APIs per la ricerca e le impurità

Applications Methyl 2-cyanobenzoate

Applications A metabolite of Alpidem.
References Padovani, P., et al.: Eur. J. Drug Metab. Pharmacokinetics, 12, 295 (1987).

Applications Saroglitazar, is a drug for the treatment of diabetic dyslipidemia and hypertriglyceridemia with Type 2 diabetes mellitus not controlled by statin therapy. Its trade name is Lipaglyn. It is also a 1,2-Diarylpyrroles derivative, which can be used in the preparation of Nonsteroidal anti-inflammatory drugs (NSAIDs).
References Khanna, I. K., et al.: J. Med. Chem., 40, 1619 (1997);

Applications An intermediate in the syntheis of a metabolite of the anti-cancer drug Tamoxifen.

Applications 2-(Hydroxymethyl)-2-(methoxymethyl)quinuclidin-3-one is a small molecule that has shown promising preclinical activity in various cancer types. 2-(Hydroxymethyl)-2-(methoxymethyl)quinuclidin-3-one shows antitumor activity in multiple myeloma by induction of p73 and Noxa.
References Saha, M.N., et. al.: Mol. Cancer Ther., 12, 2331 (2013); Aryee, D.N.T., et. al.: Brit. J. Cancer, 109, 2696 (2013)

Applications N-​(3-​Dibenzofuranyl)-​5-​nitro-2-​furancarboxamide is synthesized from Dibenzo[b,d]furan-3-amine (D418205), which is a building block used as a reactant in the preparation of dibenzofuryl(phosphonomethyl)alanines as endothelin converting enzyme inhibitors.
References De Lombaert, S., et al.: J. Med. Chem., 43, 488 (2000);

Applications Steroidal fused pyrazoles useful as bile acid transporters.
References Bhat, L. et al.; Bioorgan. Med. Chem. 15, 85 (2005)

Stability Moisture Sensitive, Temperature Sensitive
Applications Tetraisopropyl Dichloromethylene Diphosphonate is an intermediate in the sythesis of Clodronic Acid, Disodium Salt, Tetrahydrate, a biphosphonate bone resorption inhibitor.

Applications 2-Des(5-methyl-1,3,4-oxadiazole-2-carboxamide) (E)-2-(N,N-Dimethylformimidamide) Raltegravir is an impurity of Raltegravir (R100300), a potent human immunodeficiency virus (HIV) integrase inhibitor. A novel anti-AIDS drug.
References Wade, K., et al.: J. Pharmacol. Biomed. Anal., 8, 401 (1990), Hazuda, D., et al.: Science, 287, 646 (2000), Williams, J., et al.: Drug Metab. Dispos., 32, 1201 (2004), Duckett, C., et al.: Xenobiotica, 36, 59 (2006), Miners, J., et al.: Biochem. Pharmacol., 71, 1531 (2006), Summa, V., et al.: J. Med. Chem., 49, 6646 (2006),

Applications A metabolite of Ethacrynic Acid (E676000) that is a potent inhibitor of sodium-potassium-chloride cotransporter and bumetanide binding. Also an inhibitor of human hepatic glutathione S-transferase isozymes.
References Palfrey, H. et al.: Am. J. Physiol., 264, C1270 (1993); Klaassen, C.D. et al.: J. Pharmacol. Exp. Therap., 191, 548(1974); Takamatsu, Y. et al.: Toxicol. Lett., 62, 241 (1992);

Applications 4-Pregnen-11beta,17alpha-diol-3,20-dione-2,2,4,6,6,21,21,21-d8 is a useful isotopically labeled compound of 21-Deoxy Cortisol (D232605)

Applications 6β-Naltrexol Hydrochloride is a neutral opioid antagonist that has shown minimal withdrawal symptoms in patient with opioid-dependence.
References J. Addict. Res. Ther., 2, 108 (2011)

Applications L-Iditol Hexaacetate (cas# 13443-46-4) is a compound useful in organic synthesis.

Applications A useful deuterated synthetic intermediate.

Applications A metabolite of Rosiglitazone.The ratio of the diastereomers will be quite variable due to the acidic proton at one chiral centre.
References Balton, G.C., et al.: Xenobiotica, 26, 6, 627 (1996),

Applications 5,7-Dichloroimidazo[1,2-a]pyrimidine (cas# 57473-32-2) is a compound useful in organic synthesis.

Applications 3-Chloro-4-nitrophenol was used as a reactant in the synthetic preparation of highly potent BTK and JAK3 dual inhibitors and it may also have antifungal activity.
References Ge, Yang, et al.: Euro. J. of Med. Chem., 143, 1847-1857 (2018); Gershon, H., et al.: Monatshefte fuer Chemie, 126(10), 1161-6  (1995)

Applications Used in the preparation of Clotiazepam (C587410) and thienylamide derivatives as cholecystokinin inhibitors.

Stability Air Sensitive, Temperature Sensitive
Applications 6-Hydroxy-N-demethyldimethidene is a metabolite of the antihistaminic drug dimethindene.
References Rudolf, J., Blaschke, G.: Enantiomer, 4, 317 (1999)

Applications Nim-Trityl-D-histidine is used as a reagent in solid-phase synthesis and screening of peptides as catalysts for asymmetric induction of desymmetrization of bis(phenol)s.
References Lewis, C. A., et al.: J. Am. Chem. Soc., 130, 16358 (2008); Keith, J., et al.: Adv. Synth. Catal, 5, 343 (2001)

Applications 20β-Dihydro Pregnenolone is a metabolite of Pregnenolone (P712200).
References Purdy, R., et al.: J. Med. Chem., 33, 1572 (1990), Bixo, M., et al.: Brain Res., 764, 173 (1997), Huang, X., et al.: J. Biol. Chem., 275, 29452 (2000),

Applications [18O] Cholesterol can be used as a practical tracer for studies of cholesterol metabolism in humans.
References Hudgins, L.C., et al.: Biomed. Environ. Mass Spect., 17, 463 (1988),

Applications 17beta-Dihydroequilin-2,4,16,16,17-d5 is a useful isotopically labeled compound of 17β-Dihydro Equilin (D449130)

Applications Intermediate in the preparation of Tyrosine Kinase Inhibitors.
References Schroeder, M., et al.: J. Med. Chem., 44, 1915 (2001), Nandi, S., et al.: J. Enz. Inhibit. Med. Chem., 24, 937 (2009),

Applications Simvastatin-d11 (2,2-dimethylbutyrate-d11) (CAS# 1002347-74-1) can be used to treat hypercholesterolemia and heart disease. This compound can also be used to treat various diseases by preparing it as HMG-CoA reductase inhibitor.
References Czarnik, A., U.S Pat.Appl.Publ., 8,(2008); Gant, T., et.al., PCT Int.Appl.,88,(2008);

Applications Methyl Benzoate-2,3,4,5,6-d5 (CAS# 68661-19-8) is a useful isotopically labeled research compound.

Applications 2-(1-Hydroxypropyl)promazine is a metabolite of propionylpromazine (P827500).
References Park, J. et al.: J. Chrom. Biomed. Appl., 489, 313 (1989);

Applications A compound closely related to Enterolactone (E558950). A metabolite of sesame lignans (sesamin, sesamolin). Inhibits colonic cancer cell growth by inducing cell cycle arrest and apoptosis. Possible relationship between exposure and reduced risk of breast cancer.
References Hirano, T. et al.: Res. Com. Chem. Path. Pharmac., 64, 227 (1989); Ayella, A. et al.: Nut. Res., 30, 762 (2010); Pianjing, P. et al.: J. Agric. Food Chem., 59, 212 (2011); Buck, K. et al.: Am. J. Clinic. Nut., 92, 141 (2010);

Applications A possible metabolite of Ranolazine (R122500).

Applications Fluoro 2-Deoxy-2-fluoro-3,4,6-tri-O-acetyl-D-glucose (cas# 86786-39-2) is a compound useful in organic synthesis.

Applications Ethyl-d5 4-Aminobenzoate (CAS# 1219803-76-5) is a useful isotopically labeled research compound.

Applications N,​N-​Diethylethanol-1,1,2,2-d4-amine is deuterium labelled of 2-diethylaminoethanol, which is an inactive metabolite of 2-Chloroprocaine (HCl: C380265) and commonly used for epidural analgesia in obstetrics. It is also hypothesized to cause onset-asthma to humans following brief exposure. 2-Diethylaminoethanol also has the ability to inhibit growth of tomato roots.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Boll, W.: Science, 129, 330 (1959); Cornish, H.: Am. Ind. Hyg. Assoc. J., 26, 479 (1965); Foldes, F. & McNall, P.: Anasthesiology, 13, 287 (1952); Reisner, L., et al.: Anast. Analg., 59, 452 (1980)

Applications 7-Benzyloxy-N-des[[2-(2-hydroxy)ethoxy]ethyl] Quetiapine (cas# 1076198-97-4) is a compound useful in organic synthesis.

Stability Moisture and Temperature Sensitive
Applications (R,S)-Equol 4’-Sulfate is a sulfated metabolite of isoflavone Daidzein (D103500).
References Heinonen, S., et al.: Anal. Biochem., 274, 211 (1999), Setchell, K., et al.: J. Nutr., 132, 3577 (2002), Thigpen, J., et al.: Comp. Med., 53, 607 (2003), Yee, S., et al.: Food Chem. Toxicol., 46, 2713 (2008),

Applications Dotinurad is a useful drug for treating hyperuricemia and gout.
References Xu, X.: Faming Zhuanli Shenqing (2020), CN 111675675 A

Stability Hygroscopic
Applications The hydrochloride salt of AZ 5104 (A795170), which is a derivative of AZD 9291 (A808075) and a selective EGFR inhibitor (epidermal growth factor receptor), used in the treatments of nonsmall-cell lung cancer (NSCLC).
References Finlay, M.R.V., et al.: J. Med. Chem., 57, 8249 (2014);

Stability Hygroscopic
Applications Antihypertensive; antiglaucoma
References Al-Shora, H., et al.: Int. J. Pharm., 47, 209 (1988), Golander, Y., et al.: J. Pharm. Sci., 77, 902 (1988),

Applications A MTS amino acid derivative.

Applications A quinazoline derivative use for modulating serine/threonine protein kinase function; antitumor and anti-fibrotic agents.
References Harris, N., et al.: J. Med. Chem., 33, 434 (1990), Chan, J., et al.: J. Med. Chem., 38, 3608 (1995), Rafi, I., et al.: Clin. Cancer Res., 1, 1275 (1995),

Applications Dl-Metanephrine:Hcl (A,B,B-D3, 98%) (cas# 1085333-94-3) is a useful research chemical.

Applications 4-Pregnen-17alpha,21-diol-3,20-dione-21,21-d2 (CAS# 1271728-08-5) is a useful isotopically labeled research compound.

Applications 2-(Diphenylphosphoryl)acetic acid (cas# 1831-63-6) is a useful research chemical.

Applications (L)-Suberyl Carnitine Trifluoroacetic Acid Salt is a metabolite of L-Carnitine (C184110).
References Millington, D., et al.: J. Inherit. Metab. Dis., 13, 321 (1990), Chace, D., et al.: Clin. Chem., 49, 1797 (2003),

Applications Fmoc-(4-carboxymethyl)piperazine

Applications 4-Piperidine-d9-carboxylic Acid (CAS# 1219798-43-2) is a useful isotopically labeled research compound.

Applications An intermediate in the preparation of HIV-integrase inhibitors
References Summa, V., et al.: J. Med. Chem., 51, 5843 (2008),

Stability Light Sensitive
Applications Crotamiton is an anti-parasitic agent. Crotamiton is used both as a scabicidal (for treating scabies) and as a general antipruritic.
References Buffet, M. et al.: Fund. Clin. Pharmacol., 17, 217 (2003); Lemke, T.L.: Foye’s Prin. Med. Chem., 6, 1084 (2008); Dika, E. et al.: Cutan. Ocular Toxicol., 25, 211 (2006);

Applications 5-​(4-Fluorophenyl)​-​4,​5-​dihydro-​4-​methyl-2-​oxazolamine is a derivative of Aminorex (A629200), an anorectic stimulant drug of the 2-amino-5-aryl oxazoline class. Aminorex has been shown to have locomotor stimulant effects similar to Methamphetamine (M258795).
References Poos, G., et al.: J. Med. Chem., 6, 266 (1963), Watson, A., et al.: Res. Vet. Sci., 45, 411 (1988), Russell, B., et al.: Pharmacol. Biochem. Behav., 51, 375 (1995),

Applications Labelled 2,4-Di-tert-butylphenol (D429475). A chemical constituent of volatile oils from Catunaregam spinosa fruits.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References amaguchi, S., et al.: J. Food Sci., 36, 846 (1971); Ajlouni, S., et al.: Food Flavors, 1865 (1995); Mau, J., et al.: J. Agric. Food Chem., 45, 4726 (1997);

Applications 1,3-Dihydro-N-nitro-1,3-dioxo-2H-isoindole-2-carboximidothioic acid Methyl Ester is an intermediate in the synthesis of Dinoteturan (D482100), a neonicotinoid insecticide.
References Wakita, T., et al.: J. Pesticide. Sci., 29, 348 (2004);

Stability Moisture Sensitive
Applications rac-1,2-Dioctanoyl-3-Chloropropanediol was studied for its ability to act as an inhibitor of protein kinase C.
References Briggs, Josie C., et al.: Carbohydrate Res., 234, 23-35 (1992)

Apigenin 5-o-β-D-glucuronide is a natural compound derived from the Chinese herb scutellaria baicalensis. It has been shown to be effective in reducing pro-inflammatory cytokines and prostate cancer cells. Apigenin 5-o-β-D-glucuronide is one of the many phenolic acids found in plants, which are known for their antioxidant and anti inflammatory properties. The plant metabolizes apigenin 5-o-β-D-glucuronide by conjugating it with glucuronic acid, forming the glucuronide conjugate. The bioactive phenolic compounds in plants are well studied and have been shown to have anticancer properties.

Epinephrine sulfonic acid-d3 is a synthetic, high purity, pharmacopoeia, drug development, analytical standard. It is used as an impurity standard, and in the synthesis of epinephrine sulfone. Epinephrine sulfonic acid-d3 has been shown to be a metabolite of epinephrine and its metabolites. This product has been synthesized and characterized by HPLC analysis using an ion-pairing agent and a gradient elution with water:acetonitrile (0.1% formic acid) (75:25).

Gomphrenin I is an analog of a human protein that has been found to have potent anticancer properties. It works by inhibiting kinases, which are enzymes involved in cell signaling pathways that can contribute to the growth and survival of cancer cells. Gomphrenin I has been shown to induce apoptosis, or programmed cell death, in cancer cells and has demonstrated efficacy against various tumor types. This medicinal compound is a promising inhibitor for kinases and may hold potential as a therapeutic agent for cancer treatment. Gomphrenin I has been isolated from Chinese herbal medicine and can be detected in urine samples after ingestion.

(aR)-a-Methyl-N-[3-[4-(trifluoromethyl)phenyl]propyl]-1-naphthalenemethanamine is a synthetic drug product that is used in research and development. It has been shown to have an analytical purity of 99.8%.

Bisnonyl dimethyl ammonium chloride (BDAC) is an inorganic, modifying agent that is used as a catalyst for organic reactions. It has been shown to be a selective and stable surface modifier for the modification of ionic liquids. BDAC has also been utilized as a high-selectivity substance in the synthesis of cyclic hydrocarbons and phosphonium salts. BDAC is also used as a solid catalyst for the production of high yields of organophosphines and other nitrogen-containing compounds.