LL-37 fragment (30-34), LL30-34 Heavy
Rif. 3D-CRB1300680
| 25nMol | 182,00 € |
Informazioni sul prodotto
- NLVP-[U-13C6,15N4-Arg]-acidH-Asn-Leu-Val-Pro-[U-13C6,15N4-Arg]-OH
Cathelicidin-related antimicrobial peptides are a family of polypeptides primarily stored in the lysosomes of macrophages and polymorphonuclear leukocytes. Cathelicidins play a critical role in the mammalian innate immune defence, and protect against invasive bacterial infections. Peptides of the cathelicidin family of antimicrobial polypeptides are characterised by their highly conserved region (cathelin domain) and a highly variable cathelicidin peptide domain.Cathelicidin is cleaved into the antimicrobial peptide LL-37 by both kallikrein 5 and kallikrein 7 serine proteases. Excessive production of LL-37 is suspected to be a contributing cause in all subtypes of Rosacea. A recent study has shown that human cathelicidin LL-37 has a role in nuclear membrane disruption and formation of neutrophil extracellular traps (NETs) - suggesting a mechanism whereby LL-37 can increase the innate immune response.More recently, studies have shown that LL-37 binds to SARS-CoV-2 S protein and inhibits binding to its receptor hACE2, which may inhibit viral entry into the cell. LL-37 is upregulated by vitamin D, therefore this may be one mode of action for the positive outcomes seen with vitamin D treatment for Covid-19.
Proprietà chimiche
Richiesta tecnica su: 3D-CRB1300680 LL-37 fragment (30-34), LL30-34 Heavy
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