Chetoni e Derivati
I chetoni sono composti organici che contengono un gruppo carbonilico (C=O) legato a due atomi di carbonio, formando una struttura in cui il gruppo carbonilico è affiancato da gruppi alchilici o arilici. In farmacologia, i chetoni sono utilizzati nella formulazione di API grazie alla loro capacità di migliorare la solubilità e la stabilità dei principi attivi. Alcuni chetoni possiedono proprietà antinfiammatorie, analgesiche e antimicrobiche. I derivati dei chetoni includono composti in cui il gruppo carbonilico è modificato, come gli enoli, che trovano applicazione nella sintesi di farmaci e come intermedi chimici nella produzione di altri composti bioattivi. I derivati dei chetoni sono impiegati nella progettazione di nuovi farmaci, inclusi quelli per il trattamento di malattie neurodegenerative, disturbi metabolici e alcuni tipi di cancro, grazie ai loro effetti specifici sugli enzimi e sui processi cellulari.
Trovati 2393 prodotti di "Chetoni e Derivati"
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3-Methoxy Acetaminophen-d3
CAS:Prodotto controllato<p>Applications 3-Methoxy Acetaminophen-d3 is deuterium labeled 3-Methoxy Acetaminophen (M226050). 3-Methoxy Acetaminophen is a metabolite of Acetaminophen (A161220), an analgesic and antipyretic agent used as a pain reliever to treat headache, muscle aches, and arthritis (1,2,3).<br>References (1) McGill, M. R. and Jaeschke, H. Pharm Res. 30, 2174 (2013)(2) Fairbrother, J.E., et al.: Anal. Profiles Drug Subs., 3, 1 (1974) (3) Hinson, J.A., et al.: Rev. Biochem. Toxicol., 2, 103 (1980)<br></p>Formula:C92H3H8NO3Colore e forma:NeatPeso molecolare:184.207(-)-N-Desmethyl Tramadol
CAS:Prodotto controllato<p>Applications An optically active metabolite of Tramadol.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lintz, V.W., et al.: Arzneim.-Forsch./Drug Res., 31, II, 11, 1932 (1981)<br></p>Formula:C15H23NO2Colore e forma:NeatPeso molecolare:249.35rac-2’,4’-Dimethyl Ketoprofen
CAS:Prodotto controllato<p>Applications rac-2’,4’-Dimethyl Ketoprofen is an impurity of Ketoprofen (K200800), an anti-inflammatory and analgesic agent.<br>References Ueno, K., et al.: J. Med. Chem., 19, 941 (1976); Liversidge, G.G., Anal. Profiles Drug Subs., 10, 443 (1981); Jamali, F., et al.: Clin. Pharmacokinet., 19, 197 (1990)<br></p>Formula:C18H18O3Colore e forma:NeatPeso molecolare:282.335-(6-Methoxy-2-naphthalenyl)-3-methyl-2-cyclohexen-1-one
CAS:Prodotto controllatoFormula:C18H18O2Colore e forma:NeatPeso molecolare:266.334'-Isobutyl-2,2-dibromopropiophenone
CAS:Prodotto controllato<p>Applications Intermediate in the synthesis of Ibuprofen.<br></p>Formula:C13H16Br2OColore e forma:NeatPeso molecolare:348.07(±)-Carisoprodol-d7 (iso-propyl-d7)
CAS:Prodotto controllato<p>Applications (±)-Carisoprodol-d7 (iso-propyl-d7) (CAS# 1218911-01-3) is a useful isotopically labeled research compound. As a deuterated drug analog, this compound can be used for inter-patient variability.<br>References Gant, T., et.al., U.S. Pat. Appl. Publ., 28,(2010);<br></p>Formula:C12H17D7N2O4Colore e forma:NeatPeso molecolare:267.38L-Propoxyphene-d5 HCl (propionyl-d5)
CAS:Prodotto controllato<p>Applications L-Propoxyphene-d5 Hydrochloride is the isotope labelled analog and L-isomer of Propoxyphene Hydrochloride (P831500); a controlled substance (opiate) and analgesic (narcotic). The α-DL-and D-diastereoisomers possess marked analgesic activity in contrast to the β-diastereoisomers which are substantially inactive. Oral administration of L-Propoxyphene Hydrochloride enhances the analgesic activity of D-Propoxyphene Hydrochloride.<br>References Goldenthal, E.I., et al.: Toxicol. Appl. Pharmacol., 18, 185 (1971); McEwan, B., et al.: Anal. Profiles Drug Subs., 1, 301 (1972); Murphy, P.J., et al.: J. Pharmacol. Exp. Ther., 199, 415 (1976)<br></p>Formula:C22H25D5ClNO2Colore e forma:NeatPeso molecolare:380.96Methyl 5-Methoxy-2-methylindole-3-acetate
CAS:Prodotto controllato<p>Applications Intermediate in the preparation of Indomethacin<br>References Kalgutkar, A.S., et al.: Bioorg. Med. Chem., 13, 6810 (2005),<br></p>Formula:C13H15NO3Colore e forma:NeatPeso molecolare:233.26Nabumetone-d3
CAS:Prodotto controllato<p>Applications Labelled Nabumetone. Anti-inflammatory. Antibacterial.<br>References Kumpulainen, H., et al.: J. Med. Chem., 49, 1207 (2006),<br></p>Formula:C152H3H13O2Colore e forma:NeatPeso molecolare:231.30(+)-N,O-Didesmethyl Tramadol
CAS:Prodotto controllato<p>Applications An optically active metabolite of Tramadol.<br>References Garrido, M., et al.: J. Pharmacol. Exp. Ther., 305, 710 (2003), Pedersen, R., et al.: Eur. J. Clin. Pharmacol., 62, 513 (2006),<br></p>Formula:C14H21NO2Colore e forma:NeatPeso molecolare:235.324-Morpholineethanol-d4
CAS:Prodotto controllato<p>Applications Labelled analogue 4-(2-Hydroxyethyl)morpholine, a morphiline derivative used in the preparation of ester prodrugs of naproxen. 4-(2-Hydroxyethyl)morpholine was also shown to induce repair in rat hepatocyte primary culture/DNA.<br></p>Formula:C6H9D4NO2Colore e forma:NeatPeso molecolare:135.203,4-Methylenedioxy Propiophenone
CAS:Prodotto controllato<p>Applications Intermediate in the production of Isosafrole and Ethylone.<br>References Katoch-Rouse, R., et al.: J. Med. Chem., 46, 642 (2003), Andrade, E., et al.: Chem. Biodivers., 5, 197 (2008),<br></p>Formula:C10H10O3Colore e forma:NeatPeso molecolare:178.18Nabumetone Dimer Impurity
CAS:Prodotto controllato<p>Impurity Nabumetone Dimer Impurity<br>Applications An impurity in a Nabumetone (N200500) drug substance.<br>References Friedel, H., et al.: Drugs, 35, 504 (1988), Davies, N., et al.: Clin. Pharmacokinet., 33, 403 (1997),<br></p>Formula:C27H26O3Colore e forma:NeatPeso molecolare:398.49Trimebutine-d9 Maleate Salt
CAS:Prodotto controllato<p>Applications Trimebutine-d9 Maleate Salt, is the labeled analogue of Trimebutine Maleate Salt (T795605), acting as an opioid receptor agonist. Antispasmodic.<br>References Delvaux, M., et al.: J. Int. Med. Res., 25, 225 (1997), Lavit, M., et al.: Arzneim.-Forsch., 50, 640 (2000),<br></p>Formula:C22H20D9NO5·C4H4O4Colore e forma:NeatPeso molecolare:512.6Ketoprofen-13CD3 Methyl Ester
CAS:Prodotto controllato<p>Applications An intermediate for the synthesis of Labelled Ketoprofen.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Derewenda, Z., et al.: J. Mol. Biol., 227, 818 (1992), Grochulski, P., et al.: J. Biol. Chem., 268, 12843 (1993).<br></p>Formula:C1613CH13D3O3Colore e forma:NeatPeso molecolare:272.32N-Desethyl 3-Bromo Lidocaine
CAS:Prodotto controllato<p>Applications Intermediate in the preparation of hydroxylated Lidocaine metabolites.<br></p>Formula:C12H17BrN2OColore e forma:NeatPeso molecolare:285.18(S)-(+)-Ibuprofen Propylene Glycol Ester
CAS:Prodotto controllatoFormula:C16H24O3Colore e forma:NeatPeso molecolare:264.3616,17-Dehydro Capsaicin
CAS:Prodotto controllato<p>Stability Light Sensitive<br>Applications A dehydrogenated metabolite of Capsaicin (C175680).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Glinsukon, T., et al.: Toxicon, 18, 215 (1980), Obach, R., et al.: Drug Metab. Dispos., 29, 1599 (2001), Reilly, C., et al.: Toxicol. Sci., 73, 170 (2003),<br></p>Formula:C18H25NO3Colore e forma:Off-White To BrownPeso molecolare:303.4N-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-N-methylnitrous amide
CAS:Prodotto controllatoFormula:C12H14N4O2Colore e forma:NeatPeso molecolare:246.273-(Cyanomethyl)benzoic Acid
CAS:Prodotto controllato<p>Impurity Ketoprofen EP Impurity H<br>Applications 3-(Cyanomethyl)benzoic Acid (Ketoprofen EP Impurity H) is a reagent used in the synthesis of various pharmaceutically important compounds, such as its use in the synthesis of neprilysin inhibitors.<br>References Solomon, S.D., et al.: Lancet., 380 1387 (2012); Dadd, M.R., et al.: Enzyme. Microb. Tehcnol., 29, 20 (2001);<br></p>Formula:C9H7NO2Colore e forma:NeatPeso molecolare:161.16
