Antidepressivo

<p>Applications A metabolite of Nortriptyline (N837000).<br>References Callaghan, R., et al.: J. Biol. Chem., 268, 16059 (1993), Dagenais, C., et al.: Biochem. Pharmacol., 67, 269 (2004), Doran, A., et al.: Drug Metab. Dispos., 33, 165 (2005),<br></p>

<p>Impurity Fluoxetine EP Impurity B; Fluoxetine USP Related Compound B<br>Applications N-Methyl-3-phenylpropylamine (Fluoxetine EP Impurity B; Fluoxetine USP Related Compound B) is a Fluoxetine (F597100) impurity.<br>References Kraiczek, S., et al.: Pharmazie, 54, 471 (1999), Krzek, J., et al.: J. Pharm .Biomed. Anal., 21, 451 (1999),<br></p>

<p>Applications Cyclizine is a piperazine derivative with anti-emetic activity that is useful in the prevention and treatment of nausea and vomiting associated with motion sickness. Antiemetic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kuntzman, R., et al.: J. Pharmacol. Exp. Ther., 158, 332 (1967), Walker, R., et al.: Eur. J. Pharm. Sci., 4, 301 (1996), Dumasia, M., et al.: Xenobiotica, 32, 795 (2002),<br></p>

<p>Applications 2-Hydroxydesipramine Dihydrochloride is a metabolite of Desipramine (D290050), a tricyclic antidepressant that is a more potent inhibitor of the norepinephrine transporter than the serotonin transporter.<br>References De Jongh, G.D., et al.: Drug Metab. Dispos., 2, 48 (1981); Suckow, R.F., et al.: J. Pharm. Sci., 73, 1745 (1984); Fraser, A.D., et al.: J. Anal. Toxicol., 11,168 (1987); Checkley, S.A, et al.: Br. J. Psychiatry, 138. 248 (1981); Zhu, M.Y., et al.: J. Neurochem., 70, 1547 (1998); Okugawa, G., et al.: J. Neuroindocrinol., 11, 887 (1999); Torres, G.E., et al.: Nat. Rev. Neurosci., 4, 13 (2003)<br></p>

<p>Impurity Duloxetine Phthalamide Impurity<br>Applications (S)-Duloxetine Phthalamide is an impurity of (S)-Duloxetine present with enteric polymer hydroxypropylmethylcellulose phthalate (HPMCP) in dosage formulations.<br>References Jansen, P.J., et al.: J. Pharmaceut. Sci., 87, 81 (1998),<br></p>

<p>Impurity Fluoxetine EP Impurity A(Atomoxetine Related Compound A)<br>Applications α-[2-(Methylamino)ethyl]benzyl Alcohol (Fluoxetine EP Impurity A(Atomoxetine Related Compound A)) is an aromatic amino alcohol used as an initiator in radical addition reactions with tetrahalomethanes.This compound is found as an impurity in fluoxetine (F597100).<br>References Tarkhanova, I.G. et al.: Russ. Chem. Bull., 55, 1624 (2006); Tarkhanova, I.G. et al.: Kin. Catal., 48, 711 (2007);<br></p>

<p>Applications Intermediate in the preparation of (S)-Norfluoxetine<br>References Zhang, P., et al.: Bioorg. Med. Chem. Lett., 18, 6067 (2008), Graves, A., et al.: J. Mol. Biol., 377, 914 (2008), Cashman, J., et al.: Bioorg. Med. Chem., 17, 337 (2009),<br></p>