TAT-AKAP79 (326-336) scrambled
Rif. 3D-CRB1001278
| 1mg | 271,00 € | ||
| 500µg | 198,00 € |
Informazioni sul prodotto
- H-YGRKKRRQRRRKEMRESKESKS-OHYGRKKRRQRRRKEMRESKESKS-acidH-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Lys-Glu-Met-Arg-Glu-Ser-Lys-Gl u-Ser-Lys-Ser-OH
The activation of transient receptor potential cation channel subfamily V member 1 (TRPV1) is believed to play a role in hyperalgesia, asthma and hypertension. TRPV1 is important for neuronal pain detection as well as the detection of heat, capsaicin, protons and the neurotransmitter anandamide. -The scaffold protein AKAP79 targets kinases to phosphorylate TRPV1, however it has been shown that inflammatory intermediates prostaglandin-E2 or bradykinin can activate these kinases creating a route for inflammation to cause hyperalgesia.This product is composed of the TRPV1 interacting domain of AKAP79 reordered into a scrambled sequence and conjugated to the cell penetrating TAT domain. This product was shown in vivo to have no effect on TRPV1 algesia and thus is a vital control for research work. This product is a vital tool for research into suitable TRPV1 antagonists.
Proprietà chimiche
Richiesta tecnica su: 3D-CRB1001278 TAT-AKAP79 (326-336) scrambled
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