Glicoscienza

<p>Polydextrose is a synthetic polymer of glucose. It is a food ingredient classified as soluble fibre by the U.S. Food and Drug Administration (FDA) as well as Health Canada, as of April 2013. It is frequently used to increase the non-dietary fibre content of food, to replace sugar, and to reduce calories and fat content. It is a multi-purpose food ingredient synthesized from dextrose (glucose), plus about 10 percent sorbitol and 1 percent citric acid. Its E number is E1200. It was approved by FDA in 1981.</p>

<p>Butyl b-D-glucopyranoside is a fluorinated monosaccharide that is used in the synthesis of oligosaccharides and polysaccharides. It is also used as a synthetic sugar for glycosylation, methylation, and click modification reactions. Butyl b-D-glucopyranoside has been shown to be stable under both acidic and basic conditions and has a CAS number of 5391-18-4.</p>

<p>2-Deoxy-2-fluoro-D-galactose, also called 3-fluoro-6-hydroxymethyl-tetrahydro-pyran-2,4,5-triol, can be added to the medium of primary cultured rat hepatocytes to inhibit N-glycosylation of proteins. Immunoglobulin G (IgG) is the most common antibody found in blood and 2-deoxy-2-fluoro-D-galactose modifies the galactosylation of the N-linked glycan in the IgG-Fc receptor.  We also have the same product MD04718.</p>

<p>Corn Cob Syrup is a custom synthesis of polysaccharides, which are complex carbohydrates. This syrup is made from corn cobs and has been modified with fluorine and methyl groups. The monosaccharides in this syrup have been modified with a click modification and the oligosaccharides have been modified with glycosylation. This product contains sugar that has been modified by glycosylation.</p>

<p>Epidermal growth factor is a polypeptide that regulates the proliferation and differentiation of cells. It has been shown to have anabolic effects on muscle, connective tissue and bone. Epidermal growth factor binds to the epidermal growth factor receptor (EGFR), which is found in the cell membrane. The binding of the ligand to this receptor induces a conformational change in the receptor, which activates downstream signalling pathways, leading to its biological effects. Epidermal growth factor has been shown to stimulate protein synthesis in skeletal muscle cells by increasing levels of messenger ribonucleic acid (mRNA) encoding for insulin-like growth factor I (IGF-I). This stimulation is mediated by an increase in cAMP concentrations induced by EGFR activation.br&gt;br&gt;</p>

Methyl 2,3,4-tri-O-benzoyl-6-O-trityl-a-D-glucopyranoside is a synthetic compound that has been modified. This modification includes the addition of fluorine at the 6th carbon on the right side of the molecule. The methylation and tritylation of the molecule have also been performed to create a new product with a better stability. Methyl 2,3,4-tri-O-benzoyl-6-O-trityl-aDglucopyranoside can be used as a monosaccharide or oligosaccharide in glycosylation reactions. It can also be used as an intermediate in the synthesis of complex carbohydrate molecules.

<p>2-Amino-2,4-dideoxy-4-fluoro-D-glucose HCl is a synthetic carbohydrate. It is a modification of the sugar glucose with fluorine substitution. The CAS Number for this compound is 53635-91-5. 2-Amino-2,4-dideoxy-4-fluoro-D-glucose HCl has an average molecular weight of 258.1 g/mol and it can be synthesized in custom amounts. This product is available as a white crystalline powder and it can be used in various applications such as glycosylation, methylation, or click chemistry modifications.</p>

1,4-Dideoxy-1,4-imino-D-mannitol HCl is a custom synthesis, modification and fluorination of mannitol. This compound is synthesized by the click modification of a monosaccharide and oligosaccharide. It is a saccharide with an average molecular weight of 584.45 g/mol. 1,4-Dideoxy-1,4-imino-D-mannitol HCl has been used to study glycosylation and sugar binding in carbohydrate research. CAS No.: 114976-76-0

<p>2-Allyloxycarbonylamino-1,6-anhydro-2-deoxy-b-D-glucopyranose is a synthetic saccharide that has been modified with 2,5-difluoroacetophenone. This modification generates a fluorine atom at the C2 position of the glucose ring. The synthesis of this compound is performed by custom synthesis for Click chemistry. The desired reaction product is obtained in high purity and with good yield. The chemical formula for 2,5-difluoroacetophenone is C8H7F3O2 and the molecular weight is 191.19 g/mol.<br>2,5-Difluoroacetophenone has been shown to be an efficient reagent in glycosylation reactions because it can react selectively with primary alcohols and amines without affecting other functional groups present in the molecule. In addition, 2,5-difluoroacetophenone</p>

<p>2-Azido-2,6-dideoxy-3,5-((R)-benzylidene-L-mannofuranose) is a synthetic, fluorinated carbohydrate that can be used to modify saccharides, oligosaccharides, or polysaccharides with click chemistry. This product has been modified by the addition of an azido group at the 2 position and a fluoride atom at the 6 position. The CAS number for this product is 52765-69-0.</p>

<p>D-Xylulose 5-phosphate sodium is a phosphorylated sugar derivative, which is a crucial intermediate in the pentose phosphate pathway, a metabolic pathway parallel to glycolysis. It is naturally sourced from biochemical processes within organisms where it plays a pivotal role in carbohydrate metabolism.The mode of action involves its function as a substrate in the non-oxidative phase of the pentose phosphate pathway, where it facilitates the interconversion of sugars necessary for nucleotide and amino acid biosynthesis. This intermediary step is vital for the production of ribose-5-phosphate and NADPH, which are essential for anabolic reactions and antioxidant defense mechanisms.D-Xylulose 5-phosphate sodium is predominantly used in biochemical research to study metabolic pathways. It helps researchers investigate cellular processes, understand disease mechanisms where metabolism is disrupted, and explore metabolic engineering applications. By examining its role and transformations, scientists gain insights into energy production, redox balance, and cellular growth, providing foundational knowledge crucial for the development of therapies targeting metabolic disorders and cancer.</p>

2, 5-Anhydro-4,6-O-isopropylidene-D-idonic acid is a carbohydrate that can be used as a saccharide or oligosaccharide. This product has been fluorinated and methylated. It is also glycosylated and click modified. 2,5-Anhydro-4,6-O-isopropylidene-D-idonic acid can be synthesized to order and is available in high purity.

<p>Chitin is a polysaccharide which is found widely in nature, where it functions in a manner similar to collagen in chordates. It forms the tough fibrous exoskeletons of insects, crustaceans and other arthropods, and, in addition to its presence in some fungi, it occurs in at least one alga. The structure of chitin is similar to that of cellulose but with glucose replaced with N-acetyl-D-glucosaminyl units linked β-D-(1,4) in a linear chain. It is normally produced from the shells of lobster, crab or shrimp.</p>

Blood group antigen conjugated to spacer and biotin

Ursodeoxycholic acid acyl-b-D-glucuronide (UDCA) is a synthetic bile acid that is used to treat liver diseases such as cirrhosis, primary biliary cirrhosis and cholelithiasis. UDCA inhibits the enzyme 7α-hydroxylase in the liver, which converts cholesterol into bile acids. This prevents the formation of lithocholic acid from cholesterol and the accumulation of lipids in the liver. UDCA also suppresses inflammatory cytokines and oxidative stress by inhibiting NF-κB activation.Supplied as the sodium salt

<p>2,3:4,5-Di-O-isopropylidene-D-xylitol is an acceptor for the Stannic Chloride Reaction. It is a lacto-n-biose derivative of D-xylitol that has been shown to have antibiotic activity against Streptococcus section A and B. The temporary protection of the hydroxyl group in 2,3:4,5diOisopropylidene-Dxylitol with methyl glycosides provides a convenient method for glycosylations. The chloride ion can be replaced by hexaacetate to yield 1amino1deoxyDxylitol hydrochloride, which is a benzyl derivative. This reaction allows for research into the transfer of 2,3:4,5diOisopropylideneDxylitol.</p>

<p>2,3,5-Tri-O-benzyl-b-D-xylofuranose is a synthetic carbohydrate with a complex structure. It is an oligosaccharide that has been modified by methylation and glycosylation. It has a molecular weight of 582.16 g/mol and the CAS number is 1174234-12-8.</p>

UDP-2-deoxy-2-fluoro-D-glucose sodium salt (UDPFG) is a fluorinated analog of the sugar donor, UDP-glucose. It is an acceptor for the enzyme, glycosylation protein glucosyltransferase, which catalyzes the transfer of glucose to proteins. This compound has been shown to be an activating sugar donor in vitro and in vivo. In addition, it was found that UDFG can bind to the active site of glucosyltransferase in a hydrogen bond interaction that may be important for catalysis.

<p>L-g-Ethylidene glutamic acid is an organic compound that is used in the production of pharmaceuticals, agrochemicals, and other chemicals. It can be synthesized by the methylation of L-glutamic acid with formaldehyde and sodium cyanoborohydride. L-g-Ethylidene glutamic acid has also been modified by a click reaction to create a fluorinated derivative. This product is a white crystalline solid that has a CAS number. The product is available at high purity and can be ordered as either monosaccharide or polysaccharide.<br>L-g-Ethylidene glutamic acid is a sugar that belongs to the carbohydrate family and can be classified as complex carbohydrates because it comprises two or more sugars linked together. This product may also be referred to as an oligosaccharide or polysaccharide, depending on its molecular size.</p>

<p>(3S, 4R) -3- (Hydroxymethyl) - 3, 4- pyrrolidinediol is a synthetic sugar molecule that is used in the synthesis of polysaccharides and oligosaccharides. It can be modified with fluorination, methylation, or glycosylation. This product has a purity of 99% or higher.</p>

<p>3-Azido-3-deoxy-1,2:5,6-di-O-isopropylidene-a-D-glucofuranose is a synthetic sugar that has been modified by Fluorination, Monosaccharide, Synthetic, Oligosaccharide, complex carbohydrate, CAS No. 13964-23-3 and Glycosylation. It is also a Polysaccharide with modifications of Click modification and Methylation. 3A3DG can be used to modify the sugar content of glycoproteins and glycolipids in order to study their role in cellular processes such as transcriptional regulation and apoptosis. This product is available for custom synthesis in quantities from milligrams to kilograms.</p>

<p>1,3:1,4-b-Glucotetraose (B) is a high purity, custom synthesis sugar. It can be modified with a click modification, fluorination, glycosylation, or methylation. This compound has CAS No. 58484-02-9 and is a Modification of the carbohydrate saccharide group. 1,3:1,4-b-Glucotetraose (B) is an Oligosaccharide that consists of Monosaccharides and Carbohydrates. It is a complex carbohydrate that can be used as a medicine for diabetes mellitus type 2.</p>

D-Glucosamine-2-N-sulfate sodium is a synthetic, high purity carbohydrate with a custom synthesis. It is an oligosaccharide that is also a sugar and a saccharide. The methylation of D-glucosamine 2-N-sulfate sodium can be achieved by glycosylation or click modification. Click modification is the addition of a carbon atom to the molecule through the reaction with an electrophile, such as N-hydroxysuccinimide ester. This modification can be used to introduce fluorine atoms into the molecules, which can improve their solubility and stability. The product has shown anti-inflammatory activities in animal models, which may be due to its ability to inhibit prostaglandin synthesis.

<p>Streptamine derivative; antibiotic agent</p>

<p>Calcium L-Arabonate is a calcium salt of arabic acid. Calcium L-Arabonate is an absorbable form of calcium that has been shown to be effective in the prevention and treatment of osteoporosis. This compound was discovered in 1867, but was not used for medicinal purposes until the early 1900s when it was found to be effective in treating the symptoms of rickets.</p>

<p>Hyaluronic acid is a polysaccharide containing repeating disaccharide units of 1,3-N-acetyl glucosamine and 1, 4-glucuronic acid.  This tetrasaccharide and other enzymatically produced polymer homologs have been of value in the study of hyaluronic acid metabolism in both healthy and diseased tissues (Hascall, 2019).</p>

<p>2,3,4,6-Tetra-O-acetyl-β-D-thiogalactopyranose sodium salt is a high purity custom synthesis sugar with a click modification. The fluorination and glycosylation are carried out to give the desired product. It has CAS No. 73962-00-2 and is a synthetic carbohydrate that can be used in oligosaccharides, monosaccharides, saccharide and complex carbohydrates.</p>

<p>D-Fructose-¹³C6 is a liquid chromatograph that can be used for the analysis of alditols. It can also be used as a cavity, dissolvable, or quadrupole mass spectrometer. The chemical diversity of D-fructose-¹³C6 makes it an important research tool that can be used to study different products. Its use in tobacco and humectant production is also quite common. The quadrupole mass spectrometer has been shown to have a global reach in its applications.</p>

<p>Methyl 6-O-acetyl-3-O-benzyl-2-benzyloxycarbonylamino-2-deoxy-a-Dglucopyranoside is a synthetic sugar with an acetyl group at the 6th position and a benzyloxycarbonyl group at the 3rd position. This sugar has been modified to produce complex carbohydrates, oligosaccharides, and polysaccharides. Methyl 6-O-acetyl 3 -O -benzyl 2 -benzyloxycarbonylamino 2 -deoxy a D glucopyranoside is used in the synthesis of glycosylates, which are sugars that have been modified by the addition of other molecules. This molecule is also used in click chemistry as it can be modified by adding fluorine atoms to its structure. Methyl 6 -O -acetyl 3 -O -benzyl 2 -benzyloxycarbonylam</p>

<p>Non-denaturing, non-ionic detergent for membrane protein solubilisation. Previously under code O-2710 and DO06354.</p>

<p>5-Deoxy-3,4-di-O-methyl-L-arabinose is a sugar building block that is used as a monosaccharide or polysaccharide. It can be modified with fluorination, methylation, and click chemistry to produce glycosylations and oligosaccharides. 5DAMOL can also be used in the synthesis of complex carbohydrates. The CAS number for 5DAMOL is 107879-64-2.</p>

<p>D-Xylonic acid-1,4-lactone is a substrate that participates in the synthesis of glyceric acid. It has been shown to be a synthetic substrate for benzyl groups and leukemia HL-60 cells. D-Xylonic acid-1,4-lactone can react with chloride ions to form D-xylose. The product of this reaction is an epimerization reaction that occurs when the hydroxyl group on the carbon atom adjacent to the carbonyl group (C1) reacts with a proton from water to form a double bond at C2. This conversion produces xylonic acid and lactone.</p>

<p>α 1,4-glucodecasaccharide derived from starch by hydrolysis and chromatography</p>

<p>2,3,4,6-Tetra-O-benzoyl-b-D-glucopyranosyl trichloroacetimidate is a chemical compound that has been shown to be an effective anti-inflammatory agent. It is a pharmaceutical formulation that can be fabricated into tablets or capsules and is used for the treatment of acute phase response. 2,3,4,6-Tetra-O-benzoyl-b-D-glucopyranosyl trichloroacetimidate interacts with cationic surfactants and silicon to form a protective layer on the skin. The frequency shift of light in the optical system indicates that there are no acid molecules in this formulation. Acute phase response occurs when there is an inflammatory disease or infection where the body produces proteins such as fibrinogen and C reactive protein (CRP). These proteins are released by cells in order to stop bleeding and fight infection.</p>

<p>2'-O-Fucosyllactulose is a modified carbohydrate that has been synthesized from a natural source. It is an oligosaccharide that contains the monosaccharide, fucose. This product can be used in the synthesis of polysaccharides and glycosylation reactions. 2'-O-Fucosyllactulose has been methylated, fluorinated, and glycosylated, which makes it suitable for use as a sugar in biotechnology applications.</p>

GM2-oligosaccharide (sodium salt) is a trisaccharide (GalNAcβ1,4Galβ1,4Glc) with sialic acid linked α2,3 to the central galactose residue (Ledeen, 2009). The parent GM2 ganglioside is present on neuronal cells and plays a key role in the regulation of dendritogenesis in cortical pyramidal neurons. In lysosomal storage disorders, such as, Tay-Sachs and Sandhoff disease, where hexosaminases A and B are deficient, GM2 ganglioside accumulates in the nervous system (Cachon-Gonzalez, 2018). GM2 ganglioside is also overexpressed in melanomas and other tumours of neuro-ecto origin (Yoshida, 2020). Moreover, the sugar moiety of GM2 ganglioside is a receptor allowing viral infection of cells with reovirus and rotavirus (Zhu, 2018).

<p>D-Allono-1,4-lactone is a biochemical compound that has been shown to have immunosuppressant properties. D-Allono-1,4-lactone is an inhibitor of maltase, an enzyme involved in the digestion of starch and glycogen. D-Allono-1,4-lactone also inhibits transglucosylase, an enzyme involved in the conversion of sucrose into glucose. It binds to sulfur transfer proteins and has been shown to be effective against mutants with altered biochemical properties.</p>

<p>4-Azido-4,6-dideoxy-2,3-O-isopropylidene-L-talono(L-gulono)-1.5 lactone is a high purity synthetic carbohydrate. It is a custom synthesis and can be fluorinated, glycosylated, methylated or modified to meet your specifications. It has CAS number 1263289-75-9. This product is an oligosaccharide with a saccharide repeating unit of 3 to 7 units. The monosaccharides are D and L glucose and the oligosaccharides are D and L maltose. The complex carbohydrate is composed of one or more glycans linked by glycosidic bonds. This product is a sugar that consists of one or more monosaccharides with at least one hexose (D or L) and at least one pentose (D or L).</p>

<p>D-Mannono-1,5-lactone is a custom synthesis. It is fluorinated to give 1,5-difluoro-D-mannono-1,4,6-lactone. The methylation of the C2 hydroxyl group and the C3 keto group gives 1,5-difluoro-D-mannono-1,4,6-(methylenedioxy)lactone. Click modification of this product with azide or acetylene gives 1,5-[(azido)-(acetylenyl)] D-mannono lactone or 1,5-[(acetylene)-(azido)] D manno lactone respectively. Monosaccharides can be synthesized from these products by glycosylation with a sugar donor. Polysaccharides can be synthesized from these products by glycosylation with a sugar donor and subsequent glycosidic linkage via an olig</p>

<p>2-Acetamido-2-deoxy-4-O-(beta-D-[UL-13-C-6]-galactopyranosyl)-D-glucopyranose 6-sulfate is an oligosaccharide that has been fluorinated and methylated. This compound has a CAS number and can be custom synthesized, as well as modified with a click reaction. It is a high purity, complex carbohydrate that can be modified with a variety of modifications.</p>

Methyl 2,4-Di-O-acetyl-3-O-benzyl-b-D-xylopyranoside is a custom synthesis of an oligosaccharide. It is a modification of a monosaccharide and a polysaccharide. The fluorine atom in the methyl group prevents the glycosylation from occurring. This product can be used for various purposes, such as for use in sugar chemistry, as a carbohydrate or complex carbohydrate and as an additive to food products.

<p>Competitive inhibitor of β-glucosidase from Streptomyces sp. and Paenibacillus polymyxa, occupying enzyme’s aglycone-binding site.  The compound is also a potent inducer of cellulase and other lignin-degrading enzymes in Schizophyllum commune.</p>

<p>Methyl 2-deoxy-3,5-di-O-toluoyl-L-ribofuranoside is a custom synthesis that is a complex carbohydrate that is used in the modification of saccharides. It has been shown to be able to methylate and glycosylate carbohydrates and can be fluorinated for use in click chemistry experiments. Methyl 2-deoxy-3,5-di-O-toluoyl-L-ribofuranoside is highly pure and can be synthesized with high yield.</p>

<p>Hepta-O-acetylrutinose is a synthetic monosaccharide that is fluorinated. It can be used in the synthesis of oligosaccharides, polysaccharides, and glycosylations. Hepta-O-acetylrutinose has been shown to be useful in click chemistry and other modifications due to its reactive groups. The CAS number for this compound is 29202-64-0.</p>

<p>Methyl 2,3,4,6-tetra-O-benzyl-b-D-thiogalactopyranoside is a synthetic monosaccharide that has been modified with fluorination and glycosylation. It is a product of the click reaction, which is a chemical modification that involves the formation of an aziridine and an alkene in one step. This product has been used for the synthesis of oligosaccharides and complex carbohydrates.</p>

(2S, 3S, 4S) -1-Butyl-4- (hydroxymethyl) - 3- (phenylmethoxy) - 2- azetidinecarboxylic acid, methyl ester is a product that can be custom synthesized. It can be used for the modification of complex carbohydrates, for example oligosaccharides and polysaccharides. This product has been fluorinated to improve its stability and modify saccharide linkages. The hydroxy methyl group at C2 position in this product is capable of being modified with Click chemistry.

<p>Monosialyllacto-N-hexaose is a high purity, custom synthesis sugar that belongs to the group of oligosaccharides. This carbohydrate is modified with fluorination and glycosylation, which are Click modifications. Monosialyllacto-N-hexaose has a CAS number of 68638-04-3. This product is available for purchase in bulk quantities.</p>

<p>Synthetic building block</p>

Substrate for N-acetylgalactosaminyltransferases

Core antigen fragment in ABO blood group system