APIs per la ricerca e le impurità
I principi attivi farmaceutici (API) sono le sostanze nei farmaci responsabili dei loro effetti terapeutici. In questa sezione troverai una vasta gamma di API destinati all'uso in ricerca. Questi composti sono essenziali per lo sviluppo, il test e la validazione di nuove formulazioni farmaceutiche. Presso CymitQuimica, offriamo API di alta qualità per supportare la ricerca nella scoperta e nello sviluppo di farmaci.
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Sar-[D-Phe8]-des-Arg9-bradykinin
CAS:Sar-[D-Phe8]-des-Arg9-bradykinin is a selective Bradykinin B1 receptor agonist that exhibits resistance to aminopeptidase cleavage. This peptide plays a crucial role in various physiological processes, including inflammation, pain perception, and angiogenesis. Sar-[D-Phe8]-des-Arg9-bradykinin has been shown to have potent hypotensive effects and can stimulate the release of prostaglandins and nitric oxide. It is resistant to endopeptidase cleavage, making it an ideal candidate for therapeutic applications. Additionally, this peptide has been found to possess antibacterial properties against certain bacteria strains. Sar-[D-Phe8]-des-Arg9-bradykinin is available in pure form with minimal impurities, ensuring its efficacy and safety for use in research and medical applications.Formula:C47H66N12O11Purezza:Min. 95%Peso molecolare:975.1 g/molClopidogrel EP Impurity B hydrochloride
CAS:Please enquire for more information about Clopidogrel EP Impurity B hydrochloride including the price, delivery time and more detailed product information at the technical inquiry form on this page
Formula:C16H16ClNO2S•HClPurezza:Min. 95%Peso molecolare:358.28 g/molPravastatin impurity A
CAS:Pravastatin impurity A is a synthetic impurity found in the drug product pravastatin. It is not listed as an impurity in the pharmacopoeia and has no CAS number assigned to it. This impurity is a yellow crystalline solid. It has been shown to be metabolized by cytochrome P450 3A4/5, CYP2C8, CYP2C9, and CYP3A4 isoforms with half-lives of 1.6 hours, 2.2 hours, 3.7 hours, and 6.1 hours respectively.Formula:C23H36O7Purezza:Min. 95%Peso molecolare:424.5 g/molPSI 7976
CAS:PSI 7976 is an analog of the nucleophilic attack drug, ribavirin. PSI 7976 inhibits the hepatitis C virus (HCV) replicon by inhibiting the function of the NS5B polymerase. In clinical studies, PSI 7976 has been shown to be active against HCV genotype 1 and 3. It has also been shown to inhibit replication of HIV-1 in vitro and to act synergistically with lamivudine against HIV-1 in human cells. PSI 7976 may be useful as a potential antiviral agent for treatment of other viral infections such as hepatitis B virus (HBV), herpes simplex virus type 2 (HSV-2), or cytomegalovirus (CMV).Formula:C22H29FN3O9PPurezza:Min. 95%Peso molecolare:529.45 g/molEmtricitabine carboxylic acid
CAS:Emtricitabine (FTC) is a synthetic nucleoside analog that is approved for the treatment of HIV infection. FTC is metabolized in the liver by cytochrome P450 enzymes into two metabolites, EMTR-diol and EMTR-triol. The pharmacopoeia defines impurity standards for both metabolites. FTC also causes metabolism studies to be conducted to determine its effect on other drugs such as cyclosporin and phenytoin. EMTR-diol: CAS No. 1238210-10-0 EMTR-triol: CAS No. 1238210-11-1Formula:C8H8FN3O4SPurezza:Min. 95%Peso molecolare:261.23 g/mol(3S,5S,6S)-Bupropion impurity
CAS:This is a drug product that has been developed for use in HPLC as a standard. It is a natural substance and is custom synthesized to meet the specific needs of research and development. It is an impurity standard that can be used for analytical purposes or pharmacopoeia, as well as metabolism studies. This compound is also available in high purity and at niche quantities to meet the needs of researchers who require it.Formula:C12H14ClNO3SPurezza:Min. 95%Peso molecolare:287.76 g/mol(R)-Sitagliptin rac-fumarate adduct
CAS:(R)-Sitagliptin rac-fumarate adduct is an analytical reference material and impurity standard. It is a natural product that is synthesized using a custom synthesis with analytical data available. The impurities of the synthetic process are well defined, with the exception of (1) an unknown peak at retention time 9.7 min and (2) a peak at retention time 12.5 min that may be due to the presence of fumaric acid or its derivatives. This product can be used for drug development research and development, as well as for establishing HPLC standards for pharmacopoeia testing.Formula:C20H19F6N5O5Purezza:Min. 95%Peso molecolare:523.40 g/molMitoxantrone (2-hydroxyethyl)piperazine impurity
CAS:Mitoxantrone is an anticancer drug that is used to treat various types of cancer. Mitoxantrone is a prodrug, which means it needs to be metabolized by the body to become active. The main metabolic pathway for mitoxantrone involves hydrolysis of the 2-hydroxyethyl piperazine impurity and formation of N-desmethylmitoxantrone, which is a metabolite that has been found to be more potent than the parent compound in inhibiting DNA synthesis. This impurity standard is used as a reference substance for quality control purposes during drug development. Mitoxantrone can also be synthesized with high purity and custom synthesis services are available upon request.Formula:C22H26N4O6Purezza:Min. 95%Colore e forma:Brown PowderPeso molecolare:442.47 g/molN-Desmethyl atracurium besylate
CAS:Please enquire for more information about N-Desmethyl atracurium besylate including the price, delivery time and more detailed product information at the technical inquiry form on this page
Formula:C58H74N2O15SPurezza:Min. 95%Peso molecolare:1,071.3 g/molOMDM-5
CAS:OMDM-5 is a potent vanilloid receptor type 1 (TRPV1, EC50 = 75 nM) agonist, showing weak ligand activity at cannabinoid type 1 receptor (CB1, Ki=4.9 μM).Formula:C26H44N2O3Purezza:99.73%Colore e forma:SolidPeso molecolare:432.64Ref: TM-T12306
1mg93,00€5mg177,00€10mg269,00€25mg429,00€50mg610,00€100mg820,00€200mg1.071,00€1mL*10mM (DMSO)210,00€Stigmastanol
CAS:Stigmastanol is a phytosterol isolated from Hypericum riparium, which is a Cameroonian medicinal plant.Formula:C29H52OPurezza:98.07%Colore e forma:SolidPeso molecolare:416.722,2',4,4',6,6'-Hexachlorobiphenyl
CAS:Prodotto controllato2,2',4,4',6,6'-Hexachlorobiphenyl (PCB-136) is a potent anticancer agent that has been shown to induce apoptosis in cancer cells. It acts as a kinase inhibitor by blocking the activity of specific kinases involved in tumor growth and progression. PCB-136 has been studied extensively in human and Chinese hamster ovary cells and has been found to be highly effective against various types of cancer. This medicinal analog also exhibits inhibitory effects on the protein kinases that regulate cell division and proliferation, making it a promising candidate for cancer therapy. In addition, PCB-136 shows potential for use as a urinary biomarker for exposure to environmental pollutants due to its persistence in the environment and ability to accumulate in body tissues.
Formula:C12H4Cl6Purezza:Min. 95%Peso molecolare:360.9 g/mol14-Hydroxy clarithromycin
CAS:14-Hydroxy clarithromycin is an analog of clarithromycin that has been shown to have anticancer properties. It is excreted in urine and has been found to inhibit several kinases, including cyclin-dependent kinases and protein kinase C. This drug induces apoptosis in cancer cells and inhibits tumor growth in Chinese hamsters. 14-Hydroxy clarithromycin has also been studied as a potential inhibitor of the human kinase, which may have implications for the development of new cancer therapies. Overall, this drug shows promise as an effective anticancer agent with potential for further research and development.Formula:C38H69NO13Purezza:Min. 95%Peso molecolare:748 g/molAnhydro abiraterone
CAS:Prodotto controllatoAnhydro abiraterone is a metabolite of abiraterone, which is a drug used in the treatment of prostate cancer. It has been shown to be active in the inhibition of human cytochrome P450 and has been found to be an impurity in commercial preparations of abiraterone. Anhydro abiraterone is almost insoluble in water, but can be purified by recrystallization from ethanol.Formula:C24H29NPurezza:Min. 95%Colore e forma:PowderPeso molecolare:331.49 g/molPidotimod diketopiperazine-6-propanoic acid
CAS:Pidotimod is an impurity in the drug product, which is a synthetic diketopiperazine-6-propanoic acid. Pidotimod is an impurity standard that is used in the development of drugs and as a pharmacopoeia. It has been shown to be metabolized by human liver microsomes and human erythrocytes.Formula:C9H12N2O4SPurezza:Min. 95%Peso molecolare:244.27 g/molChlorthalidone impurity E
CAS:Chlorthalidone impurity E is an analytical standard for the HPLC analysis of chlorthalidone in pharmaceutical drug products and is a metabolite of chlorthalidone. Chlorthalidone impurity E is an API impurity that can be found in the synthesis of chlorthalidone, and it has been detected as a minor component in certain drug products. It is important to have an accurate specification for this compound, since it can affect the pharmacological properties of the drug product. The purity level of this compound must be at least 98% or greater to ensure that there are no contaminants present. This compound is also a metabolite of chlorthalidone and is used as a pharmacopoeia reference substance for testing equipment calibration.END>
Formula:C14H11ClN2O3SPurezza:Min. 95%Peso molecolare:322.77 g/mol6-Oxo mometasone furoatemometasone furoate impurity F
CAS:6-Oxo mometasone furoatemometasone furoate impurity F is a drug product that is an impurity standard for the synthesis of 6-oxo mometasone furoatemometasone furoate. This impurity has been shown to have a metabolite profile similar to that of 6-oxo mometasone furoatemometasone furoate, but with a different retention time in HPLC analysis. It has also been shown to be present in natural products and to inhibit metabolism studies. This impurity should be used as an analytical standard for HPLC analysis of 6-oxo mometasone furoatemometasone furoate.Formula:C27H28Cl2O7Purezza:Min. 95%Peso molecolare:535.4 g/molAcarbose EP Impurity H
CAS:Acarbose EP Impurity H is an impurity of acarbose, a drug product used in the treatment of type II diabetes. Acarbose is a natural product and its synthesis starts from a chemical called alpha-D-glucopyranosyl-3-O-[2,4,6-trichloro-3-(trifluoromethyl)phenyl]pyridine. Acarbose is metabolized by the liver to form Acarbose EP Impurity H. The metabolism studies of this impurity have shown that it has niche pharmacological properties. Acarbose EP Impurity H can be used as an analytical or API impurity for HPLC standard or as a synthetic intermediate for pharmaceutical research and development.Formula:C25H43NO17Purezza:Min. 95%Peso molecolare:629.61 g/mol
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