PAR-2 Agonist amide
Rif. 3D-CRB1000569
| 1mg | 271,00 € | ||
| 500µg | 198,00 € |
Informazioni sul prodotto
- mpa-F(Cha)(Cha)RKPNDK-NH2 mpa is 3-mercaptopropionic acid
- Cha is cyclohexyl-L-alanineX-F-[Cha]-[Cha]-RKPNDK-amide3-Mercaptopropi onyl-Phe-[Cha]-[Cha]-Arg-Lys-Pro-Asn-Asp-Lys-NH2
- where X-OH is 3-mercaptopropionic ac id
- where Cha is cyclohexyl-L-al
Thrombin receptor inhibitory peptide (TRIP). Thrombin activates members of the PAR family of receptors to initiate a variety of signalling pathways.Protease activated receptors (PARs) are a distinctive four-member family of seven transmembrane G protein-coupled receptors (GPCRs) widely expressed in inflammatory cells. PARs are cleaved by certain serine proteases to expose a tethered ligand domain, this ligand domain then binds to and activates the receptors to initiate multiple signalling cascades. This peptide mimics the tethered peptide ligand of PAR- 2, but lacks the S42 residue which is important for receptor activation, and therefore acts as a thrombin antagonist peptide.
Proprietà chimiche
Richiesta tecnica su: 3D-CRB1000569 PAR-2 Agonist amide
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