CIGB 300
Rif. 3D-CRB1001190
| 1mg | 271,00 € | ||
| 500µg | 198,00 € |
Informazioni sul prodotto
- [Cyc(15,25)]H-GRKKRRQRRRPPQ(bA)CWMSPRHLGTC-OHP15-TatGRKKRRQRRRPPQ-X-CWMSPRHLGTC-acid
- disulphide bridged Cys15-Cys25H-Gly-Arg-Lys -Lys-Arg-Arg-Gln-Arg-Arg-Arg-Pro-Pro-Gln-[β-Ala]-Cys-T rp-Met-Ser-Pro-Arg-His-Leu-Gly-Thr-Cys-OHP15-Tat
CIGB-300 is an anti-casein kinase 2 (CK2) peptide. CK2 is a serine-threonine protein kinase with more than 300 substrates which plays a role in several cellular processes including cell growth and proliferation, cell viability, and apoptosis. CK2 is also frequently dysregulated in many human tumours phosphorylation by CK2 is a biochemical event involved in human oncogenesis. CIGB-300 binds to the phospho-acceptor domain of CK2 substrates, impairing the correct phosphorylation by the enzyme, thus reducing tumour cell adhesion, migration and invasion. CIGB-300 therefore has potential as a cancer therapy. P15 is fused to the cell-penetrating peptide derived from the HIV-Tat protein that has been extensively used for delivering peptides cargoes within cells. P15-Tat induces apoptosis in a variety of tumour cell lines.
Proprietà chimiche
Richiesta tecnica su: 3D-CRB1001190 CIGB 300
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