Altri

<p>Crimson-Gal (Crimson-beta-D-galactopyranoside) is a chromogenic indicator for beta-galactosidase activity. The colorless product is cleaved by lactose-utilizing bacteria in liquid media or on agar plates and yields a crimson colored precipitate. Crimson-Gal can also be used as detecting agent for beta-galactosidase activity in reporter gene assays or for identification of positive transformants on agar plates when using the α-complementation approach. Read more in the Application Notes.</p>

<p>Chromogenic substrate targeting lipase, C8 esterase</p>

<p>4-Nitrophenyl 5-O-trans-feruloyl-alpha-L-arabinofuranoside is a chromogenic substrate for alpha-L-arabinofuranosidase. Upon hydrolysis, para-nitrophenol is released yielding a yellowish colour. 4-Nitrophenyl 5-O-trans-feruloyl-alpha-L-arabinofuranoside is used in different applications such as the Plant cell wall degradation assays, bacterial enzyme profiling</p>

<p>Applications Fulvestrant (F862500) impurity C.<br></p>

<p>Stability Hygroscopic<br>Applications α-Epoxyabiraterone Acetate is an impurity of Abiraterone (A108490), a steroidal cytochrome P 450 17α-hydroxylase-17,20-lyase inhibitor (CYP17), is currently undergoing phase II clinical trials as a potential drug for the treatment of androgen-dependent prostate cancer.<br>References Denis, L., et al.: Cancer, 72, 3888 (1993); Potter, G.A., et al.: J. Med. Chem., 38, 2463 (1995); Denmeade, S., et al.: Nat. Rev., 2, 389(2002); Scher, H., et al.: J. Clin. Oncol., 23, 8253 (2005)<br></p>

<p>Applications Zafirlukast m-Tolyl Isomer is a positional isomer and impurity of the cysteinyl leukotriene type 1 receptor antagonist, Zafirlukast (D226955).<br>References Krishnaiah, C. et al.: Anal. Chem. Ind. J., 8, 471 (2009); Madhavi, A. et al.: Chromatographia, 70, 233 (2009); Goverdhan, G. et al.: J. Pharmac. Biomed. Anal., 49, 895 (2009);<br></p>

<p>Applications It has been used to promote wound healing. Biological stain. Dyes and metabolites, Environmental Testing.<br>References Findlay, J., et al.: J. Pharm. Biomed., Anal., 21, 1249 (2000), Han, D., et al.: J. Agric. Food Chem., 55, 6424 (2007), Jiang, Z;., et al.: J. Environ. Anal. Chem., 88, 649 (2008),<br></p>

<p>Applications 1,3-Propanediol is a common organic reagent used in the synthesis of polymers and used in industrial organic chemistry for the synthesis of lubricants, foods, medicines and cosmetics.<br>References Sun, Y. et al.: Bioproc. Renew. Res. Commod. Bioprod., 289 (2014);<br></p>

<p>Applications N-Nitroso-1-(2-methoxyphenyl)piperazine is a reagent used in the preparation of 9-aminoacridine-based agents that impair bovine viral diarrhea virus replication.<br>References Loddo, R. et al.: Bio. &amp; Med. Chem., 26(4), 855-868, (2018)<br></p>

<p>Applications 2-((3-Fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methylpropanoic acid (cas# 1289942-66-0) is a useful research chemical.<br></p>

<p>Applications (2E)-2-Cyano-3-(3-ethoxy-4-hydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide is an impurity of Entacapone (E558500), a peripherally acting inhibitor of catechol-O-methyl transferase (COMT), an enzyme involved in the metabolism of catecholamine neurotransmitters and related drugs. Antiparkinsonian.<br>References Karlsson, M., et al.: J. Pharm. Biomed. Anal., 10, 593 (1992), Nissinen, E., et al.: Arch. Pharmacol., 346, 262 (1992), Wikberg, T., et al.: Eur. J. Drug Metab. Pharmacokinet., 18, 359 (1993),<br></p>

<p>Applications Zafirlukast p-Tolyl Isomer is a positional isomer and impurity of the cysteinyl leukotriene type 1 receptor antagonist, Zafirlukast (D226955).<br>References Krishnaiah, C. et al.: Anal. Chem. Ind. J., 8, 471 (2009); Madhavi, A. et al.: Chromatographia, 70, 233 (2009); Goverdhan, G. et al.: J. Pharmac. Biomed. Anal., 49, 895 (2009);<br></p>

<p>Stability Moisture Sensitive<br>Applications 4-​Amino-​2-​fluoro-​N-​methylbenzamide acts as a reagent in the design, synthesis and biological evaluation of novel 5-oxo-2-thioxoimidazolidine derivatives as potent androgen receptor antagonists. Also, in the preparation and structure-activity relationship of chiral benzyloxypyridinone derivatives as c-Met kinase inhibitors<br>References Ivachtchenko, A. V., et al.: Eur. J. Med. Chem., 99, 51 (2015); Zhang, D., et al.: Bioorg. Med. Chem. Lett., 23, 2408 (2013)<br></p>

<p>Stability Hygroscopic<br>Applications A novel active metabolite of the anti-cancer drug Tamoxifen (T006000).<br>References Furr, B., et al.: Pharmacol. Ther., 25, 127 (1984), Leonessa, F., et al.: Cancer Res., 54, 441 (1994), Stearns, V., et al.: Lancet, 360, 1851 (2002), Rae, J., et al.: Pharmacogenetics, 13, 501 (2003), Zheng, Y., et al.: Drug Metab. Dispos., 35, 1942 (2007),<br></p>

<p>Applications Labelled analogue of cis-Entacapone, the (Z)-Isomer of Entacapone (E558500) polymorphic form B. Antiparkinsonian.<br>References Karlsson, M., et al.: J. Pharm. Biomed. Anal., 10, 593 (1992), Nissinen, E., et al.: Arch. Pharmacol., 346, 262 (1992), Wikberg, T., et al.: Eur. J. Drug Metab. Pharmacokinet., 18, 359 (1993),<br></p>

<p>Applications Fulvestrant 17-Ketone, is an impurity of Fulvestrant (F862500), a novel steroidal estrogen antagonist reported to lack any partial agonist activity. Antineoplastic (hormonal).<br>References Wakeling, A.E., et al.: Cancer Res., 51, 3867 (1991), Howell, A., et al.: Br. J. Cancer, 74, 300 (1996), Robertson, J.F., et al.: Cancer Res., 61, 6739 (2001),<br></p>