Antimicrobici

<p>EIDD 2801 is an orally bioavailable prodrug of β-D-N4-hydroxycytidine and was shown to inhibit SARS-CoV-2 replication in human airway epithelial cells. EIDD 2801 was also tested in mice infected with SARS-CoV and MERS-CoV viruses. EIDD 2801 targets the RNA-dependent RNA polymerase (RdRp) and reduces virus titer and improved pulmonary function in experimental animals when used in prophylactic and therapeutic regime.</p>

<p>Ticarcillin disodium salt is a beta-lactam antibiotic that has in vitro activity against Gram-positive and Gram-negative bacteria. Ticarcillin is active against penicillinase-producing strains of Staphylococcus aureus, Enterobacter aerogenes, Proteus mirabilis, Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, Serratia marcescens, Streptococcus pyogenes, Streptococcus faecalis, and Streptococcus pneumoniae. Furthermore, it inhibits transpeptidase activity of the cell wall of bacteria which prevents peptidoglycan synthesis. It is bactericidal for many bacteria at low concentrations.</p>

<p>Ritonavir is a HIV protease inhibitor. It has an anti-retroviral activity as it inhibits the protease enzymes specific of both HIV-1 and HIV-2 and has been shown to be effective in controlling virus replication in humans and animals. Ritonavir works by preventing the HIV viral protease enzyme from cleaving the structural and replicative proteins produced by HIV genes such as gag and pol.</p>

<p>Azithromycin N-oxide is a macrolide antibiotic derivative and is used for research purposes. Its mode of action is similar to azithromycin.</p>

<p>Membrane pore-forming agent; H+, K+, Pb2+ ionophore; polyether antibiotic</p>

<p>Kanamycin sulfate is a water-soluble antibiotic. Genes encoding kanamycin resistance are commonly used as selection markers in molecular biology .It acts during the translation mechanism in prokaryotic ribosomes to avoid bacterial cell growth.</p>

<p>PI4KIII beta inhibitor</p>

<p>Inhibitor of protein synthesis; aminoglycoside</p>

<p>Amicoumacin A is an antibiotic compound, which is derived from the bacterium Bacillus subtilis. This natural source is known for its production of a variety of biologically active compounds that contribute to its utility in numerous scientific contexts. The mode of action of Amicoumacin A involves the inhibition of bacterial protein synthesis by targeting the ribosomal subunit. Specifically, it interferes with the translation process, effectively disrupting the growth and proliferation of susceptible bacterial strains.<br><br>Amicoumacin A is primarily utilized in research settings to study bacterial resistance mechanisms, as well as to explore novel antibacterial therapies. Its application in scientific research extends to examining its potential synergistic effects with other antimicrobial agents, and it serves as a model compound for understanding ribosomal inhibition. The study of Amicoumacin A not only contributes to the broader field of antibiotic development but also offers insights into the molecular interactions that underlie bacterial protein synthesis and antibiotic resistance. This compound's unique properties make it an important subject of investigation for microbiologists and pharmacologists alike, emphasizing its relevance in the ongoing battle against antibiotic-resistant pathogens.</p>

<p>Amphotericin A is a polyene macrolide antibiotic, which is derived primarily from the soil bacterium *Streptomyces nodosus*. This compound functions by binding to ergosterol, an essential component of fungal cell membranes. This binding creates pores in the membrane, increasing its permeability and ultimately leading to cell death. Unlike its more widely used counterpart Amphotericin B, Amphotericin A is less frequently utilized but is critical in the study and understanding of antifungal activity.</p>

<p>Tosufloxacin is a fluoroquinolone antibiotic that inhibits DNA gyrase and topoisomerase IV, which are enzymes that maintain the integrity of bacterial DNA. It binds to bacterial 16S ribosomal RNA and inhibits protein synthesis, leading to cell death by inhibiting the production of proteins vital for cell division. Tosufloxacin has been shown to be effective against a variety of bacterial infections.</p>

<p>Potassium clavulanate is a beta-lactamase inhibitor and an antibacterial agent. The presence of potassium clavulanate in culture media inhibits the activity of beta-lactamases, which are enzymes that confer resistance to penicillin and other beta-lactam antibiotics. It also has been shown to be active against bacterial infections such as tuberculosis, sepsis, and pneumonia, where it can inhibit the growth of bacteria by interfering with their ability to form cell walls. Potassium clavulanate is also used as an antimicrobial agent for blood culture technique and antimicrobial treatment.</p>

<p>Dibekacin sulfate is an aminoglycoside antibiotic with action on bacterial protein synthesis inhibition and is used for treating severe gram-negative bacterial infections.</p>

<p>Amphotericin B is a macrocycle antibiotic with very potent antifungal effects and resistance very rarely occurs. Amphotericin B is a polyene antifungal that binds to fungal cell membrane, i.e., ergosterol disrupts the membrane permeability leading to leakage of intracellular components. It is often used as an alternative therapy for leishmaniasis and to treat severe mycoses including: systemic Candida, Cryptococcus, blastomycosis, and histoplasmosis.</p>

<p>Tenofovir is an acyclic nucleoside phosphonate that exhibits anti-viral properties through its inhibition of reverse transcriptases. In particular, Tenofovir is a potent inhibitor of Human Immunodeficiency Virus (HIV) and chronic Hepatitis B Virus (HBV) reverse transcriptases, thus preventing the replication of genetic viral material. This property is beneficial in virus research areas and developing antiviral treatments. Once inside the body tenofovir is metabolized into its active form, tenofovir diphosphate, by the lysosomal protease cathepsin A, nucleotide kinases and adenylate kinases. <br>Tenofovir is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready to use products for assay development, screening or other R&amp;D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.</p>

<p>Erythromycin derivative</p>

<p>Dermaseptin is a type of antimicrobial peptide, which is sourced predominantly from the skin secretions of frogs, specifically from the Phyllomedusinae subfamily. These peptides function by disrupting the microbial cell membranes through their amphipathic and cationic nature, leading to cell lysis and death. Dermaseptins exhibit a broad spectrum of antimicrobial activity, including action against bacteria, fungi, protozoa, and certain viruses, making them of significant interest in biomedical research.</p>