Modulatore dell'interazione proteina-proteina
I modulatori delle interazioni proteina-proteina sono composti che influenzano l'interazione tra proteine, sia migliorandone che interrompendone il legame. Questi modulatori sono strumenti preziosi per studiare le reti proteiche, comprendere i meccanismi delle malattie e sviluppare nuove strategie terapeutiche. Le interazioni proteina-proteina sono fondamentali per molti processi biologici, tra cui la trasduzione del segnale, la risposta immunitaria e la regolazione cellulare. Presso CymitQuimica, offriamo una vasta gamma di modulatori delle interazioni proteina-proteina di alta qualità per supportare le tue ricerche in biochimica, biologia molecolare e scoperta di farmaci.
Trovati 63 prodotti di "Modulatore dell'interazione proteina-proteina"
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17-Allylaminogeldanamycin
CAS:<p>17-AAG is the first clinically tested hsp90 inhibitor that exhibits antitumor activity. Its antitumor effects are documented in vivo for various animal models, including erbB2-dependent breast cancer, prostate cancer models, and melanoma.</p>Formula:C31H43N3O8Purezza:Min. 95%Colore e forma:PowderPeso molecolare:585.69 g/molEED 226 monohydrate
CAS:<p>Potent and selective inhibitor of polycomb repressive complex 2 (PRC2), by binding to the K27me3-pocket of the regulatory EED subunit. Inhibits H3K27 methylation in histone 3. Has anti-tumor activity in murine xenograft models. Synergistic with EZH2 inhibitor against cancer cell growth.</p>Formula:C17H15N5O3S·H2OPurezza:Min. 95%Colore e forma:White To Yellow SolidPeso molecolare:387.41 g/molBardoxolone methyl
CAS:<p>Activater of the Nrf2 pathway and an inhibitor of the NF-κB pathway. Possible applications have extended to anti-viral treatment of COVID-19.</p>Formula:C32H43NO4Purezza:Min. 95%Colore e forma:White PowderPeso molecolare:505.69 g/molCBR 470-1
CAS:<p>Activates NRF2 signalling</p>Formula:C14H20ClNO4S2Purezza:Min. 95%Colore e forma:PowderPeso molecolare:365.9 g/molCCG 63808
CAS:<p>Reversible inhibitor of RGS proteins</p>Formula:C25H15FN4O2SPurezza:Min. 95%Peso molecolare:454.08998AMG 510
CAS:<p>KRAS G12C inhibitor</p>Formula:C30H30F2N6O3Purezza:(%) Min. 98%Colore e forma:PowderPeso molecolare:560.59 g/molAPTO 253
CAS:<p>Induces Kruppel like factor 4 (KLF4) and reduces the expression of MYC. Anti-tumor activity of APTO 253 has been demonstrated in AML and haematological malignancies. Inducing KLP4 expression in ovarian cancer cells using APT0 253 sensitises cells to cisplatin and paclitaxel. BRCA1/2-deficient cancer cells are hypersensitive to APTO 253, which mediates its action by causing DNA damage.</p>Formula:C22H14FN5Purezza:Min. 95%Colore e forma:SolidPeso molecolare:367.38 g/molMCC 950 sodium
CAS:<p>Inhibitor of NLRP3 inflammasome and suppressor of the inflammatory cytokine IL-1β secretion. The compound was tested in diabetic mice and was shown to decrease the incidence of cardiac arrythmias, which are common secondary complications in diabetes mellitus. MCC 950 has potential to reverse diabetes-induced pathologies in cardiac electrophysiology.</p>Formula:C20H23N2O5S·NaPurezza:Min. 98 Area-%Colore e forma:White PowderPeso molecolare:426.46 g/molVinorelbine
CAS:Prodotto controllato<p>Microtubule disrupter; anti-mitotic drug; anti-cancer alkaloid</p>Formula:C45H54N4O8Purezza:Min. 95%Colore e forma:SolidPeso molecolare:778.93 g/molPaquinimod
CAS:<p>A calcium-binding protein S100A9 inhibitor with immunomodulatory activity that reduces pathology in experimental collagenase-induced osteoarthritis.</p>Formula:C21H22N2O3Purezza:Min. 98 Area-%Colore e forma:White Off-White PowderPeso molecolare:350.41 g/molObatoclax mesylate
CAS:<p>Obatoclax mesylate is a synthetic small molecule, which is derived from chemical synthesis with a primary mode of action as a pan-BCL-2 inhibitor. This compound antagonizes multiple anti-apoptotic proteins within the BCL-2 family, ultimately promoting apoptosis in malignant cells. Its ability to inhibit these proteins disrupts the survival mechanisms that cancer cells exploit, potentially restoring apoptotic pathways that are often dysregulated in cancerous tissues.</p>Formula:C20H19N3O·CH4O3SPurezza:Min. 95%Colore e forma:Black SolidPeso molecolare:413.49 g/molWS 383 hydrochloride
CAS:<p>Potent inhibitor of the interaction between defective cullin neddylation protein DCN1 and NEDD8-conjugating enzyme UBC12 with IC50 of 11 nM. WS 383 blocks the DCN1-UBC12 interaction in a reversible manner, selectively inhibits Cul3/1 neddylation and induces accumulation of p21, p27, and NRF2 proteins.</p>Formula:C18H20ClN9S2·HClPurezza:Min. 95%Colore e forma:SolidPeso molecolare:498.46 g/molSR 18292
CAS:<p>Inhibitor of transcriptional coactivator PGC-1a; anti-diabetic agent</p>Formula:C23H30N2O2Purezza:Min. 95%Colore e forma:PowderPeso molecolare:366.5 g/mol(2R-)Arimoclomol
CAS:<p>A co-inducer of HSP that acts through heat shock factor 1 (HSF1) in cells undergoing cellular stress. Has therapeutic potential in motor neuron degenerative diseases. Potential treatment for liposomal storage disorders, such as Niemann-Pick disease type C.</p>Formula:C14H20ClN3O3Purezza:Min. 95%Colore e forma:White PowderPeso molecolare:313.78 g/molABT 737
CAS:<p>Inhibits anti-apoptotic proteins Bcl-2, Bcl-xl and Bcl-w. Synergistic with chemotherapy and radiotherapy in several tumour cell lines. Potent activity as a single agent in lymphoid cancer and small cell lung cancer (SCLC) cell lines. Causes tumour regression in SCLC xenograft tumour in vivo.</p>Formula:C42H45ClN6O5S2Purezza:Min. 95%Colore e forma:Yellow SolidPeso molecolare:813.43 g/molRCM 1
CAS:<p>Inhibitor of the Forkhead box M1 (FOXM1), an oncogene and a transcription factor regulating cell cycle progression, DNA damage repair and cell renewal. RCM 1 weakens the FOXM1 activity by inhibiting its nuclear localisation and increasing its degradation in proteasomes. The compound showed potential for asthma treatment since it inhibited goblet cell metaplasia and IL-13 signalling in mice.</p>Formula:C20H12N2OS4Purezza:Min. 95%Colore e forma:SolidPeso molecolare:424.59 g/molRVX 208
CAS:<p>Inhibitor of BET bromodomain</p>Formula:C20H22N2O5Purezza:Min. 95%Colore e forma:PowderPeso molecolare:370.4 g/molSirt-IN-1
CAS:Inhibitor of pan-sirtuins (IC50 = 15, 10, 33 µM for SIRT1, 2 and 3 respectively), by binding to the active catalytic site. Selectivity for sirtuins was demonstrated when tested for activity on a panel of kinases, nuclear receptors, ion channels, transporters and GPCRs.Formula:C19H27N5O2SPurezza:Min. 95%Peso molecolare:389.52 g/molNutlin 3A
CAS:<p>Antagonist of proto-oncogene MDM2 and its interaction with p53</p>Formula:C30H30Cl2N4O4Purezza:Min. 95%Peso molecolare:581.49 g/molVinorelbine tartrate
CAS:Prodotto controllatoMicrotubule disrupter; anti-mitotic drug; anti-cancer alkaloidFormula:C53H66N4O20Purezza:(Hplc) Min. 98.0%Colore e forma:White PowderPeso molecolare:1,079.11 g/mol
