Angiotensin IV (3-8)
Rif. 3D-CRB1000686
| 1mg | 271,00 € | ||
| 500µg | 198,00 € |
Informazioni sul prodotto
- H-VYIHPF-OH
Angiotensin-IV is primarily produced from angiotensin-III by the removal of an arginine residue from the N-terminal by membrane alanyl aminopeptidase N (AP-N). Ang-IV can however also be formed by the action of aminopeptidases on Ang-I directly.Ang-IV has been shown to enhance cognitive functions, although how it does this in still unclear. It has been suggested that Ang-IV is able to inhibit the insulin-regulated aminopeptidase (IRAP) receptor in the brain (originally defined as the AT(4) receptor). IRAP is a single-spanning transmembrane zinc-metallopeptidase that belongs to the M1 family of aminopeptidases and its substrates include vasopressin, somatostatin, and cholecystokinin. The half-life of these compounds are prolonged when IRAP is inhibited by Ang-IV, and this may result in the enhanced cognitive abilities seen with Ang-IV treatment. c-Met, a tyrosine kinase receptor that binds hepatocyte growth factor (HGF) has also been proposed as an Ang IV targets. c-Met is associated with memory and learning consolidation.
Proprietà chimiche
Richiesta tecnica su: 3D-CRB1000686 Angiotensin IV (3-8)
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