2015); Seela, F. et al.: ChemBioChem., 11, 1443 (2010);

Applications 7-(Hydroxymethyl)-1,8-naphthyridin-2(1H)-one is used as a reactant in the synthesis of photoswitchable unsymetrical ligands possessing pairs of different base recognition elements for DNA hetero-mismatches.
References Dohno, C., et al.: Eur. J. Org. Chem., 1, 4051 (2009);

Applications Methyl(4-methylnaphthalen-1-ylmethyl)amine-d3 is the isotope analog of Methyl(4-methylnaphthalen-1-ylmethyl)amine. Methyl(4-methylnaphthalen-1-ylmethyl)amine is a reagent in the preparation of heterocyclic compounds as enoyl-acyl carrier protein reductase FabI inhibitors and antibacterial agents.
References Stuetz, A., et al.: J. Med. Chem., 29, 112 (1986); Berman, J., et al.: PCT Int. Appl., 2004:515512 (2004)

Applications 9-Chlorophenanthrene is a monochlorinated phenanthracene with mutagenic activity. Studies suggest that its carcinogenicity might be associated with aryl hydrocarbon receptor signaling.
References LaVoie, E.J. et al.: Mut. Res. Gen. Toxicol. Test., 116, 91 (1983); Ohura, T. et al.: Environ. Toxicol., 24, 180 (2010);

Applications Intermediate in the preparation of Azasetron.
References Kawakita, T., et al.: Chem. Pharm. Bull., 40, 624 (1992),

Applications 2-Bromo-4-nitrophenol

Applications naphthalene-2-sulfonohydrazide (cas# 10151-46-9) is a useful research chemical.

Applications 1,3-Di(methyl-d3)-naphthalene is the labeled analogue of 1,3-Dimethylnaphthalene (D476385), a polycyclic aromatic hydrocarbon (PAH) that has been shown to have cytochrome P 450 2A6 and 2A5 inhibitory activities.
References Wammer, K.H., Peters, C.A.: Environ. Sci. Technol., 39, 2571 (2005); Roy, K., Roy, P.P.: Eur. J. Med. Chem., 44, 1941 (2009)

Stability Hygroscopic
Applications 3,3'-Diaminobenzidine

Stability Hygroscopic
Applications 3,3'-Oxydipropanol is an intermediate in the synthesis of 3,3'-[Oxybis(3,1-propanediyloxy)]bis[1-propanol] (O870290). 3,3'-[Oxybis(3,1-propanediyloxy)]bis[1-propanol] is derived from 3-(Benzyloxy)propyl 4-Toluenesulfonate (B288830), which is used as a reagent in the synthesis of Silodosin (S465000); an antidysuria drug. 3-(Benzyloxy)propyl 4-Toluenesulfonate is also used as a reagent in the preparation of aryloxyalkyl derivatives of adenine which have antiviral activity.
References Calogero, F., et al.: Eur. J. Org. Chem., 2015, 6011 (2015); Petrov, V.I., et al.: Chem. Heterocyc. Compd., 39, 1218 (2003)

Applications 2,3,6,7-Tetramethyl Anthracene is an Anthracene (A678400) homologue. 2,3,6,7-Tetramethyl Anthracene is used in synthesis of naphthalenes, anthracenes, 9H-fluorenes, and other acenes.
References Robertson, D., et al.: J. Med. Chem., 29, 1577 (1986), de Koning, C., et al.: Tetrahedron, 59, 7 (2003), Smith, K., et al.: Org. Biomol. Chem., 1, 1552 (2003),

Applications Used in the new synthesis of coumarino(3,4:3',2')chromones. An antioxidant.
References Born, M., et al.: Helv. Chim. Acta, 79, 1147 (1996),

Applications 3-Amino-5-nitrophenylboronic acid

Applications 1-(6-HYDROXYNAPHTHALEN-2-YL)ETHAN-1-ONE (cas# 10441-41-5) is a useful research chemical.

Applications 4-(2-Fluoro-4-nitrophenyl)morpholine is a reactant in the synthesis of 5-​substituted oxazolidinone derivatives with high antimicrobial activity.
References De Rosa, M., et. al.: Eur. J. Med. Chem., 69, 779 (2013)

Applications 4-Amino-5-chloro-2,3-dihydro-7-benzofurancarboxylic Acid, can be used as an intermediate for the synthesis of Prucalopride (P838950), a selective 5-HT4 receptor agonist used effective for chronic constipation.
References Hirokawa, Y., et al.: J. Med. Chem., 46, 702 (2003);

Applications 1-Aminonaphthalene-d9 (CAS# 78832-56-1) is a useful isotopically labeled research compound.

Applications ESCULIN SESQUIHYDRATE (cas# 66778-17-4) is a useful research chemical.

Applications Methyl 1,4-Dihydro-4-(2’-trifluoromethyl)phenyl-pyridine-3-carboxylate-5-ethyl Carboxamide (cas# 887407-06-9) is a compound useful in organic synthesis.

Applications 2'-Hydroxyflavone (cas# 35244-11-2) is a useful research chemical.

Applications 2-Quinoxalinecarboxylic Acid Methyl Ester has been used as a reactant in the synthesis of quinoxaline derivatives that show antimycobacterial activity, while displaying minor activity itself. In addition to having the substructure that exhibits antitumor activity, it is also used in the design of guanine-guanine selective DNA cleaving agents.
References Seitz, L.E. et al.: J. Med. Chem., 45, 5604 (2002); Toshima, K. et al.: Chem. Comm., 3, 212 (2002);

Applications S-Benzoyl Tiopronin-d5 is labelled S-Benzoyl Tiopronin (B209585) which is used to prepare radiolabeled platelet GPIIb/IIIa receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders.
References DeGrado, W., et al.: PCT Int. Appl., WO 9422494 A1 19941013 (1994)

Applications 2-Naphthylamine Hydrochloride is listed as a known human carcinogen used in the manufacturing of dyes and as antioxidant in rubber.
References IARC Monographs, 4, 97 (1974),

Applications 3-Methoxy Acetaminophen-d3 is deuterium labeled 3-Methoxy Acetaminophen (M226050). 3-Methoxy Acetaminophen is a metabolite of Acetaminophen (A161220), an analgesic and antipyretic agent used as a pain reliever to treat headache, muscle aches, and arthritis (1,2,3).
References (1) McGill, M. R. and Jaeschke, H. Pharm Res. 30, 2174 (2013)(2) Fairbrother, J.E., et al.: Anal. Profiles Drug Subs., 3, 1 (1974) (3) Hinson, J.A., et al.: Rev. Biochem. Toxicol., 2, 103 (1980)

Applications 13-cis-Retinoic Acid-d5, is the labeled analogue of 13-cis-Retinoic Acid (R250000) used as a treatment for severe acne. Presently being studied in conjuction with the treatment of photoaged skin.
References Lerche, C., et al.: Exp. Dermatol., 17, 972 (2008), Sato, T., et al.: J. Med. Chem., 51, 7705 (2008), Gan, J., et al.: Chem. Res. Toxicol., 22, 690 (2009), Macejova, D., et al.: Toxicol. Lett., 184, 114 (2009), Chen, P., et al.: Toxicol. App. Pharmacol., 234, 143 (2009),

Applications 2-Amino-3’-hydroxy-acetophenone Hydrochloride is a reactant in the synthesis of TRPM8 modulators.
References PCT Int. Appl. (2014), WO 2014130582 A2 20140828;