PF-06869206
CAS: 2227425-05-8
Rif. 3D-CPD42505
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Informazioni sul prodotto
PF-06869206 is a binder that binds to the parathyroid hormone receptor and inhibits its activity. It is used for the treatment of chronic kidney disease, where it reduces urinary flow rate and inhibits growth factor production, thereby reducing bone loss. PF-06869206 has been shown to lower blood calcium levels in wild-type mice with high-calcium diets, but does not affect the calcium levels of wild-type mice with low-calcium diets. This drug also inhibits parathyroid hormone secretion and decreases renal excretion of phosphate and chloride in vivo studies.
PF-06869206 is orally bioavailable and can be given both once or twice daily. In vivo studies have shown that this drug has nonselective binding properties as it binds to both active and inactive forms of the parathyroid hormone receptor.br>
Proprietà chimiche
Richiesta tecnica su: 3D-CPD42505 PF-06869206
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