Altri

Applications (S)-2-((S)-4-Methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenylpropanoic Acid is an intermediate for Carfilzomib (C183460), which is a second-generation proteasome inhibitor that is used as a treatment in relapsed and refractory multiple myeloma.
References Fostier, K., et al.: Oncotargets. Therap., 5, 237 (2012); Geurink, P.P., et al.: J. Med. Chem., 56, 1262 (2013); McCormack, P.L., et al.: Drugs., 72, 2023 (2012);

Applications N-(5-Chloro-2-pyridinyl)-2-pyrazinecarboxamide is an impurity of Zopiclone (Z700500) which is a nonbenzodiazepine hypnotic agent used in the treatment of insomnia.
References Noble, S., et al.: Drugs, 55, 277 (1998), Musch, B., et al.: Int. J. Clin. Psychopharmacol., 5, 147 (1990),

Applications Methyl 4-Hydroxyphenylacetate has been shown to have potent inhibitory activity against tobacco mosaic virus (TMV).
References Shen, S., Li, W., Wang, J.: Nat. Prod. Res., 27, 2286 (2013); Golovleva, L.A., et. al.:

Applications (αE)-α-[(3,4-Dihydroxy-5-nitrophenyl)methylene]-β-oxo-1-piperidinepropanenitrile is an impurity of Entacapone (E558500), a peripherally acting inhibitor of catechol-O-methyl transferase (COMT), an enzyme involved in the metabolism of catecholamine neurotransmitters and related drugs. Antiparkinsonian.
References Karlsson, M., et al.: J. Pharm. Biomed. Anal., 10, 593 (1992), Nissinen, E., et al.: Arch. Pharmacol., 346, 262 (1992), Wikberg, T., et al.: Eur. J. Drug Metab. Pharmacokinet., 18, 359 (1993),

Applications N-Nitroso-1-(2-methoxyphenyl)piperazine is a reagent used in the preparation of 9-aminoacridine-based agents that impair bovine viral diarrhea virus replication.
References Loddo, R. et al.: Bio. & Med. Chem., 26(4), 855-868, (2018)

Impurity Fulvestrant Impurity E;
Applications Fulvestrant (F862500) impurity E.

Applications: Labelled Almotriptan (A575200). Almotriptan is a serotonin 5HT1B /1D-receptor agonist used for treatment of migraine.
References Fleishaker, J.C., et al.: Clin. Pharmacol. Ther., 67, 498 (2000), Kamali, F., et al.: Curr. Opin. Cent. Peripher. Nerv. Syst. Invest. Drugs, 2, 197 (2000), Dodick, D.W., et al.: Expert Opin.Pharmacother., 4, 1157 (2003)

Stability Hygroscopic
Applications (S)-4-Oxo-homophenylalanine Hydrochloride is a derivative of L-Homophenylalanine (H600500); an antitumor agent.
References Brunner, Henri., et al.: Eur. J. Med. Chem., 25, 35 (1990)

Applications Labelled analogue of cis-Entacapone, the (Z)-Isomer of Entacapone (E558500) polymorphic form B. Antiparkinsonian.
References Karlsson, M., et al.: J. Pharm. Biomed. Anal., 10, 593 (1992), Nissinen, E., et al.: Arch. Pharmacol., 346, 262 (1992), Wikberg, T., et al.: Eur. J. Drug Metab. Pharmacokinet., 18, 359 (1993),

Stability Hygroscopic
Applications A novel active metabolite of the anti-cancer drug Tamoxifen (T006000).
References Furr, B., et al.: Pharmacol. Ther., 25, 127 (1984), Leonessa, F., et al.: Cancer Res., 54, 441 (1994), Stearns, V., et al.: Lancet, 360, 1851 (2002), Rae, J., et al.: Pharmacogenetics, 13, 501 (2003), Zheng, Y., et al.: Drug Metab. Dispos., 35, 1942 (2007),

Applications N-[4-[[(Z)-(1,2-Dihydro-2-oxo-3H-indol-3-ylidene)phenylmethyl]amino]phenyl]-N,4-dimethyl-1-piperazineacetamide was used in the study to discover a potent inhibitor of MELK that inhibits expression of the anti-apoptotic protein Mcl-1 and TNBC cell growth. N-[4-[[(Z)-(1,2-Dihydro-2-oxo-3H-indol-3-ylidene)phenylmethyl]amino]phenyl]-N,4-dimethyl-1-piperazineacetamide is an impurity of Intedanib (I666650), which is an antitumor agent.
References Edupuganti, R., et al.: Bioorg. Med. Chem., 25, 2609 (2017); Sun, L., et al.: J. Med. Chem., 41, 2588 (1998); Xie, H., et al.: J. Med. Chem., 50, 4898 (2007); Hilberg, F., et al.: Cancer Res., 68, 4774 (2008); Roth, G., et al.: J. Med. Chem., 58, 1053 (2015)

Impurity Atenolol EP Impurity H
Applications 2-[4-[(2RS)-2-Hydroxy-3-[(1-methylethyl)amino]propoxy]phenyl]acetonitrile is an impurity of Atenolol (A790075), a cardioselective β-adrenergic blocker. Atenolol EP Impurity H
References Caplar, V., et al.: Anal. Profiles Drug Subs., 13, 1 (1984);

Applications The trans-isomer used in the improved process for the production and purification of Bimatoprost (B386800).

Applications Substrate specificity of haloalkane dehalogenases.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Koudelakova, T., et al.: Biochem. J., 435, 345 (2011),

Applications Zafirlukast p-Tolyl Isomer is a positional isomer and impurity of the cysteinyl leukotriene type 1 receptor antagonist, Zafirlukast (D226955).
References Krishnaiah, C. et al.: Anal. Chem. Ind. J., 8, 471 (2009); Madhavi, A. et al.: Chromatographia, 70, 233 (2009); Goverdhan, G. et al.: J. Pharmac. Biomed. Anal., 49, 895 (2009);

Applications Palbociclib N-Aldehyde is an intermediate in synthesizing Palbociclib N-β-D-Glucuronide Sodium Salt (P139910), a derivative of Palbociclib (P139900) which is an experimental drug for the treatment of breast cancer being developed by Pfizer. It is a selective inhibitor of the cyclin-dependent kinases CDK4 and CDK6.
References Finn, R., et al.: Breast Cancer Res., 11, 5 (2009)

Applications Hydroxyatenolol-d7 is the isotope labelled analog of Hydroxyatenolol (H802480); a metabolite of Atenolol (A790075) which is a cardioselective β-adrenergic blocker, antihypertensive, antianginal, and antiarrhythmic (class II).
References Escher, B., et al.: Environ. Sci. Technol., 40, 7402 (2006); Caplar, V., et al.: Anal. Profiles Drug Subs., 13, 1 (1984)

Impurity Eletriptan Impurity 14
Applications Tri-o-tolyl-Phosphine Oxide (Eletriptan Impurity 14) is an impurity of Eletriptan, a selective serotonin 5-HT1B and 5-HT1D receptor agonist and used to treat migraines.
References Willems, E., et al.: Arch. Pharmacol., 358, 212 (1998); Napier, C., et al.: Eur. J. Pharmacol., 368, 259 (1999); Goadsby, P.J., et al.: Neurology, 54, 156 (2000)

Applications (2E)-2-Cyano-3-(3-ethoxy-4-hydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide is an impurity of Entacapone (E558500), a peripherally acting inhibitor of catechol-O-methyl transferase (COMT), an enzyme involved in the metabolism of catecholamine neurotransmitters and related drugs. Antiparkinsonian.
References Karlsson, M., et al.: J. Pharm. Biomed. Anal., 10, 593 (1992), Nissinen, E., et al.: Arch. Pharmacol., 346, 262 (1992), Wikberg, T., et al.: Eur. J. Drug Metab. Pharmacokinet., 18, 359 (1993),

Applications An impurity of Nintedanib, which is an antifibrotic drug.
References Holdsworth, G.; et al.: Scientific Reports, 7, 1 (2017)

Applications OR 486 is an anti-inflammatory agent used in the treatment of rheumatoid arthritis and osteoarthritis. Entacapone (E588500) impurity.
References Jenei-Lanzl, Z. et al.: Annal Rheum. Dis., 74, 444 (2015); Karlsson, M., et al.: J. Pharm. Biomed. Anal., 10, 593 (1992), Nissinen, E., et al.: Arch. Pharmacol., 346, 262 (1992), Wikberg, T., et al.: Eur. J. Drug Metab. Pharmacokinet., 18, 359 (1993),

Applications Fulvestrant (F862500) impurity C.

Applications Deschloro-Zopiclone is a metabolite of Zopiclone (Z700500) which is a cyclopyrrolone member of a family of non-benzodiazepine GABAA receptor agonists.
References Noble, S., et al.: Drugs, 55, 277 (1998), Musch, B., et al.: Int. J. Clin. Psychopharmacol., 5, 147 (1990),

Applications Zafirlukast m-Tolyl Isomer is a positional isomer and impurity of the cysteinyl leukotriene type 1 receptor antagonist, Zafirlukast (D226955).
References Krishnaiah, C. et al.: Anal. Chem. Ind. J., 8, 471 (2009); Madhavi, A. et al.: Chromatographia, 70, 233 (2009); Goverdhan, G. et al.: J. Pharmac. Biomed. Anal., 49, 895 (2009);

Applications A labelled metabolite of the anti-cancer drug Tamoxifen (T006000).
References Heiman, D., et al.: J. Med. Chem., 23, 994 (1980), Kier, L., et al.: Pharm. Res., 7, 801 (1990),

Applications An alkyladamantane derivative that are biotransformed via strains of Pseudomonas. It is used to study alkyladamantane adsorption on graphitized thermal carbon black.
References Yashkin, S.N. et al.: Rus. Che,. Bull., 57, 2472 (2008); Slepen’kin, A. et al.: Nefeckhim., 33, 406 (1993);

Applications Desmethyl Nintedanib Carboxylic Acid is an impurity of Intedanib (I666650), which is an indolinone derivative potently blocking VEGF-, PDGF-, and FGF-receptor kinases. it is an indolinone as triple angiokinase inhibitors and an antitumor agent.
References Sun, L., et al.: J. Med. Chem., 41, 2588 (1998); Xie, H., et al.: J. Med. Chem., 50, 4898 (2007); Hilberg, F., et al.: Cancer Res., 68, 4774 (2008); Roth, G., et al.: J. Med. Chem., 58, 1053 (2015)

Impurity Leuprolide Acetate EP Impurity B TFA salt
Applications Synthetic nonapeptide agonist analog of LH-RH. Antineoplastic (hormonal).
References Vilchez-Martinez, J.A., et al.: Biochem. Biophys. Res. Commun., 59, 1226 (1974), Sennello, L.T., et al.: J. Pharm. Sci., et al.: 75, 158 (1986), Wheeler, J.M., et al.: Am.J. Obstet. Gynecol., 167, 1367 (1992), Eri, L.M., et al.: J. Urol., 150, 359 (1993),

N-Acetyl-L-glutamine p-nitroanilide is a fluorogenic substrate that can be used in the diagnosis of bacterial infections. It is a ligand that can bind to enzymes involved in the production of bioluminescence, such as luciferase, and can be used for the detection of bacteria. It is also used for food testing, environmental testing, and diagnostics. N-Acetyl-L-glutamine p-nitroanilide has high purity and high quality, which makes it suitable for conjugation with other molecules.

5-Bromo-6-chloro-3-indolyl b-D-cellobiopyranoside is a fluorogenic substrate for the enzyme β-glucuronidase. It is used in diagnostic applications such as food testing, bacterial culture media and environmental testing. The product has CAS number: 123591-77-0.

Chromogenic substrate targeting amylase

Aldol® 515 palmitate is a high quality, non-toxic and water soluble chromogenic substrate for enzymes. It is used to detect the presence of lipase activity due to yielding a red color.

2-Chloro-4-nitrophenyl a-D-fucopyranoside (CNPF) is a chromogenic enzyme substrate used primarily to detect fucosidase activity. CNPF is cleaved by the enzyme, which results in the release of a colored product that can be measured spectrophotometrically. Fucosidases are important enzymes that catalyze the hydrolysis of fucose-containing oligosaccharides, and CNPF is a commonly used substrate for the detection and quantification of these enzymes in various research studies.

4-Bromo-2-nitrophenyl b-D-galactopyranoside is a chemiluminescent substrate that reacts with an excess of luciferase to produce light. It is used as a reagent in the detection of ATP, NADH, and other compounds in biochemistry and biology. 4-Bromo-2-nitrophenyl b-D-galactopyranoside is also used in diagnostic kits for detecting bacterial or fungal contamination in food.

Aldol® 470 N-tosyl-L-alanine ester is a fluorogenic substrate that is used in enzyme and chromogenic assays. It is a high purity, high quality, and highly soluble substrate for chemiluminescent reactions. Aldol® 470 N-tosyl-L-alanine ester can be used to detect the presence of bacteria in culture media and as an indicator of bacterial growth. It is also used to test for the presence of different types of enzymes that catalyze the oxidation of alcohols.

5-Bromo-6-chloro-1H-indol-3-yl-a-D-mannopyranoside is a chromogenic substrate that yields a magenta-colored product after cleavage. The chromophore 5-bromo-6-chloro-indoxyl is released, generating the observable color. It is used in lysosomal storage disorder screening.

5-Bromo-4-chloro-3-indoxyl sulfate p-toluidine salt is a staining agent used for the detection of glucose in urine and tissues. It is also an enzyme substrate that can be used to detect the presence of lipases, amylases, esterases, phosphatases, and proteases. This product has a CAS number of 6581-23-3 and comes in high quality.

4-Nitrophenyl 2,3,4,6-tetra-O-acetyl-a-D-glucopyranoside is a useful substrate for enzymatic assays. This high-sensitivity chromogenic pNP substrate offers enhanced selectivity and increased detection ability, allowing for a broad range of applications in the field of glycosidase research. Featuring rapid colorimetric readouts with easily detectable endpoint determination, this substrate delivers clear and accurate results every time.

2-Bromo-4-nitrophenyl b-D-galactopyranoside is a chemiluminescent substrate that is used for the detection of β-galactosidase activity in the biochemical reaction. It has been shown to be an excellent ligand for metal ions and can be used as a reagent in the determination of metal ions in biological systems. This product is manufactured with high purity and quality, which ensures its suitability for use in culture media, environmental testing, and diagnostics. 2-Bromo-4-nitrophenyl b-D-galactopyranoside has been tested as a fluorogenic substrate for β-galactosidase. It has also been used as a chromogenic substrate for β-galactosidase and an enzyme substrate for β-galactosidase. This product can be conjugated with other molecules such as biotin to enable rapid analysis of proteins or