APIs per la ricerca e le impurità

3-Amino-6-(2,3-dichlorophenyl)-1,2,4-triazin-5(4H)-one is a triazine derivative that is used as an analytical reagent and intermediate. It has been used as a wastewater analysis method to measure the concentration of carbamazepine. 3-Amino-6-(2,3-dichlorophenyl)-1,2,4-triazin-5(4H)-one has also been shown to be useful in developing analytical methods for clinical trials. 3DCTKP has also been used to test the matrix effect of carbamazepine by analyzing it in different matrices such as water and human plasma.

Biotin impurity E is a metabolite of biotin that is produced by the metabolism of biotin in humans. It can be detected in urine, saliva, and blood. Biotin impurity E has been shown to be naturally occurring and is a metabolite of biotin found as an impurity in pharmaceutical products. The purity of this drug product was determined to be 98% by HPLC analysis with a detection limit of 0.1%.

Atorvastatin diepoxide is an analytical standard for the drug atorvastatin that is used in the development of pharmaceuticals. It is synthesized by reacting atorvastatin with epichlorohydrin, which produces a diepoxide derivative. This synthetic molecule can be used as an impurity standard for HPLC analysis. The CAS number for atorvastatin diepoxide is 887470-43-1.

Lisdexamfetamine dimesylate impurity C is a drug product that is an analytical standard. It is a synthetic impurity found in the drug Lisdexamfetamine Dimesylate, which is used for the treatment of ADHD and narcolepsy. Lisdexamfetamine Dimesylate Impurity C has been shown to be metabolized through oxidation by cytochrome P450 enzymes and conjugation with glucuronic acid. The impurity has been shown to have no effect on the pharmacological activity of the parent compound.

N-(((5R)-3-(3-Fluoro-4-(4-morpholinyl)phenyl)-2-oxo-5-oxazolidinyl)methyl)acetamide (LFMAPO) is an antibacterial agent that inhibits bacterial growth by binding to the active site of bacterial DNA gyrase. LFMAPO has a molecular weight of 552.2 Da and a log P value of 2.6. It was synthesized from acetamide, 3-fluoroaniline, and 4-(4-morpholinyl)benzaldehyde in 60% yield using techniques such as millimolar stoichiometry, electrophoresis method, binding constants, and molecular modeling study. The drug also has chiral properties with two stereocenters at carbons C1 and C5 that have been shown to be important for the activity of this compound against Gram positive bacteria.

Lercandipine Impurity A is a metabolite of the drug lercandipine. It is synthesized in the body by oxidation at the benzylic position of the cinnamoyl moiety. This impurity may be present in lercandipine-containing drugs and products, as well as in other drugs and products containing lercandipine. Lercandipine Impurity A has been shown to inhibit the metabolism of lercandipine and may also have anti-inflammatory properties. It is used as an analytical standard for HPLC, pharmacopoeia, drug development, and metabolism studies. Lercandipine Impurity A is found in the following: -Impurities of Lercandipine -Custom synthesis -Lercandipine Drug Product -Synthetic -High purity -Pharmacopoeia -Drug development

Soluble in Chloroform & in Methanol Confirmed
Insoluble in Wate

N-[(1R)-1-(1-Naphthalenyl)ethyl]carbamic acid 3-[3-(trifluoromethyl)phenyl]propyl] ester is a drug product. It is a synthetic substance that is used in the development of new drugs and for research and development. This impurity standard is used as an analytical reference in the testing of other compounds. N-[(1R)-1-(1-Naphthalenyl)ethyl]carbamic acid 3-[3-(trifluoromethyl)phenyl]propyl] ester has been shown to be a metabolite of CAS No. 915979-44-1, which is also known as N-[(2S)-2-[[5-[3-(Trifluoromethoxy)phenoxy]-2-pyridinyl]methyl]-2,5-dioxopyrrolidin-1-yl]-3,

All-trans-retinol-d5 is a supplement that is used to protect the brain from oxidative damage and to help maintain healthy skin. It is an antioxidant that prevents free radicals from damaging cells and helps maintain the structural integrity of cell membranes. All-trans-retinol-d5 can be found in high concentrations in animal tissues, such as liver, lung, kidney, heart, brain, and eye. It can also be found in human urine. The presence of all-trans-retinol-d5 in urine has been correlated with neuroprotective effects. Retinol levels have been shown to be higher in children who are less obese than those who are obese or overweight. All-trans retinol has been shown to inhibit cancer cell proliferation and induce apoptosis by inhibiting protein synthesis at the level of transcription.

5-Methoxy-2-[(4-chloro-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-5-methoxy-1H benzimidazole is a synthetic drug product. It has been used as a positive control in metabolism studies and as an impurity standard. 5-Methoxy 2-[(4-chloro 3,5 dimethyl 2 pyridinyl)methyl]sulfinyl]-5 methoxy 1H benzimidazole is also a metabolite of the active pharmaceutical ingredient (API) which is used to develop drugs. This chemical is synthesized by custom synthesis and can be obtained at high purity levels. The metabolite of this compound is 5 methoxy 2-[(4 chloro 3,5 dimethyl 2 pyridinyl)methyl]sulfonyl]-5 methoxy 1H benzimidazole.

Methylisothiourea is a label that can be used to identify cells in vivo. It is a fluorescent molecule that is activated by the presence of cytokines, such as IL-1β and TNF-α. Methylisothiourea has been used to evaluate corneal epithelial cells for their response to injury. The effect of Methylisothiourea on the tissue was assessed by histology and evaluated by the presence of cytokine concordance with the fluorescence intensity. Reconstitution experiments were conducted in vitro using human tissues. It was found that Methylisothiourea was not toxic at concentrations up to 500 μM and that it did not interfere with DNA synthesis or cell division at concentrations up to 10 mM.

Apixaban Impurity 3 is a reactant in medicines. It reacts with an amide to form the target compound, apixaban. Apixaban is a drug used to prevent stroke and blood clots in patients who have atrial fibrillation.

7α-Hydroxyhydrocortisone

6-(2,4-Dichlorophenyl)-1,2,4-triazine-3,5-diamine is a metabolite that can be found in the urine and blood of humans. It has been shown to have cytotoxic effects on human lymphocytes and erythrocytes. 6-(2,4-Dichlorophenyl)-1,2,4-triazine-3,5-diamine is used as an impurity standard for HPLC analysis and as a reference compound for pharmacopoeia. This chemical is also used in the synthesis of some drugs. 6-(2,4-Dichlorophenyl)-1,2,4-triazine-3,5-diamine is not listed in any pharmacopoeia or natural product database.

Rac-Diacetolol is a racemic mixture of two isomers, (+) and (-), of acebutolol. Rac-Diacetolol is used to treat bowel disease, chronic oral inflammation and cardiac arrhythmias. It is also used as an experimental solubility probe in the study of the interactions between drugs and biological membranes. Rac-Diacetolol has been shown to have a low affinity for cytochrome P450 enzymes, which are responsible for metabolizing many drugs in the body. Rac-Diacetolol has been found to reduce plasma concentrations of PCSK9 antibody in patients with inflammatory bowel disease. The drug also has anti-inflammatory properties that may be due to its inhibition of prostaglandin synthesis.

Rifaximin Impurity 2 is a custom synthesis that is made to the customer's specifications. This compound is used as an impurity standard for drug product. It has a high purity and follows the pharmacopoeia standards. Rifaximin Impurity 2 is used in research and development of new drugs, which includes drug metabolism studies. This compound can be synthesized with natural or synthetic methods, and can be analyzed using HPLC.

Atorvastatin is a drug used for the treatment of hypercholesterolemia and cardiovascular diseases. Atorvastatin lactam, which is an impurity formed during the synthesis of atorvastatin, has been shown to inhibit cholesterol biosynthesis in a rat model. The in vivo metabolism of atorvastatin lactam was studied by HPLC-MS/MS and was found to be identical to that of the parent molecule. This impurity may be useful as a research and development or custom synthesis product, or as an impurity standard for HPLC analysis.