APIs per la ricerca e le impurità

<p>3-(Cyanomethyl)-N-methyl-1H-indole-5-methanesulfonamide is an analytical standard, used for HPLC analysis of impurities. It is also used as a reference in certain pharmacopoeia standards, such as the USP and EP. 3-(Cyanomethyl)-N-methyl-1H-indole-5-methanesulfonamide has a purity of 99% and can be found in the drug product Impurity Standard.</p>

<p>4-Hydroxy-α1-[[[6-(3-phenylpropoxy)hexyl]amino]methyl]-1,3-benzenedimethanol (4OHBZ) is a metabolite of the drug product 4OHBZ. It is an impurity standard for HPLC analysis of the drug product 4OHBZ. The impurity has been characterized by LCMS and MS studies. The purity of this compound is &gt;99%.</p>

<p>2-Ethoxy-4-[2-[[(1R)-3-methyl-1-[2-(1-piperidinyl)phenyl]butyl]amino]-2-oxoethyl]benzoic acid is a synthetic amino acid. It is used for research and development purposes, including the manufacture of pharmaceuticals. The impurity standard for this compound is CAS No. 147852-26-4. The drug product may be custom synthesized by our experienced chemists or it may be obtained from an established supplier. The purity of this compound is typically high, with purity levels exceeding 99%. This compound can also be used as a metabolite in metabolism studies, such as HPLC standards.</p>

<p>N-(2,2-dimethoxyethyl)-3,4-dimethoxybenzeneacetamide is a drug impurity that is used as a research and development or impurity standard. It is also available for custom synthesis as an intermediate for drug product and synthetic. This product has high purity, with a purity of 99%. The CAS number for this compound is 73954-34-4. N-(2,2-Dimethoxyethyl)-3,4-dimethoxybenzeneacetamide's role in metabolism studies can be found in the pharmacopoeia and Drug Development. Synthesis of this compound is done by natural means through the use of plants such as Salvia officinalis L. (sage).</p>

<p>Ent-dorzolamide is a carbonic anhydrase inhibitor that binds to the β-adrenergic receptor, which is a G protein-coupled receptor. This binding leads to activation of the receptor and subsequent activation of adenylyl cyclase and increased production of cAMP. It has been shown to have insulin sensitizing effects in animal models. The synthesis of ent-dorzolamide involves a scalable, fluorine-mediated cross coupling reaction between an amine and a nitroarene. Ent-dorzolamide has been shown to inhibit symptoms of allergic rhinitis in animal models. The effect was shown to be due to inhibition of histamine release from mast cells. Ent-dorzolamide also inhibits transfer reactions, such as the transfer of glucose from serum albumin into erythrocytes.</p>

<p>Ssr 180711 hydrochloride is a synthetic compound with a molecular weight of 557.5. It has been used as an analytical reference standard in the development of drugs and as a natural product in research and development. Ssr 180711 hydrochloride is metabolized to form its active form, Ssr 180711, which is an antibiotic that kills bacteria by inhibiting protein synthesis and DNA replication. This drug also inhibits the growth of Mycobacterium tuberculosis, Mycobacterium avium complex, and Staphylococcus aureus. The purity of this product is 99.0% pure (HPLC).</p>

<p>2-Methoxy-5-sulfamoylbenzamide is a white crystalline solid that is soluble in water. This compound has been shown to be an antiemetic agent, and also possesses antidopaminergic properties. It is used as an antiemetic, but has not been studied extensively for this indication. 2-Methoxy-5-sulfamoylbenzamide has also been shown to be effective in the treatment of Parkinsonism.</p>

<p>Clarithromycin impurity O is a crystalline form of clarithromycin that is obtained by the sulfation of the free base. It is prepared by adding an acid binding agent to the free base and then dissolving it in water. The sulfate salt of clarithromycin impurity O can be purified by recrystallization. Clarithromycin impurity O has been used as a raw material for clarithromycin, which is a β-lactam antibiotic with activity against Gram-positive bacteria and some Gram-negative bacteria. Clarithromycin impurity O is also used in other pharmaceuticals such as anti-inflammatory drugs and antibiotics. The preparation process starts with the methylation reaction of potassium hydroxide, followed by hydrolysis to produce methyl sulfate and dimethyl sulfate. The methylated product is purified through distillation, vacuum drying, or crystallization, yielding a pure form of methylated product that can be further processed into other</p>

<p>Milrinone impurity 7 is a synthetic impurity of Milrinone. It is a white, crystalline solid that is soluble in water and methanol. This product has been shown to be metabolized by human liver microsomes with the formation of an unknown metabolite. Milrinone impurity 7 has been used as a pharmacopoeia reference substance for HPLC analysis in drug development studies.</p>

<p>4-(Phthalazin-1-yloxy)aniline is an analog of cyclin-dependent kinase (CDK) inhibitors that has shown promising anticancer activity. It inhibits the activity of CDKs, which are enzymes involved in regulating cell division and proliferation. This compound has been tested on Chinese hamster ovary cells and has demonstrated potent antiproliferative activity against various cancer cell lines. 4-(Phthalazin-1-yloxy)aniline induces apoptosis in tumor cells, leading to their death. This compound may be a potential candidate for the development of novel anticancer drugs that target CDKs and promote tumor cell death. Additionally, this compound can be detected in urine samples, making it a useful biomarker for cancer diagnosis and monitoring.</p>

<p>Please enquire for more information about 2,4-DDE-d8 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>4-[2-[[(6R,7R)-7-Amino-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]thio]-4-thiazolyl]-1-methylpyridinium Chloride Monohydrochloride is a drug product under development for the treatment of bacterial infections. 4-[2-[(6R,7R)-7Amino--2carboxy8oxo5thia1azabicyclo[4.2.0]oct2en3yl]thio]-4thiazolyl]-1methylpyridinium Chloride Monohydrochloride is an impurity in the API Methicillin (CAS No. 40082764). Impurities are not necessarily undesirable and may have substantial therapeutic value or provide a desired</p>

<p>N1.9,N1.9-Dimethyldesmopressin is a synthetic analog of the natural hormone vasopressin. It is used as a drug product in research and development to study drug metabolism, but it has not been approved for use as a drug product by any regulatory agency. Impurities are determined by the USP or EP pharmacopoeia and are present at less than 1% or 2% respectively. The compound is synthesized through high purity chemical synthesis methods with purity greater than 99%.</p>

<p>(6E,8Z)-5-Oxo-6,8-octadecadienoic acid is a potent anticancer agent that has shown promising results in the treatment of various types of cancer. It works as an inhibitor of tumor growth by inducing apoptosis and inhibiting the cell cycle progression. This compound has been extensively studied in Chinese medicinal practices and has been found to be effective against cancer cells. It acts as a protein kinase analog, which makes it a valuable tool for studying the signaling pathways involved in cancer development. Additionally, this compound can be detected in human urine and may serve as a potential biomarker for cancer diagnosis and monitoring. Overall, (6E,8Z)-5-Oxo-6,8-octadecadienoic acid holds great promise as a therapeutic agent for the treatment of cancer.</p>

<p>Neostigmine impurity A is a potent inhibitor of kinases that have been implicated in cancer cell growth and tumor progression. It is an analog of cyclin-dependent kinase inhibitors and has shown anticancer activity in human cancer cell lines. Neostigmine impurity A has been isolated from Chinese urine samples and has been shown to induce apoptosis in cancer cells. This compound has the potential to be used as a therapeutic inhibitor for the treatment of cancer. Its mechanism of action involves the inhibition of protein kinases, which are responsible for regulating many cellular processes, including cell division and proliferation. Overall, Neostigmine impurity A is a promising compound for the development of novel cancer therapies.</p>

Rizatriptan impurity-A is an analog of Rizatriptan that has shown potential as an anticancer agent. It has been found in urine and has been studied for its ability to induce apoptosis in human cancer cells. This compound is a kinase inhibitor, which means it can inhibit the activity of specific proteins involved in cell replication and growth. As a result, it may be useful as a medicinal inhibitor for the treatment of various tumors and cancers. The research on Rizatriptan impurity-A is ongoing, but it shows promise as a potential new therapy for cancer patients.

<p>10-Allyl-2-chloro-phenothiazine is a metabolite of the drug product, Clopidogrel. It is a white crystalline powder that is soluble in water and alcohol. 10-Allyl-2-chloro-phenothiazine is used as an analytical standard for HPLC and NMR studies of Clopidogrel. It also is used as an impurity standard for the determination of purity of this drug product. This chemical belongs to the group of synthetic compounds that are metabolized by humans. Studies have been conducted on its metabolism, which has led to the discovery of its metabolites and their properties. This compound has not been evaluated by any pharmacopoeia or regulatory agency and should be handled accordingly.</p>

<p>Please enquire for more information about [(2E)-4-Chloro-2-methylbut-2-ene-1-sulfonyl]benzene including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about N-Methyl omeprazole (Mixture of isomers with the methylated nitrogens of imidazole) including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Chlorhexidine dihydrochloride impurity B is an impurity found in chlorhexidine dihydrochloride, a drug that is used as an antiseptic and disinfectant. It is a metabolite of chlorhexidine and has been detected in urine and plasma samples. This impurity has no known pharmacological activity. The purity of this compound is not less than 99%.</p>

<p>Pioglitazone Pyridine-6-[4-[2-[5-ethyl-6-[4-[2-(5-ethyl-2-pyridinyl)ethoxy]phenyl]propionamido]-1,3,4-thiadiazol-2(3H)-ylidene]aminocarbonyl]-1,3,4-thiadiazole is a drug that belongs to the group of thiazolidinediones. It is an oral hypoglycemic agent that lowers blood sugar by stimulating insulin release from the pancreas and increasing peripheral tissue sensitivity to insulin. Pioglitazone Pyridine-6-[4-[2-[5-ethyl-6-[4-[2-(5-ethyl-2 pyridinyl)ethoxy]phenyl]propionamido]-1,3,4-thiadiazol 2(3H)-ylidene]aminocarbonyl]-</p>

<p>(Z)-Fluvoxamine-EP is a drug product that is used as an analytical standard. It is a synthetic metabolite of fluvoxamine, which is a drug used for the treatment of depression. The synthesis of (Z)-fluvoxamine-EP is based on the asymmetric synthesis of fluvoxamine and the use of chiral chromatography to purify the product. This synthetic process allows for the production of high-purity (Z)-fluvoxamine-EP with a purity greater than 99%.</p>

<p>Please enquire for more information about Ethyl 4-(2-N-Boc-2-aminoethyl)benzenesulfonamide carbamate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Fluticasone furoate EP impurity E is an analytical reference standard for pharmacopoeia and research. It is a synthetic fluticasone furoate EP impurity that has been custom synthesized for use as a high-purity, HPLC-grade standard. Fluticasone furoate EP impurity E is characterized by its natural origin and purity, making it appropriate for use in drug development and research. The CAS number for this product is 398454-97-2.</p>

<p>Desmethoxyamino hydroxy gemifloxacin is a drug product that belongs to the class of fluoroquinolones. It is a synthetic compound with a molecular weight of 551.4 g/mol and an empirical formula of C21H25FN3O2. Desmethoxyamino hydroxy gemifloxacin has been shown to inhibit bacterial DNA gyrase and topoisomerase IV in vitro, which are enzymes that maintain the integrity of bacterial DNA. The compound binds to 16S ribosomal RNA and inhibits protein synthesis, leading to cell death by inhibiting the production of proteins vital for cell division. This drug product is metabolized into gemifloxacin, desmethoxyamino acid, and desmethylgemifloxacin. These metabolites have not been shown to be active against bacterial DNA gyrase or topoisomerase IV in vitro, but may be active against other targets in</p>

<p>Please enquire for more information about Desphenol 1-hydroxyethyl cefoperazone furolactone including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>2,2-Bis[4-(2-diethylaminoethoxy)phenyl]-1,2-diphenylethanone (bis-DEA) is a synthetic metabolite that has been shown to inhibit human liver microsomal cytochrome P450 enzymes. This product is intended for use as an analytical reference standard for the purity of drug products. It is also used in pharmacological and metabolic studies.</p>

<p>Impurity C is a minor impurity of Minocycline Hydrochloride Dihydrate. It is an impurity that is the result of the metabolism of Minocycline Hydrochloride Dihydrate in the body. This impurity is an active metabolite that has been detected in urine, plasma, and various tissues. Impurity C can be found in concentrations up to 50% of the total amount of minocycline in the blood plasma and controls for this impurity are required as it can be toxic to humans.</p>

<p>Tryptoquivaline D is a metabolite of tryptoquivaline A, which is an impurity in the drug product. Tryptoquivaline D can be used as a standard for research and development or for custom synthesis. This compound has been shown to have anti-inflammatory effects and may also act as an analgesic. It has also been shown to inhibit the production of prostaglandin E2 from arachidonic acid, thereby reducing inflammation.</p>

<p>N-[(2R)-3-{[3-Fluoro-4-(4-morpholinyl)phenyl]amino}-2-hydroxypropyl]acetamide is an impurity in a high purity analytical reference standard of 3-fluoro-4-(4-morpholinyl)aniline. It is also a metabolite that may be present in drug products containing 3-fluoro-4-(4-morpholinyl)aniline as the active ingredient, such as fluoroquinolones. N-[(2R)-3-{[3-Fluoro-4-(4-morpholinyl)phenyl]amino}-2-hydroxypropyl]acetamide has been shown to inhibit DNA gyrase and topoisomerase IV, which are enzymes that maintain the integrity of bacterial DNA. It binds to bacterial 16S ribosomal RNA and inhibits protein synthesis, leading to cell death by inhib</p>

<p>Please enquire for more information about 11-Oxo-betamethasone-17-carboxylic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Gatifloxacin is a fluoroquinolone antibiotic that inhibits the DNA gyrase and topoisomerase IV, which are enzymes that maintain the integrity of bacterial DNA. It binds to bacterial 16S ribosomal RNA and inhibits protein synthesis, leading to cell death by inhibiting the production of proteins vital for cell division. Gatifloxacin has been shown to be effective against methicillin-resistant Staphylococcus aureus (MRSA) and Clostridium perfringens, although is not active against acid-fast bacteria such as Mycobacterium tuberculosis or Mycobacterium avium complex. Gatifloxacin has shown anti-inflammatory properties, which may be due to its inhibition of prostaglandin synthesis.<br>4'-[(4'Methyl-2'-propyl[2,6'-bi-1H-benzimidazol]-1'-yl)methyl][</p>

<p>4-Phenybutyl 2-carboxyethylphosphinic acid is used as an analytical standard and has been shown to be a metabolite of other drugs. It is also used as an impurity standard for HPLC, and provides a niche for drug product development.</p>

<p>2-Hydroxy cephalexin is a metabolite of cephalexin. It is an impurity that is present in the final drug product. 2-Hydroxy cephalexin has been used as an analytical standard and as a HPLC standard for quantification of cephalexin. 2-Hydroxy cephalexin is also used as a research and development tool for drug development.</p>

<p>Cis-1,2-dihydroperillic acid is an endogenous metabolite of perillyl alcohol. It is formed in the liver from perillyl alcohol and is excreted in the urine. Cis-1,2-dihydroperillic acid has been shown to inhibit cell growth and induce cancer in animals and humans. Its mechanism of action may be due to its ability to inhibit the production of a growth factor called growth factor β (GFβ). This hormone stimulates the proliferation of mammary carcinomas and may also be involved in carcinogenesis. Cis-1,2-dihydroperillic acid is present in plasma at low concentrations, which have been measured using a human bioassay.</p>

<p>1,3-Bis-O-(tert-butyldimethylsilyl)-calcipotriene is a synthetic silyl ether of calcipotriene. It is used for the synthesis of drugs and as an impurity standard for HPLC analysis. 1,3-Bis-O-(tert-butyldimethylsilyl)-calcipotriene has been studied in metabolism studies and found to be natural, but it is not an API because it does not have a biological activity. It is also used in the development process of drugs and has been shown to be pharmacopoeia grade with a purity of at least 98%.</p>

<p>2-Acetoxy-1,4-naphthoquinone is a potent inhibitor of kinases and has shown to have anticancer properties. It is an analog of the natural compound shikonin found in Chinese medicinal plants. This compound induces apoptosis in cancer cells and has been shown to inhibit the growth of tumor cells. 2-Acetoxy-1,4-naphthoquinone has been found in human urine and may play a role in the prevention of cancer. This compound is a promising candidate for the development of kinase inhibitors for use in cancer treatment.</p>

<p>3,4-Bis(2-methoxyethoxy)benzoic acid ethyl ester is a compound that has been shown to have bactericidal activity against Gram-positive bacteria. It is currently being evaluated for use in the preparation of samples for microbiological analysis and as an antimicrobial agent. 3,4-Bis(2-methoxyethoxy)benzoic acid ethyl ester has been shown to inhibit the growth of tumor cells in vitro and may be useful in the treatment of cancers. This compound also inhibits the production of nitric oxide by nitro groups and hydrogen bonds with amino acids on proteins or carbohydrates that are required for bacterial cell wall biosynthesis.</p>

<p>NUC-7738 is a medicinal compound that has been shown to be an effective inhibitor of cyclin-dependent kinases (CDKs). It has potent anticancer activity and has been studied extensively in Chinese hamster ovary (CHO) cells, human leukemia cells, and other cancer cell lines. NUC-7738 works by selectively inhibiting CDK4/6, which are critical regulators of the cell cycle. This leads to the induction of apoptosis in cancer cells, making it a promising new therapeutic agent for the treatment of various types of cancer. Additionally, NUC-7738 has been shown to have low toxicity and good pharmacokinetic properties in preclinical studies. Overall, this compound holds great promise as a novel anticancer therapy that may help improve outcomes for patients with cancer.</p>

<p>Brexpiprazole impurity 10 is a drug product that is used as an analytical reference standard for the quality control of brexpiprazole. This drug product is a synthetic substance with a high purity and is designed for use in HPLC analyses. This impurity can be used as a reference to identify other metabolites of brexpiprazole, such as 3-desacetyl-brexpiprazole, which are not necessarily identified by mass spectrometry. The CAS number for Brexpiprazole impurity 10 is 15116-41-3 and it has been assigned the IUPAC name 2-[2-[(2S)-2-[[(3S)-3-[4-(1,1-dimethylethyl)phenoxy]propyl]amino]-3-methylbutanoyl]-1H-indol-5-yl]acetic acid.</p>

1-[2-(2,3-Dihydroxypropoxy)phenyl]-3-phenyl-1-propanone is a metabolite that is formed from the drug product. It is a synthetic compound that has been shown to have anti-inflammatory and analgesic activities in animal models. 1-[2-(2,3-Dihydroxypropoxy)phenyl]-3-phenyll -1-propanone has been shown to be effective against carrageenan, Freund's adjuvant, and Complete Freund's Adjuvant induced arthritis in rats. This metabolite also inhibits prostaglandin synthesis, which may contribute to its anti-inflammatory effects.

<p>Decarbazolyl desmethyl carvedilol is a potent anticancer agent that inhibits elastase and protein kinases, which are involved in cancer cell growth and tumor progression. It induces apoptosis, or programmed cell death, in cancer cells by inhibiting the activity of specific kinases. Decarbazolyl desmethyl carvedilol has been shown to be effective against a variety of human cancers, including lung, breast, and prostate cancers. It is also an inhibitor of Chinese hamster ovary (CHO) cell kinase activity and can be detected in urine samples. This analog of carvedilol has potential as a therapeutic agent for the treatment of cancer.</p>

<p>Mercaptopurine impurity standard is a drug product that is used as an analytical reference standard in the development of drugs. Mercaptopurine impurity standard is a natural metabolite of 6-mercaptopurine, which is used to treat leukemia and other forms of cancer. It has been shown to have an anti-inflammatory effect, but this has not been confirmed. Mercaptopurine impurity standard is a synthetic compound that is made synthetically for use as an impurity standard. It has also been shown to be metabolized by cytochrome P450 enzymes, glutathione reductase, or conjugation with glucuronic acid. Mercaptopurine impurity standard has been shown to be stable under acidic conditions and heat treatment at temperatures up to 200°C.</p>

<p>Dibenzhydryl disulfide is a compound that includes sulfide and olefinic groups. It is an impurity in the reaction products of sulfide with olefins, which may be removed by washing, distillation, and crystallization. Dibenzhydryl disulfide has been shown to react with nucleophiles (e.g., OH-, CO2) to form an anion or proton. The reaction mechanism for this product is not well understood, but it most likely proceeds through the intermediacy of diphenylmethane. The product can also undergo a transfer reaction with butyllithium or thiobenzophenone to form methylbenzene, ethylbenzene, or propylbenzene respectively.</p>

<p>Ivacaftor carboxylic acid is a pharmaceutical drug that is used to treat cystic fibrosis. It is a prodrug, which means it is inactive until it is metabolized by the body into its active form, ivacaftor. Ivacaftor carboxylic acid binds to CFTR proteins, which are responsible for transporting chloride ions across cell membranes. This causes an increase in the transport of chloride ions into cells and improves the flow of salt and water out of the lungs. Ivacaftor carboxylic acid has been shown to be safe and effective in patients with cystic fibrosis who have two copies of the F508del mutation in their CFTR gene, including those who have never received treatment with ivacaftor before.</p>

<p>Belinostat glucuronide is an analytical standard that is used in HPLC. This compound is a metabolite of Belinostat, which is a drug used to treat lymphoma and other cancers. Belinostat glucuronide has been shown to be active against leukemia cells and can inhibit the growth of cancer cells by inhibiting protein synthesis. It also inhibits the activity of topoisomerase I, II, and III.</p>

<p>Diethatyl is an anticancer drug that induces apoptosis in human tumor cells. It works by inhibiting protein kinases, which are enzymes that play a crucial role in the regulation of cell growth and division. Diethatyl is an analog of indirubin, a compound found in Chinese herbal medicine. It has been shown to be effective against various types of cancer cells, including breast, lung, and colon cancer. Diethatyl specifically targets cancer cells and does not affect normal cells. It is a promising new inhibitor in the fight against cancer.</p>

<p>Please enquire for more information about N-[2-Aminoethyl) lenalidomide trifluoroacetic acid salt including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about (1R,1’R, 2’S)-2-Desmethyl cisatracurium besylate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Bucromarone is an anticancer drug that has been shown to inhibit the growth of cancer cells by targeting specific proteins and enzymes involved in tumor formation. It acts as a protein kinase inhibitor, blocking the activity of kinases that promote cell growth and division. Bucromarone has also been found to be a potent inhibitor of glutathione S-transferase, an enzyme that plays a role in drug resistance in cancer cells. This drug has been tested on human cancer cell lines and Chinese hamster ovary cells, demonstrating its ability to induce apoptosis in these cells. Bucromarone is structurally similar to ginsenoside, a compound found in traditional Chinese medicine with anticancer properties.</p>

<p>Please enquire for more information about Fluazifop-d4 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>PSB-1584 is a medicinal analog that acts as an inhibitor of Chinese hamster ovary (CHO) cell tumor kinase (CHK). It has been shown to be effective in inhibiting the activity of various kinases, making it a promising anticancer drug. PSB-1584 has demonstrated potent anticancer activity in multiple cancer cell lines, including breast, colon, and lung cancer cells. This drug induces apoptosis in cancer cells and inhibits the growth of tumors. PSB-1584 can be detected in human urine after administration, indicating its potential for clinical use as an orally available protein kinase inhibitor.</p>

<p>Fijimycin B is a medicinal compound that acts as an inhibitor of kinases, which are proteins that play a crucial role in cancer cell growth and proliferation. This analog of the natural product fijimycin has been shown to induce apoptosis (cell death) in tumor cells and exhibits potent anticancer activity. Fijimycin B has been isolated from human urine and Chinese medicinal herbs, and it has been found to be a highly selective inhibitor of certain kinases. This compound shows promise as a potential therapeutic agent for the treatment of various types of cancer. Its ability to target specific kinases makes it an attractive option for developing targeted inhibitors that can selectively kill cancer cells while sparing healthy cells.</p>

<p>7α,24(S)-Dihydroxycholesterol (7α,24(S)-DHCH) is a fatty acid that is produced by the liver and is an intermediate in cholesterol biosynthesis. 7α,24(S)-DHCH has been detected in plasma samples of patients with cerebrotendinous xanthomatosis (CTX). It has also been found to be elevated in tuberculosis patients with carotid involvement. The levels of 7α,24(S)-DHCH were found to be higher than those of other oxysterols in CTX patients. In order to identify the origin of this molecule, a LC-MS/MS method was developed for the detection and quantification of 7α,24(S)-DHCH. This method uses chemical ionization for mass spectrometric analysis and can detect 7α,24(S)-DHCH at concentrations as low as 1 ng/mL. Histological analyses were conducted on human tissue samples</p>

<p>Please enquire for more information about Tyk2-in-5 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Tetramethyl-5-bromomethyl-1,3-benzenediacetonitrile (TMBDAC) is an impurity standard and a metabolite of the drug product. It is an analytical standard for HPLC. Tetramethyl-5-bromomethyl-1,3-benzenediacetonitrile is a high purity research and development chemical that can be custom synthesized to meet specific needs. This synthetic compound has shown potential as a niche metabolite in metabolism studies. CAS No. 120511-84-4.</p>

<p>7-o-Benzyl luteolin is a synthetic compound that is used as an impurity standard for the pharmaceutical industry. It is also a metabolite of luteolin, which can be found in plants such as parsley and sage. The structure of 7-o-benzyl luteolin has been determined using X-ray crystallography. This compound is used in drug development to study metabolism and to develop new drugs with fewer side effects. 7-o-Benzyl luteolin has been shown to have antiinflammatory properties, which may be due to its inhibition of prostaglandin synthesis.END&gt;</p>

<p>Demethylpiperazinyl Sildenafil Sulfonic Acid is a prodrug of sildenafil, which is an organic compound. It is used in the treatment of erectile dysfunction and pulmonary arterial hypertension. This drug is metabolized by hydrolysis to form sildenafil citrate, which then acts as an inhibitor of cGMP-specific phosphodiesterase type 5 (PDE5). This enzyme regulates the intracellular levels of cyclic guanosine monophosphate (cGMP), which are needed for the relaxation of smooth muscles in the corpus cavernosum and pulmonary arteries. Demethylpiperazinyl Sildenafil Sulfonic Acid has been shown to have a good safety profile with no major adverse effects or interactions with other drugs.</p>

<p>Seco everolimus B is a drug product that has not been approved by the FDA. It is an impurity standard used for analytical purposes and in drug development. It is a synthetic, natural, and pharmacopoeia-grade impurity. The CAS number of this product is 769905-89-7. This product is currently being researched and developed as a niche drug with high purity.</p>

<p>4-Epiminocycline is a pharmaceutical preparation that belongs to the class of antibiotics. It is a drug substance that is used in the manufacture of other drugs and as an individual drug for the treatment of various skin conditions and for the prevention of malaria. 4-Epiminocycline has been shown to be effective against bacteria by binding to DNA, preventing transcription and replication. The drug binds to plasma proteins and erythrocytes with high affinity, but it does not bind well to intestinal cells or lung tissue. 4-Epiminocycline has been shown to be effective against Mycobacterium tuberculosis, Mycobacterium avium complex, Staphylococcus aureus, Streptococcus pyogenes, and Enterococcus faecalis. This antibiotic also prevents the formation of biofilms by these bacteria.</p>

<p>(S)-Mirabegron is a drug development, API impurity, and HPLC standard. It is an analytical reagent for research and development purposes, as well as a High purity and Impurity standard. This product is also used in the synthesis of drugs or drug products. The CAS number for this product is 1796931-48-0 and it has the molecular formula C22H27N3O2S. (S)-Mirabegron is a metabolite of mirabegron that has been shown to be a selective agonist of beta-3 adrenergic receptors. Metabolites are substances that are produced when the body breaks down another substance (in this case, mirabegron).</p>

<p>Ivermectin is a drug that belongs to the anthelmintic class of drugs. It is active against roundworms, pinworms, and hookworms. Ivermectin has been shown to have an effect on autoimmune diseases such as multiple sclerosis, systemic lupus erythematosus, and rheumatoid arthritis by inhibiting the inflammatory response. The drug has been shown to inhibit matrix metalloproteinases in vitro and in vivo. The matrix effect is seen when the drug binds to proteins in the blood plasma or tissue matrix, where it inhibits their activity. This inhibition prevents the degradation of collagen, which can lead to tissue damage or renal failure. Ivermectin also binds to striatal dopamine receptors and inhibits dry weight gain in animals infected with Ostertagia ostertagi. Ivermectin is given orally in a single dose of 200 micrograms/kg body weight for treatment of intestinal worms (roundworm,</p>

Tecloftalam imide is a drug product that is an analytical standard. It is a natural product, which can be obtained from the fermentation of Streptomyces sp. (CAS No. 26491-30-5). Tecloftalam imide is also an impurity in some APIs. It can be synthesized, and has been used as an impurity standard for HPLC, with a purity of >99%. Tecloftalam imide has been used in drug development and research and development. It has been shown to have niche applications in pharmacopoeia.

<p>Gyromitrin is a potent inhibitor of tumor growth and apoptosis in human cancer cells. It is an analog of tylosin, a macrolide antibiotic used in veterinary medicine. Gyromitrin has been shown to inhibit the activity of kinases involved in cell proliferation and survival, leading to decreased cell growth and increased apoptosis. In Chinese hamster ovary cells, gyromitrin has been demonstrated to be a potent inhibitor of protein synthesis. This compound has also been found in urine samples from humans who have ingested mushrooms containing gyromitrin. Menthol has been found to be an effective inhibitor of gyromitrin-induced DNA damage and may have potential as a chemopreventive agent against cancer.</p>

<p>b-1-Cyclohexen-1-yl-4-methoxy-N,N-dimethylbenzeneethanamine is a drug product that is used in the development of drugs. It is a metabolite of cyclizine and has been shown to have antihistaminic effects. This chemical compound is an impurity standard for HPLC analyses of other substances. b-1-Cyclohexen-1-yl-4-methoxy-N,N-dimethylbenzeneethanamine has also been shown to be a synthetic intermediate in the synthesis of pharmaceuticals.</p>

<p>Telmisartan is a drug that belongs to the class of angiotensin II receptor antagonists and is used in the treatment of hypertension. Telmisartan can be quantitatively analyzed with high sensitivity by liquid chromatography. Impurities in telmisartan can be analyzed qualitatively and quantitatively by liquid chromatography, which requires a shorter time than GC analysis.</p>

<p>Apigenin 5-o-β-D-glucuronide is a natural compound derived from the Chinese herb scutellaria baicalensis. It has been shown to be effective in reducing pro-inflammatory cytokines and prostate cancer cells. Apigenin 5-o-β-D-glucuronide is one of the many phenolic acids found in plants, which are known for their antioxidant and anti inflammatory properties. The plant metabolizes apigenin 5-o-β-D-glucuronide by conjugating it with glucuronic acid, forming the glucuronide conjugate. The bioactive phenolic compounds in plants are well studied and have been shown to have anticancer properties.</p>

<p>Please enquire for more information about Daunorubicin EP impurity B including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Atorvastatin lactam lactone is a synthetic drug product that has been used in the research and development of atorvastatin. It is an impurity standard for atorvastatin and has been shown to be the major metabolite of atorvastatin. Atorvastatin lactam lactone is a white powder with a melting point of 122-124°C, soluble in ethanol and acetone, but insoluble in water. This substance is not found naturally in any plants or animals, but it can be synthesized by reacting 3-hydroxyatorvastatin (3HA) with lithium hydroxide.</p>

<p>Please enquire for more information about 13-Cis acitretin o-β-D-glucuronide including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>N-Formyl-D-leucine (1R)-1-[[(2R,3R)-3-Hexyl-4-oxo-2-oxetanyl]methyl]dodecyl ester is a synthetic metabolite that is used as an impurity standard for the analysis of N-formylmetabolites in drugs. It is also used to study the metabolism of drugs. This product has been assigned CAS number 104872-27-7 and appears on the USP high purity&gt; list.</p>

<p>Paliperidone Z-oxime is a metabolite of paliperidone that is used as an impurity standard. It is a white crystalline powder with a molecular weight of 437.2 g/mol. Paliperidone Z-oxime has been shown to be the major metabolite of paliperidone in human plasma and urine, accounting for about 60% of the total dose after oral administration. The chemical name for Paliperidone Z-oxime is 3-(4-hydroxyphenyl)propionate 2-oxime (1:1).</p>

<p>3,4-Dimethoxy-a-(1-methylethyl)benzeneacetonitrile (DXM) is a synthetic phenylethylamine that is usually found in cough suppressant preparations. It has been shown to be able to cross the blood-brain barrier, and it has a constant, steady-state concentration. DXM is metabolized by N-demethylation in the liver by cytochrome P450 enzymes. This metabolism can be inhibited with the use of drugs such as chlorpromazine or ketoconazole. Pharmacokinetic modeling has been used to analyze and predict the pharmacokinetics of DXM. The drug DXM can also be synthesized from phenylacetonitrile and hydrochloric acid.</p>

<p>2,6-Diethyl-4-thioisonicotinamide is a metabolite of 2,6-diethyl-4-(methylsulfonyl)pyrimidine and is used as an analytical standard for HPLC. It is also used in the development and quality control of pharmaceutical drugs. 2,6-Diethyl-4-thioisonicotinamide is a white solid that can be synthesized from the reaction of ethyl thiocyanate with diethyl 4-(methylsulfonyl)pyrimidine. It has been shown to be rapidly metabolized in vivo to form the corresponding sulfoxide or sulfone.</p>

<p>N-Desalkyl itraconazole is a triazole antifungal drug that belongs to the group of medicines. It is used in the treatment of systemic mycoses, including blastomycosis and histoplasmosis. N-Desalkyl itraconazole has been shown to inhibit the growth of fungi by interfering with their cell membranes and inhibiting their production of ergosterol. Calibration studies have shown that this drug binds to human liver microsomes and plasma proteins, as well as transporters such as P-glycoprotein. These interactions may influence its pharmacokinetics, which can be determined using a bioanalytical method.</p>

<p>Azilsartan Dimer is a crystalline solid with a melting point of 95-98°C. It is insoluble in water and soluble in acetone, acetonitrile, and dimethyl sulfoxide. Azilsartan Dimer has shown antihypertensive effects in animal models. The chemical structure of Azilsartan Dimer is based on the alkyl ester of azilsartan and an acetone solvent.</p>

<p>Cocsulin is a medicinal compound that has shown promising results in the treatment of cancer. It is an analog of a naturally occurring kinase inhibitor found in Chinese urine, and has been shown to induce apoptosis (cell death) in cancer cells. Cocsulin inhibits the activity of specific proteins involved in cell cycle regulation, leading to decreased proliferation and growth of cancer cells. This anticancer agent has shown efficacy against various human cancers, including breast, colon, and lung tumors. Studies have also demonstrated that Cocsulin can enhance the effects of other cancer inhibitors when used in combination therapy. If you are looking for a potent anticancer agent with low toxicity, Cocsulin may be the solution you need.</p>

<p>Famotidine is a pharmaceutical agent that belongs to the class of H2-receptor antagonists. It is used for the treatment of peptic ulcers and gastroesophageal reflux disease. Famotidine inhibits gastric acid secretion by blocking the H2-receptors in the parietal cells in the stomach. There are two major impurities, 4-amino-N-[(4-[[[2-(aminosulphonyl)thiazol-4-yl]methyl]sulphanyl]ethyl]-3,5-bis[[2-[(aminoiminomethyl)amino]thiazol-4-yl]methyl]sulphanyl]ethyl]-1,2,4,6-thiatriazine 1,1 dioxide and 2-[(aminoiminomethyl)amino]-N-[(4-[[2-(aminosulphonyl)thiazol-4-yl</p>

<p>7-(3-Bromopropoxy)-3,4-dihydrocarbostyril is a white crystalline powder that is soluble in ethanol and ether. It is used as an analytical standard in HPLC or GC, as well as in the development of drugs. 7-(3-Bromopropoxy)-3,4-dihydrocarbostyril has a purity of 99% and is available for custom synthesis with a minimum order quantity of 50 grams. This compound can be synthesized from natural or synthetic sources.</p>

<p>Oasomycin B is a drug product that is used as an analytical reagent, or as an API impurity. It has a natural origin and is synthesized from the fermentation of Streptomyces sp. Oasomycin B is often used to standardize HPLC equipment and calibrate column materials. This compound can also be used for research purposes in the development of new drugs.</p>

<p>Propoxyphenyl thiosildenafil is a linker that has been synthesized from the amino acid sildenafil. The compound can be used in pharmaceutical preparations, health food, and medicinal preparations. It is also used as an additive to prepare the desired drug. This product is a resonance-type organic compound that can be detected using resonance spectroscopy or magnetic resonance spectroscopy. The compound has a molecular weight of 348.08 g/mol and a boiling point of 440°C at 760 mmHg pressure.</p>

<p>Please enquire for more information about 2-Amino-3-benzoyl-5-chlorobenzeneacetamide including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>9-Methylamino minocycline is a semi-synthetic antibiotic with excellent oral bioavailability. It can be used in the treatment of acne, inflammatory bowel disease, and rheumatoid arthritis. 9-Methylamino minocycline is an impurity that occurs during the synthesis of minocycline. It has been shown to inhibit protein synthesis by binding to the ribosome and preventing peptide bond formation. This impurity also inhibits RNA polymerase activity, which may account for its antimicrobial properties.</p>

<p>Brexpiprazole impurity 3 is a drug product that has been custom synthesized for research purposes. The purity of this product is high and it has been analyzed using analytical methods. This product can be used to study the metabolism of brexpiprazole, which is an atypical antipsychotic medication. Brexpiprazole impurity 3 also has pharmacopoeia standards, which can be used to develop new drugs or as a quality control standard in research and development.</p>

<p>Carbidopa is an impurity of the drug L-DOPA, which is used as a treatment for Parkinson's disease. Carbidopa is a prodrug that is converted to L-DOPA by decarboxylase, an enzyme in the body. The conversion process can be inhibited by the presence of carbidopa impurity F (CIF), which binds to carboxamides and forms a stable complex with them. This prevents CIF from binding to decarboxylase and blocking its ability to convert carbidopa into L-DOPA. CIF has been shown to have anti-parkinsonian effects by reducing the severity of symptoms associated with Parkinson's disease such as muscular rigidity and tremors.</p>

<p>4-Hydroxy moxonidine (4HM) is a metabolite of moxonidine. It is a synthetic, high purity, pharmacopoeia grade chemical that can be used as an impurity standard for the drug product. Metabolism studies have shown that 4HM is not involved in any major metabolic pathways in humans. The CAS number for 4HM is 352457-34-2.</p>