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Terpenoidi e Derivati

Terpenoidi e Derivati

I terpenoidi, noti anche come isoprenoidi, sono composti derivati dall’isoprene (C₅H₈) e presentano una struttura basata su unità ripetute di questo monomero. Sono responsabili delle proprietà aromatiche di molte piante e possiedono una vasta gamma di attività biologiche, tra cui effetti antibatterici, antinfiammatori e antiossidanti. I derivati dei terpenoidi comprendono composti come i carotenoidi e gli steroidi, che svolgono ruoli essenziali in processi biologici come la fotosintesi e la regolazione ormonale. Questi composti sono ampiamente utilizzati nell’industria farmaceutica, cosmetica e alimentare grazie ai loro benefici terapeutici e alle loro proprietà sensoriali. Presso CymitQuimica, offriamo terpenoidi e i loro derivati di alta purezza per applicazioni in farmacologia, cosmetica e biotecnologia.

Trovati 3845 prodotti di "Terpenoidi e Derivati"

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  • Methyl (1S)-(+)-10-Camphorsulfonate

    CAS:
    <p>Applications An Impurity from the synthesis of Frovatriptan Succinate (F768500).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Parsons, A.A., et al.: J. Cardiovasc. Pharmacol., 30, 136 (1997), Siow, C.H., et al.: Cephalalgia, 24, 1045 (2004), Poolsup, N., et al.: J. Clin. Pharm. Ther., 30, 521 (2005),<br></p>
    Formula:C11H18O4S
    Colore e forma:White To Off-White
    Peso molecolare:246.32

    Ref: TR-M294690

    1g
    297,00€
    10g
    1.907,00€
  • Docetaxel-d9

    Prodotto controllato
    CAS:
    <p>Applications A labelled semisynthetic derivative of Paclitaxel. An antimitotic agent that promotes the assembly of micro-tubules and inhibits their de-polymerization to free tubulin. An antineoplastic.<br>References Ringel, I., et al.: J. Natl. Cancer Inst., 83, 288 (1991), Extra, J.-M., et al.: Cancer Res., 53, 1037 (1993)<br></p>
    Formula:C43D9H44NO14
    Colore e forma:Neat
    Peso molecolare:816.93

    Ref: TR-D494422

    1mg
    544,00€
    10mg
    3.838,00€
  • all-trans-Retinal

    Prodotto controllato
    CAS:
    <p>Stability Hygroscopic<br>Applications Corotenoid component of the visual pigments. All-trans retinal is converted to retinoic acid in vivo by the action of retinal dehydrogenase.<br>References Ball, et al.: Biochem. J., 42, 516 (1948), O’Brien, D.F., et al.: Science, 218, 961 (1982),<br></p>
    Formula:C20H28O
    Colore e forma:Yellow To Dark Orange
    Peso molecolare:284.44

    Ref: TR-R240000

    1g
    436,00€
    5g
    1.318,00€
    100mg
    136,00€
  • Ginsenoside Rc

    Prodotto controllato
    CAS:
    <p>Stability Hygroscopic<br>Applications Ginsenoside Rc displays anti-proliferative effects in human breast cancer cell lines.<br>References Lee, Y. et al.: Arch. Pharm. Res., 26, 53 (2003);<br></p>
    Formula:C53H90O22
    Colore e forma:White To Light Yellow
    Peso molecolare:1079.27

    Ref: TR-G410210

    5mg
    137,00€
    10mg
    224,00€
    25mg
    504,00€
  • 7-Epi Docetaxel

    Prodotto controllato
    CAS:
    <p>Impurity Docetaxel EP Impurity C<br>Applications 7-Epi Docetaxel (Docetaxel EP Impurity C) is an isomer of Docetaxel (D494420). Docetaxel injection impurity C.<br>References Hanna, I., et al.: Cancer Res., 60, 3440 (2000), Bournique, B., et al.: Br. J. Clin. Pharmacol., 52, 53 (2001), McFadyen, M., et al.: Biochem. Pharmacol., 62, 207 (2001), Vasu Dev, R., et al.: J. Pharm. Biomed. Anal., 40, 614 (2006),<br></p>
    Formula:C43H53NO14
    Colore e forma:White
    Peso molecolare:807.88

    Ref: TR-E585300

    1mg
    387,00€
    5mg
    1.624,00€
    10mg
    2.234,00€
  • Ref: 10-F538115

    100mg
    Prezzo su richiesta
  • Ref: 10-F214471

    1g
    Prezzo su richiesta
  • 6-α-Hydroxy Paclitaxel (~90%)

    CAS:
    <p>Applications The major human metabolite of Paclitaxel.<br>References Walle, T., et al.: Biochem. Pharm., 46, 1661 (1993), Kumar, G., et al.: Drug Metab. Dispos., 22, 177 (1994),<br></p>
    Formula:C47H51NO15
    Purezza:~90%
    Colore e forma:Neat
    Peso molecolare:869.91

    Ref: TR-H948890

    1mg
    511,00€
    5mg
    2.148,00€
    500µg
    382,00€
  • 1-(2-Fluorophenyl)cyclopentan-1-amine

    CAS:
    Purezza:98%
    Peso molecolare:179.23800659179688

    Ref: 10-F781396

    1g
    Prezzo su richiesta
  • (+)-β-Pinene

    Prodotto controllato
    CAS:
    Formula:C10H16
    Colore e forma:Neat
    Peso molecolare:136.23

    Ref: TR-P466618

    100mg
    207,00€
    250mg
    326,00€
    500mg
    496,00€
  • Tert-Butyl 2-oxocyclopentane-1-carboxylate

    CAS:
    Purezza:98%
    Peso molecolare:184.23500061035156

    Ref: 10-F621742

    1g
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  • 1-(carboxymethyl)cyclopentanecarboxylic acid

    CAS:
    Purezza:95.0%
    Peso molecolare:172.17999267578125

    Ref: 10-F518674

    1g
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  • Ginkgolide A

    Prodotto controllato
    CAS:
    <p>Applications Family of bioactive terpenes treating cardiovascular and cerebrovascular diseases. Specific platelet activating factor (PAF) antagonists.<br>References Korth, R., et al.: Eur. J. Pharmacol., 152, 101 (1988), Braquet, P., et al.: Med. Res. Rev., 11, 295 (1991), van Beek, T.A., et al.: Bioorg. Med. Chem., 13, 5001 (2005)<br></p>
    Formula:C20H24O9
    Colore e forma:Neat
    Peso molecolare:408.40

    Ref: TR-G387425

    25mg
    136,00€
    50mg
    241,00€
    100mg
    396,00€
  • 7-Epi Paclitaxel

    Prodotto controllato
    CAS:
    Formula:C47H51NO14
    Colore e forma:Off-White
    Peso molecolare:853.91

    Ref: TR-E588630

    5mg
    331,00€
    10mg
    552,00€
    25mg
    1.291,00€
  • 3-Phenoxybenzoic Acid

    Prodotto controllato
    CAS:
    <p>Applications 3-Phenoxybenzoic Acid, can be used in the preparation of widely used insecticides, such as Permethrin (P288500). which is a synthetic chemical, used as an insecticide, acaricide, and insect repellent.<br>References Elliott, M., et al.: Nature, 246, 169 (1973); Zheng, M., et al.: Zhongguo Ertong Baojian Zazhi, 20, 409 (2012);<br></p>
    Formula:C13H10O3
    Colore e forma:White To Off-White
    Peso molecolare:214.22

    Ref: TR-P228010

    1g
    103,00€
    5g
    121,00€
    10g
    159,00€
  • Triptolide

    Prodotto controllato
    CAS:
    <p>Applications Triptolide is a diterpenoid triepoxide with immunosuppressant and antitumor properties.<br>References Hikim, S., et al.: J. Androl., 21, 431 (2000), Chang, W.-T., et al.: J. Biol. Chem., 276, 222 (2001), Kiviharju, T.M., et al.: Clin. Cancer Res., 8, 2666 (2002), Leuenroth, S.J., et al.: Chem. Biol., 12, 1259 (2005),<br></p>
    Formula:C20H24O6
    Colore e forma:White To Off-White
    Peso molecolare:360.40

    Ref: TR-T815600

    5mg
    145,00€
    10mg
    210,00€
    25mg
    488,00€
  • Deoxy Artemisinin

    Prodotto controllato
    CAS:
    <p>Applications An analogue of Artemisinin, an antimalarial agent.<br>References Mitchell, T., et al.: Clin. Microbiol. Rev., 8, 515 (1995), Posner, G., et al.: Bioorg. Med. Chem., 5, 1257 (1997) , Li, X., et al.: J. Nat. Prod., et al.: 62, 674 (1999),<br></p>
    Formula:C15H22O4
    Colore e forma:Neat
    Peso molecolare:266.33

    Ref: TR-D232150

    5mg
    161,00€
    10mg
    251,00€
    100mg
    1.650,00€
  • Brassinolide >90%

    CAS:
    <p>Applications Plant hormone; natural steroid containing a seven-membered B-ring lactone, that promotes both cell elongation and cell devision. Over ten brossinosteroids have been isolated and characterized from sources such as pollen, seedling, leaf. Used as plant growth regulator.<br>References Grove, M.D., et al.: Nature, 281, 216 (1979), Schlagnhaufer, C., et al.: Physiol. Plant., 60, 347 (1984), Wada, K., et al.: Agric. Biol. Chem., 48, 719 (1984),<br></p>
    Formula:C28H48O6
    Purezza:>90%
    Colore e forma:White To Off-White
    Peso molecolare:480.68

    Ref: TR-B677050

    10mg
    166,00€
    25mg
    318,00€
  • all-trans-Retinoic Acid-d5 (major)

    Prodotto controllato
    CAS:
    <p>Stability Light Sensitive, Temperature Sensitive<br>Applications An isotopically Labelled analog of retinoic acid. Physiological metabolite of vitamin A. Effects gene expression via nuclear retinoic acid receptors (RAR); mediates cellular growth and differentiation.A representative lot contains 11% d4, no d0 or d1 present.<br>References Kamm, J.J., et al.: J. Am. Acad. Dermatol., 6, 652 (1982), Warrel, R.P., et al.: Leukemia, 8, 929 (1994), Sasai, Y., et al.: J. Neurol., 249, 41 (2002),<br></p>
    Formula:C20H23D5O2
    Colore e forma:Neat
    Peso molecolare:305.47

    Ref: TR-R250202

    1mg
    452,00€
    500µg
    248,00€
    2500µg
    942,00€
  • Gibberellin A5

    Prodotto controllato
    CAS:
    Formula:C19H22O5
    Colore e forma:Neat
    Peso molecolare:330.38

    Ref: TR-G377465

    10mg
    305,00€
    100mg
    2.055,00€
  • N-(sec-butyl)cyclopentanamine hydrobromide

    CAS:
    Purezza:95.0%
    Peso molecolare:222.1699981689453

    Ref: 10-F361421

    1g
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  • all-trans-Retinol

    Prodotto controllato
    CAS:
    <p>Stability Liight Sensitive, Temperature Sensitive<br>Applications Occurs preformed only in animals; metabolized from carotenoids, such β-carotene, in the intestinal mucosa. Dietary sources include liver, milk, butter, cheese, eggs and fish liver oils or as carotenois from fruits and vegetables. Stored primarily in the liver in esterified form; transported in the blood by retinol binding protein (RBP). Nutritional factor.<br>References Davis, M., et al.: J. Biol. Chem., 15, 167 (1913), Crouch, R.K., et al.: Photochem. Photobiol., 64, 613 (1996),<br></p>
    Formula:C20H30O
    Colore e forma:Off-White To Dark Yellow
    Peso molecolare:286.45

    Ref: TR-R252000

    1g
    298,00€
    25mg
    86,00€
    100mg
    113,00€
  • 2-Debenzoyl Paclitaxel 2-Pentanoate

    Prodotto controllato
    CAS:
    <p>Impurity Paclitaxel - In House Impurity<br>Applications Paclitaxel (Taxol) analog. Paclitaxel - In House Impurity.<br></p>
    Formula:C45H55NO14
    Colore e forma:Neat
    Peso molecolare:833.92

    Ref: TR-D204500

    10mg
    843,00€
    25mg
    1.697,00€
    2500µg
    252,00€
  • Geraniol

    Prodotto controllato
    CAS:
    <p>Applications Geraniol is used in the synthesis of insect repellant. It is also used in the synthesis of Angelicoin A and Herecinone J, which inhibit collagen-induced platelet aggregation.<br>References Barnard, D. et al.: J. Med. Entomol., 41, 726 (2004); Mori K. et al.: Phytomedicine, 17, 1082 (2010);<br></p>
    Formula:C10H18O
    Colore e forma:Colourless
    Peso molecolare:154.25

    Ref: TR-G367000

    5g
    92,00€
    10g
    115,00€
    250g
    367,00€
  • Guaiazulene

    Prodotto controllato
    CAS:
    <p>Applications Guaiazulene is a lipophilic azulene that is commonly used as a skin conditioning agent in cosmetic, beauty and body care products. It is photomutagenic in Salmonella and also causes DNA damage in human cells.<br>References Chiang, H., et al.: J. Photochem. Photobiol. A: Chem., 211, 123 (2010); Fiori, J., et al.: Toxicol. Vitro, Kourounakis, A., et al.: J. Pharm. Pharmacol., 49, 938 (1997); Wang, L., et al.: Mut. Res., 530, 19 (2003)<br></p>
    Formula:C15H18
    Colore e forma:Neat
    Peso molecolare:198.30

    Ref: TR-G805000

    10g
    498,00€
    50g
    891,00€
    2500mg
    175,00€
  • 3-Amino- N -cyclopentyl-benzenesulfonamide

    CAS:
    Formula:C11H16N2O2S
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:240.32

    Ref: 10-F030805

    1g
    394,00€
  • 1-cyclopentyl-4-piperidinamine

    CAS:
    Purezza:95.0%
    Colore e forma:Liquid
    Peso molecolare:168.28399658203125

    Ref: 10-F309787

    1g
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  • Olivetol

    Prodotto controllato
    CAS:
    <p>Stability Light Sensitive<br>Applications Olivetol is a precursor in various syntheses of tetrahydrocannabinol.<br>References Kumano, T., et al.: Bioorg. Med. Chem., 16, 8117 (2008), Appendino, G., et al.: J. Nat. Prod., 71, 1427 (2008), Sampietro, D., et al.: Food Chem., 115, 1170 (2009),<br></p>
    Formula:C11H16O2
    Colore e forma:Neat
    Peso molecolare:180.24

    Ref: TR-O533000

    1g
    89,00€
    10g
    204,00€
    25g
    390,00€
  • Oxazolidine Cabazitaxel

    Prodotto controllato
    CAS:
    <p>Applications Oxazolidine Cabazitaxel is an impurity of Cabazitaxel (C046500) which is a novel semi-synthetic taxane with antitumor activity used for the treatment of castration-resistant prostate cancer.<br>References Agarwal, N. et al.: Fut. Oncol., 7, 15 (2011); Mita, A. et al.: Clin. Cancer Res., 15, 723 (2009); Figg, W.D. et al.: Cancer Biol. Ther., 10, 1233 (2010);<br></p>
    Formula:C48H61NO14
    Colore e forma:Neat
    Peso molecolare:875.996

    Ref: TR-O846530

    50mg
    347,00€
    500mg
    2.241,00€
  • Neophytadiene

    CAS:
    Neophytadiene is a diterpene compound extracted from Turbinaria ornate, with anti-inflammatory, anticonvulsant, antioxidant, and cardioprotective effects.
    Formula:C20H38
    Colore e forma:Solid
    Peso molecolare:278.52
  • β-OXO-CYCLOPENTANEPENTANOIC ACID ETHYL ESTER

    CAS:
    Purezza:95.0%
    Colore e forma:Liquid, No data available.
    Peso molecolare:212.28900146484375

    Ref: 10-F470138

    1g
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  • Ref: 10-F721018

    100mg
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  • Humulene

    CAS:
    <p>Applications Humulene is a monocyclic sesquiterpene derived from farnesyl diphosphate and naturally found in clove, basil, hops, and cannabis sativa. Humulene has potential anti-inflammatory, anti-tumor, and anti-bacterial properties.<br>References Legault, J., et al.: Planta Med. 69, 402 (2003); Wei, M. C., et al.: Food Chem. 210, 172 (2016); Fernandes, E. S., et al.: Eur J Pharmacol. 569, 228 (2007)<br></p>
    Formula:C15H24
    Colore e forma:Colourless
    Peso molecolare:204.35

    Ref: TR-H674570

    1g
    549,00€
    100mg
    185,00€
    250mg
    297,00€
  • 2-Chloro-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7(8H)-one

    CAS:
    Purezza:95.0%
    Colore e forma:Solid
    Peso molecolare:263.7300109863281

    Ref: 10-F231578

    1g
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    10g
    31,00€
    25g
    43,00€
    100g
    118,00€
  • rac-trans-Permethrinic Acid

    Prodotto controllato
    CAS:
    <p>Stability Light Sensitive<br>Applications trans-Permethrinic acid is a potent insecticide used in the agricultural industry to eliminate unwanted pests from crops. trans-Permethrinic acid is also metabolite of pyrethroid compounds, a group of pesticides that are relatively low toxicity (to organisms that are not intended to be targeted) and biodegradable.<br>References Kale, M., et al.: Toxicol. Lett., 105, 197 (1999); Leszczynski, J., et al.: J. Am. Chem. Soc., 115, 5891 (1993); Sodurlund, D. &amp; Bloomquist, J.: Ann. Rev. Entomol., 34, 77 (1989)<br></p>
    Formula:C8H10Cl2O2
    Colore e forma:Off-White
    Peso molecolare:209.07

    Ref: TR-P287705

    100mg
    247,00€
    250mg
    344,00€
    2500mg
    2.288,00€
  • D-(+)-Carvone

    CAS:
    <p>Applications D-(+)-Carvone, is used for the synthesis of (-)-terpestacin, a fungal metabolite with anticancer activity.It is also found in the essential oils of the in vitro M. longifolia plantlets and callus, that can be used as a potential source of a safe flavouring agent.<br>References Jin , Y., et al.: Org. Biomol. Chem., 10(28), 5452 (12012); Morcia, C., et al.: Acta. Biochimica. Polonica., 58(4), 581 (2011);<br></p>
    Formula:C10H14O
    Colore e forma:Neat
    Peso molecolare:150.22

    Ref: TR-C184690

    10g
    100,00€
    25g
    133,00€
    100g
    186,00€
  • (E,E)-Farnesol 11,11,11,12,12,12-d6

    Prodotto controllato
    CAS:
    Formula:C15H20D6O
    Colore e forma:Neat
    Peso molecolare:228.4

    Ref: TR-F102432

    1mg
    315,00€
    5mg
    1.322,00€
    10mg
    2.039,00€
  • (E)-Labd-13-ene-8,15-diol

    Prodotto controllato
    CAS:
    <p>Applications (E)-Labd-13-ene-8,15-diol possesses antiviral and anticancer activities and has been the most effective growth inhibitor of murine leukemia cell lines P388.<br>References Kim, J., et. al.: J. App. Bio. Chem., 56, 49 (2013)<br></p>
    Formula:C20H36O2
    Colore e forma:Neat
    Peso molecolare:308.5

    Ref: TR-L096410

    1g
    2.075,00€
    100mg
    315,00€
  • Paclitaxel-13C6

    Prodotto controllato
    CAS:
    <p>Applications Paclitaxel-13C is the labeled analogue of Paclitaxel (P132500). Paclitaxel is an antineoplastic. Used in the study of structure and function of microtubles into tubulin. Paclitaxel is now used to treat patients with lung, ovarian, breast cancer, head and neck cancer, and advanced forms of Kaposi's sarcoma. Paclitaxel is a mitotic inhibitor used in cancer chemotherapy.<br>References Letourneau, P.C., et al.: J. Cell Biol., 98, 1355 (1984), Manfredi, J.J., et al.: Pharmacol. Ther., 25, 83 (1984), Danesi, R., et al.: Mol. Pharmacol., 47, 1106 (1995), Markman, M., et al.: Expert. Opin. Pharmacother., 3, 755 (2002), Stone, G.W., et al.: N. Engl. J. Med., 350, 221 (2004),<br></p>
    Formula:C4113C6H51NO14
    Colore e forma:Neat
    Peso molecolare:859.86

    Ref: TR-P132504

    5mg
    3.935,00€
    500µg
    583,00€
  • N-cyclopentylcyclopropanesulfonamide

    CAS:
    Purezza:95.0%
    Peso molecolare:189.27000427246094

    Ref: 10-F512143

    250mg
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  • 2-cyclopentyl-1H-pyrrolo[2,3-b]pyridine


    Peso molecolare:186.25799560546875

    Ref: 10-F300355

    1g
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  • 2-(3-Oxo-1,3-diphenylpropyl)cyclopentan-1-one


    Peso molecolare:292.37799072265625

    Ref: 10-F182369

    1g
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  • Spirotetramat (>90%)

    CAS:
    <p>Applications Movento is a synergistic insecticide. Useful in cannabis testing kits as a component of pesticide mixes (P698240).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Byrne, F., et al.: Crop. Prot., 25, 831 (2006), Kanrar, B., et al.: Bull Environ. Contam. Toxicol., 77, 631 (2006), Venkateswarlu, P., et al.: Food Chem., 105, 1760 (2007), Khay, S., et al.: Biomed. Chromatogr., 22, 581 (2008),<br></p>
    Formula:C21H27NO5
    Purezza:>90%
    Colore e forma:Beige
    Peso molecolare:373.44

    Ref: TR-S683300

    1g
    478,00€
    100mg
    133,00€
    250mg
    187,00€
  • Ref: 10-F075051

    1g
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  • 1-(Benzo[d][1,3]dioxol-5-yl)cyclopentane-1-carboxylic acid

    CAS:
    Purezza:98%
    Peso molecolare:234.25100708007812

    Ref: 10-F701359

    1g
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  • Tert-butyl 3-(cyclopentylamino)-2-methylpropanoate

    CAS:
    Purezza:95.0%
    Peso molecolare:227.34800720214844

    Ref: 10-F522845

    2g
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  • Rolipram

    CAS:
    <p>M02441 - Rolipram</p>
    Formula:C16H21NO3
    Purezza:>98%
    Colore e forma:Solid
    Peso molecolare:275.3479919433594

    Ref: 10-M02441

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  • b-Ionone

    Prodotto controllato
    CAS:
    <p>Stability Light Sensitive<br>Applications An aroma compound commonly found in essential oils such as rose oil. It is an important fragrance chemical used in perfumery. β-Ionone is effective in the chemoprevention of rat mammary carcinogenesis.<br>References Bondar, C. et al.: Cosm. Toil., 122, 73 (2007); Yu, S. et al.: J. Agric. Food Chem., 43, 2144 (1995); Zhou, R. et al.: Jing. Huag., 28, 253 (2011);<br></p>
    Formula:C13H20O
    Colore e forma:Neat
    Peso molecolare:192.30

    Ref: TR-I731280

    1g
    252,00€
    25g
    318,00€
    100g
    456,00€
  • 20(S)-Ginsenoside Rg2

    Prodotto controllato
    CAS:
    <p>Stability Hygroscopic<br>Applications 20(S)-Ginsenoside Rg2 is used as an aldose reductase inhibitor and my exert anti-inflammatory and immunomodulatory activity. It exists as a bioactive metabolite of the ginsenoside component of Panax ginseng.<br>References Cho, K. et al.: Biomol. Ther., 22, 55 (2014); Fatmawati, S. et al.: Bioorg. Med. Chem. Lett., 24, 4407 (2014);<br></p>
    Formula:C42H72O13
    Colore e forma:Neat
    Peso molecolare:785.01

    Ref: TR-G387580

    50mg
    179,00€
    500mg
    1.223,00€
  • Paclitaxel-d5 (Benzoyloxy)

    Prodotto controllato
    CAS:
    <p>Applications Labelled Paclitaxel (P132500). An antineoplastic. Used in the study of structure and function of microtubles into tubulin.<br>References Letourneau, P.C., et al.: J. Cell Biol., 98, 1355 (1984), Manfredi, J.J., et al.: Pharmacol. Ther., 25, 83 (1984), Danesi, R., et al.: Mol. Pharmacol., 47, 1106 (1995), Markman, M., et al.: Expert. Opin. Pharmacother., 3, 755 (2002), Stone, G.W., et al.: N. Engl. J. Med., 350, 221 (2004),<br></p>
    Formula:C472H5H46NO14
    Colore e forma:Neat
    Peso molecolare:858.94

    Ref: TR-P132503

    5mg
    3.236,00€
    500µg
    473,00€