APIs per la ricerca e le impurità

2-Aminoethyl-amino palbociclib is a versatile compound used in various industrial applications. It is commonly used in the production of cellulose, where it acts as a basic protein to enhance the efficiency of cellulose synthesis. Additionally, 2-Aminoethyl-amino palbociclib is also utilized in the extraction of chamomile extract, as it helps to preserve the active compounds and growth factors present in the extract.

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Teopranitol is a potent inhibitor of kinases, which are enzymes that play a critical role in cellular signaling pathways. It belongs to the class of protein kinase inhibitors and has been shown to have inhibitory activity against a wide range of kinases. Teopranitol has been tested on various cell lines, including human cancer cells and Chinese medicine-derived cell lines. It has been found to be effective in inhibiting the growth of mutant cancer cells by blocking the activity of specific kinases. This inhibitor shows promise as a potential treatment for cancer and tumors due to its ability to target specific pathways involved in cancer progression.

4-Epi-dolutegravir is the active metabolite of dolutegravir. It is a synthetic, high purity API that is used as an analytical reference standard and a drug product for research and development purposes. The CAS number for 4-epi-dolutegravir is 1357289-37-2. 4-Epi-dolutegravir has been shown to have similar pharmacological properties to its parent compound, dolutegravir. Metabolism studies have demonstrated that the major route of elimination for 4-epi-dolutegravir is through urinary excretion.

3-(Benzyloxy)-5-nitrobenzoic acid is a benzimidazole derivative that is synthesized in three steps. It can be formed by reacting potassium chloride, formic acid and 3-hydroxy-5-nitrobenzoic acid. The reaction yields are dependent on the concentration of the reactants. The isomeric mixture can be separated by distillation into two fractions; one fraction contains the desired product and the other fraction contains the undesired product. This compound has been shown to have antibacterial activity against both Gram-positive and Gram-negative bacteria, as well as antifungal activity against Candida albicans. 3-(Benzyloxy)-5-nitrobenzoic acid binds to ribosomes of bacteria, inhibiting protein synthesis by preventing peptide bond formation between amino acids. This compound also reacts with sulfate ion to produce sulfate ester, which inhibits bacterial growth by disrupting membrane integrity.

2,2',3,3'-Tetrachlorobiphenyl is an inhibitor that has been shown to have anticancer properties. It inhibits the growth of tumor cells by blocking the activity of protein kinases, which are enzymes that regulate cell division and proliferation. This compound has been tested in Chinese hamster ovary cells and has been found to induce apoptosis in cancer cells. Additionally, 2,2',3,3'-Tetrachlorobiphenyl has analog inhibitors that have been tested in human urine samples and have shown potential as anticancer agents. These analogs inhibit cyclin-dependent kinases (CDKs), which play a crucial role in regulating the cell cycle. The inhibition of CDKs leads to the suppression of cancer cell growth and division, making this compound a promising candidate for future cancer treatments.

Taxine A is a potent inhibitor of kinases that has been isolated from the Chinese yew tree. It has shown promising results in inhibiting the growth of cancer cells and inducing apoptosis. Taxine A exhibits a unique mechanism of action by binding to a specific site on the kinase, which prevents its activation and subsequent downstream signaling. This analog of linezolid has been shown to have potent anticancer activity against various tumor cell lines, including human breast cancer and lung cancer. Taxine A is also excreted in urine, making it an attractive candidate for non-invasive diagnostic tests for cancer. Its ability to inhibit kinases makes it a potential therapeutic agent for a wide range of cancers.

GSK-2793660 is a potent and selective analog of a human protein kinase inhibitor that has been shown to induce apoptosis in cancer cells. It is a medicinal compound that inhibits the activity of kinases, which are enzymes involved in cell signaling pathways. GSK-2793660 has demonstrated anticancer activity in preclinical studies, particularly against Chinese hamster ovary (CHO) tumor models. This inhibitor has also been found in urine samples from cancer patients, indicating its potential as a diagnostic tool for cancer. Its ability to selectively target specific kinases makes it a promising candidate for the development of new cancer therapies.

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Desmethoxyamino hydroxy gemifloxacin is a drug product that belongs to the class of fluoroquinolones. It is a synthetic compound with a molecular weight of 551.4 g/mol and an empirical formula of C21H25FN3O2. Desmethoxyamino hydroxy gemifloxacin has been shown to inhibit bacterial DNA gyrase and topoisomerase IV in vitro, which are enzymes that maintain the integrity of bacterial DNA. The compound binds to 16S ribosomal RNA and inhibits protein synthesis, leading to cell death by inhibiting the production of proteins vital for cell division. This drug product is metabolized into gemifloxacin, desmethoxyamino acid, and desmethylgemifloxacin. These metabolites have not been shown to be active against bacterial DNA gyrase or topoisomerase IV in vitro, but may be active against other targets in

R-96544 Hydrochloride is an analytical standard used in HPLC analysis. It is also a metabolite of R-96544, which is an investigational drug for the treatment of schizophrenia. The impurity standard is a mixture of the racemic form and the pure enantiomeric form. This product is available in both natural and synthetic forms.

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Roxithromycin impurity H is an analytical standard for Roxithromycin. It is a metabolite that has been identified in human urine and bile samples as well as in rat plasma following oral administration of Roxithromycin. It is also a byproduct of the synthesis of Roxithromycin, which can be eliminated through purification steps. This compound has not yet been evaluated in humans or animals, but it may cause adverse effects such as gastrointestinal disturbances, headache, or hepatotoxicity.

8-Methyl etodolac is an impurity of etodolac that is used in the drug development and analytical chemistry industry. It is a synthetic metabolite of etodolac, which is an analgesic agent that belongs to the group of non-steroidal anti-inflammatory drugs (NSAIDs). 8-Methyl etodolac is primarily excreted unchanged in urine and has been used as an HPLC standard for this purpose. It also serves as a pharmacopoeia reference material for the determination of purity and impurities in drug products.

Cefpodoxime proxetil impurity E is an active compound that belongs to the group of mixtures. It has been shown to have a film-forming property and it may contain sugar.

Hydroxymethyl tolperisone is a medicinal compound that has been identified as a kinase inhibitor with potential anticancer properties. It has shown promising results in inhibiting the growth of leukemia cells and tumor cell lines in human studies. Hydroxymethyl tolperisone works by interfering with protein synthesis, disrupting the cell cycle, and inducing apoptosis in cancer cells. This compound has also been found to be effective against various types of cancer, including breast, lung, and colon cancer. Hydroxymethyl tolperisone is an analog of tolperisone, a muscle relaxant that is excreted primarily through urine. The use of this compound as an anticancer agent is still under investigation, but it holds great promise for the future of cancer treatment.