Peptidi
I peptidi sono catene corte di amminoacidi legate da legami peptidici, che svolgono ruoli chiave come molecole biologiche importanti nei processi cellulari. Funzionano come ormoni, neurotrasmettitori e molecole di segnalazione, e sono ampiamente utilizzati in applicazioni terapeutiche e diagnostiche. I peptidi sono anche cruciali nella ricerca per lo studio delle interazioni proteiche, delle attività enzimatiche e dei percorsi di segnalazione cellulare. Presso CymitQuimica, offriamo una vasta selezione di peptidi di alta qualità per supportare le vostre esigenze di ricerca e sviluppo in biotecnologia e farmacologia.
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Trovati 29609 prodotti di "Peptidi"
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Suc-LLVY-[Rh110]-[D-Pro]
Fluorogenic substrate peptide of the 20S proteasome. In its intact state this peptide is non-fluorescent, however when Rhodamine fluorophore is released upon hydrolysation, fluorescence can be detected. This peptide is therefore a useful tool for analysing the activity of the 20S proteasome as well as other chymotrypsin-like proteases and calpains. This peptide is also a substrate for chymase, papain, carboxypeptidase Y, proteinase yscE (kexin) and ingensin.The presence of the D-proline residue on the C terminal of the rhodamine molecule ensures one directional rhodamine cleavage which simplifies fluorescence studies. Rhodamine 110 is a laser grade fluorescent dye with excitation maxima at 496 nm and emission maxima at 522 nm.Peso molecolare:1,015.5 g/molAlloferon 1
Alloferon 1, a member of the Alloferons is extracted from the blood of experimentally infected Callifora vicina fly and demonstrates both antimicrobial and anti-tumour activity . The Alloferons are bioactive, cationic peptides and exhibit the ability to stimulate Natural Killer cell activity and IFN synthesis. Due to studies investigating the effect Alloferon 1 would have on the central nervous system it was shown that Alloferon 1 had no toxic effects and therefore has the potential to be used as an anti-tumour therapeutic.Colore e forma:PowderPeso molecolare:1,264.6 g/molNeuroendocrine Regulatory Peptide-1 (Rat)
CAS:This Neuroendocrine Regulatory Peptide-1 (rat) product can be used as an endogenous suppressor of vasopressin release and is available as a 0.1mg vial. The neuroendocrine regulatory peptide-1 (NERP1) is derived from VGF and it colocalizes with vasopressin in the hypothalamus and it has been found that NERPs prevent vasopressin release from the hypothalamus. Thus NERP1 is involved in body fluid homeostasis through modulating the release of vasopressin.Formula:C110H180N32O38Purezza:Min. 95%Peso molecolare:2,558.8 g/molHXB2 gag NO-33
Custom research peptide; min purity 95%. For different specs please use the Peptide Quote ToolPeso molecolare:1,719 g/molSpinorphin, Bovine
CAS:Custom research peptide; min purity 95%. For different specs please use the Peptide Quote ToolFormula:C45H64N8O10Peso molecolare:877.04 g/molIGRP Catalytic Subunit-related Protein (206-214)
Peptide corresponding to residues 206-214 of murine islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP), the autoantigen targeted by pathogenic CD8+ T cells in non obese diabetic (NOD) mice. Cells that recognize IGRP(206-214) are present in the earliest islet infiltrates of NOD mice and undergo avidity maturation as islet inflammation progresses to overt disease.Peso molecolare:1,094.6 g/molIntegrin-binding cell adhesive peptide
Derived from fibronectin, integrin-binding cell adhesive peptide can be used as an adhesion ligand, it contains the cell binding motif RGD. Providing integrin-mediated cell adhesion is a valuable tool for a wide variety of research applications particularly in cell culture and implants. The integrin-binding cell adhesive peptide can also functionalise biomolecules. This has been successfully demonstrated by the generation of a protease-degradable hydrogel containing the integrin-binding cell adhesive peptide that can support skin formation in vitro. Integrin-binding cell adhesive peptide has also been used to form hydrogels to adhere numerous cell lines, for example to study extracellular vesicle secretion.
Colore e forma:PowderPeso molecolare:861.3 g/molCLEAR-OX™ Resin
CLEAR-OXTM is a highly effective polymer-supported reagent for the formation of disulfide bonds. Developed by Peptides International, incorporated to the Cymit Quimica Group through vivitide, CLEAR-OXTM combines the power of solid phase chemistry with the versatility of solution-phase reactions. CLEAR resin, compatible with both aqueous and organic environments, is transformed to CLEAR-OX through attaching a lysine-preformed cyclic Ellman’s reagent (DTNB) to a CLEAR polymeric support. Since the mechanism is based on peptide capture, sensitive residues such as Tyr, Trp, and Met are not affected, leading to increased purity and yield. Single disulfide-bridged peptides with constrained amino acids have been successfully produced using CLEAR-OX with various ring sizes and lengths. Oxidations are performed at higher concentrations than solution methods, leading to reduced solvent use at scale. Furthermore, oxidations can be carried out immediately after cleavage with only two-fold CLEAR-OX excess to obtain satisfactory yields. There is also potential for recycling and automation.Purezza:Min. 95%H-His-D-Trp-D-Lys-Trp-D-Phe-Lys-NH2
CAS:H-His-D-Trp-D-Lys-Trp-D-Phe-Lys-NH2 is an inhibitor of cyclase that blocks the conversion of ATP to cAMP. It has shown to have potential as a biomarker for cancer tissues and can be used in experimental models of cancer. HHDLKPDTDLKYSHN2 also inhibits phosphodiesterase, which is involved in the breakdown of cAMP, and can be used to treat bowel disease.Formula:C49H63N13O6Purezza:Min. 95%Peso molecolare:930.13 g/molH-YNWNSFGLR^Y-NH2
Peptide H-YNWNSFGLR^Y-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
H-LPFPIIDDR^-OH
Peptide H-LPFPIIDDR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.Neuropeptide K
Custom research peptide; min purity 95%. For different specs please use the Peptide Quote ToolFormula:C175H284N52O52SPeso molecolare:3,980.4 g/molH-YGIDWASGR^-OH
Peptide H-YGIDWASGR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
OVA Peptide (323-339)
CAS:OVA Peptide (323-339) is a Chicken ovalbumin fragment that has been shown to have an immune checkpoint activity. It has been shown to be reactive with ISQAVHAAHAEINEAGR and can be used in the treatment of infectious diseases. This peptide is also used for histological analysis of microglia and toll-like receptor expression in skin cancer. OVA Peptide (323-339) also has the potential for use as a basic protein in α7 nicotinic acetylcholine therapy.Formula:C74H120N26O25Purezza:Min. 95%Peso molecolare:1,773.94 g/molAc-VQIVYK-OH
Peptide Ac-VQIVYK-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.H-KIPNPDFFEDLEPFR^-OH
Peptide H-KIPNPDFFEDLEPFR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.Triptorelin acetate
CAS:Triptorelin is an agonist of gonadotrophin-releasing hormone (GnRH-R). Androgen-deprivation therapy (ADT), based on GnRH agonists and antagonists, is the standard therapeutic approach for prostate cancer (PCa) patients. In castration-resistant prostate cancer (CRPC) GnRH agonists are associated with significant anti-proliferative/pro-apoptotic, anti-metastatic and anti-angiogenic effects, mediated by the Gαi/cAMP signalling cascade. The tryptophan residue in this peptide is replaced with the D-amino acids making the peptide resistant to degradation from proteases and therefore increasing the half-life of the peptide in vivo. Peptide is for research purposes only, strictly not for human use.Peso molecolare:1,310.6 g/molH-VPNALTDDR^-OH
Peptide H-VPNALTDDR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
Fluor-RRGG-OH
Peptide Fluor-RRGG-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.Biot-RKRSRAE-OH
Peptide Biot-RKRSRAE-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
SIVmac239 - 101
Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool
Peso molecolare:1,812.1 g/molLixisenatide
CAS:Custom research peptide; min purity 95%. For different specs please use the Peptide Quote ToolFormula:C215H347N61O65SPeso molecolare:4,858.49 g/mol[DABCYL]/[Glu(EDANS)] SARS-CoV-2 3C-like protease (3CLpro) substrate
3CLpro are the key enzymes required by coronaviruses to replicate. They cleave polyproteins to form replicase. This makes 3CLpro a drug target for protease inhibitors with particular interest to COVID-19. Synthetic 3CLpro substrates are being generated for their potential to inhibit the protease activity and thus replication cycle of coronaviruses.When this peptide is intact, fluorescence from the fluorophore (donor) EDAN is undetectable due to the proximity of the acceptor (quencher) Dabcyl. However, upon cleavage the fluorescence of the EDANS moiety, as measurably by excitation/emission 340/490nm, can be detected due to separation from the Dabcyl quencher. This product was shown to be a potent inhibitor of 3CLpro activity therefore, it has the potential to be a vital tool in the fight against SARS-CoV.Peso molecolare:2,079 g/molBiot-KAGFFKRQYKSILQEENRRDSWSYINSKSNDD-OH
Peptide Biot-KAGFFKRQYKSILQEENRRDSWSYINSKSNDD-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.TAT (48-59) amide
Biotin-Tat (47-57) is a cell penetrating cationic peptide derived from the N-terminus of the Tat protein, which is a trans-activator of the transcription protein present in the human immunodeficiency virus (HIV). Specifically Biotin-TAT (47-57) is located within the arginine-rich basic domain 48-60 of the TAT peptide which as a whole has three domains which function to aid HIV through transactivation, DNA binding and nuclear transport. As a cell penetrating peptide (CPP) TAT aids in the cellular uptake of molecules and hence serves a valuable purpose in transduction methods. This property has been demonstrated through its ability of allowing toxins such as the neurotoxin Botulinum neurotoxin Type A, produced by the Clostridium botulinum type A bacteria to penetrate the skin barrier non-invasively.This peptide has an uncharged C-terminal amide.Peso molecolare:1,589 g/molBuforin II
CAS:Buforin II is a highly potent antimicrobial peptide which was derived from buforin I, a peptide isolated from the stomach of the Asian toad, Bufo bufo garagrizans. Buforin II is an alpha-helical antimicrobial peptide, however it has far stronger antimicrobial activity against a broad spectrum of microorganisms compared with other alpha-helical antimicrobial peptides. Buforin II may have a different mode of action to that of other alpha-helical peptides targeting nucleic acids instead of cell membranes.Formula:C106H184N40O26Colore e forma:PowderPeso molecolare:2,434.85 g/molLCBiot-YGRKKRRQRRR-OH
Peptide LCBiot-YGRKKRRQRRR-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
[Sulfo-Cyanine5]-Val-Pro-Valp(OPh)2
Boc-Val-Pro-ValP(OPh)2 is a good inhibitor for HLE (Human Leukocyte Elastase) and porcine pancreatic elastase (PPE).Peso molecolare:1,379.7 g/molGP120 - W61D - 17
Custom research peptide; min purity 95%. For different specs please use the Peptide Quote ToolPeso molecolare:1,661.8 g/molE-64
CAS:E-64 is a chemical inhibitor that binds to the ATP synthase in mitochondria, inhibiting oxidative phosphorylation. This inhibition of mitochondrial energy production leads to cell death by apoptosis. E-64 has been shown to inhibit tumor growth in vitro and in vivo by inducing autophagy and inhibiting cancer cell proliferation. E-64 has also been shown to have proteolytic activity against serum proteins, which may be due to its ability to bind to the phosphate groups of proteins.Formula:C15H27N5O5H2OPurezza:Min. 95%Peso molecolare:366.42 g/molNMDAR3B/GRIN3B
Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool
H-LLIYWASTR^-OH
Peptide H-LLIYWASTR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.H-YNGIITDTIK^-OH
Peptide H-YNGIITDTIK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
C-Peptide (Human)
CAS:C-peptide is a peptide hormone that is cleaved from proinsulin in the pancreatic beta cells. Both C-peptide and insulin are released by the beta cells in the event of glycaemia. Due to it having a relatively long half life, compared to insulin, and the fact it is not immediately metabolised by the liver, makes C-peptide a useful biomarker to monitor beta cell function. Increased levels of C-peptide occurring in patients with insulin resistant type 2 diabetes mellitus, have been associated with macrovascular complications and cardiovascular morbidity. During in vitro studies it has also been found that C-peptide prevents endothelial cell reactive oxygen species from being formed and therefore oxidative stress is reduced. This also may lead to anti-inflammatory and anti-apoptotic responses.Formula:C129H211N35O48Purezza:Min. 95%Peso molecolare:3,020.27 g/molIFNB1 (118-132) Human deimmunised
Recombinant human interferon-β (IFNB) is a therapeutic for specific stages of multiple sclerosis (MS). However, a significant portion of patients develop neutralising antibodies within two years which prevent the clinical efficacy of the treatment- this was correlated to a specific rise in IgG. Sequencing of IFNB1 revealed CD4+ T cell epitope residues (118-132) that contain critical T cell activation residues. Identifying these sequences allows them to be manipulated to provide new interferon treatments that reduce the capacity to induce neutralising antibodies in MS patients. In addition, the critical residue isoleucine has been mutated to valine and shown to reduce the immunological response to this epitope. This IFNB1 (118-132) epitope can be used for immunological investigations as a deimmunised version of the epitope. In addition, it can be used as a control for T cell activation and antibody recognition via immunoassays and immunohistochemistry. This may provide further insights into specific haplotypes correlating to IFNB responses in MS treatment.Peso molecolare:1,891 g/molPAR-2 Agonist amide
Thrombin receptor inhibitory peptide (TRIP). Thrombin activates members of the PAR family of receptors to initiate a variety of signalling pathways.Protease activated receptors (PARs) are a distinctive four-member family of seven transmembrane G protein-coupled receptors (GPCRs) widely expressed in inflammatory cells. PARs are cleaved by certain serine proteases to expose a tethered ligand domain, this ligand domain then binds to and activates the receptors to initiate multiple signalling cascades. This peptide mimics the tethered peptide ligand of PAR- 2, but lacks the S42 residue which is important for receptor activation, and therefore acts as a thrombin antagonist peptide.Colore e forma:PowderPeso molecolare:1,297.7 g/molPA protein (Influenza A virus)
The PA protein is a subunit of the influenza virus polymerase complex and its endonuclease activity is vital in viral genome replication. As a phosphoprotein it is a casein kinase substrate and its N-terminus is responsible for the activation of a proteolytic process in which co-expressed proteins are degraded.During viral RNA synthesis PA produces 5' capped RNA oligonucleotides due to it cleaving the 5' terminus on pre-mRNA. It is possible that the PA protein could be used as a target in antiviral chemotherapy.Peso molecolare:1,054.6 g/molH-SFGWDLAK^-OH
Peptide H-SFGWDLAK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.Hepcidin (Mouse) (Bulk)
Bulk product of the mouse Hepcidin peptide hormone, which displays both iron regulation properties and anti-microbial activity. The disulfide bonds within this product are undetermined and it is available as a Trifluoroacetate Salt. Hepcidin is crucial to iron homeostasis in that it binds to ferroportin and inhibits it post translationally from exporting iron. Additionally Hepcidin is also known as LEAP-1 (liver-expressed antimicrobial peptide) due to it limiting the amount of circulating iron that is available to pathogens when it is induced by inflammatory cytokines. However this reduction in circulating iron lowers the amount needed for erythropoiesis. Thus conditions such as anemia of chronic disease may occur. This product can be used for researching disorders where iron is dysregulated.Formula:C111H169N31O35S8Purezza:Min. 95%Peso molecolare:2,754.2 g/molH-G^V^Y^D^G^R^E^HT^V^-OH
Peptide H-G^V^Y^D^G^R^E^HT^V^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.Biotin Apolipoprotein A-I (APOA1)(86-101)
Apolipoprotein A-I enables the efflux of fat molecules from within cells as high-density lipoprotein (HDL) particles for transport back into LDL particles or to the liver for excretion. HDLs are one of five major groups of lipoproteins. Increasing concentrations of HDL particles are strongly associated with decreasing accumulation of atherosclerosis within the walls of arteries. Apolipoprotein A-I is often used as a biomarker for prediction of cardiovascular diseases, such that low levels of APOA1 are associated with an increased risk of adverse events in patients with coronary artery disease. In such cases, APOA1 can be used as a biomarker to predict cardiovascular disease progression.This peptide contains a covalently bonded N-terminal Biotin tag that can be used for detection and purification.Peso molecolare:2,157 g/molAmylin (1-37) Human
Amylin, also known as islet amyloid polypeptide (IAPP), is a peptide hormone which is deficient in patients with diabetes mellitus (DM). Amylin is co-secreted with insulin from the pancreatic β-cells. It inhibits glucagon secretion, delays gastric emptying, and thus acts as a satiety agent. Amylin peptide is capable of forming aggregates, and pancreatic amyloid plaques are present in 90% of patients with DM. Formation of these plaques may be inhibited by insulin via the formation of heteromolecular complexes. Amylin is also involved in adiposity signalling and body weight regulation.Amylin is expressed in the human placenta during pregnancy where it may help regulate food intake by both the mother and foetus, and is involved in foetal development of bone, kidneys and pancreas.Colore e forma:PowderPeso molecolare:3,901.85 g/molHIV-1 Gag Protein p17 (76-84)
CAS:The HIV-1 Gag Protein p17 (76-84) is a basic protein that is involved in the virus life cycle. This peptide is a HLA-A*21-restricted immunodominant CD8+ T cell epitope and can be used to study the interaction between the immune system and HIV. The HIV Gag Protein p17 (76-84) has been shown to bind to mesomeric and acridone, which are biologically active peptides. These peptides can also be found in Epitope, Biologically Active Peptides, Peptides & Biochemicals.Formula:C44H72N11O15Purezza:Min. 95%Peso molecolare:981.12 g/molAc-SGVGNDLVL-NH2
Peptide Ac-SGVGNDLVL-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.IDR 1002
Synthetic host defence peptide derivative with strong anti-inflammatory properties.
Peso molecolare:1,651 g/molObestatin (Rat, Mouse)
CAS:Obestatin is a 23 amino acid gastrointestinal peptide, encoded for by the ghrelin gene and is known to reduce food intake through supressing appetite. This peptide has been found to influence the pancreas, cardiovascular system and adipose tissues as well as the gastrointestinal system. One study showed that when high-fat diet fed rats were given chronic administration of obestatin it prevented the development of non-alcoholic fatty liver disease. Consequently Obestatin has the potential to be used in preventing obesity-related diseases.Formula:C114H174N34O31Purezza:Min. 95%Peso molecolare:2,516.87 g/molLCBiot-LSALTPSPSWLKYKAL-NH2
Peptide LCBiot-LSALTPSPSWLKYKAL-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.AF10847
Activation of the inflammatory response is critical to various infectious agents. Pro-inflammatory cytokines like-IL-1α and IL-1β are upregulated upon the initial detection of infection and bind to IL-1R1 to activate the signalling cascade. However, a hyperinflammatory response can lead to oxidative stress, apoptosis, and conditions such as diabetes, rheumatoid arthritis, cancer, and ischemia.To maintain homeostasis there are moderators of the inflammatory response. Binding of interleukin IL-1 to IL-1R1 stimulates the inflammatory cascade. Alternately, AF10847 binds to IL-1R1 resulting in significant conformational change of IL-1R1 but its lack of any cytokine activity locks IL-1R1 in an inactive state inhibiting a signalling event. AF10847 has an exceedingly high affinity for IL-1R1 compared to 1α and IL-1β.Extensive searches for lower molecular mass IL-1R antagonists-for oral delivery as a therapeutic for rheumatoid arthritis are being carried out. AF10847 is a 21-mer that has high affinity for the conserved IL-1R1 binding site that is also recognised by IL-1β. The remarkable high affinity of AF10847 for IL-1R1 makes it a perfect candidate for further investigations into novel IL-1R1 inhibitor development.Colore e forma:PowderPeso molecolare:2,604.2 g/mol
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