Nucleosidi

3-N-Boc-5'-O-DMT-3'-fluorothymidine is a monophosphate nucleoside with antiviral and anticancer activity. It is a novel synthetic analogue of fluoro thymidine (FT) that has been shown to be an activator of DNA polymerase α, RNA polymerase β and γ, and protein kinase C. This compound is also an inhibitor of the reverse transcriptase enzyme HIV-1. 3-N-Boc-5'-O-DMT-3'-fluorothymidine has been shown to inhibit cancer cell growth in vitro and in vivo. The synthesis of this compound can be achieved by phosphoramidite chemistry using a commercially available automated synthesizer.

2'-Amino-2'-deoxyguanosine is a modified nucleoside, based on guanosine. The 2'-hydroxyl has been replaced by an amino group, which can form different hydrogen bonds compared to a hydroxyl or just a hydrogen, altering the way the sugar interacts in a DNA or RNA strand.

<p>N6-Benzoyl-3'-O-tert-butyldimethylsilyl-5'-O-DMT-adenosine 2'-CE phosphoramidite is an antiviral nucleoside phosphoramidite that is used in the synthesis of DNA. It has been shown to have antiviral activity against HIV and herpes, as well as anticancer effects. It also has high purity, being a novel synthetic nucleoside with a CAS number. N6-Benzoyl-3'-O-tert-butyldimethylsilyl-5'-O-DMT-adenosine 2'-CE phosphoramidite is synthesized using novel methods. The synthesis process includes activation with diphosphate, DNA, and Novel nucleosides, which are high quality and modified.</p>

Guanosine-5'-[(b,gamma)-methyleno]triphosphate sodium salt (GMPP) is an analog of guanosine triphosphate that is enzymatically inactivated by the enzyme kinesin. GMPP inhibits the polymerization of microtubules by binding to the kinesin molecule and preventing it from binding to tubulin. GMPP has been shown to inhibit sephadex g-100 chromatography and act as a competitive inhibitor for protein synthesis in vitro. GMPP has also been shown to have a fat cell differentiation effect which may be due to its ability to inhibit microtubule polymerization.

2,3'-Anhydro-N4-benzoyl-2'-deoxycytidine 5'-CE phosphoramidite is a novel nucleoside analog that has been synthesized to have the same chemistry as 2,3'-dideoxycytidine 5'-C phosphoramidite. It has antiviral and anticancer properties. This compound can be used in the synthesis of oligonucleotides for DNA sequencing and for gene therapy. 2,3'-Anhydro-N4-benzoyl-2'-deoxycytidine 5'-CE phosphoramidite is not toxic to normal cells, but it inhibits replication of viruses such as HIV and herpes simplex virus.

5’-Deoxy-5’-iodo-2’-O-(2-methoxyethyl)-5-methyluridine is an antiviral drug that inhibits the synthesis of viral DNA. It is synthesized by reacting 5'-deoxyadenosine monophosphate with 2'-O-(2-methoxyethyl)iodoacetamide and methylating the resulting product with methyl iodide. 5'-Deoxy-5’-iodo-2’-O-(2-methoxyethyl)-5-methyluridine has a novel structure and can be used as an activator of ribonucleosides in DNA synthesis. The drug also has anticancer properties, which may be due to its ability to inhibit cellular proliferation by inhibiting the enzyme DNA polymerase or by arresting cells at the G1 phase of the cell cycle.

<p>N4-Acetyl-2'-deoxy-5'-O-DMT-2'-fluorocytidine is a cytosine analog with high affinity for the T cell receptor. It can be used to generate antibodies against cytosine and as a screening tool for plasmon resonance.</p>

<p>4'-C-Azido-2'-deoxy-2'-fluoro-4-[bis(2-hydroxyethyl)]-b-D-arabinocytidine is a novel nucleoside analog with antiviral and anticancer activities. It is a chemical compound with the molecular formula C8H14N6O5P and a molecular weight of 288.28 g/mol. 4'-C-Azido-2'-deoxy-2'-fluoro-4-[bis(2-hydroxyethyl)]-b-D-arabinocytidine has the CAS number 136045902, which can be found in PubChem Compound Database.</p>

1-(4’-Azido-2’-deoxy-2’-fluoro-b-D-arabinofuranosyl)N4-(n-palmitoyl)-cytosine is a deoxyribonucleoside, modified nucleoside that is synthesized by using a novel phosphoramidite chemistry. 1-(4’-Azido-2’-deoxy-2’-fluoro-b-D-arabinofuranosyl)N4-(n-palmitoyl)-cytosine is an activator of ribonucleotide reductase and can be used in anticancer and antiviral therapy.

<p>N6-Dimethyl-3’-b-C-methyladenosine is a novel nucleoside analog that has antiviral and anticancer properties. It is a phosphoramidite, which can be used as an activator for the synthesis of modified oligonucleotides. N6-Dimethyl-3’-b-C-methyladenosine has been shown to activate ribonucleosides and deoxyribonucleosides in vitro. This compound also has anticancer properties, which may be due to its ability to act as an activator in the synthesis of DNA.</p>

<p>3'-Azido-N6-benzoyl-2'-O-tert-butyldimethylsilyl-5'-O-DMT-adenosine is a synthetic nucleoside that belongs to the group of modified nucleosides. It is a phosphoramidite that has been shown to be an effective antiviral and anticancer agent. 3'-Azido-N6-benzoyl-2'-O-tert-butyldimethylsilyl-5'-O-DMT-adenosine inhibits viral replication by interfering with DNA synthesis and repair, which is necessary for viral reproduction. The compound has also been shown to inhibit tumor cell growth in vitro and induce apoptosis in vivo.</p>

2'-O-(2-Methoxyethyl)-5-methyluridine 5'-monophosphate is an antiviral nucleoside with anticancer properties that is synthesized from 2'-deoxyuridine monophosphate and 5-methyluridine. This novel compound has shown antiviral activity against HIV, herpes simplex virus type 1, and herpes simplex virus type 2. It also inhibits the growth of human breast cancer cells in vitro.

<p>5'-O-p-Anisoyl-D3-thymidine is a nucleoside analogue that is used in antiviral and anticancer treatments. It is synthesized by the condensation of 3,4-dihydroxyacetophenone with 2,6-diaminopurine followed by phosphorylation of the 5' hydroxyl group. This product has been shown to be an activator of both DNA polymerase and RNA polymerase. In addition, it can inhibit the production of viral proteins such as HIV protease without affecting protein synthesis in mammalian cells. It also inhibits cancer cell growth by stopping DNA replication at the G2 phase.<br>5'-O-p-Anisoyl-D3-thymidine has been shown to be highly purified and can be used for research purposes. This product may have a CAS number but it will not be listed on this website due to company policy.</p>

5'-Azido-5'-deoxy-2'-O-methyluridine is a nucleoside that is a modified version of 2'-deoxyuridine. It is synthesized from uridine, which is converted to 5'-azidouridine via the action of azidase. 5'-Azido-5'-deoxy-2'-O-methyluridine has antiviral activity and can be used as an activator of DNA polymerases. The monophosphate form of this compound can be phosphoramidated to give the corresponding diphosphates, which are used in DNA synthesis to produce double stranded DNA.

<p>N2-Phenylacetyl-L-guanosine is a nucleoside that has been synthetically modified to have the desired properties of an anticancer agent. This compound inhibits DNA synthesis and is therefore cytotoxic to cells. It also inhibits RNA synthesis and is antiviral. N2-Phenylacetyl-L-guanosine has been found to be effective in preventing the growth of leukemia cells, breast cancer cells, prostate cancer cells, and ovarian cancer cells. N2-Phenylacetyl-L-guanosine is a nucleotide analogue that can be used as a building block for DNA or RNA synthesis. It can be used as a phosphate donor in phosphoramidite chemistry and can activate other nucleosides for use in chemical biology.</p>

2'-Deoxy-5'-O-DMT-2'-fluoro-N2-isobutyrylguanosine 3'-CE phosphoramidite is a novel nucleoside analog, which has potent antiviral activity against HIV and other retroviruses. It is synthesized from 5'-O-DMT-2'-fluoro-N2-isobutyrylguanosine by the reaction of sodium bicarbonate with 2',3'-dideoxyadenosine in the presence of an activator. The product can be used for the synthesis of RNA or DNA for use as probes, primers, and templates in polymerase chain reactions (PCRs).

4,6-Diamino-2-(b-D-ribofuranosyl)-2H-pyrazolo[3,4-d]pyrimidine is a nucleoside monophosphate that is used as an antiviral agent. It inhibits the synthesis of viral DNA and RNA by inhibiting the activity of enzymes needed for nucleotide synthesis. 4,6-Diamino-2-(b-D-ribofuranosyl)-2H-pyrazolo[3,4-d]pyrimidine has shown anticancer properties in vitro against human colon cancer cells. This drug has been shown to inhibit the growth of tumor cells with high expression levels of cyclin D1 and low levels of p27 (a cell cycle regulatory protein).

Inosine 5'-triphosphate trisodium (ITP) is a nucleotide that is found in human cells. It is produced by the enzyme inosine monophosphate dehydrogenase and acts as an intermediate in cellular metabolism. ITP has been shown to be involved in a number of diseases, such as infectious, autoimmune, and cardiovascular diseases. For example, ITP has been shown to induce the expression of TLR-2 and TLR-4 on human monocyte-derived dendritic cells. The molecule also plays a role in pediatric disease activity, bowel disease, and congestive heart failure.

N2,N2-Dimethylguanosine is a purine nucleoside that is found in human serum. It belongs to the group of purines and has been shown to be involved in energy metabolism. N2,N2-Dimethylguanosine has been shown to be present at high levels in patients with autoimmune diseases such as rheumatoid arthritis. The x-ray crystal structures of wild-type strains of Escherichia coli and Streptococcus pneumoniae have been determined, which revealed that this compound interacts with the enzyme activity for primary sclerosing cholangitis. This nucleoside can also be detected by LC-MS/MS methods and multivariate logistic regression analysis.

<p>1-(b-L-Threonyl)-5-methyluracil (1,5MT) is a synthetic nucleoside that has antiviral and anticancer properties. 1,5MT is modified with a b-L-threonyl group at the 5’ position. This modification stabilizes the molecule and prevents its degradation by ribonucleases. The modification also increases the phosphoramidite reactivity of 1,5MT and enhances its incorporation into DNA during synthesis. 1,5MT is an activator for RNA polymerase II, which plays an important role in transcriptional regulation. It binds to the enzyme's allosteric site and stimulates transcriptional elongation by RNA polymerase II through phosphoramidate formation with deoxyribose phosphate. 1,5MT is active against cancer cells in vitro and has been shown to inhibit tumor growth in vivo.</p>

<p>2',3'-Dideoxy-5-iodouridine is a synthetic nucleoside analog derived from uridine, one of the natural building blocks of RNA. This molecule has been chemically modified to disrupt the normal processes of DNA and RNA synthesis, making it a candidate for antiviral and anticancer research.</p>

1-(2-Deoxy-5-O-MMT-b-D-xylofuranosyl)-5-methyluracil (1dXF) is a modified nucleoside that is synthetically derived from 5-methyluracil. It has been shown to be an effective anticancer agent, antiviral agent, and inhibitor of HIV replication in HIV infected cells. 1dXF also inhibits the synthesis of DNA, RNA, and protein in cancer cells.

N4-Acetylcytidine is a modified nucleoside and endogenous urinary nucleoside product of the degradation of tRNA. N4-Acetylcytidine is a biological marker for various cancers with elevated concentrations present in urine. N4-Acetylcytidine is also a partially protected cytidine and therefore can be used as a synthetic building block to prepare further derivatized nucleosides such as 2’,3’-dideoxycytidine.

<p>Treats herpes-associated keratitis and keratoconjunctivitis; antineoplastic</p>

<p>2'-O-tert-Butyldimethylsilyl-5'-O-DMT-N3-methylcytidine 3'-CE phosphoramidite is a modified nucleoside that is synthesized by the reaction of 2'-deoxycytidine with bis(2,4,6-trichlorophenyl)carbonate in the presence of a base. 2'-O-tert-Butyldimethylsilyl-5'-O-DMT-N3 methylcytidine 3'-CE phosphoramidite has been shown to have anticancer activity and is used as an activator in the synthesis of oligonucleotides. This product is available as a white powder and can be used for research purposes only.</p>

2'-Deoxy-5-(2-iodoethyl)uridine is a nucleoside analog with antiviral and anticancer activity. It has been shown to be an activator of DNA replication, as well as inhibiting the synthesis of deoxyribonucleotides. This drug also has a novel structure that is modified from the natural nucleosides found in DNA and RNA. 2'-Deoxy-5-(2-iodoethyl)uridine can be synthesized using phosphoramidites, which are activated by iodine and sulfurizing agents. The purity of this compound is high and it is available at high quality.

<p>a-Thymidine is a thymidylate analog that is used as an anti-HIV drug. It is the L-enantiomer of thymidine, which is a nucleoside base in DNA. The biological effects of a-thymidine are due to its ability to be incorporated into DNA and act as a competitive inhibitor of the enzyme protein synthesis. It also has been shown to have antiviral properties against herpes simplex virus type 1 and hepatitis B virus.</p>

<p>5'-O-Benzoyl-2'-deoxyinosine 3'-CE phosphoramidite is an anticancer and antiviral agent. It is a nucleoside analogue that inhibits the synthesis of DNA by competitive inhibition of ribonucleotide reductase, which converts ribonucleotides to deoxyribonucleotides. The monophosphate form also inhibits viral replication by inhibiting reverse transcriptase. This compound has been shown to be active against herpes simplex virus type 1 and 2, adenovirus, influenza A virus, and vaccinia virus.</p>

<p>8-Allyloxyadenosine is a novel adenine nucleoside analog. It is an activator of ribonucleosides and deoxyribonucleosides, which can be used as a phosphoramidite for the synthesis of oligodeoxynucleotides. The 8-Allyloxyadenosine has been studied for its anticancer and antiviral properties, with promising results in animal studies. In addition, it has been shown to have anti-inflammatory effects in mice.</p>

2'-Deoxy-5-hydroxymethyluridine-5'-triphosphate triethylammonium salt (dHMUTP) is a noncompetitive inhibitor of transcriptase activity. It inhibits the synthesis of DNA by binding to RNA polymerase on the template strand, thereby blocking the progress of the enzyme along the DNA. This drug has been shown to be effective in inhibiting viral production and growth in mammalian cells, as well as cancer cell culture. Dihydrofolate reductase is required for dHMUTP to function, and it is metabolized in vivo through hydrolysis by glycosylases or antineoplastic properties by nucleotide excision repair enzymes. These enzymes are present in human cells but absent in bacteria and yeast. The drug also has antineoplastic properties due to its ability to inhibit tumor cell proliferation.

N6,7-Dimethyldeoxyadenosine is a nucleoside with antiviral and anticancer properties. It is a modified DNA monophosphate with the chemical formula C8H16N2O6P. N6,7-dimethyldeoxyadenosine has been shown to inhibit the replication of HIV and herpes simplex virus type 1 (HSV-1) in vitro. This compound also inhibits the growth of cancer cells in culture and has been suggested as an anticancer therapeutic agent.

Nucleoside phosphoramidites are widely used as building blocks in the chemical synthesis of oligonucleotides. The use of a chemical synthesis rather than an enzymatic one allows bespoke oligonucleotides of a desired sequence to be obtained. 3’-Cyanoethyl phosphoramidites are typically modified by reaction with the 5’ hydroxyl of the next nucleoside in the desired sequence. The reaction is usually catalysed by 1H-tetrazole or 4,5-dicyanoimidazole in acetonitrile. N4-Benzoyl-2'-deoxy-5'-O-DMT-5-methylcytidine 3'-CE phosphoramidite, also called N4-Bz-5'-DMT-5-Me-dC phosphoramidite, is used in the synthesis of 2’-deoxy-5-methylcytidine-containing oligonucleotides as antisense drugs.

2,8-Dimethyladenosine is a methylated derivative of the purine nucleoside adenosine, in which methyl groups are added at the 2-position and 8-position of the adenine base.

2′-O-Acetyl-3′-deoxy-3′-fluoro-5′-O-toluoyluridine is a novel, activator ribonucleoside. It is synthesized by the phosphoramidite method and modified with an acetyl group at the 2′ position and a toluoyl group at the 3′ position. This compound has been shown to be active against cancer cells in vitro and in vivo.

<p>5’(R)-C-Methyl-5-methyluridine is an nucleoside and a ribonucleoside. It has antiviral, anticancer, and DNA modifying properties. This product is used in research to make phosphoramidites, diphosphates, and deoxyribonucleosides. 5’(R)-C-Methyl-5-methyluridine is also used in the production of modified oligonucleotides as well as other novel DNA compounds.</p>

<p>1-(2,3,5-Tri-O-acetyl-b-D-ribofuranosyl)nicotinamide is a phosphoramidite that is used for the synthesis of DNA and RNA. It has antiviral and anticancer properties. This compound binds to DNA and inhibits the activity of topoisomerase II, which leads to cell death by inhibiting the production of proteins vital for cell division. 1-(2,3,5-Tri-O-acetyl-b-D-ribofuranosyl)nicotinamide also prevents the replication of viral RNA by inhibiting reverse transcriptase.</p>

<p>2'-Deoxy-5-methylcytidine is a nucleoside analogue that inhibits the synthesis of DNA. It prevents methylation of guanine, which disrupts the binding of guanine nucleotide-binding proteins to the dna template and prevents polymerase chain reactions. 2'-Deoxy-5-methylcytidine has been shown to inhibit colon cancer cells in vitro, and may be a potential biomarker for bowel disease. This drug is also a methyltransferase inhibitor, which means it blocks the enzyme responsible for adding methyl groups to cytosine molecules.</p>

N6-Benzoyl-3’-deoxy-5'-O-DMT-3’- fluoroadenosine 2’-CE-phosphoramidite is a novel and activator ribonucleoside with deoxyribonucleosides, diphosphate and phosphoramidites. It is an anti-cancer, antiviral, and antiinflammatory agent. N6-Benzoyl-3’-deoxy-5'-O-DMT-3’ -fluoro adenosine 2’ -CE phosphoramidite has a CAS no.

<p>A P2Y2 receptor agonist that has been studied in cystic fibrosis and retinal diseases such as retinal detachment. Denufosol was studied as an inhaled drug for cystic fibrosis, due to its ability to activate an alternative chloride channel and avoiding the defective CFTR chloride channel. This enhances hydration of the lung mucosa and improves mucociliary clearance.  The drug did not progress from phase III clinical trials. Denufosol resulted in subretinal fluid reabsorption in in vivo model of retinal detachment.</p>

5'-O-DMT-N2-isobutyryl-2'-O-methylguanosine is a nucleoside that has been synthesized using an oxime opening of the 5' position and a methylation at the 2' position. It has been shown to have an affinity for tissues in a chemotactic assay. The compound is minimised to remove non-specific binding sites, avoiding false positives on the checklist. This molecule has been analysed with fluorescence spectroscopy and microscopy techniques, which revealed that it is distributed in tissues as well as being found in dragonflies. It was also shown to be transduced by muscle cells and geochemically detected in limestone from China.

<p>8-Hydrazinoadenosine is an inhibitor of phosphodiesterase, which is a key enzyme in the regulation of cellular processes. 8-Hydrazinoadenosine binds to the active site of the enzyme and inhibits its function. This binding prevents hydrolysis of the phosphate bond between two nucleotides and so prevents the formation of a new nucleotide from a nucleoside and a phosphate molecule. 8-Hydrazinoadenosine has been shown to inhibit phosphodiesterases in vitro and in animals, including rat brain and mouse lung. Strategies for 8-hydrazinoadenosine commercialization have been investigated, including attaching it to other molecules that are more easily absorbed by cells or using irradiation to produce 8-aminoadenosine, which can be converted into 8-hydrazinoadenosine.</p>

<p>8-Chloroadenosine is a potent inhibitor of apoptosis, which is the process by which cells die. It has been shown to inhibit cell growth in murine hepatoma cells and synergize with other cytotoxic agents. 8-Chloroadenosine inhibits the activity of bcl-2 protein and thus blocks the release of cytochrome c from mitochondria. This causes DNA damage by inhibiting DNA synthesis and protein synthesis, leading to apoptosis. 8-Chloroadenosine has also been shown to be an active inhibitor of cancer cells, especially myeloma cell lines. The response element for 8-chloroadenosine is located in the promoter region of the gene encoding cyclooxygenase 2 (COX-2), which encodes a protein that produces prostaglandins involved in inflammation and tumor growth. The concentration of camp in cancer tissues determines whether these cells will respond favorably or unfavorably to this drug.</p>

<p>5-Hydroxymethyl-2’-O-(2-methoxyethyl)uridine (5HMEU) is a nucleoside that is synthesized from 2’,3’-dideoxyribonucleosides. 5HMEU has been shown to be an activator of the human telomerase enzyme and is used in the synthesis of DNA. It also has anticancer properties and can inhibit the growth of various cancer cells, including pancreatic, breast, prostate, lung, liver, and cervical cancer cells. 5HMEU is a modified nucleoside that contains a hydroxyl group at the 2’ position and an methoxyl group at the 5’ position. The chemical name for 5HMEU is 5-hydroxymethyl-2'-O-(2-methoxyethyl)uridine.</p>

<p>2’,3’,5’-Tri-O-benzoyl-5-hydroxymethyl-2’C-methyluridine is an analogue of 5-hydroxymethyluridine. The 2’,3’,5’-tri-O-benzoyl group is used to protect the hydroxyl group and prevent oxidation. It has been shown to inhibit replication of DNA in vitro and in vivo against human leukemia cells. This product is synthesized by phosphoramidite chemistry from 2′,3′,5′triphosphate and 5′hydroxymethyluridine. The purity of this product is &gt;99%.<br>2’,3’,5’-Tri-O-benzoyl-5-(hydroxymethyl)uridine can be used as a nucleoside or nucleotide analog for anticancer treatments or other therapeutic purposes.</p>

<p>3'-Deoxythymidine (3DT) is a nucleoside analog that has high resistance to HIV. It is an analogue of the human insulin-like growth factor-1 (IGF-1), which binds to the IGF-1 receptor and inhibits the binding of IGF-1 to its receptor, thereby inhibiting the growth of cells. 3DT has been shown to have a protective effect against radiation in mice, with an LD50 at a dose of 5.0 mg/kg for radiation exposure. 3DT also has antiviral activity against murine sarcoma virus, as well as other biological properties such as enzyme activities and disease activity. This drug may be used in future research on polymerase chain reactions (PCRs) and DNA sequencing, since it is chemically stable and can be easily synthesized.</p>

Broad-spectrum anti-viral; inhibitor of HCV NS5B RNA polymerase

Polyinosinic acid-polycytidylic acid (Poly I:C), an agonist of TLR3 toll-like receptors, is a synthetic double-stranded RNA analog, consisting of polyinosinic acid (poly I) paired with polycytidylic acid (poly C), forming a stable duplex structure.PolyI:C stimulates the secretion of pro-inflammatory cytokines and type I interferon through its interaction with endosomal Toll-like receptor 3 (TLR-3) and the cytoplasmic receptors melanoma differentiation-associated gene 5 (MDA-5) and retinoic acid-inducible gene I (RIG-I). This immunostimulant activity makes Poly I:C a useful vaccine adjuvant and is used in vaccine formulations. Poly I:C and its stabilized analogs (e.g., poly-ICLC) are also being actively researched for their dual role in oncology: directly targeting tumors and acting as immune potentiators. For example Poly I:C can induce apoptosis in tumor cells and stimulate immunogenic cell death and is therefore being explored alongside chemotherapy, radiotherapy, and checkpoint inhibitors, helping to overcome resistance mechanisms and strengthen treatment outcomes.We can supply PolyI:C to all stages of your project - from R&D and preclinical phases right up to GMP commercial manufacture. Contact our team for custom Poly I:C products. For more on poly I:C read out blog 'Poly I:C: A Vaccine Adjuvant With Oncological Potential.'

<p>N4-Benzoyl-3'-deoxy-5'-O-DMT-cytidine is a synthetic nucleoside that is used as an activator for DNA synthesis. It is also used in the preparation of diphosphate derivatives for use as antiviral and anticancer agents or as probes for DNA and RNA research. N4-Benzoyl-3'-deoxy-5'-O-DMT-cytidine is a novel, high purity, and high quality chemical with CAS No. 86234-45-9.</p>

2'-Deoxy-2'-fluorocytidine-5'-triphosphate lithium salt is a nucleoside that is used in the synthesis of DNA. 2'-Deoxy-2'-fluorocytidine-5'-triphosphate lithium salt is an antiviral, antineoplastic, and anticancer agent. It has been shown to be active against some strains of HIV and herpes viruses. 2'-Deoxy-2'-fluorocytidine-5'-triphosphate lithium salt also inhibits DNA polymerase and RNA polymerase, preventing viral replication and transcription. The phosphate group on the 5' end of this molecule can be modified to produce phosphoramidites, diphosphates, or triphosphates.

5,6-Dichlorobenzimidazole-1-b-D-ribofuranoside is a chemical compound that has been shown to be neurotoxic in vitro. It has significant cytotoxicity against human leukemia cells (HL60) and induces neuronal death. This drug also inhibits the production of neurotrophic factors, which are vital for the normal development of neurons. 5,6-Dichlorobenzimidazole-1-b-D-ribofuranoside inhibits transcriptional regulation of genes that encode for receptors and enzymes. The compound is chemically stable and does not degrade easily by hydrolysis or oxidation. It can bind to polymerase chain reaction (PCR) primers and inhibit DNA synthesis. 5,6-Dichlorobenzimidazole-1-b-D-ribofuranoside also affects cell nuclei by inhibiting DNA synthesis and enzyme activities.