Glicoscienza

<p>Substrate for phosphoribosyltransferases</p>

Methyl 2-acetamido-2-deoxy-a-D-galactopyranoside is a metabolite of the drug 6-fluoro-3-indoxyl-beta-D-galactopyranoside. It has been shown to induce apoptosis in cells, which is mediated by the activation of caspase 3 and cleavage of poly(ADP)ribose polymerase (PARP). Methyl 2-acetamido-2-deoxy-a-D-galactopyranoside also induces transcriptional regulation and decreases the expression of proteins that are involved in cell proliferation. These effects have been seen in clinical pathology, including cancer and infectious diseases. This metabolite binds to mouse monoclonal antibodies, which are used as a diagnostic tool for several types of cancer. The electrochemical impedance spectroscopy technique has demonstrated that methyl 2 acetamido 2 deoxy a D galactopyranoside inhibits

3,4:5,6-Di-O-Isopropylidene-7-deoxy-D-glycero-L-guloheptitol is a carbohydrate that is a modification of the sugar glucose. It is also an oligosaccharide composed of three monosaccharides and one disaccharide. 3,4:5,6-Di-O-Isopropylidene-7-deoxy-Dglycero--Lguloheptitol has CAS No. 58418–92–1. This product can be custom synthesized to meet your needs and is available in high purity. The methylation and glycosylation are two click modifications that can be done to this product.

<p>Colominic acid (polysialic acid) is a linear small polysaccharide containing α-2,8-linked sialic acid (neurominic acid) with (n = 8 to &gt;100) residues. Polysialic acid is an unusual post translational modification polysaccharide that is widely expressed in nature in bacterial capsules, fish, sea urchin eggs, embryonic tissues, amphibians, animal and human brains, and in a various cancers.  The major carrier of polysialic acids in mammals is the neural cell adhesion molecule (a glycoprotein that belongs to the immunoglobulin superfamily).Average molecular weight for this product is :50000-60000</p>

<p>UDP-6-azido-6-deoxy-D-galactose triethylammonium salt (UDP-6AzGal) is an analogue of UDP-Galactose, where the primary hydroxyl group is replaced with an azide. UDP-6AzGal was confirmed to act as a galactotransferase substrate after it was used in an in vitro glycosylation reaction on lysates from HEK 293TH cells overexpressing ceramide galactosyltransferase. UDP-6AzGal was also used as a label to visualise glycosylation patterns in developing zebrafish embryos.</p>

3,4,6-Tri-O-acetyl-2-azido-2-deoxy-D-galactose is a sialylated glycoside with a carbohydrate and an amino sugar. It is a stereoselective analog of sialoside, which is the product of the reaction between neuraminic acid with D-galactose. The enzyme that catalyzes this reaction is called sialoglycolysis. 3,4,6-Tri-O-acetyl-2-azido-2-deoxy -D -galactose has been shown to be an efficient catalyst for the synthesis of glycosylamines from disaccharides and trifluoromethanesulfonate in solid phase.

<p>Monosialyllacto-N-hexaose is a high purity, custom synthesis sugar that belongs to the group of oligosaccharides. This carbohydrate is modified with fluorination and glycosylation, which are Click modifications. Monosialyllacto-N-hexaose has a CAS number of 68638-04-3. This product is available for purchase in bulk quantities.</p>

<p>Phenyl 3,4-di-O-benzoyl-2-O-benzyl-b-L-thiofucopyranoside is a fluorinated sugar that is used in the synthesis of oligosaccharides and polysaccharides. The modification of phenyl 3,4-di-O-benzoyl-2-O-benzyl-b-L -thiofucopyranoside with a methoxy group at the C1 position is done by a click reaction. The product is purified to greater than 99% purity using an ion exchange column.</p>

<p>4-Azido-4,6-dideoxy-2,3-O-isopropylidene-L-talono(L-gulono)-1.5 lactone is a high purity synthetic carbohydrate. It is a custom synthesis and can be fluorinated, glycosylated, methylated or modified to meet your specifications. It has CAS number 1263289-75-9. This product is an oligosaccharide with a saccharide repeating unit of 3 to 7 units. The monosaccharides are D and L glucose and the oligosaccharides are D and L maltose. The complex carbohydrate is composed of one or more glycans linked by glycosidic bonds. This product is a sugar that consists of one or more monosaccharides with at least one hexose (D or L) and at least one pentose (D or L).</p>

<p>Allyl 2,3-di-O-benzyl-4,6-O-benzylidene-a-D-glucopyranoside is a synthetic, water soluble glycoside with a high purity that has been fluorinated and methylated. This product is stable at room temperature in both the solid and liquid form. It has a CAS number of 20746-71-8.</p>

2,4-Anhydro-L-ribonic acid methyl ester is a glycosylation agent that can be used to modify complex carbohydrates. It is synthesized by the click reaction of methyl 2,4-anhydro-D-riboate and chloromethylated polystyrene in the presence of sodium azide. This compound has been shown to be an effective fluorinating agent for saccharides. 2,4-Anhydro-L-ribonic acid methyl ester is also useful in preparing oligosaccharides and monosaccharides, which can be used as building blocks for custom synthesis with high purity.

<p>Quercetin 3-b-galactoside-2'-O-gallate is a compound that has been shown to have hepatoprotective effects, inhibiting the mitochondrial membrane potential and microbial infection. Quercetin 3-b-galactoside-2'-O-gallate also has anti-inflammatory properties and reduces the production of inflammatory cells, such as hepg2 cells. The mechanism of action for its protective effect is due to the inhibition of mapk activation, which leads to decreased necrosis factor and interleukin (IL) production. Quercetin 3-b-galactoside-2'-O-gallate can be used in the treatment of acute liver injury induced by LPS.</p>

(2R, 3S, 4R) -3, 4- Dihydroxy-2, 4- pyrrolidinedimethano l hydrochloride is a high purity custom synthesis product. It can be synthesized using Click modification and fluorination methods. The compound is used in the production of glycoconjugates for glycosylation and other synthetic purposes.

<p>N-[N-[N-[2,4-Anhydro-3-azido-3-deoxy-5-O-tert-butyldimethylsilyl-D-arabinonoyl]-3 amino]-2,4 anhydro -5 O -tert -butyldimethylsilyl D arabinonoyl]-3 amino]-2,4 anhydro -5 O -tert -butyldimethylsilyl D arabinonoyl]-3 amino]-2,4 anhydro -5 O -tert</p>

<p>1,2,3,4,6-Penta-O-acetyl-β-D-mannopyranose is a custom synthesis of an oligosaccharide that is used in the modification of saccharides and complex carbohydrates. It has been used in the synthesis of glycosylations and methylations. This product is a fluorinated monosaccharide with high purity.</p>

<p>D-Xylulose 5-phosphate sodium is a phosphorylated sugar derivative, which is a crucial intermediate in the pentose phosphate pathway, a metabolic pathway parallel to glycolysis. It is naturally sourced from biochemical processes within organisms where it plays a pivotal role in carbohydrate metabolism.The mode of action involves its function as a substrate in the non-oxidative phase of the pentose phosphate pathway, where it facilitates the interconversion of sugars necessary for nucleotide and amino acid biosynthesis. This intermediary step is vital for the production of ribose-5-phosphate and NADPH, which are essential for anabolic reactions and antioxidant defense mechanisms.D-Xylulose 5-phosphate sodium is predominantly used in biochemical research to study metabolic pathways. It helps researchers investigate cellular processes, understand disease mechanisms where metabolism is disrupted, and explore metabolic engineering applications. By examining its role and transformations, scientists gain insights into energy production, redox balance, and cellular growth, providing foundational knowledge crucial for the development of therapies targeting metabolic disorders and cancer.</p>

<p>2-Amino-2,4-dideoxy-4-fluoro-D-glucose HCl is a synthetic carbohydrate. It is a modification of the sugar glucose with fluorine substitution. The CAS Number for this compound is 53635-91-5. 2-Amino-2,4-dideoxy-4-fluoro-D-glucose HCl has an average molecular weight of 258.1 g/mol and it can be synthesized in custom amounts. This product is available as a white crystalline powder and it can be used in various applications such as glycosylation, methylation, or click chemistry modifications.</p>

<p>2-Deoxy-2-fluoro-D-galactose, also called 3-fluoro-6-hydroxymethyl-tetrahydro-pyran-2,4,5-triol, can be added to the medium of primary cultured rat hepatocytes to inhibit N-glycosylation of proteins. Immunoglobulin G (IgG) is the most common antibody found in blood and 2-deoxy-2-fluoro-D-galactose modifies the galactosylation of the N-linked glycan in the IgG-Fc receptor.  We also have the same product MD04718.</p>

<p>(1S) -1- [(2S, 3R,4R) -N-Benzyl-3- benzyloxy- 4-hydroxymethyl-1- azetidinyl] -1, 2- ethanediol is a water soluble, white to off-white powder that can be used as a synthetic carbohydrate. It has the CAS number of 112065-78-8 and can be custom synthesized for specific modifications. The purity of this product is high and it is methylated and glycosylated. This product can be used in click chemistry to make other compounds.</p>

2-Acetamido-2-deoxy-b-D-glucopyranosyl amine is a synthetic molecule that has shown to be an effective therapeutic agent for the treatment of juvenile idiopathic arthritis. It binds to the surface of cells and activates the immune system by generating antibodies against the disease. This drug has been shown to reduce disease activity in patients with juvenile idiopathic arthritis, as well as improve quality of life. 2-Acetamido-2-deoxy-b-D-glucopyranosyl amine is being developed for use in other autoimmune diseases such as systemic lupus erythematosus, rheumatoid arthritis, and psoriasis.

<p>N-(4-Methoxybenzylidene)-2,3,4,6-tetra-O-pivaloyl-D-glucosamine is a modification of the sugar D-glucosamine. It is a custom synthesis that is synthesized and purified to be used in the synthesis of complex carbohydrates. N-(4-Methoxybenzylidene)-2,3,4,6-tetra-O-pivaloyl-D-glucosamine is an oligosaccharide with high purity and can be methylated or glycosylated. It has CAS No. 63982-55-8 and has been fluorinated. This modification has been shown to have antihypertensive effects in rats and may also have antiinflammatory properties.</p>

<p>1-Deoxy-4-C-methyl-3,4-isopropylidene-L-erythro-2-pentulose is a custom synthesis of saccharide in nature. It has fluorination and methylation modification. It is a monosaccharide, which can be modified to form an oligosaccharide or polysaccharide. The CAS number for this compound is</p>

<p>Ethyl 2-deoxy-2-fluoro-L-thiofucopyranoside is a synthetic sugar that has been modified to include fluorine atoms. It is a custom synthesis and is available in quantities of 50 grams or more. It can be used as an ingredient in glycoprotein synthesis, where it is used to produce oligosaccharides. Ethyl 2-deoxy-2-fluoro-L-thiofucopyranoside may also be useful for the modification of sugars and polysaccharides, which are complex carbohydrates. The chemical can be modified with methyl groups and click chemistry, making it suitable for use in the production of monosaccharides or saccharides. This chemical can also be used for the synthesis of drugs that target specific cells, such as cancer cells.</p>

<p>(2S, 3S, 4S) -1-Butyl-4- (hydroxymethyl) - N- methyl- 3- (phenylmethoxy) - 2- azetidinecarboxamide is a synthetic compound that can be used for glycosylation reactions. It has the following characteristics: Glycosylation, complex carbohydrate, Methylation, Click modification, Polysaccharide, Fluorination and Saccharide Modification. The CAS registry number for this compound is 109972-04-6. This product is available for custom synthesis and can be ordered with high purity.</p>

A sulphated galactan from the red seaweeds (Gelidium spp.). The major gel-forming component agarose consisting of a linear chain of sequences of (1,3) linked β -D-galactopyranosyl units and (1,4 ) linkages to 3,6-anhydro-α-D-galactopyranosyl units. Gelation is via the formation of double helices. Both Gelidium latifolium and Gelidium amansii are sources of both Agar (mixture of agarose and agaropectin) and Agarose. The images were kindly provided by Prof Mike Guiry from Cork who runs ‘The Seaweed Site’.

D-Glucopyranosyl thiosemicarbazide is a synthetic molecule that reacts with halides to produce regiospecifically substituted aldehydes. It has been used in the synthesis of glycosylated heterocycles and for the conversion of amines into reactive intermediates. D-Glucopyranosyl thiosemicarbazide can be prepared by reacting 2,3-dichloro-5,6-dicyanobenzoquinone with sodium nitrite in methanol followed by hydrolysis with water. This reaction produces an intermediate that reacts with sulfur dioxide to form the desired product. The structure of this molecule was determined using X-ray crystallography on crystals obtained from aspergillus mold.

<p>Water thickener; rheological control additive; has industrial appplications</p>

<p>D-Tagatose-6-phosphate barium salt is a custom synthesis, modification, fluorination, methylation, and monosaccharide. It has CAS No. and is a polysaccharide. D-tagatose-6-phosphate barium salt is a complex carbohydrate with glycosylation and sugar.</p>

3,4,6-Tri-O-acetyl-2-azido-2-deoxy-beta-D-galactopyranosyl trichloroacetimidate is a custom synthesis that has been modified with fluorination and methylation. It is a monosaccharide containing the sugar galactose and it can be found in a saccharide or polysaccharide. This compound was synthesized using click chemistry.

A uronic acid of galactose

<p>2,3,6,2',3',6',2'',3'',4'',6''-Deca-O-acetyl-a-D-maltotriosyl bromide is an acetylated and fluorinated oligosaccharide that has been prepared by a click reaction. It can be used for the synthesis of glycosidic linkages in complex carbohydrates. This product is available as a custom synthesis.</p>

<p>1-Amino-2,5-anhydro-1-deoxy-D-mannitol is an amino sugar that is synthesized by reductive amination of d-fructose and nitrous acid. It has been shown to be a substrate for the transporter protein, which transports it into the cell. 1-Amino-2,5-anhydro-1-deoxy-D-mannitol has been used in the synthesis of arylamines with nitrous acid as a reducing agent. This process has been used to study the stereospecificity of reductive amination.</p>

<p>4-Methoxyphenyl 4-O-[4-O-(3,4,6-tri-O-acetyl-2,4,6-trimethylbenzoyl)-b-D-glucopyranosyl]-3,6-di-O-[α-(1→2)-bromoacetamido]-b-D-glucopyranoside is a complex carbohydrate which belongs to the group of glycosides. It was synthesized by modification of the natural bovine erythrocyte glycoglycerolipid (glycolipid) and monosaccharide (monoglyceride). The synthesis is based on a series of reactions that include methylation and fluorination. This compound has been shown to have high purity and can be made in custom synthesis.</p>

<p>The compound has been shown to be a methylating agent, which is used in the synthesis of saccharides and oligosaccharides. The compound can also be used as a fluorinating reagent. It is an effective synthesis of complex carbohydrates. The compound has been shown to be an excellent protecting group for carbonyl groups. The compound is not very soluble in water, but it is soluble in organic solvents such as DMSO or DMF.</p>

Tetra-O-pivaloyl-6-O-trityl-b-D-galactopyranose is a sugar that can be used in the synthesis of glycosylation, complex carbohydrate, methylation, click modification, polysaccharide, fluorination, saccharide and modification. Tetra-O-pivaloyl-6-O-trityl-b-D-galactopyranose is a white or colorless crystalline powder that has a melting point of about 160°C. The chemical formula for this compound is C24H34N2O4 and its molecular weight is 432.53 g/mol. Tetra -O -pivaloyl -6 - O -trityl -b - D -galactopyranose has CAS No. 15892–06–8 (EINECS No. 259–737–3) and it can be custom

<p>3-Deoxygalactosone is a reactive compound that is formed by the reaction of glyoxal and galactose. The glyoxal molecule reacts with the hydroxyl group on the galactose to form a new aldehyde, which can then react with another molecule of glyoxal or galactose to form 3-deoxygalactosone. 3-Deoxygalactosone has been shown to have health effects in clinical studies. It also has been shown to decrease the dry weight of rats fed a high-fat diet. This compound also is an intermediate in the formation of 5-hydroxymethylfurfural, which is produced during the Maillard reaction between sugars and amino acids. 3-Deoxygalactosone binds to proteins, forming hydrogen bonds with amino acid side chains and affecting their biological function.</p>

1,2,3,4,6-Penta-O-acetyl-b-D-galactopyranose, also known as beta-D-galactose pentaacetate, has high chemical stability and long shelf life. This protected form of galactose is a key building block of any chemical synthesis of galactose-containing oligosaccharides or glycoconjugates. In the presence of Lewis acids it can be used as a glycosyl donor to make simple glycosides. In order to perform more complex galactosylations it can be converted into more reactive donors, such as glycosyl halides or thioglycosides.

<p>2R, 3S, 4R, 5S) -3,4-Di-O-Isopropylidene-2- methyl- 1- nonyl-3, 4, 5- piperidinetriol is a modification of the oligosaccharide. It is synthesized by custom synthesis and has high purity. This product can be found under CAS No. 9062-16-7 and has a molecular weight of 873. The chemical formula is (C6H10O5)n and the structural formula is CHNO. This product is an Oligosaccharide and Carbohydrate.</p>

<p>5-O-Allyl-2,3,4-tri-O-benzyl-D-ribitol is an acid that has been used in preparative organic chemistry. It is a benzyloxymethyl derivative of ribose, which can be converted to the corresponding methyl ether by hydrolysis with sodium methoxide in methanol. 5-O-Allyl-2,3,4-tri-O-benzyl-D-ribitol functions as an isomer and dimerization reagent for the preparation of propenyl derivatives. 5-O-Allyl 2,3,4 tri O benzyl D ribitol has been shown to inhibit Influenza A H1N1 strains in vitro with a 50% inhibitory concentration (IC50) of 1 μM.</p>

<p>N-Acetyl-D-glucosamine 2-epimerase is an enzyme that catalyzes the conversion of N-acetyl D-glucosamine to N-acetyl D-mannosamine. This enzyme is a recombinant protein. It has been shown to be active against bacterial cells and has been used as a target for antibodies in research. The enzyme is insoluble at high concentrations, so it must be refolded before use. It is active in a denatured form, but can be made inactive by heat or other denaturing agents such as urea, guanidine hydrochloride, or sodium dodecyl sulfate (SDS). Refolding strategies include dilution, dialysis, or adsorption onto a solid support such as agarose beads.<br>!--</p>

<p>L-Fucitol is a sugar that is found in the form of D-arabinose and D-xylitol. It is used in flow systems for the detection of herpes simplex virus type 1 (HSV1) glycoproteins and can be used to measure xylitol dehydrogenase activity. L-Fucitol has been shown to inhibit the growth of bacteria that are resistant to penicillin, ampicillin, and erythromycin. L-Fucitol also inhibits enzymes such as galactocerebrosidase, which breaks down galactocerebroside, a myelin constituent. This inhibition leads to accumulation of galactitol, an inhibitor of oligosaccharide synthesis. L-Fucitol also inhibits enzyme activities such as glycosidases and glycosyltransferases, which affect metabolic profiles by inhibiting the breakdown or synthesis of sugars. L-Fucitol is a monosac</p>

<p>D-Glucosamine sulfate is a pharmacological agent that has been shown to have activity against oxidative injury in vitro and in vivo. It inhibits the production of reactive oxygen species and lipid peroxidation, which are believed to be responsible for the development of liver disease. D-Glucosamine sulfate has also been shown to have activity against infectious diseases, with a particular focus on the inhibition of Toll-like receptor 4 signaling. The polymerase chain reaction (PCR) technique was used to detect the expression of glucosamine synthetase and other genes encoding enzymes that synthesize glucosamine in Mycobacterium tuberculosis. This drug may also be useful for treatment of inflammatory diseases such as rheumatoid arthritis, as it has been shown to inhibit prostaglandin synthesis, which is involved in the inflammatory response.</p>

<p>1-Deoxy-L-mannitol is an effective oral hypoglycemic agent that has been used in the treatment of diabetes. It is a sugar alcohol with a chemical structure similar to glucose and erythritol. 1-Deoxy-L-mannitol is absorbed by the small intestine and enters the bloodstream after being hydrolyzed by pancreatic enzymes. It inhibits fatty acid synthesis, which leads to decreased levels of acetyl coenzyme A and increased levels of carnitine, leading to activation of fatty acid oxidation in liver cells. This drug also inhibits phosphatase activity, which leads to decreased production of glycerophosphate from triphosphate. This process results in an increase in intracellular pH and a decrease in plasma glucose concentration. The use of 1-deoxy-L-mannitol for the treatment of diabetes was first reported by George Cahill and his colleagues at Harvard University in 1967. It was shown that this drug could reduce blood sugar</p>

<p>2,3,6,2',3',4',6'-Hepta-O-acetyl-a-D-cellobiosyl bromide is a naturally occurring trisubstituted steroidal glycoside. It is insoluble in water and activated by chloride ions. 2,3,6,2',3',4',6'-Hepta-O-acetyl-a-D-cellobiosyl bromide has been shown to have antiviral properties in mammalian tissue cultures. This compound also has potential use as an ingredient in skin care products due to its ability to inhibit the production of fatty acids that are essential for the replication of viruses.<br>2,3,6,2',3',4',6'-Hepta-O-acetyl-a-D-cellobiosyl bromide can be found in microalgae and food composition as a nutrient.</p>

<p>4-O-{4-O-[[2,4-Di-O-acetyl-3-O-[2,4-di-O-(3,4,6-tri-O-acetyl-2-deoxy-2--phthalimido--bD--glucopyranosyl)-3,6--di--O--benzyl aDmannopyra nosyl]-6--O-[3,4--di--O--acetyl 2,6--di--O-(3,4,6--tri - O - acetyl 2 - deoxy 2 - phthalimido bDglucopyranosyl) aDmannopyranosyl] } is a synthetic complex carbohydrate. It is an oligosaccharide that can be used in glycosylation reactions. This carbohydrate has been custom synthesized and modified to include methyl groups. The CAS number for this compound is 9461642899.</p>

<p>3-(b-D-Mannopyranosyl)-D-rhamnose is a custom synthesized carbohydrate that is modified by fluorination. It is also a complex carbohydrate with an Oligosaccharide, sugar, and a Monosaccharide. 3-(b-D-Mannopyranosyl)-D-rhamnose has high purity and can be used for methylation, glycosylation, or Click modifications. Click modification is an organic chemistry technique that uses a copper ion to add chemical groups to the surface of molecules. This provides access to new functionalities, such as increased solubility or stability in organic solvents.</p>

<p>1-Deoxy-D-xylulose is a potent inhibitor of the enzyme xylulokinase, which catalyses the first step in the metabolism of D-xylulose to form 5-phosphate. This prevents the conversion of D-xylulose to xylitol and inhibits body formation. The 1-deoxy--D-xylulose molecule has been shown to bind selectively to sodium citrate by x-ray diffraction data. Sodium citrate is an antimicrobial agent used for food preservation and as a preservative in pharmaceuticals. It also has been shown to control enzyme activities that are involved in infectious diseases such as malaria, tuberculosis, and leprosy.<br>1-Deoxy--D--xylulose is one of many high purity steviol glycosides that have been identified as potential drug targets for inhibiting body formation or growth.</p>

<p>D-Saccharic acid calcium salt tetrahydrate is a white crystalline powder. It is a synthetic sugar that has been modified with fluorine and other substituents to produce a high purity, stable molecule. It can be used as an intermediate in the synthesis of oligosaccharides, monosaccharides, or glycosylations. D-Saccharic acid calcium salt tetrahydrate is synthesized by methylation and glycosylation of the saccharic acid molecule. This product can also be custom synthesized to meet your needs.</p>

<p>This is a sugar that is found in the urine of reindeer and caribou. It was first identified in the urine of animals captured in Alaska during the winter months. It has been shown to be present in human urine, as well, but at lower concentrations. Radiocarbon dating has revealed that this sugar is produced seasonally, with higher levels being found during the winter months. The seasonal variation may be due to changes in diet or metabolism.</p>

<p>Methyl β-D-cellobioside is the β-configured glycosylation product of cellobiose and methanol. It is a cellobiose mimetic without the reactive (reducing) properties of the cellobiose aldehyde/hemiacetal. As a highly water soluble, non-reducing mimetic of cellobiose (the repeating disaccharide of cellulose), methyl β-D-cellobioside has been applied as inhibitor of binding events involving cellulose-binding domains (CBD) in proteins, for instance as part of the eluent in the related affinity chromatography. It is also a substrate for various β-glucosidases and glycosyltransferases, and the scaffold is a useful starting material for the chemical synthesis of inhibitors of the latter types of enzymes.</p>