[Biotin]-GLP-1
Rif. 3D-CRB1000881
1mg | 452,00 € | ||
500µg | 371,00 € |
Informazioni sul prodotto
- Biot-HDEFERHAEGTFTSDVSSYLEGQAAKEFIAWLVKGR-NH2[Biotin]-HDEFERHAEGTFTSDVSSYLEGQAAKEFIA-W-LVKGR-amide[Biotin]-His-Asp-Glu-Phe-Glu-Arg -His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-S
Glucagon-like peptide (GLP)-1 is a gastrointestinal peptide hormone with multiple roles in relation to metabolism. The primary role of GLP-1 is increasing insulin secretion in the presence of high plasma glucose levels, in addition, GLP-1 also suppresses glucagon secretion from the pancreas. GLP-1 slows down gastric emptying and regulates appetite, both valuable in reducing food intake and body weight. These roles of GLP-1 make it a useful target in the management of type 2 diabetes mellitus (T2DM).GLP-1 exerts its effects by binding to and activating the class B G protein-coupled receptor (GPCR): GLP-1 receptor (GLP-1R). Receptor activation in turn activates signalling pathways which culminates in insulin secretion via CAMP and Ca2+ signalling.Recently evidence has increased for GLP-1 playing a cardio-protective role as well as regulating immune responses and even in kidney function. GLP-1 may also exert neuroprotective and neurotropic effects as it can decrease endogenous levels of amyloid-β (Aβ) and prevent Aβ-induced cell death.This peptide contains an N-terminal Biotin tag for simple detection and purification.
Proprietà chimiche
Richiesta tecnica su: 3D-CRB1000881 [Biotin]-GLP-1
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