APIs per la ricerca e le impurità

N-Methyllidocaine iodide is a drug that is used to treat cardiac arrhythmias. It has been shown to inhibit the uptake of fatty acids into cardiac cells, which leads to an increase in diacylglycerol and a reduction in intracellular pH. This drug also has a depressant effect on heart function by inhibiting the depolarization of ventricular myocytes. N-Methyllidocaine iodide induces arrhythmia in animals and genetic ablation of the gene for fatty acid synthase enhances this effect.

Amlodipine dimethyl ester is a drug product that has been custom synthesized by our company. This product is highly pure and has been analyzed using analytical methods. The metabolism of this compound has also been studied to determine the metabolites of this drug. Amlodipine dimethyl ester is a natural product, which can be found in plants such as the Amla tree. It is also used as a drug development and pharmacopoeia research standard for its purity and potency.

Mono(3-hydroxybutyl)phthalate-d4 is a research and development, impurity standard, custom synthesis, drug product, synthetic and high purity chemical that is used as an analytical standard in the pharmacopoeia. Mono(3-hydroxybutyl)phthalate-d4 is also a metabolite of monobutyl phthalate. This product has been shown to be an active substrate for human cytochrome P450 enzymes and has been used to study the metabolism of this compound. Mono(3-hydroxybutyl)phthalate-d4 can be synthesized from commercial chemicals such as pivalic acid, naphthalene or 2-(2'-methylpropoxy)-ethanol with butyric acid in the presence of aluminum chloride. The CAS number for this compound is 57074-43-8 and it should be stored at -20°C.

4-Amino-1-[3,5-di-O-(4-chlorobenzoyl)-2-deoxy-α-D-ribofuranosyl]-1,3,5-triazin-2(1H)-one (4AAT) is an analytical chemical that is used for research and development purposes. 4AAT is a metabolite of the antibiotic ampicillin and has been identified as an impurity in the drug product. It can be synthesized from 2-(4'-chlorophenyl)benzaldehyde, 3,5'-di-O-(4'-chlorobenzoyl)-2',3'-dideoxyribose and sodium azide in a two step process with 98% purity. 4AATs are also found to be present in natural products such as honey or sugar cane juice.

2,6-Diethyl-4-thioisonicotinamide is a metabolite of 2,6-diethyl-4-(methylsulfonyl)pyrimidine and is used as an analytical standard for HPLC. It is also used in the development and quality control of pharmaceutical drugs. 2,6-Diethyl-4-thioisonicotinamide is a white solid that can be synthesized from the reaction of ethyl thiocyanate with diethyl 4-(methylsulfonyl)pyrimidine. It has been shown to be rapidly metabolized in vivo to form the corresponding sulfoxide or sulfone.

Cefdinir impurity H is a metabolite of the drug cefdinir. It is an impurity in the drug product that was discovered during research and development of cefdinir. Cefdinir impurity H has a CAS number, which indicates that it is a drug product. It also has high purity and can be used for analytical purposes or as a metabolism study standard. Metabolism studies have been conducted on this compound to determine its pharmacological effects. This metabolite is not natural, but synthetic and may be considered a niche compound due to its limited use in research and development.br>
This impurity may be found in the form of an HPLC standard and can be used for developing new drugs against bacterial infections such as tuberculosis, which are caused by Mycobacterium tuberculosis.br>br>

Impurity F is a metabolite of Fexofenadine. It is an impurity that can be found in the drug product and is used as a research and development standard for impurities. Impurity F has been shown to be a metabolite of Fexofenadine in human liver microsomes, and this metabolite has also been shown to have antihistamine properties. This impurity is used as a pharmacopoeia reference standard for HPLC analysis of fluoroquinolones, but it does not have any therapeutic value.

Please enquire for more information about Haloperidol decanoate EP impurity J hydrochloride including the price, delivery time and more detailed product information at the technical inquiry form on this page

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Propylthiouracil-d5 is a drug product that is used in the development of drugs. Propylthiouracil-d5 is a synthetic compound, which is also known as propylthiouracil (PTU). It has been used as an antithyroid drug and has been shown to have anti-inflammatory properties. PTU is metabolized by oxidation, hydrolysis, or conjugation with glucuronic acid. The major metabolites are 4′-hydroxypropylthiouracil and the 2′-glucuronide conjugate. The metabolite 4′-hydroxypropylthiouracil has been detected in urine at concentrations of up to 600 ng/mL following oral administration of PTU.

Di-M-tolyl phosphate is a phosphorus compound with a chemical formula of (CH3)2PO2. It has a melting point of –20 degrees Celsius and is insoluble in water, but soluble in organic solvents. Di-M-tolyl phosphate has optical properties that are modulated by temperature, morphology, and diffraction. FTIR spectra show protonation at temperatures below -10 degrees Celsius and imine formation at higher temperatures. Di-M-tolyl phosphate undergoes intramolecular hydrogen bonding to form pyrrole rings that may be responsible for its processability. This compound can be synthesized from monomers such as methanol and dimethyl ether via the process of electrophilic addition of phosphorus pentoxide to an imine or pyrrole ring system. The silicon affinity of this compound increases with the concentration of alkyl groups on the phosphorus atom.

Please enquire for more information about 2-(2-Chlorobenzoyl)benzoic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page

Cycrimine hydrochloride is a molecule that is used as an anticholinergic drug. It has been shown to be effective in humans, with a half life of 3 hours and a duration of action of 8 hours. Cycrimin hydrochloride is also used as a diagnostic agent for irritant contact dermatitis and may be useful in the diagnosis of other allergic reactions. The molecule is also used as a diagnostic aid for cardiac arrhythmias.

NUC-7738 is a medicinal compound that has been shown to be an effective inhibitor of cyclin-dependent kinases (CDKs). It has potent anticancer activity and has been studied extensively in Chinese hamster ovary (CHO) cells, human leukemia cells, and other cancer cell lines. NUC-7738 works by selectively inhibiting CDK4/6, which are critical regulators of the cell cycle. This leads to the induction of apoptosis in cancer cells, making it a promising new therapeutic agent for the treatment of various types of cancer. Additionally, NUC-7738 has been shown to have low toxicity and good pharmacokinetic properties in preclinical studies. Overall, this compound holds great promise as a novel anticancer therapy that may help improve outcomes for patients with cancer.

Please enquire for more information about Methyl 1-(4-bromophenyl)-1H-pyrazole-4-carboxylate including the price, delivery time and more detailed product information at the technical inquiry form on this page

Remdesivir impurity 8 is a metabolite of remdesivir, a drug product that belongs to the class of synthetic compounds. Remdesivir impurity 8 has been used as a research and development standard for HPLC analysis. It is also used as an impurity standard in pharmacopoeia and drug development. This impurity has shown natural activity in metabolism studies, but it is not known if this activity is due to the compound itself or an artifact from its synthesis.

1-Methoxy amiodarone is a drug product that is a custom synthesis. It has CAS No. 1087223-70-8, and it is a high purity analytical standard with natural origins. Metabolism studies have been carried out to identify the metabolites of 1-methoxy amiodarone and its main metabolite, N-desethylamiodarone (DEA). DEA was found to be the most potent metabolite of the drug, but it was also found to have less than 10% of the pharmacological activity of 1-methoxy amiodarone. Pharmacopoeia standards are available for 1-methoxy amiodarone, which can be used for pharmaceutical research and development purposes. HPLC standards are also available for this compound.

Trifenofos is a potent protein kinase inhibitor that has shown promising anticancer activity in preclinical studies. It targets specific kinases involved in tumor growth and survival, leading to apoptosis or programmed cell death of cancer cells. Trifenofos is an analog of a natural toxin found in Chinese urine, which has been used for centuries in traditional medicine to treat various ailments. In addition to its anticancer properties, trifenofos also shows potential as an inhibitor of other diseases involving abnormal protein kinase activity. Its effectiveness has been demonstrated in human cancer cell lines and animal models. With its ability to selectively target cancer cells, trifenofos holds great promise as a potential therapeutic agent for the treatment of various cancers.

Amlodipine besilate impurity A is a low-energy impurity that is formed in the crystallization process. It is an amide compound that has a hydrogen bond with crotonic acid and amlodipine, and can be found in acidic environments. The structural formula for this impurity is C8H14NO2S·C4H6O4·CH3OH.

1,8,15,22-Tetraazacyclononacosane-2,9,16,23-tetrone is a potent inhibitor of kinases that have been shown to be involved in the growth and survival of cancer cells. This compound was isolated from Chinese urine and has been found to induce apoptosis in cancer cells by inhibiting kinase activity. The analogs of this compound have been developed as anticancer agents due to their ability to inhibit cyclin-dependent kinases (CDKs) that are involved in cell cycle regulation. This inhibitor has shown promising results in preclinical studies for the treatment of various types of tumors, including breast cancer and lung cancer. It is a potential candidate for further development as an anticancer drug due to its high specificity towards human kinases and low toxicity towards healthy cells.

Desloratadine N-carboxylic acid methyl ester is an impurity in the drug product, Desloratadine. The chemical name for this impurity is desloratadine N-carboxylic acid methyl ester. This product can be found in the Metabolism studies section of our catalog under natural products. Desloratadine N-carboxylic acid methyl ester is a custom synthesis with a purity level of 99%. It is used as an analytical standard and has been shown to have similar retention times as the CAS No. 165740-03-4 reference standard.

Apitoxin is a natural toxin found in the venom of honeybees. Studies have shown that it has potential anti-cancer properties due to its ability to induce apoptosis, or programmed cell death, in human cancer cells. Additionally, apitoxin contains kinases that can inhibit tumor growth and glycerol analogs that have demonstrated anticancer activity in Chinese hamster ovary cells. Indirubin, a compound found in apitoxin, has been identified as a potent inhibitor of kinases involved in cancer cell proliferation. Apitoxin may also be useful as a urinary biomarker for detecting prostate cancer. Overall, the unique properties of apitoxin make it an intriguing candidate for further research into potential cancer treatments.