APIs per la ricerca e le impurità

<p>cis-(±)-4-[4-[4-[4-[[2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]- 2,4-dihydro-2-propyl-3H-1,2,4-triazol-3-one is a drug product that is used as a research and development tool. It is an impurity standard for HPLC. This compound has a chemical name of cis-(±)-4-[4-[4-[4-(hydroxymethyl)phenyl]-1piperazinyl]phenyl]-2, 4dihydro 2propyl 3H 1 2 4 triazol 3one. The CAS number for this compound is 7485591 7. This compound</p>

<p>Pseudomonic acid D sodium is a drug product that is used for the development of novel drugs. It is a natural metabolite of pseudomonic acid A, which is found in the fungus Pseudomonas sp. Pseudomonic acid D sodium is used as an analytical standard to aid in the identification of pseudomonic acid A and its metabolites. Pseudomonic acid D sodium can be synthesized by reacting 2-chloro-4-nitrobenzene with sodium bisulfate. The synthesis proceeds through a sequence of three reactions, namely nucleophilic substitution, electrophilic substitution, and hydrolysis. The structure of pseudomonic acid D sodium has been confirmed using nuclear magnetic resonance spectroscopy (NMR) and mass spectrometry (MS).</p>

<p>Please enquire for more information about 3,4-Dihydro naratriptan oxalate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>2-[4-[2-(Cyclopropylmethoxy)ethyl]phenoxy]methyloxirane is a metabolite of the drug product 2-[[4-[2-(Cyclopropylmethoxy)ethyl]phenoxy]methyl]oxirane. It is an impurity in the drug product, which is a pharmaceutical intermediate that has been shown to have pharmacological properties. The CAS number for this compound is 63659-17-6 and it has been assigned the Chemical Abstracts Service (CAS) number of 63659-17-6. This compound has been characterized using HPLC and GC/MS methods.</p>

<p>8-Methyl etodolac is an impurity of etodolac that is used in the drug development and analytical chemistry industry. It is a synthetic metabolite of etodolac, which is an analgesic agent that belongs to the group of non-steroidal anti-inflammatory drugs (NSAIDs). 8-Methyl etodolac is primarily excreted unchanged in urine and has been used as an HPLC standard for this purpose. It also serves as a pharmacopoeia reference material for the determination of purity and impurities in drug products.</p>

<p>Cefazedone Impurity 12 is a drug product that has been custom synthesized for research and development purposes. The impurity has been shown to have a high purity level, with a CAS number of 184696-69-3. Cefazedone Impurity 12 is an analytical standard and metabolite of Cefazedone. It is also used as a natural drug development standard, which can be used for pharmacopoeia studies or as a metabolite in niche research. This impurity can be synthesized in the laboratory and can be used as an impurity standard for HPLC.</p>

<p>Indoxacarb is a racemic compound that is used as an insecticide. It belongs to the class of carbamate insecticides and is marketed under the trade name of "Provaunt". Indoxacarb inhibits acetylcholinesterase, which leads to increased acetylcholine in the synapse, resulting in death. The production of indoxacarb has been optimized to yield a high-level of stereoselectivity. This optimization was achieved through a biocatalytic process that uses a strain of Escherichia coli with high stereoselectivity. This strain produces indoxacarb with a high level of stereoselectivity, which can be confirmed by NMR analysis.</p>

<p>Pyrimisulfan is a medicinal compound that has shown potent anticancer activity in both human and Chinese hamster cancer cell lines. It is an analog of pyrimidine, a naturally occurring compound found in urine. Pyrimisulfan works by inhibiting the activity of protein kinases, which are enzymes that regulate cell cycle progression and promote cell growth. This inhibition leads to apoptosis, or programmed cell death, in cancer cells. Pyrimisulfan has been shown to be a highly selective inhibitor of certain protein kinases, making it a promising candidate for the development of targeted cancer therapies. Its unique mechanism of action and specificity make it a valuable addition to the arsenal of anticancer inhibitors currently available.</p>

<p>Endo-cis-lurasidone hydrochloride is a synthetic, high purity, analytical standard material. It is an impurity in the drug product, Lurasidone hydrochloride. The chemical name for Endo-cis-lurasidone hydrochloride is 3-[4-(2,6-dioxopiperidin-3-yl)phenoxy]propanoic acid, 1-[(1R)-1-(2,3-dihydroxypropyl)piperidin-3-yl] ester. The CAS number for Endo-cis-lurasidone hydrochloride is 1318074-20-2.</p>

<p>Tazarotenic acid sulfone is a retinoic acid, which is a metabolite of vitamin A. It is an all-trans retinoic acid that has been chemically modified to increase its water solubility and stability. Tazarotenic acid sulfone has been shown to inhibit the formation of metabolites by hydroxylase enzymes and the photolytic decomposition of tazarotene. Tazarotenic acid sulfone also interacts with the substrate binding site on cytochrome P450 enzyme, inhibiting the metabolic activation of exogenous substances such as acetonitrile and ammonium formate. The chemical structure of tazarotenic acid sulfone is acidic, which may be responsible for its inhibition of cytochrome P450 enzymes.</p>

<p>(1R,2S,5R)-5-Methyl-2-(1-methylethyl)cyclohexyl N-[(7R)-6,7-dihydro-5-[(4-methoxyphenyl)methyl]-6-oxo-5H-dibenz[b,d]azepin-7-yl]carb amate is a synthetic compound. It is an impurity in the drug product Brivaracetam (CAS No. 1083065-09-1). This impurity was observed to be present in Brivaracetam at a concentration of 0.0008%. The drug product was manufactured by Drug development and Natural, Research and Development. The impurities were detected using HPLC standard and the analytical method. Impurity standards are available for the synthesis of this compound.</p>

<p>Sorafenib is a drug that is used to treat cancer. Sorafenib impurity 31 is an impurity of sorafenib and it has been identified as a metabolite of sorafenib. It can be synthesized in the laboratory or found in nature. Sorafenib impurity 31 can be used to develop a high purity standard for HPLC analysis, an analytical standard for R&amp;D purposes, and a custom synthesis for niche or drug product development.</p>

<p>Alanycarb is a potent protein kinase inhibitor that has shown promising results in the treatment of cancer. It works by inhibiting the activity of kinases, which are enzymes that play a crucial role in cell growth and proliferation. Alanycarb induces apoptosis, or programmed cell death, in cancer cells and has been found to be particularly effective against tumors that are resistant to other anticancer drugs. This analog of cellulose has been tested on human and Chinese urine cancer cells and has shown significant tumor inhibition effects. Alanycarb is one of the most promising inhibitors for the development of new anticancer drugs due to its potent activity against various types of cancer cells.</p>

<p>1-β-D-Arabinofuranosyl-5-methylcytosine is an analog of the anticancer drug indirubin that has been shown to induce apoptosis in cancer cells. It is a potent inhibitor of human protein kinases, particularly those involved in cell cycle regulation and proliferation. This compound has been found in Chinese urine samples and has been studied extensively as a potential cancer treatment. 1-β-D-Arabinofuranosyl-5-methylcytosine inhibits tumor growth by blocking the activity of various kinases involved in cancer cell signaling pathways. As such, it is considered a promising candidate for future cancer therapies.</p>

<p>Butenachlor is a potent anticancer inhibitor that targets tumor kinases. It works by inhibiting the activity of certain proteins in cancer cells, leading to apoptosis (cell death) and preventing the growth and spread of cancer. Butenachlor has been shown to be effective against various human cancers, including lung, breast, and colon cancer. It is an analog of saxagliptin, a drug used to treat type 2 diabetes. Butenachlor is excreted primarily in urine and has been found to have low toxicity in preclinical studies. This promising new drug may hold great potential for the treatment of cancer in the future.</p>

<p>Pantoprazole is a proton pump inhibitor that inhibits the gastric acid secretion by blocking the hydrogen/potassium ATPase enzyme in the stomach. Pantoprazole N-oxide, a prodrug of pantoprazole, is converted to pantoprazole after administration and has been shown to be more stable than pantoprazole. It has been shown to have tissue-specific effects, with high concentrations found in gastrointestinal tissues such as the abomasum, ileum, and colon. Pantoprazole N-oxide is also found in plasma samples at low levels. This drug may be useful for ulceration because it prevents heartburn caused by excess stomach acid.</p>

<p>Please enquire for more information about FASN-IN-1 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>4-Amino-6-chloro-benzene-1,3-disulfonic acid 1-amide 3-ethylamide is an analytical standard that is used in drug development and as a reference material. It is used to produce the USP/NF standard for HPLC and to develop new drugs. This compound is a metabolite of the drug clonidine hydrochloride. 4-Amino-6-chloro-benzene-1,3-disulfonic acid 1-amide 3-(ethylamide) is also known by its CAS number 166863–9. It has a molecular weight of 328.5 g/mol and it's been approved by the FDA for use in food animals. Impurities found in this compound are: methanol, acetone, formic acid, acetic acid, chloroform and sulfamic acid. This product can be custom synthesized or obtained from natural sources such as plant</p>

<p>Please enquire for more information about Pinacol-d12 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Haloxyfop-d4 is an analog of the herbicide Haloxyfop that has been shown to have anticancer properties. It works by inhibiting kinases, which are enzymes that play a key role in cell division and growth. This inhibition leads to apoptosis, or programmed cell death, in cancer cells. Haloxyfop-d4 has been found to be effective against a variety of human cancer cell lines, including those resistant to other anticancer drugs. In addition, it has been shown to inhibit the growth of tumors in animal models. This drug is metabolized in the liver and excreted in urine. It is not known to interact with other drugs such as rifampicin or protein kinase inhibitors.</p>

<p>This product is a synthetic impurity of Allopurinol. It is a cyclization reaction product of dimethylhydrazine and allopurinol in the presence of an organic solvent such as DMF.</p>

<p>Please enquire for more information about Chlorpromazine N-oxide maleic acid salt including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Chloromethyl olanzapinium chloride is an analytical reference material that can be used as a standard for HPLC-UV analysis. It is also used in the development of new drugs and as an impurity standard during drug manufacturing. Chloromethyl olanzapinium chloride has been shown to be a metabolite of Olanzapine, which is a niche drug product that is not commercially available. Chloromethyl olanzapinium chloride is listed by the USP, EP and JP as a drug product impurity. It can be synthesized from natural or synthetic sources.</p>

<p>(Z)-Fluvoxamine-EP is a drug product that is used as an analytical standard. It is a synthetic metabolite of fluvoxamine, which is a drug used for the treatment of depression. The synthesis of (Z)-fluvoxamine-EP is based on the asymmetric synthesis of fluvoxamine and the use of chiral chromatography to purify the product. This synthetic process allows for the production of high-purity (Z)-fluvoxamine-EP with a purity greater than 99%.</p>

<p>Please enquire for more information about 4-(Diphenylmethylene)-1-methylpiperidine including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Buprenorphine is a semi-synthetic opioid that is used to treat pain. It has been shown to have high purity, when compared to other synthetic opioids, and is often used as an analytical standard. Buprenorphine furanyl impurity is an impurity in buprenorphine that can be detected by high-performance liquid chromatography (HPLC). It is also a metabolite of the drug and can be used as a pharmacopoeia reference material.</p>

<p>Cetirizine 3-chloro impurity dihydrochloride is a drug substance that contains the impurity cetirizine. The compound has been found to have potential risks and should be synthesized with the use of appropriate methods. Cetirizine 3-chloro impurity dihydrochloride is a drug substance that contains the impurity cetirizine, which should be synthesized with the use of appropriate methods. Cetirizine 3-chloro impurity dihydrochloride has been found to have potential risks and should be synthesized with appropriate methods.</p>

<p>Flubendazole alcohol is a drug product that is an impurity standard for the synthesis of flubendazole. It is also used as a metabolite and an analytical reference material in drug development, natural product research and development, and metabolism studies. Flubendazole alcohol is considered to be high purity, with 98% purity by HPLC standards. The CAS number for this product is 82050-12-2.</p>

<p>PBB 154 is a medicinal compound that has shown promising results in the treatment of cancer. This analog of a kinase inhibitor has been found to inhibit the activity of kinases, which are enzymes that regulate cell cycle progression and play a critical role in tumor growth. PBB 154 has been shown to induce apoptosis, or programmed cell death, in cancer cells. This compound has also been found to be effective against various types of cancer, including breast, prostate, and lung cancer. PBB 154 is an anticancer agent that works by inhibiting the activity of proteins involved in cell division and promoting apoptosis in cancer cells. It can be detected in urine and has potential for use as a diagnostic tool for detecting early stages of cancer.</p>

<p>Resolvin E2 is an analog of a protein found in human urine that has been shown to have anticancer properties. It works by inhibiting cyclin-dependent kinases, which are enzymes involved in the regulation of cell division and proliferation. Resolvin E2 induces apoptosis, or programmed cell death, in cancer cells and has been shown to inhibit tumor growth in Chinese hamsters. It is a promising inhibitor of cancer cell growth and may have potential as an anticancer drug.</p>

<p>Diethyl 2-propylimidazole-4,5-dicarboxylate is a synthesized intermediate that can be used in the synthesis of other organic compounds. It is a diethyl ester of tartaric acid and an intermediate in the preparation of other organic compounds. The diethyl ester is made by nitrating diethyl to give diethyl nitrite, which is then reacted with tartaric acid to form the desired product. Diethyl 2-propylimidazole-4,5-dicarboxylate has been shown to be toxic, but it has not been shown to have any carcinogenic effects.</p>

<p>3-Isobutyl-1-methyl-4-nitro-1H-pyrazole-5-carboxylic acid is a synthetic drug product that is used as an analytical reference standard. It is an impurity in the API 3,4,5,6,7,8,9,10 erythromycin (CAS No. 1004455-71-3). 3Isobutyl-1methyl 4nitro 1H pyrazole 5carboxylic acid has been custom synthesized for use in research and development of drugs for niche markets. It can be used as a HPLC standard for high purity and pharmacopoeia grade.</p>

<p>Dehydronitrosonisoldipine is a pyridine-containing compound that has been synthesized from dehydronitrosodiphenylamine. It is an ionic liquid with a melting point of 114°C and a boiling point of 272°C. Dehydronitrosonisoldipine has been shown to be active against some bacterial strains, but not others. It is effective for the treatment of infectious diseases such as H. influenzae, M. tuberculosis, and Listeria monocytogenes in animal studies. This compound also shows efficacy against some bacteria that are resistant to antibiotics such as penicillin and erythromycin in vitro. The molecular weight of dehydronitrosonisoldipine is 262.2 g/mol and its molecular formula is C12H14N2O4S2D6N2O6.</p>

<p>Propylthiouracil-d5 is a drug product that is used in the development of drugs. Propylthiouracil-d5 is a synthetic compound, which is also known as propylthiouracil (PTU). It has been used as an antithyroid drug and has been shown to have anti-inflammatory properties. PTU is metabolized by oxidation, hydrolysis, or conjugation with glucuronic acid. The major metabolites are 4′-hydroxypropylthiouracil and the 2′-glucuronide conjugate. The metabolite 4′-hydroxypropylthiouracil has been detected in urine at concentrations of up to 600 ng/mL following oral administration of PTU.</p>

<p>Beperidium iodide is a diagnostic agent that is used to identify the presence of glycerides and fatty acids in the skin through electrical impedance measurements. It has been shown to be effective for implanting in fatty tissue, including the nasal area. Beperidium iodide is a polyvalent ionic preparation that contains magnesium, pharmaceutical grade excipients, and fatty acid esters. This drug is usually formulated as a cream or ointment, which can be applied topically to the desired site.</p>

<p>Cetirizine impurity F is a potential impurity of cetirizine and ranitidine. It has been shown to be present in the final drug substance and has been found to have the same profile as cetirizine. Cetirizine impurity F can be synthesized from metformin, which is an active ingredient in diabetes treatment. This agent belongs to the group of medicines called antihistamines that are used for relieving allergy symptoms such as runny nose, sneezing, itchy eyes, and itchy throat. Cetirizine impurity F is a member of the drug class called H1-antihistamines that competitively binds to histamine receptors on cells responsible for allergic reactions.</p>

<p>Exicorilant is an analog of capsaicin, which has been shown to have anticancer properties. It is a potent inhibitor of protein kinases and has been demonstrated to induce apoptosis in human cancer cells. Exicorilant specifically targets tumor cells and inhibits their growth by blocking the activity of certain kinases that are essential for cell division. This anticancer drug has been tested on Chinese hamster ovary cells and found to be effective in inhibiting the growth of various types of cancer cells. In addition, exicorilant has shown promising results in urine samples from patients with advanced cancers, indicating its potential as a diagnostic tool for cancer detection. Overall, exicorilant is a promising inhibitor with potential therapeutic applications for cancer treatment.</p>

<p>The 1-aza-8-hydroxy-6-oxo-oct-2-en-1-oylimidazole is a prodrug that is hydrolyzed to form the active compound clavulanate. It can be used for the treatment of infections caused by beta lactamase producing bacteria such as penicillinase producing staphylococci and beta lactamase producing streptococci. The 1-(4-Aza)8-(6-oxo)oct-(2)en-(1)-oylimidazole binds to penicillin binding proteins, which prevents the formation of an antibiotic inhibitor complex with the enzyme cell wall synthesis that is required for cell wall biosynthesis, inhibiting protein synthesis and cell division. The clavulanic acid moiety in this drug also inhibits beta lactamases produced by bacteria, resulting in increased efficacy against these organisms.</p>

<p>(S,S)-Dihydro bupropion hydrochloride (Bupropion) is an antidepressant that is used for the treatment of major depressive disorder and seasonal affective disorder. It is a racemic mixture of the two enantiomers, (S,S) and (R,R), with the former being more active than the latter. The drug product contains a racemic mixture of (S,S) and (R,R) in a ratio of approximately 97:3. The analytical impurity in this product is N-desmethyl-bupropion. This impurity has not been found to be pharmacologically active. Bupropion may be synthesized by reacting benzaldehyde with propargyl bromide in presence of sodium hydroxide in ethanol to form a cyclic imine intermediate which is then hydrolyzed to yield bupropion</p>

<p>1,2,3,4,5-Pentabromo-6-(2,3,4-tribromophenoxy)benzene is a medicinal compound that has been used in Chinese traditional medicine as an anticancer agent. It is an analog of a natural product found in urine that inhibits kinases involved in cancer cell growth and survival. This compound has been shown to induce apoptosis (programmed cell death) in tumor cells and inhibit the activity of proteins involved in cancer development. It acts as a potent inhibitor of kinase inhibitors and has demonstrated efficacy against various types of human cancers. Its unique molecular structure makes it an attractive candidate for further development as a potential therapeutic agent for cancer treatment.</p>

<p>Methapyrilene fumarate is a synthetic maleate salt of methapyrilene. This drug is used in the treatment of high blood pressure. It has been shown to have an effect on the microvasculature, which may be due to its ability to inhibit the release of nitric oxide and other vasoactive substances from endothelial cells. Methapyrilene fumarate also inhibits the release of fatty acids from adipose tissue and ephedrine hydrochloride from catecholamines from adrenal medulla cells. The drug is also used as a nutritional supplement, although it has not been approved for this use by the FDA.</p>

<p>Oxo Simvastatin is a synthetic drug product that belongs to the class of statins. It is used as a research and development impurity standard in pharmacopoeia, and as a high-purity analytical standard in niche applications. Oxo Simvastatin is metabolized by cytochrome P450 enzymes to form a variety of metabolites, including simvastatin acid, which can be measured using HPLC.</p>

<p>PF-06843195 is a potent analog of a medicinal compound that has shown anticancer activity against various types of cancer cells. It is a kinase inhibitor that targets specific proteins involved in tumor growth and progression. PF-06843195 has been shown to induce apoptosis (cell death) in human cancer cells, making it a promising candidate for the development of new cancer treatments. This compound has been tested extensively in Chinese hamster ovary cells and urine samples from patients with cancer, demonstrating its ability to inhibit kinases and prevent the proliferation of cancer cells. Overall, PF-06843195 holds great potential as an effective anticancer agent and warrants further investigation.</p>

<p>1-Desmethyl granisetron is an impurity found in the synthesis of granisetron hydrochloride. It is a white to off-white crystalline substance which is soluble in water, methanol, and ethanol. 1-Desmethyl granisetron has a molecular weight of 328.4 and exhibits efficient pharmacological properties similar to those of granisetron hydrochloride.</p>

<p>2-[(4-Methoxy-3-methyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole is a synthetic, impurity standard that is used in the synthesis of drug products. It has been shown to inhibit the metabolism of drugs and may be used as a marker for drug metabolism. This compound may also be used as a marker in analytical studies to assess the purity of a drug product. 2-[(4-Methoxy-3-methyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole has not been evaluated for safety or efficacy.</p>

<p>Please enquire for more information about Diphenyl sulfone-3,3'-disulfonyl chloride including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Remdesivir impurity 5 is a metabolite that is generated in the body following metabolism and excretion of remdesivir. It has been shown to be present in urine, plasma, and cerebrospinal fluid following administration of remdesivir. Remdesivir impurity 5 binds to the active site of HIV reverse transcriptase with a Kd value of 0.5 nM. The chemical name for this compound is (5R)-3-[[3-[(2S,4R)-2-amino-4-(2-methylpropyl)piperidin-1-yl]-1H-indol-6-yl]carbonyl]benzoic acid methyl ester.</p>

<p>Fluticasone furoate is a synthetic corticosteroid that has anti-inflammatory and immunosuppressive properties. It binds to the glucocorticoid receptor, which inhibits the production of inflammatory cytokines and mediators. The impurity standard used in this product is Fluticasone furoate EP impurity G. This impurity is a metabolite of fluticasone furoate with a molecular weight of 488. It has been shown that this impurity may have an effect on the pharmacokinetics of fluticasone furoate.</p>

<p>N,N-Dimethyl-9-oxo-9H-thioxanthene-2-sulfonamide is a medicinal compound that has shown promising results as an anticancer agent. It is an inhibitor of kinases, which are enzymes involved in cell signaling pathways that regulate cell growth and division. This compound has been shown to induce apoptosis, or programmed cell death, in cancer cells. In Chinese hamster ovary cells, it has been shown to inhibit the activity of protein kinase C (PKC) and mitogen-activated protein kinase (MAPK), two important kinases involved in cancer development. N,N-Dimethyl-9-oxo-9H-thioxanthene-2-sulfonamide is an analog of a tumor inhibitor found in human urine and has the potential to be developed into a potent anticancer drug.</p>

<p>Montelukast impurity I is an impurity found in the drug product, Montelukast. It is a natural substance and is produced as a result of metabolism studies. The chemical name for this impurity is 3-hydroxy-4-(2-methylpropyl)-5-(4-methoxyphenyl)pentanoic acid. This impurity can be used as an analytical standard and can be synthesized for use in pharmacopoeia. This compound has not been shown to have any therapeutic effects on humans or animals. This impurity has been shown to cause nausea, vomiting, and diarrhea in some patients.</p>

<p>Aceclofenac is a nonsteroidal anti-inflammatory drug (NSAID) that belongs to the propionic acid derivative group. It is used in the treatment of mild to moderate pain and inflammation, such as arthritis. Aceclofenac is rapidly hydrolyzed by esterases in the small intestine, resulting in the release of aceclofenac acid. Aceclofenac benzyl ester is a chemical intermediate that has been shown to be an efficient method for producing aceclofenac acid. It can be obtained by reacting bromoacetic anhydride with methyl alcohol and then hydrolyzing the product with strong acids. This compound may contain impurities, such as nucleophilic impurities, which can lead to side effects.</p>

<p>3-(2-Fluorophenyl) ezetimibe is an impurity of the drug product Ezetimibe. It is a metabolite that has been shown to have analytical and research and development applications. 3-(2-Fluorophenyl) ezetimibe is soluble in organic solvents such as acetone, ethanol, or chloroform and insoluble in water. The impurity standard for 3-(2-Fluorophenyl) ezetimibe conforms to the USP/NF monograph for Ezetimibe Impurities A, B, C, D, E and F. The CAS number for this impurity is 1798008-25-9.</p>

<p>Rosuvastatin anhydro lactone is a pure chemical compound that is used as an analytical reference standard for high-performance liquid chromatography (HPLC) for the determination of purity and identification of impurities in pharmaceuticals. It is also utilized as a drug development, API impurity, and HPLC standard. Rosuvastatin anhydro lactone is a metabolite of rosuvastatin and is chemically designated as C22H29NO3. The CAS number for rosuvastatin anhydro lactone is 1246665-85-9.</p>

<p>Please enquire for more information about N-Deacetyl-N-formyl agomelatine including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about N,N-Didesmethyl N-tert-butoxycarbonyl diltiazem including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Hirsutidin chloride is a plant flavonol glycoside that has been found to be an effective ingredient for the treatment of skin conditions such as dryness and aging. Hirsutidin chloride is also known to have an anti-inflammatory effect. It is used as a matrix polymer in cosmetics, and its use in this capacity has shown promising results in clinical trials. This compound's high molecular weight and hydrophilic nature make it suitable for use as a skin moisturizer. Hirsutidin chloride can be used to target tissues with high concentrations of hyaluronic acid, such as the skin and eyes, or areas prone to dryness, such as the lips. Hirsutidin chloride is soluble in water and hydrochloric acid but insoluble in alcohols, esters, ethers, acetone, chloroform, ethyl ether, mineral oil or petroleum jelly. <br>Hirsutidin chloride has strong fluorescence properties under</p>

<p>Please enquire for more information about PD-166285-d4 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>(5S)-5-(Aminomethyl)-3-[3-fluoro-4-(4-morpholinyl)phenyl]-1,3-oxazolidin-2-one is a molecule with a broad spectrum of antimicrobial activity. It is a potent inhibitor of the enzyme metallo-β-lactamase, which is found in Streptococcus faecalis and other bacteria. This molecule also has antibacterial activity against Streptococcus pyogenes and Staphylococcus aureus. (5S)-5-(Aminomethyl)-3-[3-fluoro-4-(4-morpholinyl)phenyl]-1,3-oxazolidin-2 -one is an amide with mass spectrometric and spectroscopic properties that can be used as analytical methods to identify it in biological samples.</p>

<p>Ly-338979 dimethyl ester is a drug product that is custom synthesized for research and development. It has the CAS number of 1320346-45-9, and exhibits high purity. Ly-338979 dimethyl ester is an analytical standard that is metabolized by the liver to produce metabolites, which can be measured using HPLC. The natural form of Ly-338979 dimethyl ester is also a drug product with a niche in pharmacopoeia. This synthetic compound is an impurity standard used in research and development and HPLC standards.</p>

<p>N-(5,6-Dichloro-1,4-dihydro-2-quinazolinyl)-2,3-dihydroxypropanamide 2,2,2-trifluoroacetate is an analytical reference standard that can be used as a high purity drug product impurity in HPLC. It also has niche application as an API impurity and is a metabolite of the drug quinine.</p>

<p>Fluticasone Impurity D is a sulfoxide that is found in the drug fluticasone. It is a conjugate of fatty acid and fatty alcohol, which are esters of irritants. Fluticasone Impurity D is an experimental model for inflammatory diseases. It can be used as a pharmaceutical dosage to enhance the effects of other drugs by increasing their absorption through the skin. The effects of this drug have been tested on tissues and experimental models, but not on humans.</p>

<p>N-Hydroxy riluzole O-b-D-glucuronide is an analytical standard and drug development metabolite. It is a metabolite of the anti-convulsant agent riluzole, which is used in the treatment of amyotrophic lateral sclerosis (ALS). Riluzole is converted to N-hydroxyl riluzole O-b-D-glucuronide in the liver by UDP glucuronosyltransferase. N-Hydroxyl riluzole O-b-D-glucuronide has been shown to block protein synthesis in rat kidney cells. It also blocks the conversion of amino acid tyrosine to dopa in dopaminergic neurons, and inhibits dopamine uptake into synaptosomes.</p>

<p>N-Methyl-4-phenylpiperidine is a synthetic drug that acts as a stimulant. It is a structural analog of the neurotransmitter acetylcholine and has been shown to have similar effects in knockout mice. N-Methyl-4-phenylpiperidine is metabolized by hydrolysis of the amide group, leading to the formation of alphaprodine and hydroxyphenylacetic acid. This drug has been shown to inhibit dopamine and serotonin uptake in rats, which may be related to its psychostimulant effects. Clinical pharmacology studies have shown that this drug can increase blood pressure, heart rate, and respiration rates in humans.</p>

<p>Pep2-SVKE is an analog of a protein kinase inhibitor that has shown potent anticancer activity. It induces apoptosis in cancer cells, particularly Chinese hamster ovary (CHO) and human tumor cell lines. Pep2-SVKE inhibits kinases involved in the regulation of cell growth and proliferation, making it a promising candidate for the development of novel anticancer therapies. This compound has been isolated from urine and has potential medicinal applications in the treatment of various types of cancer. Its unique properties make it a valuable addition to any research into cancer therapies and inhibitors.</p>

<p>Gastrofensin an 5 is a drug product that is undergoing research and development. It is not yet approved for use in humans. Gastrofensin an 5 is used as a reference substance in analytical work, metabolism studies, and natural product analysis. The CAS No. for this compound is 89845-16-9. Gastrofensin an 5 has the following impurities: 0.1% (m/m) of 2-(6-chloroquinolin-2-yl)acetic acid; 0.1% (m/m) of 2-(6-chloroquinolin-3-yl)acetic acid; 0.1% (m/m) of 2-(6,7-dichloroquinolyl)-acetic acid; 0.1% (m/m) of 3-(6,7 dichloroquinolyl)-acetic acid; 0.1% (</p>

<p>Regorafenib metabolite M5 is a drug product that is custom synthesized by our company and has high purity. It can be used in metabolism studies, drug development, and pharmacopoeia due to its natural origin. It is also a synthetic compound that can be used as an impurity standard or research and development standard in HPLC.</p>

<p>Taxine A is a potent inhibitor of kinases that has been isolated from the Chinese yew tree. It has shown promising results in inhibiting the growth of cancer cells and inducing apoptosis. Taxine A exhibits a unique mechanism of action by binding to a specific site on the kinase, which prevents its activation and subsequent downstream signaling. This analog of linezolid has been shown to have potent anticancer activity against various tumor cell lines, including human breast cancer and lung cancer. Taxine A is also excreted in urine, making it an attractive candidate for non-invasive diagnostic tests for cancer. Its ability to inhibit kinases makes it a potential therapeutic agent for a wide range of cancers.</p>

<p>3,4-Dimethoxyphenyl isopropyl ketone (DMPK) is a calcium antagonist that has been shown to be hypotensive in rats. It is also used as a pharmacological agent to study muscle physiology and biotransformations. DMPK has been shown to have microbial uptake and chronotropic properties, which may explain its use in the treatment of bacterial infections. DMPK binds to sulfoxides and chiral compounds, blocking their activity by inhibiting the enzyme systems involved in oxidation reactions. The drug is an analog of benzyl alcohol, with which it shares similar pharmacological profile.</p>

<p>Defluoropitavastatin calcium salt is a synthetic, high purity, pharmacopoeia drug product. It is a metabolite of pitavastatin and has been shown to have similar pharmacological activity. Defluoropitavastatin calcium salt has a niche in the analytical industry due to its high purity and stability. It has been used as an impurity standard for HPLC analysis. Defluoropitavastatin calcium salt is not found in nature and can be synthesized with the help of our Custom Synthesis service.</p>

<p>Talaromycesone A is a natural product derived from the fungus Talaromyces erythraeus. It is a metabolite of the antibiotic talaromycin and has been identified as an impurity in the drug product talaromycin sulfate. Talaromycesone A is a metabolite of the antibiotic talaromycin, which is produced by Talaromyces erythraeus, and has been identified as an impurity in the drug product, talaromycin sulfate. The chemical name for this compound is 3-methyl-2-oxo-2H-chromene-6-carboxylic acid (1S,4R)-4-[(3S)-3,4-dimethylphenyl]-cyclohexyl ester.<br>Talaromycesone A was originally isolated from the fungus Talaromyces erythraeus and purified to be used as a reference standard for HPLC analysis</p>

<p>Solifenacin N-oxide is an anti-cholinergic agent that has been shown to be effective in the treatment of overactive bladder. Solifenacin N-oxide is a prodrug that is hydrolyzed in vivo to solifenacin, its active form. The compound reversibly binds to muscarinic receptors and inhibits the release of acetylcholine. Solifenacin N-oxide has been shown to have low levels of impurities and is highly soluble in water. It was also found to be stable when stored at room temperature for two months. This drug has a high flow rate and moderate retention time, which makes it suitable for reversed-phase liquid chromatography (RPLC). RPLC is a chromatographic technique that separates compounds by size, hydrophobicity, or charge.</p>

<p>Iso propyl ether abiraterone is a medicinal compound that has shown promising results in the treatment of cancer. It is an inhibitor of CYP17A1, which is a protein involved in the production of androgens such as testosterone. By inhibiting this protein, iso propyl ether abiraterone can reduce the levels of androgens in the body, which can slow or stop the growth of certain types of cancer cells. This compound has been shown to induce apoptosis (cell death) in cancer cells and has demonstrated anticancer activity in both human and Chinese hamster ovary cell lines. Iso propyl ether abiraterone is an analog of other kinase inhibitors and has potential for use in combination with other anticancer drugs.</p>

<p>Ranolazine-d8 dihydrochloride is a drug product that has been approved for the treatment of angina pectoris. Ranolazine is a drug that belongs to the class of antianginal drugs. It binds to ATP-sensitive potassium channels and inhibits the release of calcium from the sarcoplasmic reticulum, thereby inhibiting cardiac contractility. This chemical is an impurity in an API that was submitted for analytical purposes. The impurity standard is used as a reference in research and development and pharmacopoeia studies.</p>

<p>Amlodipine dimethyl ester is a drug product that has been custom synthesized by our company. This product is highly pure and has been analyzed using analytical methods. The metabolism of this compound has also been studied to determine the metabolites of this drug. Amlodipine dimethyl ester is a natural product, which can be found in plants such as the Amla tree. It is also used as a drug development and pharmacopoeia research standard for its purity and potency.</p>

<p>Methyl 2-(4-biphenylyl)propionate is a custom synthesis that is used for metabolism studies. It is a natural product, although it can be synthesized. Methyl 2-(4-biphenylyl)propionate has been shown to have pharmacopoeia and HPLC standards, as well as impurities and metabolites that can be used for analytical purposes. Methyl 2-(4-biphenylyl)propionate is an impurity standard in the drug development of niche drugs, such as synthetic penicillins and cephalosporins. Methyl 2-(4-biphenylyl)propionate has been used in research and development for its ability to bind to proteins in the adrenal cortex.</p>

<p>(R)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline is a chiral molecule with four stereocenters. It is synthesized by the reaction of sulfamic acid and cyclohexene in the presence of p-toluenesulfonic acid. The product formed is then dehydrogenated to produce (R)-1-phenyl-1,2,3,4-tetrahydroisoquinoline. This compound is soluble in organic solvents such as benzene and ethane and can be used as an acceptor for chiral stationary phases.</p>

<p>Tirofiban impurity 8 is an analytical standard for HPLC. It is a research-grade, high purity, impurity standard for the drug product. Tirofiban impurity 8 is a metabolite of tirofiban that has been shown to be pharmacologically active in animal models and in vitro. Tirofiban impurity 8 has a natural or synthetic origin and its CAS number is 2250244-25-6.</p>

<p>Flumethasone Impurity 10 is a synthetic drug product. It is for research and development purposes only and not for use in humans. Flumethasone Impurity 10 is metabolized through a number of metabolic transformations, including hydrolysis by esterases or glucuronidases, oxidation by cytochrome P450 enzymes, reduction by glutathione reductase, or conjugation with glucuronic acid. Flumethasone Impurity 10 can be used as an impurity standard for the determination of flumethasone in biological fluids.</p>

<p>8-(2-Pyrimidinyl)-8-aza-5-azoniaspiro[4.5]decane bromide (AZA) is a fluorogenic, low energy probe that emits light upon irradiation with ultraviolet light at 254 nm. It has been used as a reaction vessel for the study of electron transfer in the presence of various catalysts, and has been shown to have a high sensitivity for detecting reactive oxygen species. AZA also has chromatographic properties, which are based on its fluorescence properties, and can be used to identify anticholinergic agents. This probe's ability to detect chloride ions in tissue samples may be useful for the diagnosis of hypertension or heart disease.<br>AZA reacts with acetylcholine in a manner similar to other anticholinergic agents by competitively binding to muscarinic receptors, blocking the binding of acetylcholine with these receptors and preventing neurotransmission.</p>

<p>5-Acetyl-5,11-dihydro-10H-dibenz[b,f]azepin-10-one is a synthetic compound that belongs to the class of azepinones. It has been shown to have anti-inflammatory and antiallergic properties in animal models. The synthesis of 5-acetyl-5,11-dihydro-10H-dibenz[b,f]azepin-10-one involves the reaction of dodecyl chloride with ethylene diamine in the presence of hydrophilic interaction chromatography (HIC) and magnetic resonance spectroscopy (MRS). This process leads to the formation of an azepinone product.</p>

<p>Please enquire for more information about PBT Impurity 2 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>(-)-Tianeptine monosodium salt is a potent inhibitor of kinase activity that has shown anticancer properties in human urine. It has been found to inhibit the growth of cancer cells by inducing apoptosis, which is programmed cell death. (-)-Tianeptine monosodium salt also inhibits the activity of kinases, which are enzymes that regulate various cellular processes such as protein synthesis and cell division. This compound has been studied extensively for its potential use as an anticancer drug and has shown promising results in Chinese hamster ovary cells. In addition, it has been found to be a potent inhibitor of D-xylose kinase, which may have implications for the treatment of certain metabolic disorders. Overall, (-)-Tianeptine monosodium salt shows great potential as an effective inhibitor of cancer cell growth and other diseases related to kinase activity.</p>

<p>Binospirone hydrochloride is a drug product that is used in the treatment of depression. It belongs to the class of antidepressants and has been shown to be effective against major depressive disorder (MDD). Binospirone hydrochloride is metabolized by cytochrome P450 enzymes into two metabolites: 3-hydroxybinospirone and 2,3-dihydroxybinospirone. The natural form of binospirone hydrochloride is synthesized from tyrosine and phenylalanine. It is also found as an impurity in other pharmaceuticals, such as clomipramine, amitriptyline, and fluoxetine. It has been shown that this compound binds to the serotonin transporter (SERT) at high affinity. This binding inhibits the reuptake of serotonin from synapses, leading to increased extracellular concentrations of serotonin.</p>

<p>Ganciclovir mono-o-propionate is an analytical reference standard for HPLC analysis. It is also a drug development intermediate, an API impurity, and a metabolite of ganciclovir. Ganciclovir mono-o-propionate is a crystalline solid with a melting point of 119°C and a molecular weight of 312.5. This compound can be found in the USP/NF (2009) as an impurity in the ganciclovir product. Ganciclovir mono-o-propionate has been used by companies to synthesize ganciclovir or other analogues for research purposes. The natural form of this compound can be found in plants such as apple leaves and grape leaves, but it can also be synthesized from chloroacetic acid and propionic acid.</p>

<p>Oxolamine citrate salt is a pharmaceutical drug used for the treatment of scleroderma. It acts as an iron chelator and inhibits the production of the cytotoxic agent, podophyllotoxin, by inhibiting its conversion to epipodophyllotoxin. Oxolamine citrate salt has been shown to have a beneficial effect on Alzheimer's disease and may have therapeutic potential in other neurological diseases such as Parkinson's disease. The compound has been shown to inhibit acetonitrile-induced hyperactivity in mice. Oxolamine citrate salt has also been found to be effective against Pseudomonas aeruginosa and Staphylococcus aureus isolates that are resistant to oxacillin, ginkgetin, or pseudoephedrine. This drug can be analyzed using liquid chromatography with an acetonitrile gradient and a hypersil C18 column.</p>

<p>Please enquire for more information about NSC 37553 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>2-Amino-5,6-dichloro-3,4-dihydroquinazoline hydrobromide is a metabolite of the drug product 2-[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)ethylamino]benzeneacetic acid. It has been shown to inhibit protein synthesis in vitro and in vivo.</p>

<p>Serotonin β-D-glucuronide (5-HIAA) is a major metabolite of serotonin that is excreted in the urine. It can be used as an indicator for the presence of serotonin in tissues and other substances. 5-HIAA is mainly formed by the hydrolysis of serotonin by β-glucosidase, which converts it to 5-hydroxyindoleacetic acid (5-HIAA). This compound is also found in some foods, such as bananas and avocados. Serotonin β-D-glucuronide must undergo conjugation with glucuronic acid before it can be excreted from the body. The physiological effects of this compound are not well understood, but it may have a role in controlling blood sugar levels.</p>

<p>Fluticasone propionate is a synthetic corticosteroid that is used in the treatment of asthma. It is an esterified prodrug which requires hydrolysis by esterases in order to become active. Fluticasone propionate has shown clinical efficacy with oral administration and can be administered by inhalation or through the skin. This drug is available as a deuterated form for use in nuclear magnetic resonance spectroscopy and reaction monitoring. It also has a linear range of 10-1000 ng/mL and a quadrupole mass spectrometer detection limit of 0.1 pmol, which allows it to be used for plasma samples and reconstituted drugs.</p>