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APIs per la ricerca e le impurità

APIs per la ricerca e le impurità

I principi attivi farmaceutici (API) sono le sostanze nei farmaci responsabili dei loro effetti terapeutici. In questa sezione troverai una vasta gamma di API destinati all'uso in ricerca. Questi composti sono essenziali per lo sviluppo, il test e la validazione di nuove formulazioni farmaceutiche. Presso CymitQuimica, offriamo API di alta qualità per supportare la ricerca nella scoperta e nello sviluppo di farmaci.

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  • Tenofovir disoproxil

    CAS:

    Tenofovir disoproxil is the disoproxil fumarate salt of tenofovir. It is a nucleoside reverse transcriptase inhibitor that has been shown to be effective in the treatment of chronic hepatitis B virus (HBV) in combination with emtricitabine and as a single agent in the treatment of HIV-1 infection. Tenofovir disoproxil is available as tablets, capsules, or oral solution. The drug has been shown to cause an increase in serum creatinine levels, which may be due to inhibition of renal tubular secretion of creatinine by tenofovir. This drug should not be used with alafenamide and tenofovir because it can lead to kidney failure and death.

    Formula:C17H28N5O7P·(C4H4O4)
    Purezza:Min. 95%
    Peso molecolare:445.41 g/mol

    Ref: 3D-XGC28415

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  • Duloxetine phenyl carbamate

    CAS:

    Duloxetine is a drug product that belongs to the class of drugs known as selective serotonin and norepinephrine reuptake inhibitors. Duloxetine is a metabolite of duloxetine phenyl carbamate, which is an impurity standard for HPLC analysis. Duloxetine has been shown to inhibit the metabolism of serotonin and norepinephrine in the brain, leading to increased amounts of these neurotransmitters. This medication has been studied in niche populations such as those with depression and diabetic neuropathy. Duloxetine also has high purity standards, meeting the requirements of pharmacopoeia.

    Formula:C25H23NO3S
    Purezza:Min. 95%
    Peso molecolare:417.50 g/mol

    Ref: 3D-XMB68609

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  • Deschloro amlodipine

    CAS:

    Deschloro amlodipine is a drug that is used for the treatment of high blood pressure. It belongs to a group of drugs called calcium channel blockers. Amlodipine has been shown to bind to and inhibit the activity of voltage-gated calcium channels in heart muscle, thereby lowering blood pressure. Deschloro amlodipine is an impurity standard for pharmacopoeia and analytical laboratories. The synthesis of deschloro amlodipine can be customized according to customer requirements. This product will be shipped as soon as possible after purchase.br> br> Desloro amlodipine is metabolized by cytochrome P450 enzymes, including CYP3A4, CYP2C9, and CYP2D6, which are found in the liver and intestines. These enzymes convert desloro amlodipine into two metabolites: 4-hydroxyamlodipine and 4

    Formula:C20H26N2O5
    Purezza:Min. 95%
    Peso molecolare:374.43 g/mol

    Ref: 3D-NDA15052

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  • 1-(2-Furoyl)piperazine

    CAS:

    1-(2-Furoyl)piperazine is a potent inhibitor of tyrosinase, an enzyme involved in the production of melanin. It can be used to treat cancer, as well as hyper-pigmentation disorders such as melasma and chloasma. 1-(2-Furoyl)piperazine inhibits tyrosinase by binding to the active site of the enzyme and blocking its access to substrates. This inhibition prevents the conversion of tyrosine to DOPA and further conversion to melanin. 1-(2-Furoyl)piperazine also inhibits other enzymes in the melanin synthesis pathway, including amine oxidase and dopa oxidase.

    Formula:C9H12N2O2
    Purezza:Min. 95%
    Colore e forma:Powder
    Peso molecolare:180.2 g/mol

    Ref: 3D-IF36870

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  • Lysolecithin

    CAS:

    Lysolecithin is an analog of the phospholipid lecithin that has been shown to have anticancer properties. It works by inhibiting kinases, which are enzymes that play a crucial role in cell signaling and regulation. Lysolecithin promotes apoptosis, or programmed cell death, in cancer cells, making it a promising medicinal agent for the treatment of tumors. Studies have also shown that lysolecithin can inhibit protein kinase activity in human urine and inhibit the growth of cancer cells in Chinese hamsters. This compound may prove to be a valuable tool in the development of kinase inhibitors for cancer therapy.

    Formula:C24H50NO7P
    Purezza:Min. 95%
    Peso molecolare:495.6 g/mol

    Ref: 3D-PAA86327

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  • Propoxyphenyl homohydroxysildenafil

    CAS:
    Propoxyphenyl homohydroxysildenafil is a preparative mass spectrometric analysis of the metabolite of sildenafil, which is a phosphodiesterase type 5 inhibitor. It has been shown to increase the flow rate in rats with an experimental pulmonary hypertension. The product ions of propoxyphenyl homohydroxysildenafil are m/z 409.3, 417.2, and 419.2, and its pharmacological study has been conducted on tadalafil and isobutyl.
    Formula:C24H34N6O5S
    Purezza:Min. 95%
    Peso molecolare:518.6 g/mol

    Ref: 3D-PFA75587

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  • Carbidopa 4-phosphate trihydrate

    CAS:

    Please enquire for more information about Carbidopa 4-phosphate trihydrate including the price, delivery time and more detailed product information at the technical inquiry form on this page

    Formula:C10H21N2O10P
    Purezza:Min. 95%
    Peso molecolare:360.25 g/mol

    Ref: 3D-HBD68607

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  • 9-Epimitomycin B

    CAS:

    9-Epimitomycin B is a water-soluble, alkoxy-substituted amino compound that is used medicinally. It has antibacterial activity and has been shown to be effective against Gram-positive bacteria such as Staphylococcus aureus, Streptococcus pyogenes, and Enterococcus faecalis. 9-Epimitomycin B inhibits the growth of these bacteria by binding to their ribosomes and inhibiting protein synthesis. The carbon atoms in 9-epimitomycin B are linked to an alkoxy group at one end, which causes it to have a higher affinity for bacterial ribosomes than human ribosomes. 9-Epimitomycin B also binds to mitomycin C, which may be responsible for its antimetabolite properties.

    Formula:C16H19N3O6
    Purezza:Min. 95%
    Peso molecolare:349.34 g/mol

    Ref: 3D-NAA16490

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  • DL-threo-Ritalinic acid

    Prodotto controllato
    CAS:

    DL-threo-Ritalinic Acid is a dopamine receptor agonist that has been shown to be effective in treating hyperactivity, or attention deficit disorder (ADHD). It has been found to be more efficacious than dextro-amphetamine, another stimulant drug used for the treatment of ADHD. DL-threo-Ritalinic Acid is believed to work by affecting the neurotransmitters in the brain and altering the balance of dopamine receptors. In a two-way crossover study, preschool children were given either 0.5mg/kg of DL-threo-Ritalinic Acid or placebo for three days. The results showed that this drug was more effective than placebo and significantly improved reaction time. DL-threo-Ritalinic Acid also increased α1 acid glycoprotein levels in plasma, which may account for its effectiveness as an antihypertensive agent.

    Formula:C13H17NO2
    Purezza:Min. 95%
    Peso molecolare:219.28 g/mol

    Ref: 3D-IR180350

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  • Monobenzyl fosaprepitant

    CAS:

    Monobenzyl fosaprepitant is a drug product that is used for research and development purposes. It is an impurity standard for the analysis of API (Active Pharmaceutical Ingredient) impurities, which are synthetic products. Monobenzyl fosaprepitant has been shown to be metabolized in vitro. The metabolism studies have shown that this compound can be hydrolyzed by esterases or glucuronidases, oxidized by cytochrome P450 enzymes, reduced by glutathione reductase, or conjugated with glucuronic acid. Monobenzyl fosaprepitant is a high-purity analytical standard and is used as a pharmacopoeia monograph material.

    Formula:C30H28F7N4O6P
    Purezza:Min. 95%
    Peso molecolare:704.50 g/mol

    Ref: 3D-PKB85202

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  • cis-Tadalafil

    CAS:

    Cis-Tadalafil is a potent inhibitor of phosphodiesterase 5, which is used to treat erectile dysfunction (ED) and primary pulmonary hypertension (PPH). It works by increasing blood flow to the penis, allowing men with ED to achieve and maintain an erection. Cis-Tadalafil is also used to treat symptoms of prostatic hyperplasia (enlarged prostate) in men. This drug has been shown to be effective in treating PPH by reducing pulmonary arterial pressure and improving exercise capacity. Cis-Tadalafil belongs to the carboline class of drugs and is a phosphodiesterase 5 inhibitor that selectively inhibits cGMP-specific phosphodiesterase type 5 (PDE5). This drug has been shown to be highly effective in treating both ED and PPH with minimal side effects.

    Formula:C22H19N3O4
    Purezza:Min. 95%
    Colore e forma:White/Off-White Solid
    Peso molecolare:389.4 g/mol

    Ref: 3D-FT27987

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  • Ciprofloxacin ep impurity C

    CAS:

    Ciprofloxacin ep impurity C is a synthetic compound. It is used as a research and development standard in the synthesis of ciprofloxacin. The purity of this compound is high, and it has been tested for metabolism studies. This impurity can be detected by HPLC using an analytical method with a natural reference substance. This impurity has not been evaluated for pharmacopoeia or CAS number.

    Formula:C15H16FN3O3
    Purezza:Min. 95%
    Peso molecolare:305.30 g/mol

    Ref: 3D-DEA22212

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  • Oxacyclohexane open ring tacrolimus

    CAS:

    Please enquire for more information about Oxacyclohexane open ring tacrolimus including the price, delivery time and more detailed product information at the technical inquiry form on this page

    Formula:C44H71NO13
    Purezza:Min. 95%
    Peso molecolare:822.04 g/mol

    Ref: 3D-IO183660

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  • Roflumilast Impurity A

    CAS:

    Roflumilast impurity A is a metabolite of roflumilast. It is a drug product that is used as an analytical standard for the determination of roflumilast in HPLC analysis. Roflumilast impurity A is not natural and is synthetic. It has been shown to be a substrate for CYP1A2, CYP2C8, CYP2C9, and CYP3A4 enzymes. Studies have shown that it may be involved in the metabolism of roflumilast through hydroxylation and deamination.

    Formula:C16H14Cl2N2O3
    Purezza:Min. 95%
    Peso molecolare:353.2 g/mol

    Ref: 3D-IR168438

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  • Ivermectin impurity I

    CAS:

    Ivermectin impurity I is an analytical standard that is used for pharmacopoeia and custom synthesis. It is a natural metabolite of the drug Ivermectin, which has been shown to have anti-inflammatory properties in mice. Ivermectin impurity I binds to nicotinic acetylcholine receptors, leading to muscle paralysis and death. This compound is found in high purity for research and development purposes.

    Formula:C48H74O14
    Purezza:Min. 95%
    Colore e forma:Powder
    Peso molecolare:875.09 g/mol

    Ref: 3D-II167729

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  • Pramipexole EP Impurity C

    CAS:

    Pramipexole EP Impurity C is a synthetic impurity that is used as an impurity standard in the manufacture of Pramipexole EP. It is also used as a research and development tool for drug product, custom synthesis, CAS No. 1973461-14-1, and analytical studies. This compound has been shown to be a metabolite of Pramipexole EP and may have pharmacological properties. Pramipexole EP Impurity C has been found to inhibit the growth of certain bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA) isolates.

    Formula:C20H32N6S2
    Purezza:Min. 95%

    Ref: 3D-FP165425

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  • (3S,4R)-Tofacitinib

    CAS:

    (3S,4R)-Tofacitinib is a rhombic and paramagnetic compound with a Curie point of approximately 10.6°C. It is soluble in nonpolar solvents such as benzene and toluene. (3S,4R)-Tofacitinib has been shown to have magnetic properties that are dependent on the temperature and the frequency of the applied magnetic field. The paramagnetic resonance spectra were observed at 18°C and 32°C, while the paramagnetic resonance spectrum was observed at -2°C. The octahedral interactions are likely due to the presence of six different types of iron ions in the crystal structure.

    Formula:C16H20N6O
    Purezza:Min. 95%
    Peso molecolare:312.37 g/mol

    Ref: 3D-STB57848

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  • N-Benzyl albuterol

    CAS:

    N-Benzyl albuterol is a drug product that is custom synthesized to be of high purity with an analytical standard. It is used in research and development, pharmaceutical development, and as a pharmacopoeia or analytical standard. N-Benzyl albuterol has been found to be a metabolite of the drug product Albuterol Sulfate. It is also used in metabolism studies and natural product research. The CAS number for this compound is 24085-03-8.

    Formula:C20H27NO3
    Purezza:Min. 95%
    Peso molecolare:329.4 g/mol

    Ref: 3D-ZAA08503

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  • Acarbose Impurity E

    CAS:

    Acarbose Impurity E is an impurity found in acarbose. It is a natural, API impurity and is a synthetic impurity standard. Acarbose Impurity E has been used in drug development research and development, as well as in the HPLC analysis of acarbose to generate a pharmacopoeia-grade purity standard.

    Purezza:Min. 95%

    Ref: 3D-FA175652

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  • Piperacilloic acid

    CAS:

    Piperacilloic acid is a synthetic compound that exhibits antibacterial activity. It has been shown to be effective against human pathogens, including urothelial carcinoma and human serum. Piperacilloic acid binds to the amino acids lysine and arginine in bacterial proteins and inhibits protein synthesis by inhibiting the function of enzymes that require these amino acids for their activity. The potency of piperacillin is low, but it is activated by hydrolysis in the acidic environment of the stomach or intestinal tract. Piperacilloic acid also has potential as a contraceptive agent because it may inhibit transcriptional regulation of genes that are involved in sperm production.

    Formula:C23H29N5O8S
    Purezza:(Elemental Analysis) Min. 90 Area-%
    Colore e forma:Powder
    Peso molecolare:535.57 g/mol

    Ref: 3D-FP27061

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