APIs per la ricerca e le impurità

<p>Applications N-Desmethyl Regorafenib is a synthetic metabolite of Regorafenib (R143000) and is used for treatment and prevention of cancer.<br>References Wilhelm, S.: PCT Int. Appl. WO 2011130728 A1 20111020. Oct 20, 2011<br></p>

<p>Applications Methacrylyl-CoA is an intermediate in the serine cycle that converts acetyl CoA (acetyl-CoA) to glyoxylate.<br>References Korotkova, N., et al.: J. Bacteriol., 184, 1750 (2002)<br></p>

<p>Stability Hygroscopic<br>Applications A metabolite of Pravastatin, a competitive inhibitor of HMG-CoA reductase. Bioactive metabolite of mevastatin.<br>References Serizawa, N., et al.: J. Antibiot., 36, 604 (1983), White, H.D, et al.: N. Engl. J. Med., 343, 317 (2000),<br></p>

<p>Applications Piperidin-4-one Ethylene Ketal is a derivative formed from the condensation of cyclohexanone.<br></p>

<p>Applications Spiramycin Embonate is an antibiotic that is used in biological studies in the role of multidrug resistance of Strenotrophomonas maltophilia.<br>References Huang, Y., et al.: J. Antimicrob. Chemother., 68, 1987 (2013); Poole, K., et al.: Mol. Microbiol., 21, 713 (1996)<br></p>

<p>Applications Iso Sildenafil (I900800) derivative. Intermediate in the preparation of Iso Sildenafil and Iso Viagra.<br>References El-Abadelah, M. et al.; J. Heterocyclic Chem. 39, 1055 (2002)<br></p>

<p>Applications A labelled metabolite of Ketoprofen (K200800).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Skordi, E., et al.: Xenobiotica, 34, 1075 (2004),<br></p>

<p>Applications Intermediate in the preparation of Carvedilol derivatives.<br>References Mewshaw, R., et al.: J. Med. Chem., 47, 3823 (2004),<br></p>

<p>Applications N’-[2-[[[2-[(Dimethylamino)methyl]-4-thiazolyl]methyl]thio]ethyl] Nizatidine is an impurity of the histamine H2-receptor antagonist Nizatidine (N598500).<br></p>

<p>Stability Hygroscopic<br>Applications A labeled metabolite of Omeprazole, an antiulcerative.<br>References Andersson, T., et al.: Ther. Drug Monit., 12, 415 (1990), de Morais, S., et al.: J. Biol. Chem., 269, 15419 (1994), Tanigawara, Y., et al.: Clin. Pharmacol. Ther., 66, 528 (1999), Abelo, A., et al.: Drug Metab. Disos., 28, 966 (2000),<br></p>

<p>Applications Amikacin is an antibacterial compound used in the treatment of diseases and illnesses arising from gram-negative bacterium. Antituberculosis agent.<br>References Villegas, M. et al.: Antimicrob. Agents Chemother., 51, 1553 (2007); Boshoff, H. et al.: J. Biol. CHem., 279, 40174 (2004);<br></p>

<p>Applications Podophyllin is a resin extracted from the root of the plant Podophyllum sp. Berberidaceae (mandrake), which contains numerous compounds, among which podophyllotoxin.<br></p>

<p>Applications Intermediate in the preparation of Ertapenem (E635000).<br></p>

<p>Applications 9,14-Deepoxy-15-deoxo-14-deoxy-9,15-epoxy-15-hydroxy-14-oxorapamycin can be prepared as an immunosuppressant.<br>References Hughes, P.F.: U.S. 4 pp. Patent 1993 CODEN:USXXAM<br></p>

<p>Stability Hygroscopic<br>Applications Desfluoroprasugrel is a defluorinated impurity of the antiplatelet agent, Prasugrel (P701150).<br></p>

<p>2,3'-Anhydrothymidine is a piperidine-containing nucleoside analog that inhibits the replication of HIV and other viruses. It is structurally related to acyclovir, but has an increased resistance to viral inactivation by acyclovir-resistant strains. 2,3'-Anhydrothymidine binds to the ribose sugar of the viral nucleic acid and prevents the formation of a covalent bond between the 5' hydroxyl group of ribose and the 3' phosphate group. It also inhibits protein synthesis by interfering with the incorporation of amino acids into proteins. 2,3'-Anhydrothymidine has been shown to be effective against human immunodeficiency virus type 1 (HIV-1) in animal models and clinical studies.</p>

<p>4-Biphenylcarboxylic acid is a natural metabolite of the drug bibenzonium, an antipsychotic agent. It can also be obtained by synthesis from 4-biphenylacetic acid. 4'-[(1,7'-Dimethyl-2'-propyl-1H,1'H-2,5'-bibenzo[d]imidazol-1'-yl)methyl]biphenyl-2-carboxylic acid can be used as a research and development standard for HPLC. This compound has been shown to inhibit CYP3A4 and CYP2D6 liver enzymes and may impair the metabolism of other drugs.</p>

<p>Please enquire for more information about (2R,3R,4R,5S,6S)-2-(Acetoxymethyl)-6-(4-chloro-3-(4-(((R)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)tetrahydro-2H-pyran-3,4,5-triyl tri acetate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Lansoprazole sulfide is a proton pump inhibitor that inhibits gastric acid secretion and is used for the treatment of stomach acid-related disorders, such as heartburn and ulcers. Lansoprazole sulfide belongs to a class of pharmaceutical drugs called proton pump inhibitors. It is chemically related to omeprazole, which has been shown to work by inhibiting the production of hydrogen ions in the stomach. Lansoprazole sulfide has been shown to be effective at reducing gastric acid secretion in humans, with a more favorable side-effect profile than omeprazole. Lansoprazole sulfide also inhibits bacterial growth by binding to the fatty acids in their membranes and inhibiting their metabolism.</p>

Chlorhexidine diacetate impurity C is a crystalline solid with an ionic crystal structure. It belongs to the class of hydroxy-substituted quinolinium salts, which are related to a type of nonlinear optical material known as hyperpolarizability. The molecule has a centrosymmetric crystal system and can be classified as a macroscopic supramolecular ionic crystal. Chlorhexidine diacetate impurity C has been shown to have the ability to act as an optical polarizer. The molecule's optical properties are determined by the presence of a hydroxyl group and its location on the central ring (the quinolinium).

<p>1-Phenyl-1-(pyridin-4-yl)ethanol is an analytical standard that is used in drug development. It is a metabolite of the anti-inflammatory drug, ketorolac. The purity of 1-phenyl-1-(pyridin-4-yl)ethanol is &gt;98% and it can be custom synthesized to meet specific requirements.</p>

<p>3-(4-Methylbenzoyl)propionic acid (MBPA) is a corrosion inhibitor that can be used to protect metals and other materials from damage caused by acidic substances. MBPA has been shown to adsorb onto the surface of metal, forming a protective layer that prevents corrosion. This compound is synthesised by reacting methyl groups with aluminium chloride in an organic solvent to form the hydroxy group. The carboxylate group reacts with the hydroxyl group and forms the ligand, which is then reacted with phosphonic acid to produce MBPA. Molecular modelling studies have shown that this ligand binds to the metal surface through its hydrophobic interactions, which are stronger than its hydrogen bonds.</p>

<p>3-(N-Phenyl-N-methyl)aminoacrolein is a hydrophobic compound that has been shown to reversibly bind to serum albumin. This binding leads to a decrease in the lipid content of lipoproteins and a decrease in the rate of their metabolism. These effects are mediated by hydrophobic interactions with the hydrophobic regions of serum albumin. 3-(N-Phenyl-N-methyl)aminoacrolein also interacts with human serum albumin, which is involved in lipid transport and metabolism, and can be used as a contrast agent for X-ray diffraction studies.</p>

<p>Lansoprazole sulfone is a prodrug of lansoprazole that is metabolized by cytochrome P450 enzymes. Lansoprazole sulfone has a pharmacokinetic profile similar to the parent drug and is used to treat gastroesophageal reflux disease in adults. The human pharmacokinetics of lansoprazole sulfone have been determined using recombinant cytochrome P450 enzymes and analytical methods. Lansoprazole sulfone has been shown to be effective against gastric acid secretion, with an activity index of 0.15-0.3 for inhibiting gastric acid secretion. It also has low protein binding properties, which may result in drug interactions with other drugs or foods that have high protein binding properties.</p>

N-Methyl-1-methylthio-2-nitroethylemeamine (MTNE) is a synthetic amine that can be used as a precursor for the synthesis of many other organic compounds. MTNE is also a potential treatment for cancer cells because it has been shown to inhibit the growth of prostate and pancreatic cancer cells. The mechanism of this inhibition is not yet well understood, but it may be due to the hydroxyl group on MTNE's molecule that prevents hydrogen bonding with its target enzyme. This leads to the destruction of pancreatic lipase and an accumulation of fatty acids in the cell membrane, which eventually leads to cell death.

<p>N-Cyano-3-[(2-aminoiminomethyl)amino]-4-thiazolylmethyl]sulphanylpropanimidamide (NCTP) is an impurity of the drug product that is used in the synthesis of a chemotherapeutic drug. NCTP, which is also known as N-(cyano(ethoxycarbonyl)methyl)-2-[(2-aminoiminomethyl)amino]-4-thiazolecarboxamide, is a white to yellow solid that has a melting point of about 85°C. NCTP can be synthesized by reacting 1,1′-(1,3-phenylenebis(azanediyl))bis[N-(2-chloroethyl)]carbinol with sodium amide and 2-(aminomethyl)benzothiazole. It has been shown to be metabolized into 25 metabolites in vitro and</p>

<p>Varenicline Diamine Impurity - Bio-X ™ is a diamine impurity of varenicline, a medication used for smoking cessation. Varenicline acts as a partial agonist at α4β2 nicotinic acetylcholine receptors, which are involved in the addictive effects of nicotine. Researchers utilize this compound to study its effects on nicotine addiction and develop potential treatments for smoking cessation. This impurity is used as a reference standard or analytical tool in the quality control and manufacturing process of varenicline and serves as an important marker for ensuring the purity and consistency of varenicline during its production, helping to maintain the medication's safety and efficacy for patients seeking to quit smoking.</p>

<p>Fmoc-PEA is a protected amine linker used in peptide conjugation. It is cleavable under standard deprotection conditions.</p>

<p>Caspofungin impurity A is an impurity found in caspofungin, a drug used to treat fungal infections. Caspofungin impurity A has been shown to inhibit bacterial growth and is thought to be responsible for the bactericidal activity of caspofungin.</p>

<p>Desfuroyl ceftiofur S-acetamide is a drug product that has been synthesized by custom synthesis. It is a metabolite of ceftiofur, an antibiotic that belongs to the sulfonamides. The compound is a white powder with a purity of 99% and has an analytical purity of 98%. Desfuroyl ceftiofur S-acetamide is used in metabolism studies and as a natural impurity standard for HPLC analysis.</p>

<p>5-Hydroxy indoleacetylglycine is a protein analog found in human urine that has been shown to have anticancer properties. It inhibits the activity of cyclin-dependent kinases, which are involved in cell cycle regulation and tumor growth. This compound has been demonstrated to induce apoptosis (programmed cell death) in cancer cells and may have potential as an anticancer agent. Additionally, 5-Hydroxy indoleacetylglycine has been shown to inhibit the activity of certain kinases, which play a role in tumor formation and progression. Chinese researchers have identified this compound as a promising inhibitor for cancer treatment.</p>

<p>Sodium 4-phenylbutyrate (4PB) is an investigational agent that has been shown to have a significant up-regulation of the protein toll-like receptor 4 in neural cells. It also has been shown to have prophylactic antibiotic activity, which may be due to its ability to inhibit fungal growth. In addition, 4PB has been shown to have a profound effect on the levels of phenylbutyrate in cell cultures.<br>4PB is being investigated for its effect on neurological diseases such as chronic liver disease and kidney injury. The results of these studies are not yet available.</p>

<p>Betamethasone EP Impurity G is an analytical impurity that is found in the drug product Betamethasone EP. It is also a natural, synthetic, and custom synthesis impurity that has been manufactured to be an impurity standard. Betamethasone EP Impurity G has a CAS number of 85700-75-0 and is a niche HPLC standard for research and development purposes. This high purity impurity may be synthesized from other chemical compounds or created synthetically.</p>

<p>Lipid chain (stearic bi-acid) plus γ-glutamic acid or glutamate (γ-Glu) amino acid.</p>

<p>4-(1-Hydroxy-1-methylethyl)-2-propyl-1[4-[2-(trityltetrazol-5-yl)phenyl]phenyl]methylimidazo-5-carboxylate ethyl (4MPC) is a magnetic resonance imaging contrast agent. The compound has been shown to be useful for the detection of focal lesions in the breast, lung and pancreas. 4MPC is also an alternative to gadolinium diethylene triamine pentaacetic acid (GdDTPA), which can lead to nephrogenic systemic fibrosis and other side effects.</p>