Ranaconitine
CAS: 1360-76-5
Rif. 3D-BAA36076
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Informazioni sul prodotto
- (1Alpha,10Alpha,13Alpha,14Alpha,16Beta,17Xi)-20-Ethyl-7,8,9-Trihydroxy-1,14,16-Trimethoxyaconitan-4-Yl 2-(Acetylamino)Benzoate
- (1Alpha,14Alpha,16Beta)-20-Ethyl-7,8,9-Trihydroxy-1,14,16-Trimethoxyaconitan-4-Yl 2-(Acetylamino)Benzoate
- 2H-12,3,6a-Ethanylylidene-7,9-methanonaphth[2,3-b]azocine, aconitane-4,7,8,9-tetrol deriv.
- 7-Hydroxylappaconitine
- Aconitane-4,7,8,9-tetrol, 20-ethyl-1,14,16-trimethoxy-, 4-(2-(acetylamino)benzoate), (1alpha,14alpha,16beta)-
- Aconitane-4,7,8,9-tetrol, 20-ethyl-1,14,16-trimethoxy-, 4-[2-(acetylamino)benzoate], (1α,14α,16β)-
Ranaconitine is a diterpenoid alkaloid that can be found in the plants Ranunculus, Isolappula and Aconitum. It has been shown to have an uptake of 0.5-2 µg/cm2/min when applied topically to the skin of mice. Ranaconitine has also been shown to inhibit the growth of bacteria by binding to bacterial DNA gyrase and topoisomerase IV, preventing its replication and transcription. This anti-bacterial activity is reversible and not bactericidal. Ranaconitine has also been shown to have a concentration-time curve with a peak at 2 hours after application on the skin and a plateau between 8-24 hours. The mechanism studies showed that ranaconitine inhibits calcium ion transport through the cell membrane, which leads to inhibition of intracellular ATP production in bacteria.
Proprietà chimiche
Richiesta tecnica su: 3D-BAA36076 Ranaconitine
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