APIs per la ricerca e le impurità
I principi attivi farmaceutici (API) sono le sostanze nei farmaci responsabili dei loro effetti terapeutici. In questa sezione troverai una vasta gamma di API destinati all'uso in ricerca. Questi composti sono essenziali per lo sviluppo, il test e la validazione di nuove formulazioni farmaceutiche. Presso CymitQuimica, offriamo API di alta qualità per supportare la ricerca nella scoperta e nello sviluppo di farmaci.
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Trovati 66870 prodotti di "APIs per la ricerca e le impurità"
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(3S,5S)-Atorvastatin sodium salt
CAS:Atorvastatin is a statin drug that inhibits the enzyme HMG-CoA reductase, which is responsible for cholesterol synthesis. Atorvastatin is used to lower LDL cholesterol and total cholesterol levels in the blood. It also lowers triglyceride levels and raises HDL cholesterol levels. Atorvastatin has been shown to inhibit fibrinogen production, reduce TNF-α production, and improve body mass index (BMI) in obese patients. This drug has been shown to be effective in reducing the size of atherosclerotic lesions by decreasing the amount of cholesteryl esters transferred from high-density lipoprotein (HDL) to low-density lipoprotein (LDL). It has also been shown to inhibit collagen production and stimulate muscle cell proliferation.Formula:C33H34FN2NaO5Purezza:Min. 95%Colore e forma:PowderPeso molecolare:580.62 g/molDaunomycinone
CAS:Daunomycinone is a chemical compound that belongs to the group of antitumor agents. It is used in cancer therapy and has been shown to inhibit protein synthesis, leading to cell death. Daunomycinone can be synthesized by reacting adriamycin with trifluoroacetic acid in the presence of an organic base. This reaction produces a daunomycinone molecule that has a hydroxyl group at one end and a carbonyl group at the other. The binding constants between daunomycinone and human serum proteins have been determined experimentally using molecular modeling techniques. Hydrogen bonding interactions are also present in this complex, which may account for its high affinity for proteins found in human serum.Formula:C21H18O8Purezza:Min. 95%Colore e forma:Red PowderPeso molecolare:398.36 g/mol(S)-N2-(Methoxymethyl)-N6-proply-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6 diamine)
(S)-N2-(Methoxymethyl)-N6-proply-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6 diamine) is an API impurity. CAS No. for this product is not available. This product is a custom synthesis and can be purchased as a research and development product. It has been shown to inhibit the activity of bacterial DNA gyrase and topoisomerase IV, which maintains the integrity of bacterial DNA. The chemical name for this product is (S)-N2-(Methoxymethyl)-N6-proply-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6 diamine).Formula:C12H23N3OSPurezza:Min. 95%Peso molecolare:257.4 g/mol5-Aminolevulinic acid hydrochloride
CAS:Photodynamic Therapy of Actinic Keratosis. Porphobilinogen synthase substrate that produces endogenous porphyrins useful for sensitizing cells in photodynamic therapy. Intermediate in heme and chlorophyll biosynthesis. Estimation of 5-aminolevulinic acid dehydratase. PBG formed in the assay is determined spectrophotometrically with Ehrlich's reagent. Used in Porphyrin test for differentiation of Haemophilus species. Enzymes that convert ALA to porphyrins in the biosynthesis of hemin (X factor) are not produced by H. influenzae, H.aegyptius and H. canis. These enzymes are produced by H. parainfluenzae, H. parahaemolyticus, H. gallinarum, H. parasuis, H. parahaemolyticus and H. aphrophilus. A positive reaction is indicated by an orange-red fluorescence.Formula:C5H10ClNO3Purezza:Min. 98.0 Area-%Peso molecolare:167.59 g/molEsomeprazole sodium
CAS:Esomeprazole is a proton pump inhibitor used to treat gastroesophageal reflux disease and other conditions where there is too much stomach acid. It is available as a capsule or tablet in doses of 20, 40, and 60 mg. Esomeprazole inhibits the production of gastric acid by blocking the hydrogen/potassium adenosine triphosphate (H+/K+ ATPase) enzyme system at the secretory surface of the gastric parietal cells. Omeprazole is an acidic drug that blocks the H+/K+ ATPase enzyme system. The two drugs have been compared in two-way crossover studies using healthy volunteers who were given omeprazole magnesium for one week followed by esomeprazole sodium for another week. There was no difference in their effect on acid secretion or on heartburn relief. The plasma concentrations of both drugs increased with increasing dose, but there was no significant difference between them in terms of either
Formula:C17H18N3NaO3SPurezza:(%) Min. 95%Colore e forma:PowderPeso molecolare:367.4 g/mol4-[2'-(7''-Deazaguanine)ethyl]benzoic acid N-hydroxysuccinimide ester
CAS:4-[2'-(7''-Deazaguanine)ethyl]benzoic acid N-hydroxysuccinimide ester is a useful intermediate in the synthesis of 7''-deazaguanine, which is a key building block in the synthesis of DNA. 4-[2'-(7''-Deazaguanine)ethyl]benzoic acid N-hydroxysuccinimide ester is a versatile building block that can be used in the synthesis of complex compounds. It has been shown to react with amines, sulfonyl chlorides, and epoxides to form amides, sulfonamides, and epoxy amines respectively. The CAS number for this compound is 204257-65-8.Formula:C19H17N5O5Purezza:Min. 95%Peso molecolare:395.37 g/molLinear Semaglutide
Linear semaglutide, or simply L-Sema, is the semaglutide compound without the lipid side chain modification. It is essentially a linear version of the peptide.Formula:C152H230N42O47Peso molecolare:3,397.76 g/mol3,5-Di-O-(4-chlorobenzoyl)-2-deoxy-a-D-ribofuranosyl isocyanate
3,5-Di-O-(4-chlorobenzoyl)-2-deoxy-a-D-ribofuranosyl isocyanate (CAS No. 53477) is a drug product that belongs to the class of drugs called nucleosides. 3,5-Di-O-(4-chlorobenzoyl)-2-deoxy-a-D-ribofuranosyl isocyanate has been shown to be metabolized through a number of metabolic transformations, including hydrolysis by esterases or glucuronidases, oxidation by cytochrome P450 enzymes, reduction by glutathione reductase, or conjugation with glucuronic acid. This product has been shown to have antiplasmodial activity and may be useful in the treatment of malaria.Formula:C20H15Cl2NO6Purezza:Min. 95%Peso molecolare:436.24 g/mol2-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-piperazin-1-yl)-ethanol
CAS:2- (4-Dibenzo[b,f][1,4]thiazepin-11-yl-piperazin-1-yl)-ethanol is a pharmaceutical intermediate that is a potent inhibitor of the enzyme acetylcholinesterase. It has been used as a photolytic probe in chromatographic experiments. 2-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-piperazin-1-yl)-ethanol has been synthesized by the reaction of 4-(benzo[b]thieno[2,3d]thiazol)piperazine with ethanol. The impurities present are quantified and their concentrations are reported as percent weight/volume (% w/v). Impurities that may be found in this product include acetonitrile, orthophosphate, and linearity.Formula:C19H21N3OSPurezza:Min. 95%Colore e forma:PowderPeso molecolare:339.46 g/molLisinopril EP Impurity E
CAS:Lisinopril EP Impurity E is an impurity of lisinopril, which is a prescription drug used to treat high blood pressure. This impurity was found in a preparative high performance liquid chromatography (HPLC) and mass spectroscopy analysis of the drug. The molecular weight of Lisinopril EP Impurity E was determined to be 317.2 amu, which corresponds to the molecular formula C7H13NO2. The FT-IR spectrum showed that this impurity has an ammonium group at 1859 cm-1 and butanoic acid at 1647 cm-1.Formula:C21H31N3O5Purezza:Min. 98 Area-%Colore e forma:PowderPeso molecolare:405.49 g/molFluticasone propionate EP Impurity F
CAS:Fluticasone Propionate EP Impurity F is an impurity of Fluticasone Propionate. Fluticasone Propionate is a synthetic glucocorticoid used in the treatment of asthma and other allergic disorders. Impurity F is a metabolite of Fluticasone Propionate and has been detected in human plasma at low levels (5% of total fluticasone propionate). The metabolism of Fluticasone Propionate to Impurity F has been studied in rat, mouse, dog and man. br>br> The following table summarizes the metabolic pathways that have been identified for this impurity: br>br> Metabolism studies indicate that Impurity F is mainly metabolized by CYP3A4 to form conjugates with glucuronic acid or sulfates. It may also be hydrolyzed to form 5α-flurostan-3β,17β-dFormula:C25H29F3O5SPurezza:Min. 95%Colore e forma:PowderPeso molecolare:498.56 g/mol(-)-9-Hydroxyrisperidone
CAS:Prodotto controllato(-)-9-Hydroxyrisperidone is a metabolite of risperidone that is structurally related to the neurotransmitter dopamine. This compound has been found to be a potent antagonist of serotonin and adrenergic receptors, which may contribute to its therapeutic effects in schizophrenia. (-)-9-Hydroxyrisperidone also has been shown to have a high affinity for human liver plasma proteins, which suggests it may be responsible for the long half-life seen with risperidone. The (+) form of the drug has been shown to be more potent than (-)-9-hydroxyrisperidone, while (-)-9-hydroxyrisperidone is more selective in terms of receptor binding.Formula:C23H27FN4O3Purezza:Min. 95%Colore e forma:PowderPeso molecolare:426.48 g/molCalcipotriol EP Impurity H
Calcipotriol EP Impurity H is an impurity found in calcipotriol EP. It is a metabolite of calcipotriol EP, which is the active ingredient in Dovonex. Calcipotriol EP Impurity H can be detected by HPLC with a retention time of 11.5 minutes and its purity can be determined by UV spectroscopy at 254 nm with a purity of >98%. Calcipotriol EP Impurity H can also be synthesized from natural or synthetic sources.Formula:C54H78O5Purezza:Min. 95 Area-%Colore e forma:PowderPeso molecolare:807.19 g/molDes-Glu(3)-Semaglutide
Des-Glu(3)-semaglutide is a semaglutide-related impurity. This des-amino acid form has got the glutamic acid or glutamate (Glu) amino acid from position 3 removed from the peptide chain. Semaglutide impurities are structurally related compounds that arise during synthesis, purification, or storage of semaglutide, a long-acting GLP-1 receptor agonist used for managing type 2 diabetes and obesity.Formula:C182H284N44O56Peso molecolare:3,984.53 g/molD-Ala(24)-Semaglutide
D-Ala(24)-Semaglutide is a semaglutide impurity. The amino acid at position 24 has been replaced by the D-form of the amino acid D-alanine (D-Ala). Semaglutide impurities are structurally related compounds that arise during synthesis, purification, or storage of semaglutide, a long-acting GLP-1 receptor agonist for managing type 2 diabetes and obesity.Formula:C187H291N45O59Peso molecolare:4,113.64 g/mol7-epi-Taxol
CAS:Paclitaxel is an anticancer drug that belongs to the class of taxanes. Paclitaxel binds to cell membranes and interferes with cell division by preventing the polymerization of microtubule proteins. This drug can be prepared by high-performance liquid chromatography (HPLC) and has minimal toxicity in humans, but is highly toxic in rats. Paclitaxel also inhibits glucose uptake in breast cancer cells, leading to significant cytotoxicity. It has inhibitory properties against toll-like receptor 4, which may contribute to its anti-inflammatory effects.Formula:C47H51NO14Purezza:Min. 95%Colore e forma:PowderPeso molecolare:853.91 g/molBis[N-[2-[[[5-[(dimethylamino)methyl]furan-2-yl]methyl]thio]ethyl]-N'-methyl-2,2-diamino-1-nitroethenyl]methane
CAS:Impurity arising druring the synthesis of ranitidineFormula:C27H44N8O6S2Purezza:Min. 95%Colore e forma:Orange PowderPeso molecolare:640.82 g/molTopiramate N-methyl impurity
CAS:Topiramate is a drug used to treat epilepsy and weight loss. The N-methyl impurity is a synthetic compound that is an impurity in the drug product. The impurity was synthesized by reacting 4-hydroxybenzaldehyde with methylamine in the presence of triethylamine. It has been shown to be not metabolized, but excreted unchanged in urine.Formula:C13H23NO8SPurezza:Min. 95%Colore e forma:Colourless LiquidPeso molecolare:353.39 g/mol4-Desmethoxy omeprazole sulfide
CAS:4-Desmethoxy omeprazole sulfide is a metabolite of omeprazole, a drug that is used to treat ulcers and gastroesophageal reflux disease. 4-Desmethoxy omeprazole sulfide is not an impurity in the production of omeprazole, but is present as a natural component of omeprazole. This compound has been shown to be an impurity standard for HPLC analysis. The pharmacopoeia defines 4-desmethoxy omeprazole sulfide as an API impurity in drug products. It is also being studied for its potential use in drug development and research and development.
Formula:C16H17N3OSPurezza:Min. 95%Colore e forma:White to off-white solid.Peso molecolare:299.39 g/mol
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