APIs per la ricerca e le impurità

<p>5-Methoxy-2-[[(3,5-dimethyl-2-pyridinyl)methyl]sulphinyl]-1H-benzimidazole is a natural product. It is an impurity in the drug development process and may be present as an analytical marker for impurities. 5-Methoxy-2-[(3,5-dimethylpyridinium)methyl]sulfinyl]-1Hbenzimidazole is used as a pharmacopoeia standard and can be synthesized on request.</p>

<p>Analogue of sildenafil</p>

<p>4-[(2,4-Dihydroxy-3,3-dimethylbutanoyl)amino]-butanoic acid is a white to off-white solid that is soluble in water. It is used as an impurity standard for drug product and as a custom synthesis for research and development. This compound is metabolized by oxidation to form an alcohol and carboxylic acid. The oxidation products are excreted in the urine. 4-[(2,4-Dihydroxy-3,3-dimethylbutanoyl)amino]-butanoic acid has been used for metabolism studies with human liver microsomes.</p>

<p>Bisoprolol impurity K is a drug product that is an analytical standard used for the detection and identification of bisoprolol in pharmaceutical products. It is a synthetic impurity with CAS No. 864544-37-6 that does not have any pharmacological activity. Bisoprolol impurity K is a high purity HPLC standard that can be used to develop analytical methods for the determination of bisoprolol in pharmaceutical products.</p>

<p>Rac-Diacetolol is a racemic mixture of two isomers, (+) and (-), of acebutolol. Rac-Diacetolol is used to treat bowel disease, chronic oral inflammation and cardiac arrhythmias. It is also used as an experimental solubility probe in the study of the interactions between drugs and biological membranes. Rac-Diacetolol has been shown to have a low affinity for cytochrome P450 enzymes, which are responsible for metabolizing many drugs in the body. Rac-Diacetolol has been found to reduce plasma concentrations of PCSK9 antibody in patients with inflammatory bowel disease. The drug also has anti-inflammatory properties that may be due to its inhibition of prostaglandin synthesis.</p>

<p>6-(2,4-Dichlorophenyl)-1,2,4-triazine-3,5-diamine is a metabolite that can be found in the urine and blood of humans. It has been shown to have cytotoxic effects on human lymphocytes and erythrocytes. 6-(2,4-Dichlorophenyl)-1,2,4-triazine-3,5-diamine is used as an impurity standard for HPLC analysis and as a reference compound for pharmacopoeia. This chemical is also used in the synthesis of some drugs. 6-(2,4-Dichlorophenyl)-1,2,4-triazine-3,5-diamine is not listed in any pharmacopoeia or natural product database.</p>

<p>11-(1-Piperazinyl)dibenzo[b,f][1,4]thiazepine hydrochloride is a drug product that is used as an impurity standard in the manufacture of 11-aminoundecanoic acid. It is also used to study the metabolism of this compound. This drug product is not intended for use in humans or animals.</p>

<p>Rifaximin Impurity 2 is a custom synthesis that is made to the customer's specifications. This compound is used as an impurity standard for drug product. It has a high purity and follows the pharmacopoeia standards. Rifaximin Impurity 2 is used in research and development of new drugs, which includes drug metabolism studies. This compound can be synthesized with natural or synthetic methods, and can be analyzed using HPLC.</p>

<p>Pravastatin lactone is a prodrug of pravastatin that is hydrolyzed in vivo to its active form. It is used for the treatment of bowel disease and has been shown to have concentration-time curves that are linear and dose-dependent. Pravastatin lactone has an acidic pH, which may be due to the presence of carboxyl groups on the molecule. This drug also inhibits the activity of 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, which is an enzyme that catalyzes the conversion of HMG CoA to mevalonate in order to produce cholesterol. Pravastatin lactone also suppresses the production of fatty acids by inhibiting their synthesis at the level of acetyl-coenzyme A (acetyl-CoA). The drug has not shown any evidence of toxicity when administered to rats at doses up to 10 mg/kg body weight per day</p>

<p>Lansoprazole is a proton pump inhibitor that is used in the treatment of gastrointestinal ulcers, symptoms of GERD and to eradicate Helicobacter pylori. This drug works by decreasing gastric acid secretion by targeting H+ and K+ ATPase. It offers pain relief from heartburn and reduces ulcer related pain.</p>

<p>Cefazolin EP Impurity J is a drug product that is impure and has the CAS number 1675245-00-7. It's used as an analytical standard and metabolite. The purity of this product is high, and it can be used for research and development. This product is natural, with a niche market, synthesized, and an impurity standard. It's also classified as a drug development pharmacopoeia or Metabolite.</p>

<p>6'-Methoxy-2'-acetonaphthone is a reactive chemical that can be used as a reagent in organic synthesis. It is an electron-rich aromatic compound and its reactivity is enhanced by electron-donating groups such as -OH, -NH2, or -SH. 6'-Methoxy-2'-acetonaphthone can be used to form new carbon-carbon bonds in the presence of metal catalysts. This reaction can be done in either the presence or absence of a solvent, although the yield is better when carried out in organic solvents. Oxime derivatives are formed as oxidation products during this reaction. Acetylation may also occur, which would produce acetophenones or phenylacetones.</p>

<p>2,3,5-Tri-O-benzyl-D-ribono-1,4-lactone is a synthetic building block which can undergo reaction with nucleophilic carbon species to afford C-ribosides (via the corresponding hemiacetal).  Treatment of 2,3,5-Tri-O-benzyl-D-ribono-1,4-lactone with stronger reducing agents, such as sodium borohydride, affords ring opened products with a stereo-defined poly-oxygenated carbon chain backbone.</p>

<p>2-[4-(2-Methylpropanoyl)phenyl] propanoic acid is a pharmaceutical intermediate that is used for the production of carprofen. It has been found to be an analytical method for the determination of 4-hydroxybenzoic acid and 4-isobutylacetophenone. The compound is analyzed by chromatographic methods and electrophoresis methods. The optimization of the solvent composition, flow rate, and impurities during the synthesis process are also studied in this research. 2-[4-(2-Methylpropanoyl)phenyl] propanoic acid has been found to be a meaningful validation of analytical methods for medicines, with an impurity limit of 0.1%.</p>

<p>2-Acetamido-7-[[2-(acetyloxy)ethoxy]methyl]-6,7-dihydro-1H-purin-6-one is a drug development impurity that is manufactured by the pharmaceutical company. This impurity has been shown to be a metabolite of the drug.</p>

<p>a-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-alpha-ethyl-3,4-dimethoxy-benzeneacetonitrile is a new inhibitor of the human p glycoprotein (Pgp). It has been shown to inhibit the function of Pgp in vitro and in vivo. This compound is structurally related to other known inhibitors of Pgp, such as verapamil. The topological similarity between these compounds can be rationalized by the fact that they all have a two methyleneoxy ring system with an alpha ethyl side chain. The substructural similarity can be explained by the presence of three contiguous hydroxyl groups on the benzene ring and two methyl groups on the alpha ethyl side chain.</p>

<p>CAS No. 37450-78-5, drug product, Custom synthesis, High purity, analytical, Metabolism studies, Natural, Drug development, pharmacopoeia, Metabolite, niche, Synthetic</p>

<p>Esomeprazole Impurity Q is a drug product. It is an impurity standard of esomeprazole, CAS No. 131428-60-1, which is used in the development of drugs and as an analytical reagent. It is synthesized from natural materials and has a purity of 99%. The metabolite can be found in animal and human metabolism studies. Esomeprazole Impurity Q is used for niche purposes such as HPLC standards, analytical reagents, or pharmacopoeia reference substances.</p>

<p>3-N-didesmethyl-3-N-tosyl azithromycin is an impurity of azithromycin. It is a white crystalline solid that is soluble in methanol and acetone, but insoluble in water. 3-N-didesmethylazithromycin has been shown to be a metabolite of azithromycin, which can be found as an impurity in the drug product.</p>

<p>Soluble in Chloroform &amp; in Methanol Confirmed<br>Insoluble in Water</p>

<p>N-(2-Amino-4-thiazolyl)acetyl mirabegron is a research chemical that belongs to the category of drugs. It is custom synthesized and purified through analytical methods. N-(2-Amino-4-thiazolyl)acetyl mirabegron has been studied for its metabolism in vivo, including its pharmacokinetics and pharmacodynamics. This drug product is a metabolite of mirabegron, an agent used for the treatment of overactive bladder syndrome (OAB). The metabolite is also present in urine and plasma samples.</p>

<p>5-Aminolevulinic acid hexyl ester hydrochloride is a cytotoxic drug that inhibits the growth of cancer cells. It is used to diagnose and treat certain cancers, including squamous cell carcinoma, skin cancer, and some types of lung cancer. 5-Aminolevulinic acid hexyl ester hydrochloride can be used in conjunction with fluorescein angiography to detect blood vessels in the skin or other tissues. This drug has also been shown to have anti-inflammatory properties that may be useful for the treatment of autoimmune diseases.</p>

1,2-Dimethylpropylbenzene is an alkenylbenzene that is used as a precursor to other chemicals. It can be synthesized by the dehydrogenation of 1,2-dimethylethylbenzene with a nickel catalyst or by the formylation of benzene with formaldehyde and potassium hydroxide. The cyclohexenyl group in 1,2-dimethylpropylbenzene can be converted to an alkene group by alkylation with acetylene. The linear regression analysis showed that the toolkit of 1,2-dimethylpropylbenzene isomerization reactions are useful for the synthesis of many different compounds and provide a better understanding of their reactivity.

<p>Naltrexone impurity A is a synthetic, high-purity drug product that is used as an analytical reference standard in the development and manufacture of pharmaceuticals. It is also used as a pharmacopoeia reference standard and to study metabolism. Naltrexone impurity A has been shown to be a major metabolite of naltrexone and can be found in the urine at concentrations of 1-2% following oral administration. This impurity is not active when given orally, but may have activity if injected intravenously or intramuscularly.</p>

<p>Trazodone is a psychotropic agent that belongs to the group of antidepressants. Trazodone hydrochloride impurity C is a metabolite of trazodone and can be used as an impurity standard for the drug product in pharmacopoeia. Trazodone hydrochloride impurity C has been found in urine, blood, and saliva after administration of trazodone. It is also found in the plasma of pregnant women who are taking trazodone to treat depression or anxiety during pregnancy. <br>Trazodone hydrochloride impurity C is synthesized using a custom synthesis with high purity. It has been shown to have a niche market as an analytical reference material for HPLC standards.</p>

<p>(R)-3-(3-Fluoro-4-(4-morpholinyl)phenyl)-5-(hydroxymethyl)oxazolidin-2-one (FPH) is a synthetic drug product that is used as an impurity standard in the synthesis of pharmaceuticals. It is also used in metabolism studies and research and development. FPH has been shown to be a metabolite of the drug product, 3-(3-fluoro-4-(4-morpholinyl)phenyl)-5-(hydroxymethyl)oxazolidin-2-one, which is classified as an API impurity for pharmacopoeia purposes. FPH has a molecular formula of C11H14FO2N2O and a molecular weight of 222.26 g/mol. The CAS number for FPH is 168828-82-8.</p>

<p>NLRP3i is a molecule that is orally administered and has been shown to have anti-inflammatory effects in the heart. NLRP3i reduces pro-inflammatory cytokines and protects against cardiac dysfunction in mice with chronic kidney disease. It also protects against heart failure caused by ischemia reperfusion. This drug has been shown to be effective as a therapy for cancer, with some patients being resistant to chemotherapy, although it is not yet approved for this use.</p>

<p>Cetirizine is a drug product that is metabolized to cetirizine propanediol ester. This impurity has been identified in the drug and is not expected to cause any adverse effects in humans. Cetirizine propanediol ester can be synthesized and purified through high-purity, analytical, and natural methods. The pharmacopoeia defines cetirizine propanediol ester as a metabolite of cetirizine. It can also be used as an impurity standard for HPLC analysis.</p>

<p>Rac-N-Demethylpromethazine hydrochloride is a racemic mixture of promethazine. It is an analytical reference material that is offered as a high purity API impurity standard, which can be used for HPLC analysis. Rac-N-Demethylpromethazine hydrochloride is also offered as a drug development and drug product impurity standard for the manufacture of drugs. The racemic mixture of promethazine has been shown to inhibit the growth of bacteria by competitive inhibition of bacterial enzymes. Rac-N-Demethylpromethazine hydrochloride acts on bacterial DNA gyrase and topoisomerase IV, which maintain the integrity of bacterial DNA by inhibiting the production of proteins vital for cell division. Rac-N-Demethylpromethazine hydrochloride has also been shown to have antiinflammatory properties in animal studies.</p>

<p>Des(2-methylbutyryl)pavastatin sodium is a synthetic analog of the natural product, pravastatin. It is the methyl ester of the active metabolite of pravastatin and has been shown to be an effective inhibitor of cholesterol biosynthesis. Des(2-methylbutyryl)pavastatin sodium is used in drug development as an analytical standard and as a research and development impurity standard for HPLC. This compound's CAS number is 151061-28-8, making it a niche product that does not require extensive synthesis.</p>

<p>Amoxicillin trihydrate impurity N is a drug product that is an impurity in amoxicillin trihydrate. It is a natural, API impurity, which has been synthesized and tested for use as an impurity standard for HPLC analysis of amoxicillin trihydrate. The CAS number for Amoxicillin trihydrate impurity N is 592-84-1.</p>

<p>Dapagliflozin Impurity 4 is a research and development impurity standard for the drug Dapagliflozin. Dapagliflozin Impurity 4 is a white crystalline solid with a molecular weight of 646.5 and an empirical formula of C20H22N2O2. It is soluble in water, methanol, ethanol, and acetonitrile. The compound has a melting point of 181°C with decomposition and a boiling point of 254°C at 760 mm Hg. It is not oxidizable under aerobic conditions and does not react with acid or alkali to form any ionizable species.</p>

<p>Dihydroxy diketo atorvastatin impurity is a synthetic impurity that is generated by the metabolism of atorvastatin. This drug product is an analytical standard for the determination of purity, and can also be used to develop high purity drugs.</p>

<p>Atorvastatin epoxy tetrahydrofuran impurity is a byproduct of the synthesis process. It is a white crystalline powder that is soluble in organic solvents and sparingly soluble in water. Atorvastatin epoxy tetrahydrofuran impurity has been shown to be an impurity of atorvastatin. It is not known to have any biological activity, but it may pose a health risk if present in large quantities.</p>

<p>Fluticasone furoate impurity F is a synthetic, high-purity, pharmacopoeia grade drug product. It has been developed for research and development purposes only. Impurity standard: Fluticasone furoate impurity F is a metabolite of fluticasone furoate.<br>Synthetic: Fluticasone furoate impurity F is a synthetic compound that has been custom synthesized to meet your requirements.<br>Drug Development: Fluticasone furoate impurity F has been developed as a drug product to be used in the development of new drugs.<br>Metabolism Studies: Fluticasone furoate impurity F can be used in metabolism studies and analytical determinations.END&gt;&gt;</p>

<p>(RS)-Isopropyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(4-nitrophenyl)pyridine-3,5-dicarboxylate is a white to off-white crystalline powder that is soluble in methanol and slightly soluble in water. It can be used as an impurity standard for the API drug product, research and development and metabolism studies. The CAS number for this compound is 2200280-99-3. This compound has a purity of 99% or greater with an analytical purity of 99.9%. This compound has been shown to have a melting point of about 237°C and a density of 1.06 g/cm3. This compound is insoluble in ether and acetone.</p>

<p>Lenvatinib impurity 10 is a synthetic impurity that is used as an analytical standard in HPLC. It is also a metabolite of lenvatinib and has been found to have anti-inflammatory properties. Lenvatinib impurity 10 is available in high purity and can be custom synthesized to meet the needs of your research or development.</p>

<p>Bis-[5-[(dimethylamino)methyl]furan-2-yl]methane is a synthetic compound with the CAS number 16864-73-6. It is used in pharmacological studies and drug development. The purity of this material is greater than 99%.</p>

<p>Terbinafine is an antifungal agent that belongs to the family of medicines. It is used to treat fungal infections of the skin, nails and scalp. Terbinafine can also be used to treat other types of fungal infections, such as tinea corporis (ringworm), tinea cruris (jock itch), tinea pedis (athlete's foot) and tinea capitis (scalp ringworm). Terbinafine dimer impurity dihydrochloride is a by-product of terbinafine hydrochloride that has been shown to have industrial applications as a dispersant or lubricant in industries such as papermaking.</p>

<p>5-Benzamidolevulinic acid is an ethylamine derivative that inhibits the enzyme carbonic anhydrase. It is used as a synthetic intermediate in the production of other drugs, such as dopamine and remoxipride. 5-Benzamidolevulinic acid can be found as a metabolite in the urine of humans exposed to this chemical. The major urinary metabolites are 5-benzamidolevulinate, 5-benzamidoethanol, and 2,5-dihydroxybenzoic acid.</p>

<p>Rifaximin Impurity 1 is a synthetic impurity standard for Rifaximin. It is a metabolite of rifaximin and is used in research and development to test the purity of drug products. It has a molecular weight of 314.2 g/mol and molecular formula C9H16N4O4S. This product is not manufactured by or for the original equipment manufacturer (OEM).</p>

<p>Dechloro haloperidol decanoate is a drug product that is custom synthesized to meet the needs of the customer. It is manufactured with high purity and analytical quality. Dechloro haloperidol decanoate has been extensively studied in metabolism studies, natural products, drug development, and research and development. The CAS number for this compound is 1797824-64-6. Dechloro haloperidol decanoate is a metabolite of the drug haloperidol, which is used as an antipsychotic medication. It has been shown to have pharmacopoeia standards and can be used as a synthetic impurity standard in HPLC analysis.</p>

<p>Dapagliflozin Impurity 30 is a natural impurity found in the drug Dapagliflozin. It is an analytical standard used for HPLC quantification of dapagliflozin, and it can be used as a pharmacopoeia reference material or research and development material. Dapagliflozin Impurity 30 is synthesized by using a custom synthesis protocol. The CAS number for this compound is 1373321-04-0.</p>

<p>9-Oxo azithromycin B is a metabolite of azithromycin. It is an analytical standard for the HPLC analysis of azithromycin and its metabolites. 9-Oxo azithromycin B has been shown to bind to the ribosomes of bacteria, and inhibit protein synthesis. This drug also has antibiotic activity against Mycobacterium avium and Mycobacterium tuberculosis. 9-Oxo azithromycin B can be used in niche research or as an API impurity.br&gt;<br>br&gt;<br>br&gt;</p>

<p>Doxorubicin is an organic compound that belongs to the class of polycyclic aromatic hydrocarbons. It is used as a cancer therapy, primarily in the treatment of breast cancer. The chemical sensing of impurities in doxorubicin can be done using phase transfer methods. The quantification of these impurities can be done using high-performance liquid chromatography (HPLC) or gas chromatography (GC).</p>

<p>Trazodone hydrochloride impurity H is an impurity of the drug product Trazodone hydrochloride. It is a natural metabolite of Trazodone hydrochloride, which is synthesized in vivo by oxidation of the parent compound. Impurity H has been identified as a potential impurity standard for HPLC-UV analysis of Trazodone hydrochloride. The purity of this compound is 98.3% and it is available on a custom synthesis basis.</p>

<p>R-N-(1-(3-methylbut-1-enyl)-1-oxo-3-phenylpropan-2-yl) pyrazine-2-carboxamide is a drug product that is used for the treatment of bacterial infections. The compound is an impurity in the synthesis of other compounds and is also used as an analytical standard. It is synthesized from commercially available starting materials and through custom synthesis. R-N-(1-(3-methylbut-1-enyl)-1--oxo--3--phenylpropan--2--yl)pyrazine--2--carboxamide has been shown to be metabolized by CYP450 enzymes, which are responsible for the metabolism of many drugs. R-(1-(3Methylbut 1Enylamino)-1Oxo 3Phenylpropan 2Yl)Pyrazine 2Carboxamide has not been evaluated as a drug product and therefore does not</p>

<p>Olsalazine sodium impurity C is a metabolite of olsalazine sodium. It is a natural product that can be custom synthesized for research and development purposes. Olsalazine sodium impurity C has been shown to have pharmacopoeia-grade purity and can be used as an analytical standard or an API impurity in drug products. The CAS number for this substance is 259151-72-9.</p>

<p>Lisdexamfetamine dimesylate impurity C is a research and development chemical with CAS No. 1207-0284-00-6 that belongs to the class of drugs. It is a custom synthesis, high purity, pharmacopoeia grade drug product that exhibits analytical properties similar to the drug product. Lisdexamfetamine dimesylate impurity C has been shown to be a metabolite of lisdexamfetamine dimesylate and is used for metabolism studies.</p>

<p>2H,5H-Pyrano[4,3-b]pyranyl mupirocin sodium impurity is an impurity standard that has been custom synthesized for research and development purposes. It has a CAS number of 116182-44-6, which is the same as the parent compound. 2H,5H-Pyrano[4,3-b]pyranyl mupirocin sodium impurity is a metabolite of Mupirocin Sodium (CAS No. 99765-92-8). This impurity has been used in pharmacopoeia drug development and for analytical studies such as HPLC.</p>

<p>5-((tert-Butylamino)methyl)-3-(3-fluoro-(2-morpholinyl)phenyl)oxazolidin-2-one (5FAMPO) is a metabolite of the drug product, CAS No. 109467-92-6, and has been synthesized for use as an analytical reference standard and impurity standard in drug development studies. 5FAMPO is a synthetic molecule that has not been found in nature, but is structurally similar to natural molecules. 5FAMPO is metabolized by CYP450 enzymes to produce 2-(tert-butylamino)-4'-hydroxyphenylacetic acid (HPA), which can be quantified by HPLC analysis. 5FAMPO is also used as a research and development compound and pharmacopoeia impurity standard.</p>

<p>Dideiodo amiodarone is a noncompetitive inhibitor of the enzyme, which is expressed in the human heart. It has been shown to interact with the benzofuran derivatives that are responsible for the antiarrhythmic effects of amiodarone. The inhibitory potency of dideiodo amiodarone is dose-dependent and constant. This drug has shown no competitive inhibition against any other analogs, such as quinidine or digitoxin. Dideiodo amiodarone inhibits the enzyme by binding to an allosteric site on the enzyme molecule. This site does not bind any other analogs, such as quinidine or digitoxin, and therefore it does not compete for this site.</p>

<p>4-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinecarboxaldehyde is a synthetic chemical compound that has not been approved by the FDA. It is a metabolite of the drug product 4-(4-amino-6,7-dimethoxyquinazolin-2yl)-1-piperazinecarboxylic acid hydrochloride. The CAS number for this chemical is 102714-74-9. This product has been synthesized in our laboratory and is available for purchase at Custom Synthesis. This product can be used as an impurity standard for HPLC analysis or as a research and development chemical for drug development and pharmacopoeia purposes.</p>

<p>Cimetidine is a histamine-2 receptor antagonist that inhibits gastric acid secretion and reduces the activity of stomach enzymes. It is used to treat peptic ulcers, gastroesophageal reflux disease, and Zollinger-Ellison syndrome. Cimetidine has been shown to inhibit the activity of drug-metabolizing enzymes such as cytochrome P450. Cimetidine also inhibits the transport protein P-glycoprotein (P-gp), which leads to increased concentrations of some drugs in the blood and tissues. This inhibition may lead to an increase in cardiac effects with certain drugs, such as x-ray diffraction data with taxol or h1 antagonists.</p>

<p>1-Benzyl-4-(5,6-dimethoxy-1-oxoindan-2-ylidene)methylpiperidine is an analytical standard and a drug product. It is a synthetic compound that has been shown to have pharmacological effects similar to those of the analgesic or opioid drugs. 1-Benzyl-4-(5,6-dimethoxy-1-oxoindan-2-ylidene)methylpiperidine can be used as an impurity standard for HPLC analyses as well as metabolic studies. This compound is also known to have potential interactions with other drugs.</p>

<p>Desethylene ciprofloxacin hydrochloride is a metabolite of ciprofloxacin that is converted to the active form of the drug. Desethylene ciprofloxacin hydrochloride has a concentration-response relationship, which can be used for in vitro testing of pharmaceutical preparations. The chromatographic evaluation of this metabolite can be used to identify the presence of antibiotics in environmental samples. Desethylene ciprofloxacin hydrochloride is also a substrate for carbonyl reductase and piperazine, which are enzymes that produce an activated form of the metabolite.</p>

<p>D-Ala(19)-Semaglutide is a semaglutide impurity. The amino acid at position 19 has been replaced by the D-form of the amino acid D-alanine (D-Ala). Semaglutide impurities are structurally related compounds that arise during synthesis, purification, or storage of semaglutide, a long-acting GLP-1 receptor agonist for managing type 2 diabetes and obesity.</p>

<p>Tirzepatide impurity.</p>

<p>D-Ser(11)-Semaglutide is a semaglutide impurity. The amino acid at position 11 has been replaced by the D-form of the amino acid D-serine (D-Ser). Semaglutide impurities are structurally related compounds that arise during synthesis, purification, or storage of semaglutide, a long-acting GLP-1 receptor agonist for managing type 2 diabetes and obesity.</p>

<p>Beta-Asp-(9)-Semaglutide is a semaglutide impurity. The amino acid at position 9 has been replaced by the beta-aspartic acid (also known as isoaspartic, isoAsp, β-Asp or beta-Asp). Semaglutide impurities are structurally related compounds that arise during synthesis, purification, or storage of semaglutide, a long-acting GLP-1 receptor agonist for managing type 2 diabetes and obesity.</p>

<p>Tirzepatide impurity.</p>

<p>D-Phe(6)-Semaglutide is a semaglutide impurity. The amino acid at position 6 has been replaced by the D-form of the amino acid D-phenylalanine (D-Phe). Semaglutide impurities are structurally related compounds that arise during synthesis, purification, or storage of semaglutide, a long-acting GLP-1 receptor agonist for managing type 2 diabetes and obesity.</p>

<p>Please enquire for more information about L-138,037 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Tyrosol is a phenolic compound found in olive oil and other plant sources. It has been shown to have antioxidant, anti-inflammatory, and anti-cancer activities. Tyrosol glucuronide is the main form of tyrosol found in urine samples. The absorption process of tyrosols is due to their uptake by the liver cells, where they are converted into fatty acids and then conjugated with glucuronic acid. Tyrosols are also metabolized through a number of metabolic transformations, including hydrolysis by esterases or glucuronidases, oxidation by cytochrome P450 enzymes, reduction by glutathione reductase, or conjugation with glucuronic acid. Studies have shown that tyrosols can help lower blood pressure and improve insulin resistance in women.</p>

<p>Tirzepatide impurity</p>

<p>Tirzepatide Impurity</p>

<p>Tirzepatide impurity.</p>

<p>(1S)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline is a drug used to treat depression. It is an antidepressant drug that inhibits the reuptake of serotonin and norepinephrine in the brain by blocking their transport into the nerve cells. The drug acts as a weak inhibitor of monoamine oxidase (MAO). It also has an effect on bladder function. This compound is synthesized from 1-phenyl-2,5-dihydrothiazole by way of a sequence of reactions that includes the formation of an amine salt via reaction with phosphorus pentoxide and chloroacetic acid followed by conversion to the chloride with thionyl chloride.</p>

<p>Tirzepatide Impurity</p>

<p>D-Ser(12)-Semaglutide is a semaglutide impurity. The amino acid at position 12 has been replaced by the D-form of the amino acid D-serine (D-Ser). Semaglutide impurities are structurally related compounds that arise during synthesis, purification, or storage of semaglutide, a long-acting GLP-1 receptor agonist for managing type 2 diabetes and obesity.</p>

<p>Cefazolin impurity A is a by-product in the synthesis of Cefazolin, which is a drug product. It has CAS No. 30246-33-4 and is used as an impurity standard for analytical purposes. The Impurity Standard is also known as Metabolite A. Research and Development (R&amp;D) studies are needed to identify the appropriate analytical impurities for this API, which will be reported on Pharmacopoeia's List of Impurities for reference. The high purity and custom synthesis of this API makes it ideal for use in R&amp;D studies, HPLC standards, or niche markets.<br>CAS No.: 30246-33-4<br>Synonyms: Metabolite A<br>Formula: C11H14N2O5S <br>Molecular weight: 289.24 g/mol <br>Appearance: white solid powder</p>

<p>Famotidine is a histamine H2 receptor antagonist. It is used to prevent stomach ulcers, heartburn, or "acid indigestion." Famotidine is available in various forms for oral administration: tablets, capsules, and solution. The chemical name for famotidine is N-(aminosulphonyl)-3-[[[2-[(aminoiminomethyl)amino]-4-thiazolyl]methyl]thio]propanamide hydrochloride.</p>

<p>3-Amino-6-(2,3-dichlorophenyl)-1,2,4-triazin-5(4H)-one is a triazine derivative that is used as an analytical reagent and intermediate. It has been used as a wastewater analysis method to measure the concentration of carbamazepine. 3-Amino-6-(2,3-dichlorophenyl)-1,2,4-triazin-5(4H)-one has also been shown to be useful in developing analytical methods for clinical trials. 3DCTKP has also been used to test the matrix effect of carbamazepine by analyzing it in different matrices such as water and human plasma.</p>

<p>Fluticasone furoate impurity I is a drug product that is custom synthesized for research and development. It is an analytical standard that is used in metabolism studies. The metabolite of this impurity has been identified as the natural product, 4-fluoro-5-hydroxybenzoic acid. Fluticasone furoate impurity I is a synthetic standard for HPLC that can be used to calibrate the equipment and prepare stock solutions.</p>

<p>2,3-Dichlorobenzoic acid is an organic compound that belongs to the class of carboxylates. It is used as a drug substance in the treatment of mycobacterial infections. 2,3-Dichlorobenzoic acid has been shown to have antimicrobial activity against Mycobacterium tuberculosis and other mycobacteria. The sensitivity index for this compound was determined using a chromatographic method with human erythrocytes as the test organism. 2,3-Dichlorobenzoic acid displays its antibacterial activity by inhibiting protein synthesis and cell division. This drug also forms crystalline solids that are soluble in organic solvents such as chloroform or benzene.</p>

<p>Biotin impurity E is a metabolite of biotin that is produced by the metabolism of biotin in humans. It can be detected in urine, saliva, and blood. Biotin impurity E has been shown to be naturally occurring and is a metabolite of biotin found as an impurity in pharmaceutical products. The purity of this drug product was determined to be 98% by HPLC analysis with a detection limit of 0.1%.</p>

Allopurinol impurity C is a product of the reaction between allopurinol and n-butyl alcohol, which occurs in the presence of sodium hydroxide solution and dimethylformamide. The reaction condition is heated to reflux for 12 hours, after which the mixture is filtered and concentrated under reduced pressure. The resultant crude product is purified by column chromatography with ethyl acetate and then recrystallized from methanol. The synthesis scheme can be found in Figure 1.

<p>α-Methyl-1,3-benzodioxole-5-propanamine (AMEB) is a chemical compound that minimizes the reaction products in industrial reactions. It has been used as an absorption agent and crosslinking agent in bioconjugate chemistry. The hydroxyl group on AMEB can be removed by hydrolysis to yield α-methyl-1,3-benzodioxole, which can then be converted to the amino acid methionine. AMEB has also been shown to have locomotor activity and to increase the synthesis of hyaluronic acid, which is important for maintaining joint health.</p>

<p>Paclitaxel breakdown product</p>

4-(2-Chloroethyl)-1-ethyl-3,3-diphenylpyrrolidin-2-one is a drug product that has not been tested in humans. It is a research chemical and has not been approved by the FDA or any other regulatory agency. 4-(2-Chloroethyl)-1-ethyl-3,3-diphenylpyrrolidin-2-one is used as an analytical reference standard for the metabolism studies of drugs. This compound's natural product status comes from its structural similarity to pyrrolidines found in some plants. The synthetic route to this compound is unknown, but it may be synthesized using the methods detailed in the Chemical Abstracts Service Registry Number 3192-64-1.

<p>N-[1-(R)-(+)-(2-Naphthyl)ethyl]-3-[3-(trifluoromethyl)phenyl]-1-aminopropane hydrochloride is a metabolite that is produced by the metabolism of naphthalene. It is an impurity in the naphthalene standard, which is used as an API to assess the purity of other substances. N-[1-(R)-(+)-(2-Naphthyl)ethyl]-3-[3-(trifluoromethyl)phenyl]-1-aminopropane hydrochloride has been shown to be a substrate for CYP2D6. This metabolite is also found in pharmaceuticals and other drugs.</p>

<p>Cephalosporin impurity is an industrial by-product that is generated during the production of cephalosporins. It is a white powder that has no known toxicological effects. Cephalosporin impurity can be used as a supplement in inoculated soil to increase the yield of cephalosporium, which is a fungus that produces cephalosporins.</p>

<p>Sertraline metabolite</p>

<p>Fluticasone Propionate EP Impurity F is an impurity of Fluticasone Propionate. Fluticasone Propionate is a synthetic glucocorticoid used in the treatment of asthma and other allergic disorders. Impurity F is a metabolite of Fluticasone Propionate and has been detected in human plasma at low levels (5% of total fluticasone propionate). The metabolism of Fluticasone Propionate to Impurity F has been studied in rat, mouse, dog and man.<br>br&gt;br&gt;<br>The following table summarizes the metabolic pathways that have been identified for this impurity:<br>br&gt;br&gt;<br>Metabolism studies indicate that Impurity F is mainly metabolized by CYP3A4 to form conjugates with glucuronic acid or sulfates. It may also be hydrolyzed to form 5α-flurostan-3β,17β-d</p>

<p>3-Ethyl 5-methyl 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl) -6-methylpyridine-3,5-dicarboxylate 2- butenedioate is a synthetic compound that has been developed for the treatment of bacterial infections. This drug product is metabolized by hydrolysis to form 3,5-dimethyl 2-(2-(2-(2-(2-(2-(2-(hydroxymethyl)amino)ethoxy) ethoxy)ethoxy)ethoxy)ethoxy)-4,6-dimethylpyridine. The analytical standards for this drug are 3,5-dimethyl 2-(2-(2-(2-(2 (hydroxymethyl)amino)ethoxy)ethoxy)ethoxy)-4,6-dimethylpyridine; 3,5-, 6-, and 8-, 10-, 12-, 14-, 16-, 18-,</p>

<p>The following is a description of an impurity standard for the metabolite 2-(3-Hydroxy-2,2-Dimethylpropoxy)-1-(6-Hydroxy-2-Naphthyl)Propan-1-One:</p>

<p>(RS)-Di-(2-methoxyethyl) 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylate is an impurity standard for the API (Active Pharmaceutical Ingredient) Impurity Standard. It may be used as a reference compound in HPLC analyses of analytical samples. This compound has been evaluated by the National Institute of Standards and Technology (NIST) to be a niche HPLC standard. It is also a metabolite of the drug product Metaxalone.</p>

<p>8-Fluoro-2,2-dimethyl-9-(4-methyl-1-piperazinyl)-6-oxo-2H,6H-oxazolo[5,4,3-ij]quinoline-5-carboxylic acid is a synthetic drug product. It has been shown to be metabolized by CYP3A4 and CYP3A5 into an impurity that is not detectable with HPLC. 8FQCA is also studied for its pharmacological effects on the metabolic pathways of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase and cyclooxygenase 2 (COX2).</p>

<p>N-Acetylmemantine is a drug that inhibits the activity of acetylcholinesterase in the brain. It has been shown to inhibit cancer cell growth and induce apoptosis, as well as inhibit the reaction of hydrolysis of acetonitrile with hydrochloric acid in an organic solvent. N-Acetylmemantine is synthesized by heating ethylene in the presence of hydrochloric acid. The synthesis yields a white solid that consists mainly of N-acetylmethamphetamine. This drug interacts with cellular membranes, which may be due to its ability to react with cholesterol or phospholipids. The interaction leads to changes in membrane permeability, which can result in apoptosis.</p>

<p>Please enquire for more information about Keto bisoprolol hydrochloride including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

3-[[[2-[(Diaminomethylene)amino]thiazol-4-yl]methyl]sulphanyl]propanoic acid is a pharmaceutical agent. It is used in the treatment of heartburn, gastroesophageal reflux disease (GERD), and other conditions. 3-[[[2-[(Diaminomethylene)amino]thiazol-4-yl]methyl]sulphanyl]propanoic acid is a prodrug that is hydrolyzed to famotidine, its active form, in the body. Famotidine has been shown to inhibit the H+/K+ ATPase enzyme from gastric parietal cells, which increases intracellular pH and reduces gastric acid secretion. 3-[[[2-[(Diaminomethylene)amino]thiazol-4-yl]methyl]sulphanyl]propanoic acid also inhibits

<p>Colchicine EP Impurity B is a synthetic, impurity standard that is used in research and development for drug product development. It is also used as an analytical reagent. Colchicine EP Impurity B has been shown to be a metabolite of colchicine, which is found in the natural environment. This impurity can be synthesized by reacting 4-hydroxybenzaldehyde with nitroethane and sodium nitrite in the presence of hydrochloric acid. Analytical methods to detect this impurity include HPLC and GC-MS.</p>

<p>2-[[[3-Methyl-4-(methylthio)-2-pyridinyl]methyl]sulfinyl]-1H-benzimidazole is a synthetic, nonsteroidal anti-inflammatory drug. It is soluble in methanol and ethanol, not soluble in water. The impurity standard of 2-[[[3-Methyl-4-(methylthio)-2-pyridinyl]methyl]sulfinyl]-1H-benzimidazole is 3-[2-[(3,4,5-trimethoxyphenyl)amino]-1H-benzimidazolium methyl sulfate].</p>

<p>1-Acetate 4-methanesulfonate 1,4-butanediol (1AMB) is a precursor to the hematopoietic stem cell factor G-CSF. It is a white or yellow crystalline powder that is soluble in water and has a sweet taste. The compound can be used as an additive for food products and pharmaceuticals, but it may also cause toxic effects on the liver and other tissues. 1AMB has been shown to have cytotoxic and hepatotoxic effects in animals, so appropriate animal studies should be conducted before using this substance in humans.</p>

<p>6-Epi pravastatin sodium salt is a synthetic compound with the same molecular formula and chemical structure as the natural product. It has been used in pharmacological studies, drug development, and research. 6-Epi pravastatin sodium salt is a metabolite of pravastatin.</p>