APIs per la ricerca e le impurità

Applications Labelled Lamivudine Acid (L172490). Lamivudine Acid is an impurity of Lamivudine (L172500). Labelled Impurity A per European Pharmacopoeia.
References Dwyer, O., et al.: Synlett, 11, 1163 (1995),

Applications N,​N-​Diethylethanol-1,1,2,2-d4-amine is deuterium labelled of 2-diethylaminoethanol, which is an inactive metabolite of 2-Chloroprocaine (HCl: C380265) and commonly used for epidural analgesia in obstetrics. It is also hypothesized to cause onset-asthma to humans following brief exposure. 2-Diethylaminoethanol also has the ability to inhibit growth of tomato roots.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Boll, W.: Science, 129, 330 (1959); Cornish, H.: Am. Ind. Hyg. Assoc. J., 26, 479 (1965); Foldes, F. & McNall, P.: Anasthesiology, 13, 287 (1952); Reisner, L., et al.: Anast. Analg., 59, 452 (1980)

Applications 3,4-Difluoroaniline-2,6-d2 (CAS# 1061566-62-8) can be used in its derivative form as an antiviral agent for Hepatitis B.
References Qiu, Y.L., et.al., U.S. Pat. Appl. Publ., 187,(2019);

Stability Moisture and Temperature Sensitive
Applications (R,S)-Equol 4’-Sulfate is a sulfated metabolite of isoflavone Daidzein (D103500).
References Heinonen, S., et al.: Anal. Biochem., 274, 211 (1999), Setchell, K., et al.: J. Nutr., 132, 3577 (2002), Thigpen, J., et al.: Comp. Med., 53, 607 (2003), Yee, S., et al.: Food Chem. Toxicol., 46, 2713 (2008),

Applications Deferoxamine Trifluoroacetic Acid Salt is an iron chelating agent used in therapy for patients with sickle cell diseases and iron overload. Studies suggest that it can exert potential antioxidant neuroprotective effects in stroke patients.
References Inati, A. et al.: Am. J. Hematol., 85, 782 (2010); Selim, M.: Translat. Stroke Res., 1, 35 (2010); Cappellini, M.D. et al.: Hemoblobin, 33, 258 (2009)

Applications 4-Pregnen-17alpha,21-diol-3,20-dione-21,21-d2 (CAS# 1271728-08-5) is a useful isotopically labeled research compound.

Applications Maintains anti-proliferative activity against human malignant cell strains.
References Pratsinis, H. et al.: J. Med. Food, 13, 286 (2010);

Applications 20β-Dihydro Pregnenolone is a metabolite of Pregnenolone (P712200).
References Purdy, R., et al.: J. Med. Chem., 33, 1572 (1990), Bixo, M., et al.: Brain Res., 764, 173 (1997), Huang, X., et al.: J. Biol. Chem., 275, 29452 (2000),

Applications 4-Piperidine-d9-carboxylic Acid (CAS# 1219798-43-2) is a useful isotopically labeled research compound.

Applications Ethyl-d5 4-Aminobenzoate (CAS# 1219803-76-5) is a useful isotopically labeled research compound.

Applications Neopatulin is a mycotoxic substance which is produced by Penicillium and Aspergillus species. The molecule possesses useful antibiotic and antibacterial properties, but it is also an unwelcome contaminant in food and a general plant toxin.
References Ellis, J.R., et al.: Appl. Microbiol., 25, 562 (1973), Priest, J.W., et al.: Biochemistry, 28,  9192 (1989),

Stability Light Sensitive
Applications Crotamiton is an anti-parasitic agent. Crotamiton is used both as a scabicidal (for treating scabies) and as a general antipruritic.
References Buffet, M. et al.: Fund. Clin. Pharmacol., 17, 217 (2003); Lemke, T.L.: Foye’s Prin. Med. Chem., 6, 1084 (2008); Dika, E. et al.: Cutan. Ocular Toxicol., 25, 211 (2006);

Applications Methyl Benzoate-2,3,4,5,6-d5 (CAS# 68661-19-8) is a useful isotopically labeled research compound.

Applications Butachlor ESA Sodium Salt (cas# 1173022-75-7) is a compound useful in organic synthesis.

Applications 2-(Hydroxymethyl)-2-(methoxymethyl)quinuclidin-3-one is a small molecule that has shown promising preclinical activity in various cancer types. 2-(Hydroxymethyl)-2-(methoxymethyl)quinuclidin-3-one shows antitumor activity in multiple myeloma by induction of p73 and Noxa.
References Saha, M.N., et. al.: Mol. Cancer Ther., 12, 2331 (2013); Aryee, D.N.T., et. al.: Brit. J. Cancer, 109, 2696 (2013)

Applications 2-Desmethylene-2-hydroxymethyl Ethacrynic Acid is a degradation product of Ethacrynic Acid (E676000), a diuretic used to treat high blood pressure and swelling caused by congestive heart failure, liver failure and kidney failure.
References Yarwood, R. J., et. al.: J. Pharmaceut. Sci., 74, 220 (1985); Beyer, et al.: J. Pharmacol. Exp. Ther., 147, 1 (1965); Kim., et al.: Am. J. Cardiol., 27, 407 (1971); Williamson, H.E., et al.: J. Clin. Pharmacol., 17, 663 (1977)

Applications [18O] Cholesterol can be used as a practical tracer for studies of cholesterol metabolism in humans.
References Hudgins, L.C., et al.: Biomed. Environ. Mass Spect., 17, 463 (1988),

Applications Dl-Metanephrine:Hcl (A,B,B-D3, 98%) (cas# 1085333-94-3) is a useful research chemical.

Applications Anti-inflammatory agent.
References Jeong, G. et al.; Eur. J. Pharmacol. 644, 230 (2010); Washiyama, M. et al.; Biol. Pharm. Bull. 32, 941 (2009)

Applications 5-​(4-Fluorophenyl)​-​4,​5-​dihydro-​4-​methyl-2-​oxazolamine is a derivative of Aminorex (A629200), an anorectic stimulant drug of the 2-amino-5-aryl oxazoline class. Aminorex has been shown to have locomotor stimulant effects similar to Methamphetamine (M258795).
References Poos, G., et al.: J. Med. Chem., 6, 266 (1963), Watson, A., et al.: Res. Vet. Sci., 45, 411 (1988), Russell, B., et al.: Pharmacol. Biochem. Behav., 51, 375 (1995),

Applications An intermediate in the preparation of HIV-integrase inhibitors
References Summa, V., et al.: J. Med. Chem., 51, 5843 (2008),

Applications 2-Chloro-2’,3’-O-isopropylideneadenosine-5’-N-ethylcarboxamide is a potent and selective adenosine receptor agonist (1). It is also used to prepare photoreactive 2-​phenethylamine derivatives (2).
References (1) Hutchison, A.J., et al.: J. Med. Chem., 33, 1919 (1990)(2) Murai, Y., et al.: Eur. J. Org. Chem 2013, 2428 (2013)

Stability Light and Moisture Sensitive
Applications A photoaffinity reagent.
References Hatanaka, Y. et al: Bioorg. Med. Chem., 2, 1367 (1994); Hatanaka, Y. et al: J. Org. Chem., 59, 383 (1994); Hatanaka, Y. et al: Bioorg. Med. Chem. 2, 1367 (1994)