APIs per la ricerca e le impurità

N-Acetylsulfathiazole is a sulfa drug that acts as an inhibitor of bacterial growth. It reacts with sulfonic acids in the receptor molecule and forms hydrogen chloride, which inhibits bacterial growth by denaturing proteins. N-Acetylsulfathiazole has been shown to be effective against bacteria such as E. coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Staphylococcus aureus, Streptococcus pyogenes, and Salmonella enterica. This antibiotic binds to the active site of the enzyme dihydropteroate synthase and inhibits pyrimidine synthesis by competing with para-aminobenzoic acid (PABA) for binding sites on the enzyme. The formation of PABA is necessary for the synthesis of folic acid (vitamin B9). N-Acetylsulfathiazole is also used to treat vitamin B6 deficiency caused by

NUC-7738 is a medicinal compound that has been shown to be an effective inhibitor of cyclin-dependent kinases (CDKs). It has potent anticancer activity and has been studied extensively in Chinese hamster ovary (CHO) cells, human leukemia cells, and other cancer cell lines. NUC-7738 works by selectively inhibiting CDK4/6, which are critical regulators of the cell cycle. This leads to the induction of apoptosis in cancer cells, making it a promising new therapeutic agent for the treatment of various types of cancer. Additionally, NUC-7738 has been shown to have low toxicity and good pharmacokinetic properties in preclinical studies. Overall, this compound holds great promise as a novel anticancer therapy that may help improve outcomes for patients with cancer.

Please enquire for more information about Tadalafil spiro-urethane impurity (EP impurity F) including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 3,4-Difluoro-2-(trifluoromethyl)-benzenamine including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about Fenbufen-d9 including the price, delivery time and more detailed product information at the technical inquiry form on this page

(S)-4-(2-Methylpropyl)-2-pyrrolidinone is a lactam that has been synthesized in the laboratory. It is an organic solvent that is used in the synthesis of other compounds. The compound has a potential for producing impurities, such as isopropyl and phosphite, during synthesis. (S)-4-(2-Methylpropyl)-2-pyrrolidinone can be synthesized by reacting 2-methylpropionic acid with one equivalent of methylamine. This reaction takes place in an organic solvent and requires kinetic control to avoid side reactions.

Applications epi-Glycochenodeoxycholic Acid Sodium Salt-d7 is a labelled epimer analogue of Glycochenodeoxycholic Acid Sodium Salt (G641255), which is a bile salt formed in the liver from chenodeoxycholate and glycine. It acts as a detergent to solubilize fats for absorption and is itself absorbed. It is a cholagogue and choleretic.
References Ollila, F., et al.: Langmuir, 17, 7107 (2001); Uekama, K., et al.: Chem. Pharm. Bull., 52, 900 (2004); Tongiani, S., et al.: J. Pharm. Sci., 94, 2380 (2005);

Applications 3,5-Diiodo-4’-O-methyl Thyroacetic Acid Ethyl Ester is a derivative of 3,5-Diiodo Thyroacetic Acid (D455140), the acetic acid analog of Thyroxine (T425601). It is a reactant in the preparation of bifunctional thyrointegrin inhibitors, thyroxine (T425601) and triiodothyronine (T795380).
References Bridoux, A. et al.: J. Enz. Inh. Med. Chem., 26, 871 (2011); Wilkinson, J.: Biochem. J., 63, 601 (1956); Wilkinson, J.: Chem. Ind., 1352 (1955)

Please enquire for more information about Clopidogrel EP Impurity B hydrochloride including the price, delivery time and more detailed product information at the technical inquiry form on this page

Atorvastatin is a drug product with an impurity of atorvastatin cyclic sodium salt (isopropyl). The synthesis of this compound can be found in the natural and synthetic routes. Impurity standard is used to identify impurities in drugs and is necessary for pharmacopoeia, research and development, and analytical work. This compound has been shown to have high purity, analytical, metabolism studies, natural, drug development, and pharmacopoeia. CAS No. 1316291-19-6 is the impurity standard for this compound.

Please enquire for more information about Emtricitabine impurity 17 including the price, delivery time and more detailed product information at the technical inquiry form on this page

Amiodarone impurity E is a nucleophilic compound that is synthesized by the acylation of a diazonium salt with an amine. It has been shown to be active against staphylococci, but not against subtilis. The reaction may be catalyzed by acid or chloride. Amiodarone impurity E is also demethylated and dehydrated to form the final product, amiodarone.

3-Chloro-4-hydroxyacetanilide is a chemical compound that belongs to the class of acetanilides. It has long-term toxicity and is used as a drug substance in the production of aniline derivatives. 3-Chloro-4-hydroxyacetanilide has been shown to be carcinogenic in hamsters. The long term exposure to this chemical was shown to cause liver damage and increased incidence of tumours in rats. This drug also contains impurities and traces of chloride, chlorine, and thionyl chloride, which are toxic substances that can cause irritation or burns on contact with skin or eyes.

Pemetrexed is an antifolate drug that is used to treat cancer. It is a prodrug of pemetrexed disodium, which is converted to pemetrexed in the body by esterases. Pemetrexed is metabolized to its active form, D-pemetrexed, which inhibits DNA synthesis and the growth of cells by inhibiting thymidylate synthase. D-Pemetrexed hydrate is a high purity, pharmacopoeia grade impurity standard for use in research and development or as a custom synthesis. It has been shown to inhibit the growth of certain types of cancer cells and can be used in combination with other treatments such as chemotherapy or radiation therapy.

Sitagliptin monohydrochloride monohydrate is an inhibitor of dipeptidyl peptidase-4 (DPP-4), which is responsible for the degradation of incretin hormones. It is used in the treatment of type 2 diabetes mellitus, as it increases insulin secretion and reduces blood glucose levels. Recent studies have shown that Sitagliptin has anticancer properties, as it induces apoptosis in cancer cells. It also inhibits protein kinases, which are involved in tumor growth and metastasis. Capsaicin, a compound found in chili peppers, has been shown to enhance the anticancer activity of Sitagliptin in Chinese hamster ovary cells. The drug is excreted primarily through urine and has a low potential for drug interactions with other kinase inhibitors. Overall, Sitagliptin monohydrochloride monohydrate shows great promise as both a diabetes medication and an anticancer agent.

Apixaban Impurity 1 is an impurity found in Apixaban, a drug used for the prevention of stroke. It is produced by condensation of 2-aminopyridine and 3-hydroxybenzaldehyde in ethanol with sodium hydroxide as a catalyst. The reaction proceeds via amination of the pyridine ring followed by transesterification. The yield of this impurity is low at about 4%.

Amlodipine EP Impurity F maleate is an impurity of amlodipine, a drug product. It is a natural substance that has been classified as an API impurity in the United States Pharmacopeia (USP). The chemical name for this drug is 3-(2-chlorophenyl)-1-methyl-5-(o-tolyloxy)-2,4-dihydro-6H-[1,3]thiazolo[3,2-a]pyrimidin-7-one. Amlodipine EP Impurity F maleate has the following properties: C12H9ClNO2S and a melting point of 210°C with a purity of 99.5%. This compound was synthesized by custom synthesis and is used as an analytical standard for HPLC. This compound was also used during the development of amlodipine to determine its metabolism studies.

Simvastatin is a statin that reduces cholesterol synthesis by inhibiting the enzyme HMG-CoA reductase. Simvastatin is an amide, which is a derivative of the drug substance with a chloride group. It is commonly used in pharmaceutical formulations as an impurity in the synthesis of simvastatin. The presence of this impurity can be detected using chromatographic techniques, such as liquid chromatography and gas chromatography.

Dabigatran impurity E is a potent kinase inhibitor that has shown promising results in the field of cancer research. It is an analog of a Chinese medicinal herb that has been traditionally used to treat various ailments, including cancer. Dabigatran impurity E has been shown to induce apoptosis in human cancer cells by inhibiting the activity of specific kinases involved in cell replication and survival. This compound also exhibits anticancer properties by inhibiting the growth and proliferation of tumor cells. Additionally, Dabigatran impurity E has been found in urine samples from cancer patients, suggesting its potential as a biomarker for cancer diagnosis and monitoring. Overall, this compound holds great promise as a novel therapeutic agent for the treatment of various types of cancers.

N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-gamma-glutamyl-L-glutamic acid is used as a research and development purity standard. It is a white crystalline powder that is soluble in water and ethanol. N-[4-[2-(2Amino 4,7dihydro 4oxo 3Hpyrrolo 2,3d]pyrimidin 5yl)ethyl]benzoyl]-L gamma glutamyl L glutamic acid has CAS number 144051 68 3. The drug product is a synthetic compound with high purity. It has been shown to be an analytical reference substance for HPLC standards and to have niche applications in metabolism studies of other drugs.

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(24R)-Calcipotriene is a synthetic analog of calcitriol, the active form of vitamin D3. It is a proapoptotic agent that inhibits tumor growth by causing mitochondrial membrane potential collapse in cancer cells. (24R)-Calcipotriene has been shown to inhibit tumor growth in animals and human cells in vitro. This drug also potentiates the effects of other anticancer drugs such as doxorubicin and etoposide. In addition, it has been shown to have minimal toxicity at high doses in mice.

Lapatinib is a tyrosine kinase inhibitor that blocks the epidermal growth factor receptor (EGFR) and other tyrosine kinases. It is used in cancer treatment to inhibit tumor growth, with a high success rate. Lapatinib is also used to treat lung cancer and other types of cancer. The drug has been shown to inhibit EGFR phosphorylation in vitro, which leads to inhibition of cell proliferation and induction of apoptosis. Lapatinib also inhibits the expression of EGFR downstream target genes such as b-raf, serine/threonine-protein kinase, and cyp3a5.