Derivati delle Purine e Pirimidine
Le purine hanno una struttura biciclica, composta da un anello a sei membri fuso con un anello a cinque membri, entrambi contenenti atomi di azoto in posizioni chiave. I derivati delle purine, come l’adenina e la guanina, sono essenziali per la formazione del DNA e dell’RNA. Questi composti trovano applicazione terapeutica nei trattamenti contro il cancro e le malattie virali, inibendo la replicazione cellulare. Le pirimidine, invece, hanno una struttura monociclica a sei membri con due atomi di azoto. I loro derivati, come la citosina, la timina e l’uracile, sono anch’essi componenti fondamentali del DNA e dell’RNA e vengono utilizzati in chemioterapia e nei trattamenti antivirali.
Presso CymitQuimica, offriamo derivati delle purine e pirimidine per la ricerca in biologia molecolare, genomica e sviluppo di terapie innovative.
Trovati 8898 prodotti di "Derivati delle Purine e Pirimidine"
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5-Carboxy-2'-deoxyuridine
CAS:Prodotto controllato<p>Applications 5-Carboxy-2'-deoxyuridine, is a derivative of Trifluridine, an anti-herpesvirus antiviral drug, used primarily on the eye.<br>References Kuster, P., et al.: CLAO J. 24(2), 122 (1998); O’Brien, W., Invest. Opthalmol. Vis. Sci., 32 (9), 2455 (1991);<br></p>Formula:C10H12N2O7Colore e forma:NeatPeso molecolare:272.21nPOC-POC Tenofovir Fumarate(Mixture of Diastereomers)
CAS:Prodotto controllato<p>Stability Hygroscopic<br>Applications Tenofovir (T018500) impurity.<br></p>Formula:C19H30N5O10P·C4H4O4Colore e forma:White To Off-WhitePeso molecolare:635.511-(3-(2-(Dimethylamino)ethyl)-1-((5-((N-methylsulfamoyl)methyl)-1H-indol-3-yl)methyl)-1H-indol-5-yl)-N-methylmethanesulfonamide Formate Salt
CAS:Prodotto controllatoFormula:C25H33N5O4S2·CH2O2Colore e forma:NeatPeso molecolare:531.694603Hydroxy Urea-15N
CAS:Prodotto controllato<p>Applications Labelled Hydroxyurea. An anti-neoplastic - inhibits ribonucleoside reductase and DNA replication. A potential therapy for sickle cell anemia which involves the nitrosylation of sickle cell hemoglobin. Horseradish peroxidase catalyzes nitric oxide formation from hydroxyurea in the presence of hydrogen peroxide.<br>References Ratcliffe, W., et al.: Lancet, 339, 164 (1992), Roodman, G., et al.: Cancer, 80, 1557 (1997), Horwitz, M., et al.: J. Clin. Endocrinol. Metab., 2003, 88, 1603 (2003),<br></p>Formula:CH415NNO2Colore e forma:NeatPeso molecolare:77.05Lestaurtinib
CAS:Prodotto controllato<p>Stability Photosensitive<br>Applications It is used for the treatment of pancreatic cancer and acute myelogenous leukaemia (AML).<br></p>Formula:C26H21N3O4Colore e forma:NeatPeso molecolare:439.462-Chloro-6-amino-9-(2’,3’,5’-tri-O-acetyl-β-D-ribofuranosyl)purine
CAS:Prodotto controllato<p>Applications 2-Chloro-6-amino-9-(2’,3’,5’-tri-O-acetyl-β-D-ribofuranosyl)purine (cas# 79999-39-6) is a compound useful in organic synthesis.<br></p>Formula:C16H18ClN5O7Colore e forma:NeatPeso molecolare:427.80Methotrexate Tetraglutamate Trifluoroacetate
CAS:Prodotto controllato<p>Applications Methotrexate Tetraglutamate is a metabolite of Methotrexate (M260675); a folic acid antagonist, antineoplastic, and antirheumatic.<br>References Freeman, M.V., J. Pharmacol. Exp. Ther., 122, 154 (1958); Weinblass, M.E., et al.: N. Engl. J. Med., 312, 818 (1985)<br></p>Formula:C35H43N11O14xC2HF3O2Colore e forma:NeatPeso molecolare:841.78(N,N-Dimethyl-1-butanamine) Zolmitriptan Dimer
CAS:Prodotto controllato<p>Impurity Zolmitriptan USP Related Compound F<br>Stability Hygroscopic<br>Applications (N,N-Dimethyl-1-butanamine) Zolmitriptan Dimer (Zolmitriptan USP Related Compound F) is an impurity from the synthesis of Zolmitriptan (Z639000). Zolmitriptan is a Serotonin 5HTID-receptor agonist.<br>References Glen, R.C., et al.: J. Med. Chem., 38, 3566 (1995), Seaber, E., et al.: Brit. J. Clin. Pharmacol., 41, 141 (1996), Tepper, S.J., et al.: Curr. Med. Res. Opin., 15, 254 (1999)<br></p>Formula:C38H53N7O4Purezza:>90%Colore e forma:NeatPeso molecolare:671.87Sumatriptan Hydroxy-Oxindole Impurity (Sumatriptan Impurity 1)
CAS:Prodotto controllato<p>Applications Sumatriptan Impurity 1, is an impurity of Sumatriptan (S810000), which is a serotonin 5HT1-receptor agonist, used for the treatment of migraine headaches.<br>References Humphrey, P.P.A., et al.: Brit. J. Pharmacol., 94, 1123 (1988), Doenicke, A., et al.: Lancet 1, 1309 (1988),<br></p>Formula:C14H21N3O4SColore e forma:NeatPeso molecolare:327.4Chloroformic Acid Chloromethyl Ester
CAS:Prodotto controllato<p>Stability Very Very Moisture sensitive<br>Applications Chloroformic Acid Chloromethyl Ester is used as a reagent in the synthesis of carbamates and carbonates.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Safadi, M. et al.: Pharm. Res. 10, 1350 (1993); Loren, J.C. et al.: Synlett, 18, 2847 (2005);<br></p>Formula:C2H2Cl2O2Colore e forma:Colourless OilyPeso molecolare:128.942-Oxo Clopidogrel-13C,d3 Hydrochloride(Mixture of Diastereomers)
CAS:Prodotto controllatoFormula:C1513CH14D3Cl2NO3SColore e forma:NeatPeso molecolare:378.29Almotriptan-d6 Hydrochloride
CAS:Prodotto controllato<p>Applications: Labelled Almotriptan (A575200). Almotriptan is a serotonin 5HT1B /1D-receptor agonist used for treatment of migraine.<br>References Fleishaker, J.C., et al.: Clin. Pharmacol. Ther., 67, 498 (2000), Kamali, F., et al.: Curr. Opin. Cent. Peripher. Nerv. Syst. Invest. Drugs, 2, 197 (2000), Dodick, D.W., et al.: Expert Opin.Pharmacother., 4, 1157 (2003)<br></p>Formula:C172H6H19N3O2S·ClHColore e forma:NeatPeso molecolare:377.962,4-Diamino-6-(hydroxymethyl)pteridine Hydrochloride
CAS:Prodotto controllato<p>Stability Hygroscopic<br>Applications Methotrexate intermediate.<br>References Feng, Y., et al.: J. Med. Chem., 49, 770 (2006),<br></p>Formula:C7H8N6O·ClHColore e forma:YellowPeso molecolare:228.64D-Alanine Isopropyl Ester Hydrochloride
CAS:Prodotto controllato<p>Applications D-Alanine Isopropyl Ester Hydrochloride is a chiral reagent used in the synthesis of nucleotide prodrugs such as (PSI-7977) for the treatment of hepatitis C. Also used in the preparation of synthetic sweeteners.<br>References Sofia, M. et al.: J. Med. Chem., 53, 7202 (2010); Mazur, R. et al.: J. Med. Chem., 16, 1284 (1973);<br></p>Formula:C6H14ClNO2Purezza:~90%Colore e forma:NeatPeso molecolare:167.634-[2-(4-Chlorobutylidene)hydrazinyl]-N-methylbenzenemethanesulfonamide
CAS:Prodotto controllato<p>Stability Hygroscopic, Temperature Sensitive<br>Applications 4-[2-(4-Chlorobutylidene)hydrazinyl]-N-methylbenzenemethanesulfonamide is an intermediate in the synthesis of 3-(2-Aminoethyl)-N-methyl-1H-indole-5-methanesulfonamide (Didesmethyl Sumatriptan) (Sumatriptan EP Impurity E) (A609165), which is an antimigraine agent. A Sumatriptan intermediate.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>Formula:C12H18ClN3O2SColore e forma:NeatPeso molecolare:303.81(R)-Methotrexate-d3 (Technincal Grade)
CAS:Prodotto controllatoFormula:C20H19D3N8O5Colore e forma:NeatPeso molecolare:457.46Diethyl p-Toluenesulfonyloxymethylphosphonate
CAS:Prodotto controllato<p>Applications Diethyl p-Toluenesulfonyloxymethylphosphonate is an antiviral agent and a Tenofovir (T018500) intermediate. Tenofovir is an acyclic phosphonate nucleotide analogue and reverse transcriptase inhibitor used as an anti-HIV agent.<br>References Shaw, J.-P., et al.: Pharm. Res., 14, 1824 (1997), Wyles, D., et al.: Clin Infect. Dis., 40, 174 (2005), Peng, J., et al.: J. Clin. Pharmacol., 46, 265 (2006), Seminari, E., et al.: J. Antimicrob. Chemother., 60, 831 (2007),<br></p>Formula:C12H19O6PSColore e forma:NeatPeso molecolare:322.31Methotrexate Hexaglutamate Trifluoroacetate
CAS:<p>Stability Hygroscopic<br>Applications Methotrexate Hexaglutamate is a metabolite of Methotrexate (M260675); a folic acid antagonist, antineoplastic, and antirheumatic.<br>References Freeman, M.V., J. Pharmacol. Exp. Ther., 122, 154 (1958); Weinblass, M.E., et al.: N. Engl. J. Med., 312, 818 (1985)<br></p>Formula:C45H57N13O20·x(C2HF3O2)Colore e forma:Yellow SolidPeso molecolare:1214.03Pemetrexed Disodium Heptahydrate
CAS:Prodotto controllato<p>Applications Pemetrexed Disodium Heptahydrate is an chemotherapy drug for the treatment of pleural mesothelioma and non-small cell lung cancer. Pemetrexed Disodium Heptahydrate exhibit inhibitory activities towards thymidylate synthase as well as other folate dependent enzymes.<br>References Vogelzang, N.J., et al.: J. Clin. Oncol., 21,2636 (2003); Paz-Ares, L., et al.: Lancet. Oncol., 13, 247 (2012);<br></p>Formula:C20H19N5O6·2Na·7H2OColore e forma:NeatPeso molecolare:597.486-Oxo-(S,S)-Palonosetron (~90%)
CAS:Prodotto controllato<p>Applications 6-Oxo-(S,S)-Palonosetron is an impurity of (S,S)-Palonosetron (P165800), a serotonin 5-HT3 receptor antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). Antiemetic.<br>References Clark, R.D., et al.: J. Med. Chem., 36, 2645 (1993), Wong, E.H.F., et al.: Br. J. Pharmacol., 114, 851 (1995), Grunberg, S.M., et al.: Expert. Opin. Pharmacother., 4, 2297 (2003), Eisenberg, P., et al.: Ann. Oncol., 15, 330 (2004), Siddiqui, M.A.A., et al.: Drugs, 64, 1125 (2004),<br></p>Formula:C19H22N2O2Purezza:~90%Colore e forma:NeatPeso molecolare:310.39
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