Protacs e Impurezze

PROTAC GPX4 Degrader-1 (DC-2) is a PROTAC-based compound that efficiently degrades GPX4, demonstrating a degradation …

SIM1, a potent PROTAC®Degrader, preferentially degrades BET proteins (BRD4, BRD2, BRD3) and induces apoptosis in …

PROTAC PD-L1 degrader-2, an orally administered compound, targets HPK1 and boosts the efficacy of PD-L1 …

CPS2: potent, selective PROTAC CDK2 degrader. IC50=24nM, targets acute myeloid leukemia research.

ARD-69, a potent PROTAC, degrades AR in prostate cancer, with low DC50 values in AR+ …

HD-TAC7 is a PROTAC HDAC degrader; IC50s: HDAC1 (3.6μM), HDAC2 (4.2μM), HDAC3 (1.1μM); reduces NF-κB …

TCO-PEG4-NHS ester is a PROTAC linker bridge belonging to the PEG class.TCO-PEG4-NHS ester can be …

Methyltetrazine-Amine is a methyl-substituted tetrazine amine used in the synthesis of PROTAC molecules.

LC-2 (PROTAC KRASG12C Degrader-LC-2) is a novel von Hippel-Lindau-based PROTAC degrader of endogenous KRAS G12C …

PROTAC CDK9 Degrader-1 is a selective CDK9 degrader.

Diazo Biotin-PEG3-alkyne is a PROTAC linker belonging to the PEG class and can be used …

KT-474 (KYM-001) is a PROTAC degrader targeting IRAK4 with antitumor activity for the study of …

Benzyl-PEG12-alcohol is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming …

JET-209 is a potent proteolysis-targeting chimera (PROTAC) that effectively degrades CBP/p300, exhibiting half-maximal degradation concentration …

PROTAC EZH2 Degrader-1 inhibits EZH2 enzyme, crucial in cancer, with an IC50 of 2.7 nM.

FKBP12 PROTAC RC32 is a PROTAC-like degrader targeting FKBP12. It can degrade FKBP12 in organs …

BI-3663 is a selective PTK2/FAK PROTAC with cereblon ligands, degrading PTK2 (IC50: 18 nM), and …

ARV-825: PROTAC recruits BRD4 to cereblon for rapid BRD4 degradation in all tested BL cells.