Altri

<p>Folinic acid (Leucovorin) is a biofolic acid that can be used in the treatment of methotrexate, often in combination with Methotrexate (MTX) to reduce MTX-</p>

<p>M01914 - myo-Inositol</p>

<p>Applications 1,1,1-Tris(hydroxymethyl)propane is a building block often used to make polymers. 1,1,1-Tris(hydroxymethyl)propane has been used as a precursor to prepatre alkyd resins for linseed oil based paint.<br>References Wang, X., et. al.: J. Polym. Res., 18, 721 (2011); Isiri-Caglar, D., et. al.: Rog. Org. Coat., 77, 81 (2014); Heiskanen,N., et. al.: J. Appl. Polym. Sci., 119, 209 (2011)<br></p>

<p>M06199 - BOC-SER(TBU)-OH DCHA</p>

<p>Applications Carfilzomib is a second-generation proteasome inhibitor that is used as a treatment in relapsed and refractory multiple myeloma.<br>References Fostier, K., et al.: Oncotargets. Therap., 5, 237 (2012); Geurink, P.P., et al.: J. Med. Chem., 56, 1262 (2013); McCormack, P.L., et al.: Drugs., 72, 2023 (2012);<br></p>

<p>Applications Desmethyl Nintedanib is an impurity of Intedanib (I666650), which is an antitumor agent. Desmethyl Nintedanib was used in the study of synthesizing indolinones as triple angiokinase inhibitors.<br>References Roth, G., et al.: J. Med. Chem., 52, 4466 (2009);<br></p>

<p>Applications Selective non-benzodiazepine GABAA receptor agonist.<br>References Allen, D., et al.: Eur. J. Clin. Pharmacol., 45, 313 (1993), Beer, B., et al.: J. Clin. Pharmacol., 34, 335 (1994), Rosen, A.S., et al.: Biopharm. Drug Dispos., 20, 171 (1999), Elie, R., et al.: J. Clin. Psychiatry, 60, 536 (1999), Heydorn, W.E., et al.: Expert Opin. Invest. Drugs, 9, 841 (2000)<br></p>

<p>Impurity Atenolol USP Related Compound D; Atenolol EP Impurity F<br>Applications 4,4'-[[(1-methylethyl)imino]bis[(2-hydroxy-3,1-propanediyl)oxy]]bis-benzeneacetamide (Atenolol USP Related Compound D; Atenolol EP Impurity F) is an impurity of Atenolol (A790075), a cardioselective β-adrenergic blocker.<br>References Caplar, V., et al.: Anal. Profiles Drug Subs., 13, 1 (1984); Caplar, V., et al.: Acta. Pharma. Jugoslavica., 33, 71 (1983);<br></p>

<p>Applications (E)-4-Hydroxy Tamoxifen-d5 is an labelled metabolite of Tamoxifen (T006000). A hydroxylated analogue of Tamoxifen with anti-estrogenic properties.<br>References Muerdter, T.E., et al.: Clin. Pharmacol. Therapeut., 89, 708 (2011); Dorchies, O. M., et al.: Am. J. Pathol., 182, 485 (2013);<br></p>

<p>Applications N-Boc-piperazine (cas# 57260-71-6) is a compound useful in organic synthesis.<br></p>

<p>Applications Hexamethyldisilazane is used in the preparation of 5-azacytidine, an antineoplastic drug. Also used in the preparation of β3-AR agonists used in anti-stress formulations.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Vujjini, S. et al.: Org. Proc. Res. Dev., 17, 303 (2013); Xu, F. et al.: Org. Lett., 15, 1342 (2013);<br></p>

<p>Applications An alkyladamantane derivative that are biotransformed via strains of Pseudomonas. It is used to study alkyladamantane adsorption on graphitized thermal carbon black.<br>References Yashkin, S.N. et al.: Rus. Che,. Bull., 57, 2472 (2008); Slepen’kin, A. et al.: Nefeckhim., 33, 406 (1993);<br></p>

<p>Applications Labelled MDV 3100. MDV 3100 is an androgen-receptor antagonist that blocks androgens from binding to the androgen receptor and prevents nuclear translocation and co-activator recruitment of the ligand-receptor complex. MDV 3100 has also been shown to induce tumor cell apoptosis, and has no agonist activity. MDV 3100 is a candidate for the treatment of castration-resistant prostate cancer.<br>References Scher, H.I. et al.: Lancet, 375, 1437 (2010); Bellmunt, J. et al.: Ther. Adv. Med. Oncol., 2, 189 (2010); Ryan, C.J. et al.: J. Clin. Oncol., 29, 3651 (2011);<br></p>

<p>Applications β-Hydroxyisobutanol is used as a reagent in the synthesis of pyrazolo[1,5-a]pyridinecarbonyl-substituted spirocyclic piperidine ketals as inhibitors of HCV protein NS4B and of hepatitis C viral replication and their lack of cytotoxicity in human cells.<br>References Tai, V.W.-F., et al.: Bioorg. Med. Chem. Lett., 24, 2288 (2014);<br></p>

<p>Applications Salicylic Acid β-D-O-Glucuronide is a metabolite of Acetylsalicylic Acid (Aspirin) (A187780).<br>References Grootveld, M., et al.: Biochem. Pharmacol., 37, 271 (1988), Subbegowda, R., et al.: Cancer Res., 58, 2772 (1998), Yoshida, Y., et al.: Eur. J. Pharmacol., 349, 49 (1998),<br></p>

<p>Applications A labelled metabolite of Toluene.<br>References Gargas, M., et al.: Toxicol. Appl. Pharmacol., 98, 87 (1989), Commandeur, J., et al.: Pharmacol. Rev., 47(2), 271 (1995), Campo, P., et al.: Neurotoxicol. Teratol., 21, 427 (1999), Lohse, C., et al.: J. Agr. Food Chem., 48, 5913 (2000),<br></p>

<p>Stability Hygroscopic<br>Applications d-Cloprostenol Sodium Salt is the d-enantiomer of Cloprostenol (C587300), an aryl-oxymethyl analog of prostaglandin F2α.<br>References Gumen, A., et al.: J. Animal. Sci., 56, 279 (2011); Leterlier, C.A., et al.: Reproduct. Domestic. Animals., 46, 481 (2011); Martins, J.P.N., et al.: J. Diary. Sci., 94, 2815 (2011);<br></p>

<p>Applications The primary labelled metabolite of Diazepam. A ligand for the GABAA receptor benzodiazepine modulatory site. Anxiolytic.Controlled substance (depressant).<br>References Klotz, U., et al.: Br. J. Clin. Pharmacol., 7, 119 (1979), Konishi, M., et al.: J. Pharm. Sci., 67, 1777 (1978), Andreoli, V., et al.: Arzneim.-Forsch., 27, 436 (1977), Miller, R.P., et al.: Toxicol. Appl. Pharmacol., 25, 453 (1973), Margolis, J., et al.: Drug Metab. Dispos., 31, 606 (2003),<br></p>

<p>Stability Unstable in Methanol<br>Applications Used in the synthesis of cyanogen glycoside. A component contains in antiperspirants, deodorants, body soaps, shampoos, hair rinses, and hair; it inhibits volatile steroid formation by resident bacteria.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Marouf, A., et al.: Pharm. Biol., 39, 263 (2001), Fukuda, T., et al.: Biol. Pharm. Bull., 26, 271 (2003), Butler, M., et al.: J. Nat. Prod., 67, 2141 (2004), He, J., et al.: J. Nat. Prod., 69, 121 (2006),<br></p>

<p>Applications α1-Adrenergic antagonist; derivative of Uracil (U801000). Antihypertensive.<br>References Eltze, M., et al.: Eur. J. Pharmacol., 59, 1 (1979), Barankay, A., et al.: Arzneim.-Forsch., 31, 849 (1981), Belz, G.G., et al.: Clin. Pharmacol. Ther., 37, 48 (1985),<br></p>

<p>Applications Fulvestrant (F862500) impurity D.<br></p>

<p>Applications 3-[4-(2-methoxyphenyl)piperazin-1-yl]propan-1-amine (cas# 20529-23-1) is a useful research chemical.<br></p>

<p>Applications 5-Methylfurfural is a common chemical reagent used in a wide variety of chemical reactions and organic synthesis. Polycyclic pyridazine based derivatives are synthesized with this compound to form antimicrobial agents. Also used in the preparation of antiinflammatory diarylpentanoid analogues.<br>References Deeb, A. et al.: Eur. Chem. Bull., 3, 897 (2014); Leong, S. et al.: Molecules, 19, 16058 (2014);<br></p>

<p>Applications A metabolite of Malachite Green in seafood products. A triphenylmethane dye with fungicidal and limited antiseptic activity. The term Malachine green applies to the oxalate as well as the chloride. Harmful if swallowed. Avoid release to the environment. Dyes and metabolites, Environmental Testing<br>References Carter, S.G., et al.: J. Biochem. Biophys. Methods, 7, 7 (1982), Saikan, S., et al.: J. Chem. Phys., 79, 4154 (1983), Clemmensen, S., et al.: Arch. Toxicol., 56, 43 (1984),<br></p>

<p>Applications Silodosin is an α1a-adrenoceptor antagonist. It is used in treatment of benign prostatic hypertrophy.<br>References (1) Shibata, K., et al.: Mol. Pharmacol., 48, 250 (1995) (2) Murata, S., et al.: J. Urol., 164, 578 (2000)<br></p>

<p>Applications Labelled (S)-Atenolol (A790080). Cardioselective β-adrenergic blocker. Antihypertensive, antianginal, antiarrhythmic (class II).<br>References Caplar, V., et al.: Anal. Profiles Drug Subs., 13, 1 (1984),<br></p>

<p>Applications Perfluorophenol is used in the synthesis of PGA-films as biodegradable polymers. It also participates in the synthesis of tripod macrocyclic Gd(III) chelates for cancer molecular MRI.<br>References Lee, K. et al.: Langmuir., 20, 2531 (2004); Zhou, Z. et al.: Biomater., 34, 7683 (2013);<br></p>

<p>Applications A metabolite of Zopiclone (Z700500).<br>References Fernandez, C., et al.: Clin. Pharmacokinet., 29, 431 (1995), Nordgren, H., et al.: Ther. Drug Monit., 24, 410 (2002),<br></p>

<p>Applications Desmethyl 5-Methoxycarbonyl Nintedanib is an impurity of Intedanib (I666650), which is an indolinone derivative potently blocking VEGF-, PDGF-, and FGF-receptor kinases. it is an indolinone as triple angiokinase inhibitors and an antitumor agent.<br>References Sun, L., et al.: J. Med. Chem., 41, 2588 (1998); Xie, H., et al.: J. Med. Chem., 50, 4898 (2007); Hilberg, F., et al.: Cancer Res., 68, 4774 (2008); Roth, G., et al.: J. Med. Chem., 58, 1053 (2015)<br></p>

<p>Applications Ethyl Ethanesulfonate is used as a reactant in stereoselective Friedel-Crafts alkylation reactions. Also used in the preparation of 1-alkyl-3-methylimidazolium alkanesulfonate ionic liquids.<br>References Stadler, D., Bach, T.: Chem. Asian J., 3, 272 (2008); Blesic, M., et al.: Phys. Chem. Chem. Phys., 11, 8939 (2009);<br></p>

<p>Applications A labelled metabolite of Zopiclone.<br></p>

<p>Applications 1-Bromo-3,5-dimethyladamantane (cas# 941-37-7) is a compound useful in organic synthesis.<br></p>

<p>Applications Labelled Diazepam, an anxiolytic; muscle relaxant (skeletal); anticonvulsant.Diazepam is a Controlled substance (depressant).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References MacDonald, A., et al.: Anal. Profiles Drug Subs., 1, 79 (1972); Mandelli, M., et al.: Clin. Pharmacokinet., 3, 72 (1978); Bertilsson, L., et al.: Pharmacol. Ther., 45, 85 (1990); Murray, J.B., et al.: J. Psychol., 124, 655 (1990); Pellock, J.M., et al.: Drug Saf., 27, 383 (2004);<br></p>