Nucleosidi e Nucleotidi
I nucleosidi sono composti formati da una base azotata legata a uno zucchero (ribosio o desossiribosio). Quando un gruppo fosfato viene aggiunto al nucleoside, si forma un nucleotide. Questi composti sono fondamentali nella biologia cellulare, poiché i nucleotidi sono i mattoni essenziali del DNA e dell’RNA, responsabili dell’archiviazione e della trasmissione delle informazioni genetiche. I nucleosidi trovano applicazione nel trattamento delle malattie virali, agendo come inibitori della replicazione virale. I nucleotidi, oltre al loro ruolo strutturale negli acidi nucleici, sono coinvolti nei processi energetici, come la sintesi dell’ATP.
Presso CymitQuimica, offriamo un’ampia gamma di nucleosidi e nucleotidi essenziali per la ricerca in biologia molecolare, virologia e farmacologia.
Trovati 3433 prodotti di "Nucleosidi e Nucleotidi"
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Diethylamine
CAS:Prodotto controllato<p>Applications Diethylamine, can be used for the preparation of alkali metal diethylamides, generated with n-BuLi or NaH, have been used for the cleavage of ethers. Also, in combination with Lithium aluminum hydride, generates lithium tris(diethylamino)aluminum hydride, which is a useful selective reducing agent.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Cha, J.S., et al.: J. Org. Chem., 52, 5030 (1987); Tetrahedron Lett., 32, 6903 (1991);<br></p>Formula:C4H11NColore e forma:ColourlessPeso molecolare:73.14Stavudine Triphosphate Triethylammonium Salt
CAS:Prodotto controllato<p>Stability Hygroscopic<br>Applications Stavudine Triphosphate Trisodium Salt has a free acid of Stavudine Triphosphate. Stavudine Triphosphate inhibits HIV-1 RT (reverse transcriptase). Stavudine Triphosphate Trisodium Salt is a metabolite of Stavudine.<br>References Vaccaro, J.A., Parnell K.M., Terezakis S.A., Anderson, K.S.: Antimicrob. Agents Ch., 44, 217 (2000)<br></p>Formula:C10H15N2O13P3•x(EtN)Colore e forma:NeatPeso molecolare:464.15(2R,5S)-L-Menthol-5-(acetyloxy)-1,3-oxathiolane-2-carboxylate
CAS:Prodotto controllato<p>Applications Lamivudine intermediate.<br>References Chang, C., et al.: J. Biol. Chem., 267, 13938 (1992), Jeong, L., et al.: J. Med. Chem., 36, 181 (1993).<br></p>Formula:C16H26O5SColore e forma:WhitePeso molecolare:330.44Bucladesine
CAS:Bucladesine mimics cAMP, permeates cells, and inhibits phosphodiesterase; used in research.Formula:C18H24N5O8PColore e forma:SolidPeso molecolare:469.392,3'-Anhydrothymidine
CAS:2,3'-Anhydrothymidine is a piperidine-containing nucleoside analog that inhibits the replication of HIV and other viruses. It is structurally related to acyclovir, but has an increased resistance to viral inactivation by acyclovir-resistant strains. 2,3'-Anhydrothymidine binds to the ribose sugar of the viral nucleic acid and prevents the formation of a covalent bond between the 5' hydroxyl group of ribose and the 3' phosphate group. It also inhibits protein synthesis by interfering with the incorporation of amino acids into proteins. 2,3'-Anhydrothymidine has been shown to be effective against human immunodeficiency virus type 1 (HIV-1) in animal models and clinical studies.Formula:C10H12N2O4Purezza:Min. 95%Colore e forma:White PowderPeso molecolare:224.21 g/molDiquafosol Free Base
CAS:Diquafosol Free Base is a purinoceptor P2Y(2) receptor agonist.Formula:C18H26N4O23P4Colore e forma:SolidPeso molecolare:790.316-Chloro Desacetyl Famciclovir
Prodotto controllato<p>Impurity Penciclovir Impurity F<br>Applications 6-Chloro Desacetyl Famciclovir is a prodrug of Penciclovir (P221500); an antiviral.<br>References Weinberg, A., et al.: Antimicrob. Ag. Chemother., 36, 2037 (1992); McMeekin, J.R., et al.: Anal. Proc., 29, 178 (1992)<br></p>Formula:C12H16ClN5O3Colore e forma:NeatPeso molecolare:313.742-Methoxy 2’-Deoxyadenosine
CAS:Prodotto controllato<p>Applications A 2-substituted 2’-Deoxyadenosine (D231620). Used in the synthesis of oligonucleotides.<br>References Ishikawa, F., et al.: J. Mol. Biol., 70, 475 (1972), Hattori, M., et al.: Biochemistry, 13, 2754 (1974), Kazimierczuk, Z., et al.: J. Med. Chem., 33, 1683 (1990),<br></p>Formula:C11H15N5O4Colore e forma:NeatPeso molecolare:281.27Penciclovir Monoacetate
CAS:Prodotto controllatoFormula:C12H17N5O4Colore e forma:NeatPeso molecolare:295.29Ganciclovir Mono-O-propionate
CAS:<p>Impurity Valganociclovir EP Impurity J<br>Applications Ganciclovir Mono-O-propionate is a potential prodrug of Ganciclovir (G235000). Ganciclovir Mono-O-propionate was also found to exhibit anti-viral activity through experimental studies.<br>References Dias, C.S., et al.: J. Pharma. Sci., 91, 660 (2002);<br></p>Formula:C12H17N5O5Colore e forma:NeatPeso molecolare:311.29Acyclovir Impurity O (N-Hydroxymethyl Acyclovir), Technical Grade
CAS:Formula:C9H13N5O4Colore e forma:Off-WhitePeso molecolare:255.231Sofosbuvir (R)-Phosphate
CAS:<p>Applications Sofosbuvir (R)-Phosphate is an impurity of PSI-7977 (P839640), a prodrug that is metabolized to the active antiviral agent 2'-deoxy-2'-α-fluoro-β-C-methyluridine-5'-monophosphate and is currently being investigated in phase 3 clinical trials for the treatment of hepatitis C. Studies have profiled PSI-7977 as a nucleotide inhibitor of hepatitis C virus, exerting selective inhibitory effects towards HCV NS5B polymerase.<br>References Lam, A.M.,et al.: Antimicrob. Agents. Chemotherapy., 56, 3359 (2012); Lam, A.M., et al.: J. Virol., 85, 12334 (2011); Sofia, M.J., et al.: J. Medn. Chem., 53, 7202 (2010)<br></p>Formula:C22H29FN3O9PColore e forma:NeatPeso molecolare:529.455-Azacytidine 5'-Monophosphate 60%
CAS:Prodotto controllato<p>Stability Hygroscopic<br>Applications A metabolite of 5-Azacytidine. This compound contains sodium chloride and water.<br>References Lee, T., et al.: Cancer Res., 34, 2482 ( (1974), Drake, J.C., et al.: Biochem. Pharmacol., 29, 807 (1980),<br></p>Formula:C8H13N4O8PPurezza:60%Colore e forma:NeatPeso molecolare:324.18Penciclovir Diacetate
CAS:Prodotto controllatoFormula:C14H19N5O5Colore e forma:NeatPeso molecolare:337.33Acyclovir N-Methylene Dimer
CAS:Prodotto controllatoFormula:C17H22N10O6Purezza:>90%Colore e forma:NeatPeso molecolare:462.42Emtricitabine Menthyl Ester
CAS:Prodotto controllato<p>Impurity Emtricitabine Impurity 14<br>Applications An intermediate in the synthesis of Emtricitabine (E525000). A reverse transcriptase inhibitor. It is an effective antiviral agent against HIV, HBV, and other viruses replicating in a similar manner. A nucleoside analog structurally related to Lamivudine (L172500). Emtricitabine Impurity 14.<br>References Schinazi, R.F., et al.: Antimicrob. Ag. Chemother., 36, 2423 (1992), Shockeor, J.P., et al.: Xenobioica, 26, 189 (1996), Feng, J.Y., et al.: FASEB J., 13, 1511 (1999), Molina, J.-M., et al.: J. Infec. Dis., 182, 599 (2000)<br></p>Formula:C18H26FN3O4SColore e forma:NeatPeso molecolare:399.48L-Glucono-1,5-lactone
CAS:Prodotto controllato<p>Applications L-Glucono-1,5-lactone is the lactone derivative of L-gluconic acid.<br>References Fuhrhop, J. H., et al.: J. Am. Chem. Soc., 113, 7437 (1991); Szarek, W.A., et al.: Canadian. J. Chem., 62, 671 (1984);<br></p>Formula:C6H10O6Colore e forma:NeatPeso molecolare:178.14N-Carboxybenzyl Gemcitabine
CAS:Prodotto controllato<p>Applications Gemcitabine (G305000) derivative.<br></p>Formula:C17H17F2N3O6Colore e forma:NeatPeso molecolare:397.33ent-Lamivudine
CAS:Prodotto controllato<p>Impurity Lamivudine EP Impurity D<br>Stability Hygroscopic<br>Applications ent-Lamivudine (Lamivudine EP Impurity D) is an enantiomer of Lamivudine (L172500); an antiviral that inhibits HIV-reverse transcriptase.<br>References Pepe, G. et al.: Eur. J. Med. Chem., 31, 775 (1996); Marr, E. et al.: Antiviral Res., 28, 1 (1995); Parikh, U.M. et al.: Antimicrob. Agents Chemother., 49, 1139 (2005);<br></p>Formula:C8H11N3O3SColore e forma:NeatPeso molecolare:229.26Emtricitabine N,N’-Methylene Dimer
Prodotto controllato<p>Applications Emtricitabine N,N’-Methylene Dimer is a derivative compound of Emtricitabine (E525000), a reverse transcriptase inhibitor. It is effective antiviral agent against HIV, and other viruses replicating in a similiar manner. A nucleoside analog structurally related to Lamivudine (L172500).<br>References FASEB J., 13, 1511 (1999), Molina, J.-M., et al.: J. InfecSchinazi, R.F., et al.: Antimicrob. Ag. Chemother., 36, 2423 (1992), Shockeor, J.P., et al.: Xenobioica, 26, 189 (1996), Feng, J.Y., et al.: . Dis., 182, 599 (2000)<br></p>Formula:C17H20F2N6O6S2Colore e forma:NeatPeso molecolare:506.5
