Modulatore dell'interazione proteina-proteina
I modulatori delle interazioni proteina-proteina sono composti che influenzano l'interazione tra proteine, sia migliorandone che interrompendone il legame. Questi modulatori sono strumenti preziosi per studiare le reti proteiche, comprendere i meccanismi delle malattie e sviluppare nuove strategie terapeutiche. Le interazioni proteina-proteina sono fondamentali per molti processi biologici, tra cui la trasduzione del segnale, la risposta immunitaria e la regolazione cellulare. Presso CymitQuimica, offriamo una vasta gamma di modulatori delle interazioni proteina-proteina di alta qualità per supportare le tue ricerche in biochimica, biologia molecolare e scoperta di farmaci.
Trovati 63 prodotti di "Modulatore dell'interazione proteina-proteina"
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RCM 1
CAS:Inhibitor of the Forkhead box M1 (FOXM1), an oncogene and a transcription factor regulating cell cycle progression, DNA damage repair and cell renewal. RCM 1 weakens the FOXM1 activity by inhibiting its nuclear localisation and increasing its degradation in proteasomes. The compound showed potential for asthma treatment since it inhibited goblet cell metaplasia and IL-13 signalling in mice.Formula:C20H12N2OS4Purezza:Min. 95%Colore e forma:SolidPeso molecolare:424.59 g/molRVX 208
CAS:Inhibitor of BET bromodomainFormula:C20H22N2O5Purezza:Min. 95%Colore e forma:PowderPeso molecolare:370.4 g/molSR 18292
CAS:Inhibitor of transcriptional coactivator PGC-1a; anti-diabetic agentFormula:C23H30N2O2Purezza:Min. 95%Colore e forma:PowderPeso molecolare:366.5 g/molMCC 950 sodium
CAS:Inhibitor of NLRP3 inflammasome and suppressor of the inflammatory cytokine IL-1β secretion. The compound was tested in diabetic mice and was shown to decrease the incidence of cardiac arrythmias, which are common secondary complications in diabetes mellitus. MCC 950 has potential to reverse diabetes-induced pathologies in cardiac electrophysiology.Formula:C20H23N2O5S·NaPurezza:Min. 98 Area-%Colore e forma:White PowderPeso molecolare:426.46 g/molNAcM-OPT
CAS:Inhibits N-Acetyl-mediated interaction between BE2M (E2 conjugating enzyme) and DCN1 (a component of E3 ligase complex). Also has inhibitory action on DCN2 and NEDD8 ubiquitin-like protein. Reduces anchorage-independent growth in DCN1-amplified cell line.Formula:C23H29Cl2N3OPurezza:Min. 95%Colore e forma:solid.Peso molecolare:434.4 g/mol(2R-)Arimoclomol
CAS:A co-inducer of HSP that acts through heat shock factor 1 (HSF1) in cells undergoing cellular stress. Has therapeutic potential in motor neuron degenerative diseases. Potential treatment for liposomal storage disorders, such as Niemann-Pick disease type C.Formula:C14H20ClN3O3Purezza:Min. 95%Colore e forma:White PowderPeso molecolare:313.78 g/molCBR 470-1
CAS:Activates NRF2 signallingFormula:C14H20ClNO4S2Purezza:Min. 95%Colore e forma:PowderPeso molecolare:365.9 g/molBardoxolone methyl
CAS:Activater of the Nrf2 pathway and an inhibitor of the NF-κB pathway. Possible applications have extended to anti-viral treatment of COVID-19.Formula:C32H43NO4Purezza:Min. 95%Colore e forma:White PowderPeso molecolare:505.69 g/molNL 1
CAS:Inhibits the mitochondrial outer mebrane protein mitoNEET, anti-leukaemicFormula:C18H25NO3SPurezza:Min. 95%Colore e forma:SolidPeso molecolare:335.46 g/molCCG 63808
CAS:Reversible inhibitor of RGS proteins
Formula:C25H15FN4O2SPurezza:Min. 95%Peso molecolare:454.08998LF3
CAS:A potent inhibitor of Wnt/β-catenin signalling pathway that interferes with β-catenin/TFC4 interaction. Reduces growth and motility of colon cancer cells. Inhibits self-renewal, whilst inducing differentiation in cancer stem cells.
Formula:C20H24N4O2S2Purezza:Min. 95%Colore e forma:PowderPeso molecolare:416.56 g/molDocetaxel - Bio-X ™
CAS:Docetaxel is an antineoplastic agent that is used to treat various cancers such as breast and prostate cancer. This drug interferes with the normal function of microtubule growth. It is an anti-mitotic drug used in chemotherapy. Research has shown that this drug also induces programmed cell death in cancer cells.Formula:C43H53NO14Purezza:Min. 90 Area-%Colore e forma:White/Off-White SolidPeso molecolare:807.88 g/molVinorelbine
CAS:Prodotto controllatoMicrotubule disrupter; anti-mitotic drug; anti-cancer alkaloid
Formula:C45H54N4O8Purezza:Min. 95%Colore e forma:SolidPeso molecolare:778.93 g/molPaquinimod
CAS:A calcium-binding protein S100A9 inhibitor with immunomodulatory activity that reduces pathology in experimental collagenase-induced osteoarthritis.Formula:C21H22N2O3Purezza:Min. 98 Area-%Colore e forma:White Off-White PowderPeso molecolare:350.41 g/molH 151
CAS:A potent inhibitor of STING protein (stimulator of interferon genes), a protein that partakes in intracellular DNA sensing pathway. H 151 blocks palmitoylation of STING, which is required for the formation of multimeric complexes for recruiting downstream signalling molecules. Inhibition of STING by H 151 reduces pro-inflammatory cytokine synthesis.Formula:C17H17N3OPurezza:Min. 95%Colore e forma:SolidPeso molecolare:279.34 g/molGNE 371
CAS:A chemical probe for the dual bromodomains of human transcription-initiation-factor TFIID subunit 1 (TAF1). GNE 371 binds TAF1 with an IC50 of 10 nM and is selective over other bromodomain family members. Exerts anti-proliferative effects in synergy with BET inhibitor JQ1.
Formula:C24H25N5O3Purezza:(Hplc-Ms) Min. 98 Area-%Peso molecolare:431.49 g/molES9-17
CAS:Inhibitor of clathrin-mediated endocytosis (CME) and ligand to the clathrin heavy chain (CHC). ES9-17 is an inhibitor of the CHC function with EC50 of 13 μM in plant model Arabidopsis thaliana. ES9-17 is a non-protonophoric CME inhibitor and it does not alter the cytoplasmic pH levels substantially. In a mammalian cell line HeLa, ES9-17 reduced the uptake of transferrin, which is a CME-driven process.
Formula:C10H8BrNO2S2Purezza:Min. 95%Colore e forma:Off-White PowderPeso molecolare:318.21 g/molCytochalasin D
CAS:Inhibits actin polymerizationFormula:C30H37NO6Purezza:Min. 95%Colore e forma:PowderPeso molecolare:507.62 g/molEED 226 monohydrate
CAS:Potent and selective inhibitor of polycomb repressive complex 2 (PRC2), by binding to the K27me3-pocket of the regulatory EED subunit. Inhibits H3K27 methylation in histone 3. Has anti-tumor activity in murine xenograft models. Synergistic with EZH2 inhibitor against cancer cell growth.
Formula:C17H15N5O3S·H2OPurezza:Min. 95%Colore e forma:White To Yellow SolidPeso molecolare:387.41 g/molSirt-IN-1
CAS:Inhibitor of pan-sirtuins (IC50 = 15, 10, 33 µM for SIRT1, 2 and 3 respectively), by binding to the active catalytic site. Selectivity for sirtuins was demonstrated when tested for activity on a panel of kinases, nuclear receptors, ion channels, transporters and GPCRs.Formula:C19H27N5O2SPurezza:Min. 95%Peso molecolare:389.52 g/mol
